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The map label for this gene is ubiB [C]

Identifier: 54025785

GI number: 54025785

Start: 4035947

End: 4037335

Strand: Reverse

Name: ubiB [C]

Synonym: nfa38150

Alternate gene names: 54025785

Gene position: 4037335-4035947 (Counterclockwise)

Preceding gene: 54025791

Following gene: 54025784

Centisome position: 67.05

GC content: 70.99

Gene sequence:

>1389_bases
GTGGAGGGTTGGACGATGGACGATCGGGTGCCGCGCGGCAGGCTGGCACGAGGCAGCAGGCTGGGCAGACTCGCCGCCGG
GCAGGCCGTGCGCGGTGTCGGCACCAAGGTCGCGATGCTCGGGCGCACCGAACAGGCGCGCCGGGCGTTGGCCGAGCGGT
CCGCCCTGCAGGCCGCGCAGCAGCTCGTCACCGTCCTCGGCGGAATGAAGGGCGCGGCCATGAAGCTCGGACAGATGCTC
TCGGTGCTCGACGTCGACCTGGTGCCCGAATCCCATCGCGAGCTCTTCCGCACCAAACTGGCCGAATTGCGGGACCGCGC
ACCGCACGTCGCGTTCGCGGCGATGCGCCGGGTGATCGAGGACGACCTCGGGCCGATGGCGCGGATCTTCGCCGACTTCG
ACGAGACGCCGATCGCGGCCGCCTCCATCGGGCAGGTGTACCGGGCGCGCCTGCGGGACGGGCGCGCGGTGGCCGTGAAG
GTGAAGTACCCCGGTGTCGACCAGGCCGTCGAGGCGGACCTGCGCAACCTGCGCATGATCGCGCGGTTGTGGAAATCGGT
GCTGCCCAGCGCCGCCGACACCGCCGTGCTCGACGAGGTCGCGCTCAACATCGGCGGCGAACTCGACTACCGGCGCGAGG
CCCGCGATCAGCACCGCGTCGCGAGCCGCTATCGCGGCCACCCCTACGTCCTGGTGCCCGACAGCATCATCGAGCACTGC
GGTCCGAACGTGCTCGTCACCGAACTCGTCGACGGCAGGCCCTTCGACGAGCTGCGGGCACTTCCGGATGCCGACCGCGA
CCACCTCGGCGAACTGATCTACCGCTTCTACATCAATTCCTTGTTCGTCGACTACGAATTCTGCGGCGACCCGCACCCCG
GCAACGTCCTGCTCGCCGCCGACGGCCGCGCCGCCTTCGTCGATTTCGGGCTGTACCACCGGATGAACCCGGTCGACGCC
GATTTCGAACGCGACTGCCTGCGCGCCGCGGGCGAGCACCGGGCCGACGACCTGTACGCGGCCTGGGTCGGGCGGGGCAT
CGTCGACCCGGATTCCGGTGTCACGGCCCAGGATTGCCTCGAATACGTGTGGGCGGCGGCGGGCTGGCACCTGCTCGACG
AGCCGATCACCATCACCCCCGAGATCGCCACCGGCGCCGTGGTGCTCGCCGTCGACCCGCGCGCCGTGCGCTTCCGGGGT
GTCCACCGTCAGCACCTGCCCCGCGAGCACGTGTTCTCCCGCCGCGCCGACCTGTTCACCTACGCGGTGCTCGGACAGTT
GGTGTGCACCGCCAACTGGCACCTGCTGGCGCGCGAATGGCTGCTCGGCGATACGCCGCACACGGAGGTCGGGCGCGCGA
TCGCGCGCTGGCGGGCCGAGCGGGGGTGA

Upstream 100 bases:

>100_bases
TCCGCTCAGCTTAACGACGCACAACGGGACGAACCACGAGAATCCGGCACCATACCGGGGCGGCGGTATTGTGACCGGCG
ACACCGCCGGGCCGGGAGTC

Downstream 100 bases:

>100_bases
GCGCGGGGGGCGTGCCCGGTGACAGGCGGGTGCCGGTGCTGTTTGTGCCCGGTGGCGAGGCCGGGGTGGCGGGTCACCGA
AGGGCCGTGGATCGTCCCGT

Product: putative ATP-binding protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MEGWTMDDRVPRGRLARGSRLGRLAAGQAVRGVGTKVAMLGRTEQARRALAERSALQAAQQLVTVLGGMKGAAMKLGQML
SVLDVDLVPESHRELFRTKLAELRDRAPHVAFAAMRRVIEDDLGPMARIFADFDETPIAAASIGQVYRARLRDGRAVAVK
VKYPGVDQAVEADLRNLRMIARLWKSVLPSAADTAVLDEVALNIGGELDYRREARDQHRVASRYRGHPYVLVPDSIIEHC
GPNVLVTELVDGRPFDELRALPDADRDHLGELIYRFYINSLFVDYEFCGDPHPGNVLLAADGRAAFVDFGLYHRMNPVDA
DFERDCLRAAGEHRADDLYAAWVGRGIVDPDSGVTAQDCLEYVWAAAGWHLLDEPITITPEIATGAVVLAVDPRAVRFRG
VHRQHLPREHVFSRRADLFTYAVLGQLVCTANWHLLAREWLLGDTPHTEVGRAIARWRAERG

Sequences:

>Translated_462_residues
MEGWTMDDRVPRGRLARGSRLGRLAAGQAVRGVGTKVAMLGRTEQARRALAERSALQAAQQLVTVLGGMKGAAMKLGQML
SVLDVDLVPESHRELFRTKLAELRDRAPHVAFAAMRRVIEDDLGPMARIFADFDETPIAAASIGQVYRARLRDGRAVAVK
VKYPGVDQAVEADLRNLRMIARLWKSVLPSAADTAVLDEVALNIGGELDYRREARDQHRVASRYRGHPYVLVPDSIIEHC
GPNVLVTELVDGRPFDELRALPDADRDHLGELIYRFYINSLFVDYEFCGDPHPGNVLLAADGRAAFVDFGLYHRMNPVDA
DFERDCLRAAGEHRADDLYAAWVGRGIVDPDSGVTAQDCLEYVWAAAGWHLLDEPITITPEIATGAVVLAVDPRAVRFRG
VHRQHLPREHVFSRRADLFTYAVLGQLVCTANWHLLAREWLLGDTPHTEVGRAIARWRAERG
>Mature_462_residues
MEGWTMDDRVPRGRLARGSRLGRLAAGQAVRGVGTKVAMLGRTEQARRALAERSALQAAQQLVTVLGGMKGAAMKLGQML
SVLDVDLVPESHRELFRTKLAELRDRAPHVAFAAMRRVIEDDLGPMARIFADFDETPIAAASIGQVYRARLRDGRAVAVK
VKYPGVDQAVEADLRNLRMIARLWKSVLPSAADTAVLDEVALNIGGELDYRREARDQHRVASRYRGHPYVLVPDSIIEHC
GPNVLVTELVDGRPFDELRALPDADRDHLGELIYRFYINSLFVDYEFCGDPHPGNVLLAADGRAAFVDFGLYHRMNPVDA
DFERDCLRAAGEHRADDLYAAWVGRGIVDPDSGVTAQDCLEYVWAAAGWHLLDEPITITPEIATGAVVLAVDPRAVRFRG
VHRQHLPREHVFSRRADLFTYAVLGQLVCTANWHLLAREWLLGDTPHTEVGRAIARWRAERG

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=331, Percent_Identity=30.2114803625378, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI27363457, Length=283, Percent_Identity=30.7420494699647, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI40254938, Length=307, Percent_Identity=30.2931596091205, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI41393593, Length=295, Percent_Identity=32.2033898305085, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI217416386, Length=227, Percent_Identity=31.2775330396476, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI217035081, Length=195, Percent_Identity=31.2820512820513, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI2367309, Length=350, Percent_Identity=26.8571428571429, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI32565180, Length=352, Percent_Identity=29.8295454545455, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17559152, Length=315, Percent_Identity=26.6666666666667, Blast_Score=108, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=322, Percent_Identity=28.8819875776398, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323282, Length=237, Percent_Identity=25.3164556962025, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI18859849, Length=315, Percent_Identity=31.7460317460317, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI22024280, Length=272, Percent_Identity=27.9411764705882, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24662575, Length=268, Percent_Identity=26.1194029850746, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 51378; Mature: 51378

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGWTMDDRVPRGRLARGSRLGRLAAGQAVRGVGTKVAMLGRTEQARRALAERSALQAAQ
CCCCCCCCCCCCCHHHCCCHHHHHHHCCHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHH
QLVTVLGGMKGAAMKLGQMLSVLDVDLVPESHRELFRTKLAELRDRAPHVAFAAMRRVIE
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DDLGPMARIFADFDETPIAAASIGQVYRARLRDGRAVAVKVKYPGVDQAVEADLRNLRMI
HCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH
ARLWKSVLPSAADTAVLDEVALNIGGELDYRREARDQHRVASRYRGHPYVLVPDSIIEHC
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEECHHHHHHC
GPNVLVTELVDGRPFDELRALPDADRDHLGELIYRFYINSLFVDYEFCGDPHPGNVLLAA
CCCEEEEHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEE
DGRAAFVDFGLYHRMNPVDADFERDCLRAAGEHRADDLYAAWVGRGIVDPDSGVTAQDCL
CCCEEEEEHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHH
EYVWAAAGWHLLDEPITITPEIATGAVVLAVDPRAVRFRGVHRQHLPREHVFSRRADLFT
HHHHHHCCCHHCCCCEEECCCCCCCEEEEEECCCHHHHCCCHHHHCCHHHHHHHHHHHHH
YAVLGQLVCTANWHLLAREWLLGDTPHTEVGRAIARWRAERG
HHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEGWTMDDRVPRGRLARGSRLGRLAAGQAVRGVGTKVAMLGRTEQARRALAERSALQAAQ
CCCCCCCCCCCCCHHHCCCHHHHHHHCCHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHH
QLVTVLGGMKGAAMKLGQMLSVLDVDLVPESHRELFRTKLAELRDRAPHVAFAAMRRVIE
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DDLGPMARIFADFDETPIAAASIGQVYRARLRDGRAVAVKVKYPGVDQAVEADLRNLRMI
HCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH
ARLWKSVLPSAADTAVLDEVALNIGGELDYRREARDQHRVASRYRGHPYVLVPDSIIEHC
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEECHHHHHHC
GPNVLVTELVDGRPFDELRALPDADRDHLGELIYRFYINSLFVDYEFCGDPHPGNVLLAA
CCCEEEEHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEE
DGRAAFVDFGLYHRMNPVDADFERDCLRAAGEHRADDLYAAWVGRGIVDPDSGVTAQDCL
CCCEEEEEHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHH
EYVWAAAGWHLLDEPITITPEIATGAVVLAVDPRAVRFRGVHRQHLPREHVFSRRADLFT
HHHHHHCCCHHCCCCEEECCCCCCCEEEEEECCCHHHHCCCHHHHCCHHHHHHHHHHHHH
YAVLGQLVCTANWHLLAREWLLGDTPHTEVGRAIARWRAERG
HHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]