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The map label for this gene is fdh [H]

Identifier: 54025532

GI number: 54025532

Start: 3770485

End: 3771504

Strand: Reverse

Name: fdh [H]

Synonym: nfa35620

Alternate gene names: 54025532

Gene position: 3771504-3770485 (Counterclockwise)

Preceding gene: 54025533

Following gene: 54025531

Centisome position: 62.64

GC content: 74.71

Gene sequence:

>1020_bases
ATGAAACGTCTGATGCTCTCCGGCCCCGGCGCGCTGCACTGGGAGTCCGCCCCCGAACCCGAACTCACCGGCCCCGGCCA
GGCGCTGGTCCGACCGGTCGCGCTGGCCACCTGCGACATCGATCCGGCCGTCCTGCGCGGCGCCTTTCCACTGCCCGGTC
CCTATCCCTTCGGGCACGAGGGGGTGGCCGAGGTGGTCGCGGTGGGCTCCGAGGTGCGCTCGGTCGCGGTGGGGGACCGG
GTGGTGGTGCCGTTCCAGATCTCGTGCGGCGCCTGCCCGGCGTGCCTGCGCGGGACGACCGGCAACTGCGCGAGTCATCC
GCGGTTGTCCACCTACGGTCTTGGCTCCCTGGGCGGCCTCGGCTGGGGCGGGCTGTGGGCGGATCTGGCGCTGGTGCCGC
ACGCCGACGCGATGCTGGTGCCGTTGCCACCCGGCGTCGACCCGGTGGCCGTGGCCAGTGCCAGCGACAACATCCCCGAC
GCCTACCGTGCGGTGGCGCCGCAGCTCGCCGCCCGGCCGGATGCTCCGGTGCTGGTGCTCGGCGGGCCCGGGGCGGCCTC
GATCGGCTTGTACGCGGCGGGGCTGGCCGTCGCCCTCGGCGCCGAGCGCGTGGTCTACCTCGACACCTCGGCCGAGCGCC
TGGCGATCGCCGCGCGGCTCGGCGCCGAAGCTGTCGGGGGCGCGCCGGACACGCGCGTCGGGCGATTCCCGATCGTCGTC
GAGGCGGTGGGCTCGGCCGCGGCACTGCGCGCGGCCGTCGCCGCCGCCGACTACGACGGCTGGTGCACCAGCGTCAGCGT
GCAACTCGGCGAGGTCGCGTTGCCGTTCTTCGACATGTACACCCGCTGCTGCACCGTGCACACCGGGCGCGCCCACGTGC
GGCCTGCGATCCCGCGGGTGCTGGAATTGGTGGCCGCGGGCCGCTTCGATCCGACCCCGGTCACCACCTCGACCGCGCGC
TGGGACGACGCGATCGACGCGCTGCTCGAGACGCCGCTGAAACTGGTCGCGGTGCGCTGA

Upstream 100 bases:

>100_bases
GAGGCGCCGTACCGACCTGACCGCCGCGCGGATTCGCCCGCGCGCGGTGTCGGGGCGGGCGGGTCTTGACTGGAAAGAAC
GTTCTAGCGACACTCGGTCG

Downstream 100 bases:

>100_bases
CCTGCGCGCACCGCGCACCCCGGTGACCGACTGTGGCGAATGTCGCAGCCGGTCACCCCCTTTTCTCAGGGCACCCTTAT
TAGATTTCGGGAACGAATTC

Product: putative dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKRLMLSGPGALHWESAPEPELTGPGQALVRPVALATCDIDPAVLRGAFPLPGPYPFGHEGVAEVVAVGSEVRSVAVGDR
VVVPFQISCGACPACLRGTTGNCASHPRLSTYGLGSLGGLGWGGLWADLALVPHADAMLVPLPPGVDPVAVASASDNIPD
AYRAVAPQLAARPDAPVLVLGGPGAASIGLYAAGLAVALGAERVVYLDTSAERLAIAARLGAEAVGGAPDTRVGRFPIVV
EAVGSAAALRAAVAAADYDGWCTSVSVQLGEVALPFFDMYTRCCTVHTGRAHVRPAIPRVLELVAAGRFDPTPVTTSTAR
WDDAIDALLETPLKLVAVR

Sequences:

>Translated_339_residues
MKRLMLSGPGALHWESAPEPELTGPGQALVRPVALATCDIDPAVLRGAFPLPGPYPFGHEGVAEVVAVGSEVRSVAVGDR
VVVPFQISCGACPACLRGTTGNCASHPRLSTYGLGSLGGLGWGGLWADLALVPHADAMLVPLPPGVDPVAVASASDNIPD
AYRAVAPQLAARPDAPVLVLGGPGAASIGLYAAGLAVALGAERVVYLDTSAERLAIAARLGAEAVGGAPDTRVGRFPIVV
EAVGSAAALRAAVAAADYDGWCTSVSVQLGEVALPFFDMYTRCCTVHTGRAHVRPAIPRVLELVAAGRFDPTPVTTSTAR
WDDAIDALLETPLKLVAVR
>Mature_339_residues
MKRLMLSGPGALHWESAPEPELTGPGQALVRPVALATCDIDPAVLRGAFPLPGPYPFGHEGVAEVVAVGSEVRSVAVGDR
VVVPFQISCGACPACLRGTTGNCASHPRLSTYGLGSLGGLGWGGLWADLALVPHADAMLVPLPPGVDPVAVASASDNIPD
AYRAVAPQLAARPDAPVLVLGGPGAASIGLYAAGLAVALGAERVVYLDTSAERLAIAARLGAEAVGGAPDTRVGRFPIVV
EAVGSAAALRAAVAAADYDGWCTSVSVQLGEVALPFFDMYTRCCTVHTGRAHVRPAIPRVLELVAAGRFDPTPVTTSTAR
WDDAIDALLETPLKLVAVR

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786825, Length=372, Percent_Identity=27.1505376344086, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788075, Length=348, Percent_Identity=27.0114942528736, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1788073, Length=351, Percent_Identity=27.6353276353276, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790045, Length=208, Percent_Identity=31.25, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082125, Length=172, Percent_Identity=31.3953488372093, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI226510992, Length=321, Percent_Identity=27.4143302180685, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 34620; Mature: 34620

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLMLSGPGALHWESAPEPELTGPGQALVRPVALATCDIDPAVLRGAFPLPGPYPFGHE
CCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCHHHHHCCCCCCCCCCCCCH
GVAEVVAVGSEVRSVAVGDRVVVPFQISCGACPACLRGTTGNCASHPRLSTYGLGSLGGL
HHHHHHHHHHHHHHEECCCEEEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCC
GWGGLWADLALVPHADAMLVPLPPGVDPVAVASASDNIPDAYRAVAPQLAARPDAPVLVL
CCCHHHHHHEECCCCCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEE
GGPGAASIGLYAAGLAVALGAERVVYLDTSAERLAIAARLGAEAVGGAPDTRVGRFPIVV
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCHHHCCCCCCCCCCCCCEEE
EAVGSAAALRAAVAAADYDGWCTSVSVQLGEVALPFFDMYTRCCTVHTGRAHVRPAIPRV
EECCCHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHEEECCCCCCCHHHHHH
LELVAAGRFDPTPVTTSTARWDDAIDALLETPLKLVAVR
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MKRLMLSGPGALHWESAPEPELTGPGQALVRPVALATCDIDPAVLRGAFPLPGPYPFGHE
CCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCHHHHHCCCCCCCCCCCCCH
GVAEVVAVGSEVRSVAVGDRVVVPFQISCGACPACLRGTTGNCASHPRLSTYGLGSLGGL
HHHHHHHHHHHHHHEECCCEEEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCC
GWGGLWADLALVPHADAMLVPLPPGVDPVAVASASDNIPDAYRAVAPQLAARPDAPVLVL
CCCHHHHHHEECCCCCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEE
GGPGAASIGLYAAGLAVALGAERVVYLDTSAERLAIAARLGAEAVGGAPDTRVGRFPIVV
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCHHHCCCCCCCCCCCCCEEE
EAVGSAAALRAAVAAADYDGWCTSVSVQLGEVALPFFDMYTRCCTVHTGRAHVRPAIPRV
EECCCHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHEEECCCCCCCHHHHHH
LELVAAGRFDPTPVTTSTARWDDAIDALLETPLKLVAVR
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]