Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 54026192

GI number: 54026192

Start: 4371255

End: 4372853

Strand: Reverse

Name: serA [H]

Synonym: nfa42210

Alternate gene names: 54026192

Gene position: 4372853-4371255 (Counterclockwise)

Preceding gene: 54026193

Following gene: 54026191

Centisome position: 72.62

GC content: 71.36

Gene sequence:

>1599_bases
GTGAGCCAAGCAGGCCGTCCTGTTGTTCTGATCGCCGACAAGCTCGCCCAGTCGACCGTCGACGCGCTCGGTGACGGTGT
CGAGGTTCGCTGGGTCGACGGCCCCGACCGGCCGGCCCTGCTGGCGGCGGTCCCCGAGGCCGACGCGCTGCTCGTGCGCT
CGGCCACCACCGTCGACGCGGAGGTGCTCGAGGCGGGCAAGAACCTCAAGATCGTCGCCCGCGCCGGTGTCGGCCTCGAC
AACGTCGACGTGCCCGCGGCCACCGAGCGCGGCGTCATGGTCGTCAACGCGCCGACCTCCAACATCCACACCGCCGCCGA
GCACGCGGTCACCCTGCTGCTCGCCGCGGCCCGCCAGATCCCGGCCGCCGACGCCACCCTGCGCGAGCACACCTGGCAGC
GCAGCAAGTTCAACGGCGTCGAGATCTACGGCAAGACCGTCGGCGTGGTCGGCCTCGGCCGCATCGGCCAGCTGTTCGCC
GCGCGCCTGGCCGCCTTCGAGACCAAGATCATCGCCTACGACCCCTACGTCTCCCCGGCCCGCGCCGCCCAGCTCGGCAT
CGAGCTGGTCACGCTGGACGAGCTGCTGGGCCGCGCCGACCTCATCTCGGTGCACCTGCCCAAGACCCCGGAGACCAAGG
GCCTGCTCAGCAAGGAGAAGCTGGCGCTCACCAAGAAGGGCGTCATCATCGTCAACGCCGCGCGCGGTGGCCTGATCGAC
GAGCAGGCGCTGGCCGACGCGATCACCTCCGGCCACGTGCGGGCCGCGGGCATCGACGTCTTCGAGACCGAGCCCTGCAC
CGACAGCCCGCTGTTCGAGCTGCCGCAGGTCGTGGTCACCCCGCACCTGGGCGCCTCCACCACCGAGGCGCAGGACCGCG
CGGGCACCGATGTCGCCAAGTCGGTGCTGCTGGCGCTGGCCGGTGAGTTCGTGCCGGGCGCGGTGAACGTCACCGGCGGC
GCGGTCAGCGACGAGGTCGCCCCCTGGCTCGAGATCGTCCGCAAGCAGGGTGCCCTGGTGGGTGCGCTGTCGGACGAGCT
GCCGGTCAGCGTCGAGGTGCAGGTGCGCGGCGAACTCGCCGCCGAGGACGTGGCGGTGCTGGAGCTCTCGGCGTTGCGCG
GCATCTTCTCCGCGCTGGTCGAGGACCAGGTCACCTTCGTCAACGCGCCCGCGCTGGCGAAGGAGCGCGGCATCAGCGTC
GAGGTCACCACCGCCTCCGAGAGCCCCAGCCACCGCAGCGTCGTCGACCTGCGCGCGGTGTTCGGCGACGGCCGCACCCT
GAACGTGGCGGGCACGCTCACCGAGCCGCAGCAGGTGCAGAAGATCGTCAACATCAACGGCCGCAACTACGACATGCGCG
CCGAGGGCCTGAACCTGGCCGTGCTGAACTACGACGACCGCCCCGGCGCGCTCGGCAAGATCGGCACCCGCCTCGGCGAG
GCCGACATCGACATCCTGGCCGCCCAGCTGAGCCAGGACATCGACAAGGAAGGCGCCACCGTCATCCTGCGTGTCAACAA
GCCGGTTCCGGCCGACGTGCAGACCGCGATCGCCGAGGCCGTCGGCGCGGCCAAGATCGCCCTGGTCGACCTGTTCTGA

Upstream 100 bases:

>100_bases
CTGACGGCACCCGCCCACCGGGTGGCGGCACCCGCGCGAAGCTGGACCATTAAGCTGGGGCGCGGTAATTGCCGACCCCT
TTCTCCAGGAGTACCCCACA

Downstream 100 bases:

>100_bases
TCGAAACGACGTCGCCGCGCGCCGCCACCGCACCCCGGTGGCGGCGCGTGGGGCATGACGAGGAGTTGTCATGAAGCTTG
CGGTCATCCCCGGTGACGGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MSQAGRPVVLIADKLAQSTVDALGDGVEVRWVDGPDRPALLAAVPEADALLVRSATTVDAEVLEAGKNLKIVARAGVGLD
NVDVPAATERGVMVVNAPTSNIHTAAEHAVTLLLAAARQIPAADATLREHTWQRSKFNGVEIYGKTVGVVGLGRIGQLFA
ARLAAFETKIIAYDPYVSPARAAQLGIELVTLDELLGRADLISVHLPKTPETKGLLSKEKLALTKKGVIIVNAARGGLID
EQALADAITSGHVRAAGIDVFETEPCTDSPLFELPQVVVTPHLGASTTEAQDRAGTDVAKSVLLALAGEFVPGAVNVTGG
AVSDEVAPWLEIVRKQGALVGALSDELPVSVEVQVRGELAAEDVAVLELSALRGIFSALVEDQVTFVNAPALAKERGISV
EVTTASESPSHRSVVDLRAVFGDGRTLNVAGTLTEPQQVQKIVNINGRNYDMRAEGLNLAVLNYDDRPGALGKIGTRLGE
ADIDILAAQLSQDIDKEGATVILRVNKPVPADVQTAIAEAVGAAKIALVDLF

Sequences:

>Translated_532_residues
MSQAGRPVVLIADKLAQSTVDALGDGVEVRWVDGPDRPALLAAVPEADALLVRSATTVDAEVLEAGKNLKIVARAGVGLD
NVDVPAATERGVMVVNAPTSNIHTAAEHAVTLLLAAARQIPAADATLREHTWQRSKFNGVEIYGKTVGVVGLGRIGQLFA
ARLAAFETKIIAYDPYVSPARAAQLGIELVTLDELLGRADLISVHLPKTPETKGLLSKEKLALTKKGVIIVNAARGGLID
EQALADAITSGHVRAAGIDVFETEPCTDSPLFELPQVVVTPHLGASTTEAQDRAGTDVAKSVLLALAGEFVPGAVNVTGG
AVSDEVAPWLEIVRKQGALVGALSDELPVSVEVQVRGELAAEDVAVLELSALRGIFSALVEDQVTFVNAPALAKERGISV
EVTTASESPSHRSVVDLRAVFGDGRTLNVAGTLTEPQQVQKIVNINGRNYDMRAEGLNLAVLNYDDRPGALGKIGTRLGE
ADIDILAAQLSQDIDKEGATVILRVNKPVPADVQTAIAEAVGAAKIALVDLF
>Mature_531_residues
SQAGRPVVLIADKLAQSTVDALGDGVEVRWVDGPDRPALLAAVPEADALLVRSATTVDAEVLEAGKNLKIVARAGVGLDN
VDVPAATERGVMVVNAPTSNIHTAAEHAVTLLLAAARQIPAADATLREHTWQRSKFNGVEIYGKTVGVVGLGRIGQLFAA
RLAAFETKIIAYDPYVSPARAAQLGIELVTLDELLGRADLISVHLPKTPETKGLLSKEKLALTKKGVIIVNAARGGLIDE
QALADAITSGHVRAAGIDVFETEPCTDSPLFELPQVVVTPHLGASTTEAQDRAGTDVAKSVLLALAGEFVPGAVNVTGGA
VSDEVAPWLEIVRKQGALVGALSDELPVSVEVQVRGELAAEDVAVLELSALRGIFSALVEDQVTFVNAPALAKERGISVE
VTTASESPSHRSVVDLRAVFGDGRTLNVAGTLTEPQQVQKIVNINGRNYDMRAEGLNLAVLNYDDRPGALGKIGTRLGEA
DIDILAAQLSQDIDKEGATVILRVNKPVPADVQTAIAEAVGAAKIALVDLF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=406, Percent_Identity=38.9162561576355, Blast_Score=275, Evalue=8e-74,
Organism=Homo sapiens, GI145580578, Length=294, Percent_Identity=32.6530612244898, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4557499, Length=294, Percent_Identity=32.6530612244898, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI61743967, Length=273, Percent_Identity=33.3333333333333, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI4557497, Length=273, Percent_Identity=33.3333333333333, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI145580575, Length=294, Percent_Identity=32.6530612244898, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI6912396, Length=277, Percent_Identity=33.5740072202166, Blast_Score=146, Evalue=5e-35,
Organism=Escherichia coli, GI1789279, Length=273, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI87082289, Length=280, Percent_Identity=33.9285714285714, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=38.7755102040816, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1788660, Length=271, Percent_Identity=34.3173431734317, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87081824, Length=305, Percent_Identity=25.9016393442623, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=298, Percent_Identity=45.3020134228188, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI25147481, Length=274, Percent_Identity=33.9416058394161, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320925, Length=276, Percent_Identity=32.2463768115942, Blast_Score=163, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6322116, Length=273, Percent_Identity=31.1355311355311, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=37.037037037037, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324964, Length=282, Percent_Identity=26.9503546099291, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6325144, Length=149, Percent_Identity=33.5570469798658, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=172, Percent_Identity=29.6511627906977, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=210, Percent_Identity=25.2380952380952, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19921140, Length=305, Percent_Identity=44.5901639344262, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI24585516, Length=280, Percent_Identity=31.4285714285714, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646446, Length=276, Percent_Identity=34.7826086956522, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24646448, Length=276, Percent_Identity=34.7826086956522, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24646452, Length=276, Percent_Identity=34.7826086956522, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24646450, Length=276, Percent_Identity=34.7826086956522, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI62472511, Length=276, Percent_Identity=34.7826086956522, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28571528, Length=279, Percent_Identity=36.2007168458781, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28574286, Length=281, Percent_Identity=32.7402135231317, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45552429, Length=311, Percent_Identity=30.2250803858521, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24585514, Length=311, Percent_Identity=30.2250803858521, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28574282, Length=311, Percent_Identity=30.2250803858521, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28574284, Length=311, Percent_Identity=30.2250803858521, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI45551003, Length=311, Percent_Identity=30.2250803858521, Blast_Score=132, Evalue=7e-31,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 55578; Mature: 55447

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQAGRPVVLIADKLAQSTVDALGDGVEVRWVDGPDRPALLAAVPEADALLVRSATTVDA
CCCCCCCEEEEEHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCEEEEECCCCCCH
EVLEAGKNLKIVARAGVGLDNVDVPAATERGVMVVNAPTSNIHTAAEHAVTLLLAAARQI
HHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
PAADATLREHTWQRSKFNGVEIYGKTVGVVGLGRIGQLFAARLAAFETKIIAYDPYVSPA
CCCCCHHHHHHHHCCCCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHEEEEEECCCCCHH
RAAQLGIELVTLDELLGRADLISVHLPKTPETKGLLSKEKLALTKKGVIIVNAARGGLID
HHHHHCEEEEEHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHEEECCEEEEECCCCCCCC
EQALADAITSGHVRAAGIDVFETEPCTDSPLFELPQVVVTPHLGASTTEAQDRAGTDVAK
HHHHHHHHHCCCEEEECCEEEECCCCCCCCHHHCCCEEEECCCCCCCCCHHHHCCHHHHH
SVLLALAGEFVPGAVNVTGGAVSDEVAPWLEIVRKQGALVGALSDELPVSVEVQVRGELA
HHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCC
AEDVAVLELSALRGIFSALVEDQVTFVNAPALAKERGISVEVTTASESPSHRSVVDLRAV
CCHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCEEEEEECCCCCCCCHHEEEHHH
FGDGRTLNVAGTLTEPQQVQKIVNINGRNYDMRAEGLNLAVLNYDDRPGALGKIGTRLGE
HCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCCCCHHHHHHHCCC
ADIDILAAQLSQDIDKEGATVILRVNKPVPADVQTAIAEAVGAAKIALVDLF
CHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEEEEEC
>Mature Secondary Structure 
SQAGRPVVLIADKLAQSTVDALGDGVEVRWVDGPDRPALLAAVPEADALLVRSATTVDA
CCCCCCEEEEEHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCEEEEECCCCCCH
EVLEAGKNLKIVARAGVGLDNVDVPAATERGVMVVNAPTSNIHTAAEHAVTLLLAAARQI
HHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
PAADATLREHTWQRSKFNGVEIYGKTVGVVGLGRIGQLFAARLAAFETKIIAYDPYVSPA
CCCCCHHHHHHHHCCCCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHEEEEEECCCCCHH
RAAQLGIELVTLDELLGRADLISVHLPKTPETKGLLSKEKLALTKKGVIIVNAARGGLID
HHHHHCEEEEEHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHEEECCEEEEECCCCCCCC
EQALADAITSGHVRAAGIDVFETEPCTDSPLFELPQVVVTPHLGASTTEAQDRAGTDVAK
HHHHHHHHHCCCEEEECCEEEECCCCCCCCHHHCCCEEEECCCCCCCCCHHHHCCHHHHH
SVLLALAGEFVPGAVNVTGGAVSDEVAPWLEIVRKQGALVGALSDELPVSVEVQVRGELA
HHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCC
AEDVAVLELSALRGIFSALVEDQVTFVNAPALAKERGISVEVTTASESPSHRSVVDLRAV
CCHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCEEEEEECCCCCCCCHHEEEHHH
FGDGRTLNVAGTLTEPQQVQKIVNINGRNYDMRAEGLNLAVLNYDDRPGALGKIGTRLGE
HCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCCCCHHHHHHHCCC
ADIDILAAQLSQDIDKEGATVILRVNKPVPADVQTAIAEAVGAAKIALVDLF
CHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]