BacMap

Definition	Nocardia farcinica IFM 10152 chromosome, complete genome.
Accession	NC_006361
Length	6,021,225

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The map label for this gene is hetN [H]

Identifier: 54025404

GI number: 54025404

Start: 3638154

End: 3638999

Strand: Reverse

Name: hetN [H]

Synonym: nfa34340

Alternate gene names: 54025404

Gene position: 3638999-3638154 (Counterclockwise)

Preceding gene: 54025405

Following gene: 54025402

Centisome position: 60.44

GC content: 67.61

Gene sequence:

>846_bases
GTGAGAGGACGCCGTATGAAACTGGAGACGGTCGCGGGCAAGAAGGTGCTCGTCACCGGCGCCGCCATGGGCCTGGGCAA
GTTGTTCGCCGAGCGCGCGGTCCGCGAGGGCGCGGCCGCGGTGGTGCTGTGGGACATCAACGAGCCGGCCCTGAAGGAGA
CCGCCGAGGGCATGACCGGGCGCGGCACGCAGATCCACACCCAGGTGGTCGACGTGTCCGACCGGGAGGCGATCGTGGCG
GCGGCGGCCACCACCCGCGAAACCGTCGGCGACATCGACGTGCTGGTGAACAACGCGGGCATCGTGCGCGGCAACACCTA
CTTCTGGGAGACCGAGAACGTCGCCGACATCGAGAAGACGATGGCGATCAACTCGCTCGCCCCGATGTACATCACGCTCG
AGTTCCTGCCCGCGATGGTGCGCGGCACCGGGCAGGCCCGGGTGCTCACCATCGCGTCCTCGGCGGGTCTGGTGTCGAAT
CCGCGCATGAGCGTCTACGCGGCCTCGAAGTGGGCGGCGCTGGGCTGGTCGGACTCGGTGCGCCTGGAACTCGAGCAGGC
GGGCCACGACCACGTGAAGGTCACCACGGTCTGCCCGACCTACATCGACACCGGAATGTTCGACGGCGCCAAGGGGTTCT
GGTTCACCCCGATCCTCAAGCAGGACGCGGTGGTCGACACCTCCTGGCAGGAGATGAAGAAGGGCACGCCGCTGGTGGTG
CTGCCGTGGACCTCGCGCCTGAACAAGGCGCTGTCGGGCCTGCTGCCGGTGAAGCTGCGCGACCTGTTCCTGGACACGGT
CGGCGTCTATCACTCGATGGATCAGTTCACCGGGCGCAAGAAGTAG

Upstream 100 bases:

>100_bases
AGCGGGTGCTGCCGATCGCGCCGCTGCCCGGCATGTCCGAGCAGTTGTGGGCCAAGACGATGACGCTCTACCTGGGCGTC
ATGAAGAAGCTGCGCCAGAA

Downstream 100 bases:

>100_bases
CGCTCAGCGCGTCCCGGTGACGACGGTGGCGTAGCGCTCGTCGGACTCGGCGCGCGCTGCGCGCAACCCGCGGGCACGCA
GGAAGTCGCTTGCCGCGGTT

Product: putative short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MRGRRMKLETVAGKKVLVTGAAMGLGKLFAERAVREGAAAVVLWDINEPALKETAEGMTGRGTQIHTQVVDVSDREAIVA
AAATTRETVGDIDVLVNNAGIVRGNTYFWETENVADIEKTMAINSLAPMYITLEFLPAMVRGTGQARVLTIASSAGLVSN
PRMSVYAASKWAALGWSDSVRLELEQAGHDHVKVTTVCPTYIDTGMFDGAKGFWFTPILKQDAVVDTSWQEMKKGTPLVV
LPWTSRLNKALSGLLPVKLRDLFLDTVGVYHSMDQFTGRKK

Sequences:

>Translated_281_residues
MRGRRMKLETVAGKKVLVTGAAMGLGKLFAERAVREGAAAVVLWDINEPALKETAEGMTGRGTQIHTQVVDVSDREAIVA
AAATTRETVGDIDVLVNNAGIVRGNTYFWETENVADIEKTMAINSLAPMYITLEFLPAMVRGTGQARVLTIASSAGLVSN
PRMSVYAASKWAALGWSDSVRLELEQAGHDHVKVTTVCPTYIDTGMFDGAKGFWFTPILKQDAVVDTSWQEMKKGTPLVV
LPWTSRLNKALSGLLPVKLRDLFLDTVGVYHSMDQFTGRKK
>Mature_281_residues
MRGRRMKLETVAGKKVLVTGAAMGLGKLFAERAVREGAAAVVLWDINEPALKETAEGMTGRGTQIHTQVVDVSDREAIVA
AAATTRETVGDIDVLVNNAGIVRGNTYFWETENVADIEKTMAINSLAPMYITLEFLPAMVRGTGQARVLTIASSAGLVSN
PRMSVYAASKWAALGWSDSVRLELEQAGHDHVKVTTVCPTYIDTGMFDGAKGFWFTPILKQDAVVDTSWQEMKKGTPLVV
LPWTSRLNKALSGLLPVKLRDLFLDTVGVYHSMDQFTGRKK

Specific function: May be involved in repressing heterocyst differentiation and may be essential for preventing all vegetative cells from differentiating [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40807363, Length=276, Percent_Identity=34.4202898550725, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI142976729, Length=248, Percent_Identity=35.0806451612903, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI25282469, Length=306, Percent_Identity=32.3529411764706, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI310128830, Length=287, Percent_Identity=32.0557491289199, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI310115468, Length=287, Percent_Identity=32.0557491289199, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI210032110, Length=253, Percent_Identity=31.2252964426877, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI31543615, Length=257, Percent_Identity=32.295719844358, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI20149619, Length=197, Percent_Identity=36.0406091370558, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI210032112, Length=253, Percent_Identity=26.4822134387352, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI31542939, Length=209, Percent_Identity=30.622009569378, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI157739938, Length=211, Percent_Identity=32.2274881516588, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI19743808, Length=209, Percent_Identity=31.1004784688995, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI32483357, Length=202, Percent_Identity=30.6930693069307, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI40548397, Length=280, Percent_Identity=26.4285714285714, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI214010158, Length=280, Percent_Identity=26.4285714285714, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI214010156, Length=280, Percent_Identity=26.4285714285714, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI22758144, Length=280, Percent_Identity=26.4285714285714, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI22507405, Length=197, Percent_Identity=30.9644670050761, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI224922801, Length=178, Percent_Identity=32.0224719101124, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI150247226, Length=213, Percent_Identity=31.924882629108, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI32455239, Length=199, Percent_Identity=27.6381909547739, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI5031765, Length=199, Percent_Identity=27.6381909547739, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87082100, Length=195, Percent_Identity=32.8205128205128, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786701, Length=198, Percent_Identity=32.3232323232323, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787335, Length=197, Percent_Identity=30.9644670050761, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790717, Length=202, Percent_Identity=31.1881188118812, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=275, Percent_Identity=39.2727272727273, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI193203117, Length=272, Percent_Identity=39.3382352941176, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI193203115, Length=272, Percent_Identity=39.3382352941176, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17508895, Length=267, Percent_Identity=33.3333333333333, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI193203119, Length=164, Percent_Identity=40.2439024390244, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17567345, Length=206, Percent_Identity=25.2427184466019, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17558006, Length=222, Percent_Identity=28.8288288288288, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=203, Percent_Identity=29.064039408867, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559964, Length=212, Percent_Identity=26.8867924528302, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17559962, Length=221, Percent_Identity=25.3393665158371, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323458, Length=208, Percent_Identity=28.3653846153846, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323882, Length=238, Percent_Identity=27.7310924369748, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24581726, Length=280, Percent_Identity=35, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI221510726, Length=227, Percent_Identity=38.3259911894273, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24640492, Length=270, Percent_Identity=29.2592592592593, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281364892, Length=207, Percent_Identity=28.9855072463768, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24649181, Length=201, Percent_Identity=28.3582089552239, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21355631, Length=279, Percent_Identity=28.3154121863799, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24641388, Length=218, Percent_Identity=29.3577981651376, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648693, Length=207, Percent_Identity=29.4685990338164, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355889, Length=207, Percent_Identity=29.4685990338164, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651139, Length=195, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358495, Length=207, Percent_Identity=28.0193236714976, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640442, Length=211, Percent_Identity=27.9620853080569, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281364494, Length=215, Percent_Identity=29.3023255813954, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI23397609, Length=225, Percent_Identity=30.6666666666667, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24663911, Length=229, Percent_Identity=26.2008733624454, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 30587; Mature: 30587

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGRRMKLETVAGKKVLVTGAAMGLGKLFAERAVREGAAAVVLWDINEPALKETAEGMTG
CCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHCCCCC
RGTQIHTQVVDVSDREAIVAAAATTRETVGDIDVLVNNAGIVRGNTYFWETENVADIEKT
CCCEEEEEEEECCCCCEEEEEEHHHHHHCCCEEEEEECCEEEECCEEEEECCCHHHHHHH
MAINSLAPMYITLEFLPAMVRGTGQARVLTIASSAGLVSNPRMSVYAASKWAALGWSDSV
HHHCCCCCCEEEHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEECCCEEEECCCCCE
RLELEQAGHDHVKVTTVCPTYIDTGMFDGAKGFWFTPILKQDAVVDTSWQEMKKGTPLVV
EEEEECCCCCEEEEEEECCHHHCCCCCCCCCCCEECCCCCCCCEECCCHHHHHCCCCEEE
LPWTSRLNKALSGLLPVKLRDLFLDTVGVYHSMDQFTGRKK
ECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRGRRMKLETVAGKKVLVTGAAMGLGKLFAERAVREGAAAVVLWDINEPALKETAEGMTG
CCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHCCCCC
RGTQIHTQVVDVSDREAIVAAAATTRETVGDIDVLVNNAGIVRGNTYFWETENVADIEKT
CCCEEEEEEEECCCCCEEEEEEHHHHHHCCCEEEEEECCEEEECCEEEEECCCHHHHHHH
MAINSLAPMYITLEFLPAMVRGTGQARVLTIASSAGLVSNPRMSVYAASKWAALGWSDSV
HHHCCCCCCEEEHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEECCCEEEECCCCCE
RLELEQAGHDHVKVTTVCPTYIDTGMFDGAKGFWFTPILKQDAVVDTSWQEMKKGTPLVV
EEEEECCCCCEEEEEEECCHHHCCCCCCCCCCCEECCCCCCCCEECCCHHHHHCCCCEEE
LPWTSRLNKALSGLLPVKLRDLFLDTVGVYHSMDQFTGRKK
ECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8157596; 11759840 [H]