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The map label for this gene is ygcA [C]

Identifier: 54025714

GI number: 54025714

Start: 3963275

End: 3964567

Strand: Reverse

Name: ygcA [C]

Synonym: nfa37440

Alternate gene names: 54025714

Gene position: 3964567-3963275 (Counterclockwise)

Preceding gene: 54025715

Following gene: 54025713

Centisome position: 65.84

GC content: 78.11

Gene sequence:

>1293_bases
ATGAACGGCTGGTCGGGCCGCAGCTTCGAGATCCGGCTGGGGCCGCCCGGGCACGGCGGCTTCTGCGTGGGCAGGCACGA
GGGCCGGGTGGTGTTCGTTCGGCATGGGCTGCCGGGGGAGACGGTGCTCGCGCGGGTCACCGAGGACCAGGGCGGCACGT
TCTGCCGGGCCGACGCGGTGGAGATCGTGCACGCCTCCGCCGACCGGGTGCCGCGGAGCTGCCCGGTTTCGGGCCCCGGT
GGCGCCGGATGCTGTGACTACACCCATGCCACGCCCGCCGCGCAGCGGGCGCTCAAGGCCACGGTGGTGGCGGAACTGCT
GCGCCGCGTCGCCGGACTGGAGCGGGAGGTCACCGTCGAGCCGGTGGCGGGCTGGCCCGCCGACGCCACCGGGGGCTGGC
GCACCCGGGTCCGGCTGCCGGTCGACGCCCTGGGCCGCGCGGGCGCGCACCGCTACCGCAGCGACGAGGTGATCGCCGAC
CTGCGCTGCCCGCAGCCCGTCGAGGGCGCGCTTGCGGGCATCGCGGAGCGGCGGTGGACGCCGGGCGCGGACCTGGTCGT
CGCACTCGACGCCGACGGCATCCGCCACATCGTGGAACTCGCGCCGCCCGAACCCGCGCGCGGCGGGCGCGACGGCCGCC
GCCGACCGGCCGGGCGGCGCCGCACCGCCGCCGCCCGCCGGGCCGCCGCGCACGCTCCCCGCCTCGAACAGGTGCGGGCG
GGTTCGGGCCGGGCGGTGGAGTACGTGGCCGGGCGCCGCTGGGAGATCTCGGCGACCGGGTTCTGGCAGGCGCATCGGCT
CGCGGCCCAGTGCTACTCCGATCTCGTCGCCGAGTGGGCCGAGCTGGCCGCCGGGGAGCGCGCCTGGGATCTCTACAGCG
GCGCGGGAGTGTTCGCGGCGCGGCTGGCCGAACAGGCCGGGCCGGACGGCGCCGTGCTCGCGGTGGAGTCGGCGCGGCCC
GCGGTCGCCGACGGCCGGGCCGCGCTGCGCGATCTGCCGTGGGTGGACCTGCGCGCCGCCCGCGTCGAACGCTGGGCCGG
CGAGCATGCGCGCACCGCGCCGCCGCGCGTGGTGGTGCTCGACCCGCCGCGGGCGGGTGCGGGCAAGGAGGTGGTGGCCG
CGGTGACCGCCGCCGGGCCCGAGCGCATCGTGCACATCGGGTGCGACCCGGCCTCGTTCGCCCGTGACATCGGCCTGTAC
CACCACGGCGGCTACCGGCTGGCCGGGCTGCGGGTCTTCGACGCGTTCCCGGGCACGCACCACATGGAGTGCGTGGCGCT
GTTGACCCGCTGA

Upstream 100 bases:

>100_bases
GTGCCGTGGCAGTTGAGTTCCTCGACCCGGGCCAAGCAGACCGCCGACGTCAACGCGCCGGGCGCGGTGCGGCGCGGATA
CGGCGATCGGCCGTGATCGG

Downstream 100 bases:

>100_bases
CCCGATTCCCTCGCGGCGCCAAGGCCTTTAGAGTCCACGGCATGACCGTGTATGTGATCGCCCAGCTGAAGTTCACCGAC
CGCGCCGCCTACGACCGGTA

Product: putative RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNGWSGRSFEIRLGPPGHGGFCVGRHEGRVVFVRHGLPGETVLARVTEDQGGTFCRADAVEIVHASADRVPRSCPVSGPG
GAGCCDYTHATPAAQRALKATVVAELLRRVAGLEREVTVEPVAGWPADATGGWRTRVRLPVDALGRAGAHRYRSDEVIAD
LRCPQPVEGALAGIAERRWTPGADLVVALDADGIRHIVELAPPEPARGGRDGRRRPAGRRRTAAARRAAAHAPRLEQVRA
GSGRAVEYVAGRRWEISATGFWQAHRLAAQCYSDLVAEWAELAAGERAWDLYSGAGVFAARLAEQAGPDGAVLAVESARP
AVADGRAALRDLPWVDLRAARVERWAGEHARTAPPRVVVLDPPRAGAGKEVVAAVTAAGPERIVHIGCDPASFARDIGLY
HHGGYRLAGLRVFDAFPGTHHMECVALLTR

Sequences:

>Translated_430_residues
MNGWSGRSFEIRLGPPGHGGFCVGRHEGRVVFVRHGLPGETVLARVTEDQGGTFCRADAVEIVHASADRVPRSCPVSGPG
GAGCCDYTHATPAAQRALKATVVAELLRRVAGLEREVTVEPVAGWPADATGGWRTRVRLPVDALGRAGAHRYRSDEVIAD
LRCPQPVEGALAGIAERRWTPGADLVVALDADGIRHIVELAPPEPARGGRDGRRRPAGRRRTAAARRAAAHAPRLEQVRA
GSGRAVEYVAGRRWEISATGFWQAHRLAAQCYSDLVAEWAELAAGERAWDLYSGAGVFAARLAEQAGPDGAVLAVESARP
AVADGRAALRDLPWVDLRAARVERWAGEHARTAPPRVVVLDPPRAGAGKEVVAAVTAAGPERIVHIGCDPASFARDIGLY
HHGGYRLAGLRVFDAFPGTHHMECVALLTR
>Mature_430_residues
MNGWSGRSFEIRLGPPGHGGFCVGRHEGRVVFVRHGLPGETVLARVTEDQGGTFCRADAVEIVHASADRVPRSCPVSGPG
GAGCCDYTHATPAAQRALKATVVAELLRRVAGLEREVTVEPVAGWPADATGGWRTRVRLPVDALGRAGAHRYRSDEVIAD
LRCPQPVEGALAGIAERRWTPGADLVVALDADGIRHIVELAPPEPARGGRDGRRRPAGRRRTAAARRAAAHAPRLEQVRA
GSGRAVEYVAGRRWEISATGFWQAHRLAAQCYSDLVAEWAELAAGERAWDLYSGAGVFAARLAEQAGPDGAVLAVESARP
AVADGRAALRDLPWVDLRAARVERWAGEHARTAPPRVVVLDPPRAGAGKEVVAAVTAAGPERIVHIGCDPASFARDIGLY
HHGGYRLAGLRVFDAFPGTHHMECVALLTR

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=220, Percent_Identity=28.6363636363636, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI51173878, Length=220, Percent_Identity=28.6363636363636, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1789148, Length=430, Percent_Identity=27.4418604651163, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1787083, Length=176, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 45797; Mature: 45797

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS50926 TRAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGWSGRSFEIRLGPPGHGGFCVGRHEGRVVFVRHGLPGETVLARVTEDQGGTFCRADAV
CCCCCCCEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCEEEEEECCCCCCEEECCHH
EIVHASADRVPRSCPVSGPGGAGCCDYTHATPAAQRALKATVVAELLRRVAGLEREVTVE
HHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
PVAGWPADATGGWRTRVRLPVDALGRAGAHRYRSDEVIADLRCPQPVEGALAGIAERRWT
ECCCCCCCCCCCCEEEEECCHHHHCCCCHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCC
PGADLVVALDADGIRHIVELAPPEPARGGRDGRRRPAGRRRTAAARRAAAHAPRLEQVRA
CCCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHC
GSGRAVEYVAGRRWEISATGFWQAHRLAAQCYSDLVAEWAELAAGERAWDLYSGAGVFAA
CCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHH
RLAEQAGPDGAVLAVESARPAVADGRAALRDLPWVDLRAARVERWAGEHARTAPPRVVVL
HHHHHCCCCCEEEEECCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEE
DPPRAGAGKEVVAAVTAAGPERIVHIGCDPASFARDIGLYHHGGYRLAGLRVFDAFPGTH
CCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHCCCEECCCEEEEEEEEEECCCCCC
HMECVALLTR
CHHHHEEECC
>Mature Secondary Structure
MNGWSGRSFEIRLGPPGHGGFCVGRHEGRVVFVRHGLPGETVLARVTEDQGGTFCRADAV
CCCCCCCEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCEEEEEECCCCCCEEECCHH
EIVHASADRVPRSCPVSGPGGAGCCDYTHATPAAQRALKATVVAELLRRVAGLEREVTVE
HHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
PVAGWPADATGGWRTRVRLPVDALGRAGAHRYRSDEVIADLRCPQPVEGALAGIAERRWT
ECCCCCCCCCCCCEEEEECCHHHHCCCCHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCC
PGADLVVALDADGIRHIVELAPPEPARGGRDGRRRPAGRRRTAAARRAAAHAPRLEQVRA
CCCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHC
GSGRAVEYVAGRRWEISATGFWQAHRLAAQCYSDLVAEWAELAAGERAWDLYSGAGVFAA
CCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHH
RLAEQAGPDGAVLAVESARPAVADGRAALRDLPWVDLRAARVERWAGEHARTAPPRVVVL
HHHHHCCCCCEEEEECCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEE
DPPRAGAGKEVVAAVTAAGPERIVHIGCDPASFARDIGLYHHGGYRLAGLRVFDAFPGTH
CCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHCCCEECCCEEEEEEEEEECCCCCC
HMECVALLTR
CHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]