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The map label for this gene is cocE [H]

Identifier: 54025465

GI number: 54025465

Start: 3705703

End: 3707748

Strand: Reverse

Name: cocE [H]

Synonym: nfa34950

Alternate gene names: 54025465

Gene position: 3707748-3705703 (Counterclockwise)

Preceding gene: 54025466

Following gene: 54025458

Centisome position: 61.58

GC content: 70.67

Gene sequence:

>2046_bases
GTGCGTATCGTCGAGAAGTTCCCCTACGAGGTTCTCGACACCGAGAACGTCTTCATACCCATGCGCGACGGCGCGCGGCT
GGCCGCCCGGATCTGGCGGCCGGTGACCGACGAGCCGGTACCCGCCGTCTTCGAATACATCCCGTACCGCAAACGCGATC
TCACCCGCGCCCGTGACGCGCTCAACCATCCGTACCTGGCCGGGCACGGTTACGTCAGCGTCCGGGTGGATCTGCGCGGC
AGCGGCGACTCCGACGGCGTGCTCACCGACGAGTACCTGCCCACCGAACACGACGACGCCTGTGACGTGATCGCGTGGCT
GGCCGACCAGCCCTGGTGCGACGGCAACGTCGGGATGATGGGCATCTCCTGGGGCGGATTCAACAGCCTGCAGGTCGCCG
CCCGCCGCCCGCCCGCACTGAAGGCGATCGTCAGCGCCTCGGCCACCGAGGACCTCTACGTCGACAACATGCACTACATG
GGCGGCTGCCTGCTCTCGGACAACCTGTCCGAGGCCACGGTCATGTTCGCCTTCAACAGCCTGCCCCCGGACCCGGCCAT
CGTGGGGGACCGGTGGCGGGACATGTGGCGCGAGCGGCTCGCGGGCAGCGGGCTGTGGATCGAGCAGTGGCTCGAGCACC
AGCACCGTGACGAGTACTGGAAACGCGCCTCGGTGAACGAGGACTACCGCGCCGTCGACTGCCCGGTGCTCGCGGTCGGC
GGCTGGGCCGACGGCTACACCAACGCCATCTTCCGCCTGCTCGAGCACCTGGACGTGCCGCGCCGCGGGCTGATCGGGCC
GTGGGGGCACAAGTACCCGCACCTGGGCGTGCCCGGCCCGGCGATCGGGTTCCTGCAGGAACTGGTGCGGTGGTGGGACC
ACTGGCTCAAGGGCCGCGACACCGGCGTCATGGACGAGCCGATGCTGCGGGCCTGGATGCAGGACAGCATCTCCCCGCAA
CCGTCCTACGCCGACCGCCCCGGCCGCTGGGTGGGCGAGCCGTCCTGGCCCTCTCCGAACATCGTGCCGCGCGAATTCAC
ACTCACCCGTTACGGATTGGCCGAGGACGCCGGCGACGTGCCCGCCCGCACCATGCGGGTGCAGTCGCCGCTGAGCGTCG
GCATGTTCGCGGGCAAGTGGGCCTCCTACGCCGCGACCCCCGACCTGCCGTCGGACCAGCGCGAGGAGGACGGCGGTTCG
CTGGTCTACGAGACCGAGGAACTCACCGAGACCTTCGAGGTGCTCGGCCAGCCGGAGCTGGCCCTCACCGTCGCCGCCGA
CCGGCCCAACGCGATGGTGGCCGCGCGGCTGTCCGACGTCGCCCCCAACGGTGAGGCGACCCGCGTCACCTACGGCCTGC
TCAACCTCACCCACCGCGACGGCAGCGGCGAGCCGCGCCCCCTCGAGCCCGGCCGCACCTATCGGGTCCGCCTGGCGCTC
AACGGCATGGCGCACTCGTTCCCACCGGGCCACCGCATCCGGCTGTCGATCTCCTCCTCGTACTGGCCGCTGGCCTGGCC
CTCGCCGGAACCGGTGATGCTCACCGTCACCACCGGCGAATCCCTGCTCACGCTGCCGCAGCGGCCCCGGCGCGCCGAGG
ACGAGCGCCTGCGGCCGTTCGACGACCCCGAAGCCGCCCCGCCCGCCCCGGCCACGAACATCGAACGGGGCACACACCAT
TGGAAGGTCGAGCGCGACCTCGCCACCGGCGTCTCCACCCTCGAGATCGAGAACGACCAGGGCCTCATCCGGCTCGACGA
CACCGGCACCCTGGTGCGCCGCGCCACCACCGAGTGGTTCAGTTTCCGCGGCAACGACCCCACCTCGGTGCGCGGCGAAA
CCCGCACGGTCCGCGCTTTCGCCCGCGACAACTGGCGCACCGAGATCACCACGCACACCGTGTTGCGCTGCACGCCGCAG
GATTTCGTGCTGGACGCCCGGCTGGACGCCTACGAACTCGGCGATCCGGCCGACGATCCACGGCCGGTGGCCACCCGGGT
GTACTCGCAGAACTGGCATCGGCGGATTCCACGCGATCTGGTGTGA

Upstream 100 bases:

>100_bases
CGCCACCCTCTACCTCGGCGCCGGCGACGCCGACGACCTCGAGCGCCGCTACCGGGACTGCCTGGCCGCCTTGCCGTTCG
AGTTCGAGGAGGTCGATTGA

Downstream 100 bases:

>100_bases
CCCCGGCGGCGCGCGCGACCTCGGCTCACCGCCACTCGCGCAGCTCCAGGTCCACGATCACCGGGTGCATCAGCGTCGAG
ACCGGTGCGCCGGGATCGCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 681; Mature: 681

Protein sequence:

>681_residues
MRIVEKFPYEVLDTENVFIPMRDGARLAARIWRPVTDEPVPAVFEYIPYRKRDLTRARDALNHPYLAGHGYVSVRVDLRG
SGDSDGVLTDEYLPTEHDDACDVIAWLADQPWCDGNVGMMGISWGGFNSLQVAARRPPALKAIVSASATEDLYVDNMHYM
GGCLLSDNLSEATVMFAFNSLPPDPAIVGDRWRDMWRERLAGSGLWIEQWLEHQHRDEYWKRASVNEDYRAVDCPVLAVG
GWADGYTNAIFRLLEHLDVPRRGLIGPWGHKYPHLGVPGPAIGFLQELVRWWDHWLKGRDTGVMDEPMLRAWMQDSISPQ
PSYADRPGRWVGEPSWPSPNIVPREFTLTRYGLAEDAGDVPARTMRVQSPLSVGMFAGKWASYAATPDLPSDQREEDGGS
LVYETEELTETFEVLGQPELALTVAADRPNAMVAARLSDVAPNGEATRVTYGLLNLTHRDGSGEPRPLEPGRTYRVRLAL
NGMAHSFPPGHRIRLSISSSYWPLAWPSPEPVMLTVTTGESLLTLPQRPRRAEDERLRPFDDPEAAPPAPATNIERGTHH
WKVERDLATGVSTLEIENDQGLIRLDDTGTLVRRATTEWFSFRGNDPTSVRGETRTVRAFARDNWRTEITTHTVLRCTPQ
DFVLDARLDAYELGDPADDPRPVATRVYSQNWHRRIPRDLV

Sequences:

>Translated_681_residues
MRIVEKFPYEVLDTENVFIPMRDGARLAARIWRPVTDEPVPAVFEYIPYRKRDLTRARDALNHPYLAGHGYVSVRVDLRG
SGDSDGVLTDEYLPTEHDDACDVIAWLADQPWCDGNVGMMGISWGGFNSLQVAARRPPALKAIVSASATEDLYVDNMHYM
GGCLLSDNLSEATVMFAFNSLPPDPAIVGDRWRDMWRERLAGSGLWIEQWLEHQHRDEYWKRASVNEDYRAVDCPVLAVG
GWADGYTNAIFRLLEHLDVPRRGLIGPWGHKYPHLGVPGPAIGFLQELVRWWDHWLKGRDTGVMDEPMLRAWMQDSISPQ
PSYADRPGRWVGEPSWPSPNIVPREFTLTRYGLAEDAGDVPARTMRVQSPLSVGMFAGKWASYAATPDLPSDQREEDGGS
LVYETEELTETFEVLGQPELALTVAADRPNAMVAARLSDVAPNGEATRVTYGLLNLTHRDGSGEPRPLEPGRTYRVRLAL
NGMAHSFPPGHRIRLSISSSYWPLAWPSPEPVMLTVTTGESLLTLPQRPRRAEDERLRPFDDPEAAPPAPATNIERGTHH
WKVERDLATGVSTLEIENDQGLIRLDDTGTLVRRATTEWFSFRGNDPTSVRGETRTVRAFARDNWRTEITTHTVLRCTPQ
DFVLDARLDAYELGDPADDPRPVATRVYSQNWHRRIPRDLV
>Mature_681_residues
MRIVEKFPYEVLDTENVFIPMRDGARLAARIWRPVTDEPVPAVFEYIPYRKRDLTRARDALNHPYLAGHGYVSVRVDLRG
SGDSDGVLTDEYLPTEHDDACDVIAWLADQPWCDGNVGMMGISWGGFNSLQVAARRPPALKAIVSASATEDLYVDNMHYM
GGCLLSDNLSEATVMFAFNSLPPDPAIVGDRWRDMWRERLAGSGLWIEQWLEHQHRDEYWKRASVNEDYRAVDCPVLAVG
GWADGYTNAIFRLLEHLDVPRRGLIGPWGHKYPHLGVPGPAIGFLQELVRWWDHWLKGRDTGVMDEPMLRAWMQDSISPQ
PSYADRPGRWVGEPSWPSPNIVPREFTLTRYGLAEDAGDVPARTMRVQSPLSVGMFAGKWASYAATPDLPSDQREEDGGS
LVYETEELTETFEVLGQPELALTVAADRPNAMVAARLSDVAPNGEATRVTYGLLNLTHRDGSGEPRPLEPGRTYRVRLAL
NGMAHSFPPGHRIRLSISSSYWPLAWPSPEPVMLTVTTGESLLTLPQRPRRAEDERLRPFDDPEAAPPAPATNIERGTHH
WKVERDLATGVSTLEIENDQGLIRLDDTGTLVRRATTEWFSFRGNDPTSVRGETRTVRAFARDNWRTEITTHTVLRCTPQ
DFVLDARLDAYELGDPADDPRPVATRVYSQNWHRRIPRDLV

Specific function: Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants [H]

COG id: COG2936

COG function: function code R; Predicted acyl esterases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha/beta hydrolase family. Carboxylesterase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005674
- InterPro:   IPR008979
- InterPro:   IPR013736
- InterPro:   IPR000383 [H]

Pfam domain/function: PF02129 Peptidase_S15; PF08530 PepX_C [H]

EC number: NA

Molecular weight: Translated: 76737; Mature: 76737

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVEKFPYEVLDTENVFIPMRDGARLAARIWRPVTDEPVPAVFEYIPYRKRDLTRARDA
CCCCHHCCHHHCCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHH
LNHPYLAGHGYVSVRVDLRGSGDSDGVLTDEYLPTEHDDACDVIAWLADQPWCDGNVGMM
HCCCEEECCCEEEEEEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCEE
GISWGGFNSLQVAARRPPALKAIVSASATEDLYVDNMHYMGGCLLSDNLSEATVMFAFNS
EEECCCCCCEEEECCCCCHHHHHHHCCCCCCEEECCHHHHCCEEECCCCCCEEEEEEECC
LPPDPAIVGDRWRDMWRERLAGSGLWIEQWLEHQHRDEYWKRASVNEDYRAVDCPVLAVG
CCCCCCEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEC
GWADGYTNAIFRLLEHLDVPRRGLIGPWGHKYPHLGVPGPAIGFLQELVRWWDHWLKGRD
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
TGVMDEPMLRAWMQDSISPQPSYADRPGRWVGEPSWPSPNIVPREFTLTRYGLAEDAGDV
CCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
PARTMRVQSPLSVGMFAGKWASYAATPDLPSDQREEDGGSLVYETEELTETFEVLGQPEL
CHHHEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCE
ALTVAADRPNAMVAARLSDVAPNGEATRVTYGLLNLTHRDGSGEPRPLEPGRTYRVRLAL
EEEEECCCCCEEEEEEHHHCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCEEEEEEEE
NGMAHSFPPGHRIRLSISSSYWPLAWPSPEPVMLTVTTGESLLTLPQRPRRAEDERLRPF
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCC
DDPEAAPPAPATNIERGTHHWKVERDLATGVSTLEIENDQGLIRLDDTGTLVRRATTEWF
CCCCCCCCCCCCCCCCCCCEEEEEHHHHCCCEEEEEECCCCEEEECCCCHHHHHHHHHHH
SFRGNDPTSVRGETRTVRAFARDNWRTEITTHTVLRCTPQDFVLDARLDAYELGDPADDP
EECCCCCCCCCCCCCEEEEECCCCCCEEEEEEEEEEECCHHEEEECCCCCEECCCCCCCC
RPVATRVYSQNWHRRIPRDLV
CHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRIVEKFPYEVLDTENVFIPMRDGARLAARIWRPVTDEPVPAVFEYIPYRKRDLTRARDA
CCCCHHCCHHHCCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHH
LNHPYLAGHGYVSVRVDLRGSGDSDGVLTDEYLPTEHDDACDVIAWLADQPWCDGNVGMM
HCCCEEECCCEEEEEEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCEE
GISWGGFNSLQVAARRPPALKAIVSASATEDLYVDNMHYMGGCLLSDNLSEATVMFAFNS
EEECCCCCCEEEECCCCCHHHHHHHCCCCCCEEECCHHHHCCEEECCCCCCEEEEEEECC
LPPDPAIVGDRWRDMWRERLAGSGLWIEQWLEHQHRDEYWKRASVNEDYRAVDCPVLAVG
CCCCCCEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEC
GWADGYTNAIFRLLEHLDVPRRGLIGPWGHKYPHLGVPGPAIGFLQELVRWWDHWLKGRD
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
TGVMDEPMLRAWMQDSISPQPSYADRPGRWVGEPSWPSPNIVPREFTLTRYGLAEDAGDV
CCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
PARTMRVQSPLSVGMFAGKWASYAATPDLPSDQREEDGGSLVYETEELTETFEVLGQPEL
CHHHEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCE
ALTVAADRPNAMVAARLSDVAPNGEATRVTYGLLNLTHRDGSGEPRPLEPGRTYRVRLAL
EEEEECCCCCEEEEEEHHHCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCEEEEEEEE
NGMAHSFPPGHRIRLSISSSYWPLAWPSPEPVMLTVTTGESLLTLPQRPRRAEDERLRPF
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCC
DDPEAAPPAPATNIERGTHHWKVERDLATGVSTLEIENDQGLIRLDDTGTLVRRATTEWF
CCCCCCCCCCCCCCCCCCCEEEEEHHHHCCCEEEEEECCCCEEEECCCCHHHHHHHHHHH
SFRGNDPTSVRGETRTVRAFARDNWRTEITTHTVLRCTPQDFVLDARLDAYELGDPADDP
EECCCCCCCCCCCCCEEEEECCCCCCEEEEEEEEEEECCHHEEEECCCCCEECCCCCCCC
RPVATRVYSQNWHRRIPRDLV
CHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10698749; 11742345; 12369817 [H]