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The map label for this gene is lon

Identifier: 54020568

GI number: 54020568

Start: 682899

End: 685511

Strand: Reverse

Name: lon

Synonym: mhp541

Alternate gene names: 54020568

Gene position: 685511-682899 (Counterclockwise)

Preceding gene: 54020569

Following gene: 54020567

Centisome position: 76.79

GC content: 33.95

Gene sequence:

>2613_bases
ATGCCAACTAATTCCTATCGTTTTTTAGTCGCTTCTGAGGACATTTATTTTCAAAACACCCTACAGCAATCTATTACTTT
CAGCGATCCGGAATCGATTAAAGTTCTCAAAGATTTTTATCATTCAAATTCAAGACCAACACTAACAAATAAGGATTTTT
TAATTGTTTATCGTAAAGAGAAGGAAAAAGATACTAAAAAAAAGAATTCTAGTGTTATAAAATTTCCAAGAAATGATTTT
AATAGTTTTGAAGATTCAAAAAATGATATTCAAAATCAGGCAAAAATTCTTAATGGAAAAGTTGGTGATTTTGAAAATAG
CCTTTTACCGCGCATTTATGACCTTGATGAGCTTTCAAAATATGCTTCTTTGGCAAGAATTCAGAGTTATCGGGCAAAAA
CAAGTCCAGATAAAAGTGAATGACAAACAGTAATTTTAGATTTTATTGTAACCGAAAAAGTCCAATTAGTCGAGCTAATC
AACGATCCTCAAAATCCAAAAGTTGGCCAAATTATAATAAAACCTGTCCGCGAAACCATAAAAAGTCCCGAAATTCATAT
AAATTTGATCAATGATTTATTAGAGATGGCCCGAAAAGCAAAAAATTTTAGAATTCCAACTGAATTACTTTTAATTGTTG
ATAAATTTGGTGCTAATTCTGAATATAGTACAAACGAATATATAAAAGGTGTAACAAATACCTTATCATGCTCGCCAAGT
CTGACTTATCCCCAGAAATACCAACTTTTTTCTTATAACTCTTATCCAGCAAAAATTAAAAAATTATACGAACATATTCA
TACATTTGCTGAGCAAATTAAACTAGAAGATGAAATTAATGTTATTCTAAAAACAAATTTAGACAAACAACAAACTGAAT
TTATTCTAAAAGAGAAAATTAAAGCAATTAGAAAAAAACTCGGGGAGGATTCCCGCTATGAAGATGAGATCGAAGAACTT
CTTCATTCCGAACTAGGGAAAAAAGTCTTCCCTAAAGAGGTTGCAAAAACAATTATGCGTGAGACAAACAAACTAAAGTC
AATGATAGTAACCTCGCCCGAGTCAAATATCACCAAAAGTTATCTTGATCTTTTAGTCGCTCTCCCTTGAAAAAAGGTAA
AAAAAGATATTCTTGATATTAAAAATGTCAGAGAAAAACTTGAAGAGGCCCATTATGGGCTTGATGAAATCAAGAAGCGG
ATTATTGAATATCTTGCTGCCTTAATTCATAGGCGCTCACAATCTGAAGGCAAACCCGAATTGGAAAAAGTTGGTTCAGA
TTATATTGATTCAAATTTATTTTTAAGTCATAAAATCCGTAAAGTACGAAGTAATTCAATTCCAATTCTTACTTTAGTAG
GCCCACCAGGAACTGGGAAAACTTCAATTGCAATGGCGGTGGCCGAAGCAATTGGTAAAGAATTTGTCAAAATTTCCCTT
GGCGGAATTCGTGATGAAGCTGAAATCCGAGGACATCGCCGTACTTATGTAGGGGCTCTTCCGGGAAAAATTATTCAAGC
CCTAAAAAAAGTTGGAGTTTCCAATCCCTTAATTTTACTTGATGAAATTGATAAAATGGGAGCTGATTTTAAAGGGGATC
CATCTGCGGCGATGCTTGAAGTTTTAGATCCTGAACAAAACCGTTTTTTCCAGGATCATTATCTTGAATTAGAATATGAT
CTTTCCCAAGTTTTATTTGTTGCTACTGCCAATGAAATTTATGATATTCCTGAGCCTTTACTTGATCGGGTTGAGATTAT
CGAATTATCTTCATATACTTTTATTGAAAAAATCCAGATTGCAAAATCGCACTTAATTCCGGCAGTTTTAAAAGAAAATG
CTCTAGATCCAAAATATTTTCCAATCCAAGATCAAACAATTGACTTTTTGATTCGCCACTATACACGCGAAGCCGGTGTT
AGGGGTCTTAAGCGAGTAATTGATAAAATTGTAAGAAAAATTATTGTAAAATTACTTGAAAAAACATTAGATCAAAATTT
TGTAATTGATATTGAATTTGTTCGTGAACTTTTAGGCATTGAAAAATATGATCCAGATAATGTCGATTCAAGTCCCCAAA
TTGGAACGGTAACTGGACTTGGATATTCACCACTTGGGGGATCAACTCTACAGATCGAGGTAAGCACGATTCCCGGACGA
GGCGATATTAAACTAACAGGTTCGCTTAAGGATGTAATGCAAGAATCAGCCCGGATTGCCCTTTCTTATGTTCAGTCAAA
AGCCAAGGATTTTGGGATTAATTTTGATTTTGAAAACACTTTAATTCATATTCATGTACCCGAAGGAGCAATTCCAAAAG
ATGGGCCATCAGCAGGGATAACTTTTGCAACAGCAATAATTTCAGCCCTCTCGCAAAAGCCGGTCTCACATAATATTGCA
ATGACAGGGGAGATAACCTTGCGCGGAAAGGTTTTAGCAATCGGCGGACTAAAAGAAAAGACGATGGGGGCCTATAAAAA
TGGGATTAAAATTATTTTTATTCCAAAGGCGAACGAGAAAAATTTAGTCGATATTCCGCAGGAGGTAAAAGACGTAATCC
AGTTTATTCCCGTTGATACTTATCAACAAATTTATGATTTTATTTTTAAATAG

Upstream 100 bases:

>100_bases
TTAAATTTGTTGATTTTTTATGGTATAATTATCGCATTTAAGCAACTTTTGTCATCAAGTATTTAATAAAATATAAAACA
AAAATGGAGATTTTTTAAAT

Downstream 100 bases:

>100_bases
GAAAACTATTAAAAAATAAAATCAGTTTAAAAGCCGCGGTTTTTAAGTAAAATTTCTAAATTATTTTTTTGTTAAAAAAA
TTCTTAAAATAATTTTTCAA

Product: heat shock ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 870; Mature: 869

Protein sequence:

>870_residues
MPTNSYRFLVASEDIYFQNTLQQSITFSDPESIKVLKDFYHSNSRPTLTNKDFLIVYRKEKEKDTKKKNSSVIKFPRNDF
NSFEDSKNDIQNQAKILNGKVGDFENSLLPRIYDLDELSKYASLARIQSYRAKTSPDKSEWQTVILDFIVTEKVQLVELI
NDPQNPKVGQIIIKPVRETIKSPEIHINLINDLLEMARKAKNFRIPTELLLIVDKFGANSEYSTNEYIKGVTNTLSCSPS
LTYPQKYQLFSYNSYPAKIKKLYEHIHTFAEQIKLEDEINVILKTNLDKQQTEFILKEKIKAIRKKLGEDSRYEDEIEEL
LHSELGKKVFPKEVAKTIMRETNKLKSMIVTSPESNITKSYLDLLVALPWKKVKKDILDIKNVREKLEEAHYGLDEIKKR
IIEYLAALIHRRSQSEGKPELEKVGSDYIDSNLFLSHKIRKVRSNSIPILTLVGPPGTGKTSIAMAVAEAIGKEFVKISL
GGIRDEAEIRGHRRTYVGALPGKIIQALKKVGVSNPLILLDEIDKMGADFKGDPSAAMLEVLDPEQNRFFQDHYLELEYD
LSQVLFVATANEIYDIPEPLLDRVEIIELSSYTFIEKIQIAKSHLIPAVLKENALDPKYFPIQDQTIDFLIRHYTREAGV
RGLKRVIDKIVRKIIVKLLEKTLDQNFVIDIEFVRELLGIEKYDPDNVDSSPQIGTVTGLGYSPLGGSTLQIEVSTIPGR
GDIKLTGSLKDVMQESARIALSYVQSKAKDFGINFDFENTLIHIHVPEGAIPKDGPSAGITFATAIISALSQKPVSHNIA
MTGEITLRGKVLAIGGLKEKTMGAYKNGIKIIFIPKANEKNLVDIPQEVKDVIQFIPVDTYQQIYDFIFK

Sequences:

>Translated_870_residues
MPTNSYRFLVASEDIYFQNTLQQSITFSDPESIKVLKDFYHSNSRPTLTNKDFLIVYRKEKEKDTKKKNSSVIKFPRNDF
NSFEDSKNDIQNQAKILNGKVGDFENSLLPRIYDLDELSKYASLARIQSYRAKTSPDKSE*QTVILDFIVTEKVQLVELI
NDPQNPKVGQIIIKPVRETIKSPEIHINLINDLLEMARKAKNFRIPTELLLIVDKFGANSEYSTNEYIKGVTNTLSCSPS
LTYPQKYQLFSYNSYPAKIKKLYEHIHTFAEQIKLEDEINVILKTNLDKQQTEFILKEKIKAIRKKLGEDSRYEDEIEEL
LHSELGKKVFPKEVAKTIMRETNKLKSMIVTSPESNITKSYLDLLVALP*KKVKKDILDIKNVREKLEEAHYGLDEIKKR
IIEYLAALIHRRSQSEGKPELEKVGSDYIDSNLFLSHKIRKVRSNSIPILTLVGPPGTGKTSIAMAVAEAIGKEFVKISL
GGIRDEAEIRGHRRTYVGALPGKIIQALKKVGVSNPLILLDEIDKMGADFKGDPSAAMLEVLDPEQNRFFQDHYLELEYD
LSQVLFVATANEIYDIPEPLLDRVEIIELSSYTFIEKIQIAKSHLIPAVLKENALDPKYFPIQDQTIDFLIRHYTREAGV
RGLKRVIDKIVRKIIVKLLEKTLDQNFVIDIEFVRELLGIEKYDPDNVDSSPQIGTVTGLGYSPLGGSTLQIEVSTIPGR
GDIKLTGSLKDVMQESARIALSYVQSKAKDFGINFDFENTLIHIHVPEGAIPKDGPSAGITFATAIISALSQKPVSHNIA
MTGEITLRGKVLAIGGLKEKTMGAYKNGIKIIFIPKANEKNLVDIPQEVKDVIQFIPVDTYQQIYDFIFK
>Mature_869_residues
PTNSYRFLVASEDIYFQNTLQQSITFSDPESIKVLKDFYHSNSRPTLTNKDFLIVYRKEKEKDTKKKNSSVIKFPRNDFN
SFEDSKNDIQNQAKILNGKVGDFENSLLPRIYDLDELSKYASLARIQSYRAKTSPDKSE*QTVILDFIVTEKVQLVELIN
DPQNPKVGQIIIKPVRETIKSPEIHINLINDLLEMARKAKNFRIPTELLLIVDKFGANSEYSTNEYIKGVTNTLSCSPSL
TYPQKYQLFSYNSYPAKIKKLYEHIHTFAEQIKLEDEINVILKTNLDKQQTEFILKEKIKAIRKKLGEDSRYEDEIEELL
HSELGKKVFPKEVAKTIMRETNKLKSMIVTSPESNITKSYLDLLVALP*KKVKKDILDIKNVREKLEEAHYGLDEIKKRI
IEYLAALIHRRSQSEGKPELEKVGSDYIDSNLFLSHKIRKVRSNSIPILTLVGPPGTGKTSIAMAVAEAIGKEFVKISLG
GIRDEAEIRGHRRTYVGALPGKIIQALKKVGVSNPLILLDEIDKMGADFKGDPSAAMLEVLDPEQNRFFQDHYLELEYDL
SQVLFVATANEIYDIPEPLLDRVEIIELSSYTFIEKIQIAKSHLIPAVLKENALDPKYFPIQDQTIDFLIRHYTREAGVR
GLKRVIDKIVRKIIVKLLEKTLDQNFVIDIEFVRELLGIEKYDPDNVDSSPQIGTVTGLGYSPLGGSTLQIEVSTIPGRG
DIKLTGSLKDVMQESARIALSYVQSKAKDFGINFDFENTLIHIHVPEGAIPKDGPSAGITFATAIISALSQKPVSHNIAM
TGEITLRGKVLAIGGLKEKTMGAYKNGIKIIFIPKANEKNLVDIPQEVKDVIQFIPVDTYQQIYDFIFK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=597, Percent_Identity=40.7035175879397, Blast_Score=448, Evalue=1e-125,
Organism=Homo sapiens, GI21396489, Length=623, Percent_Identity=37.8812199036918, Blast_Score=428, Evalue=1e-119,
Organism=Escherichia coli, GI1786643, Length=645, Percent_Identity=43.2558139534884, Blast_Score=522, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17505831, Length=640, Percent_Identity=36.5625, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17556486, Length=561, Percent_Identity=36.0071301247772, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319449, Length=658, Percent_Identity=36.7781155015198, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI221513036, Length=608, Percent_Identity=40.625, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24666867, Length=608, Percent_Identity=40.625, Blast_Score=462, Evalue=1e-130,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR001984
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 98321; Mature: 98189

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTNSYRFLVASEDIYFQNTLQQSITFSDPESIKVLKDFYHSNSRPTLTNKDFLIVYRKE
CCCCCEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECC
KEKDTKKKNSSVIKFPRNDFNSFEDSKNDIQNQAKILNGKVGDFENSLLPRIYDLDELSK
CHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHCCHHHHHH
YASLARIQSYRAKTSPDKSEQTVILDFIVTEKVQLVELINDPQNPKVGQIIIKPVRETIK
HHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
SPEIHINLINDLLEMARKAKNFRIPTELLLIVDKFGANSEYSTNEYIKGVTNTLSCSPSL
CCCEEEHHHHHHHHHHHHHCCCCCCHHHHHEEHHCCCCCCCCCHHHHHHHHHCCCCCCCC
TYPQKYQLFSYNSYPAKIKKLYEHIHTFAEQIKLEDEINVILKTNLDKQQTEFILKEKIK
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHH
AIRKKLGEDSRYEDEIEELLHSELGKKVFPKEVAKTIMRETNKLKSMIVTSPESNITKSY
HHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHHH
LDLLVALPKKVKKDILDIKNVREKLEEAHYGLDEIKKRIIEYLAALIHRRSQSEGKPELE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
KVGSDYIDSNLFLSHKIRKVRSNSIPILTLVGPPGTGKTSIAMAVAEAIGKEFVKISLGG
HHCCHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHEEEEECCC
IRDEAEIRGHRRTYVGALPGKIIQALKKVGVSNPLILLDEIDKMGADFKGDPSAAMLEVL
CCCHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCCCHHHHHHC
DPEQNRFFQDHYLELEYDLSQVLFVATANEIYDIPEPLLDRVEIIELSSYTFIEKIQIAK
CCCHHCCHHHHHEEEEECHHHEEEEEECHHHHCCCHHHHHHHHEEEECCHHHHHHHHHHH
SHLIPAVLKENALDPKYFPIQDQTIDFLIRHYTREAGVRGLKRVIDKIVRKIIVKLLEKT
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDQNFVIDIEFVRELLGIEKYDPDNVDSSPQIGTVTGLGYSPLGGSTLQIEVSTIPGRGD
CCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCC
IKLTGSLKDVMQESARIALSYVQSKAKDFGINFDFENTLIHIHVPEGAIPKDGPSAGITF
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCCCCCCCHHH
ATAIISALSQKPVSHNIAMTGEITLRGKVLAIGGLKEKTMGAYKNGIKIIFIPKANEKNL
HHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCC
VDIPQEVKDVIQFIPVDTYQQIYDFIFK
CCCCHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PTNSYRFLVASEDIYFQNTLQQSITFSDPESIKVLKDFYHSNSRPTLTNKDFLIVYRKE
CCCCEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECC
KEKDTKKKNSSVIKFPRNDFNSFEDSKNDIQNQAKILNGKVGDFENSLLPRIYDLDELSK
CHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHCCHHHHHH
YASLARIQSYRAKTSPDKSEQTVILDFIVTEKVQLVELINDPQNPKVGQIIIKPVRETIK
HHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
SPEIHINLINDLLEMARKAKNFRIPTELLLIVDKFGANSEYSTNEYIKGVTNTLSCSPSL
CCCEEEHHHHHHHHHHHHHCCCCCCHHHHHEEHHCCCCCCCCCHHHHHHHHHCCCCCCCC
TYPQKYQLFSYNSYPAKIKKLYEHIHTFAEQIKLEDEINVILKTNLDKQQTEFILKEKIK
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHH
AIRKKLGEDSRYEDEIEELLHSELGKKVFPKEVAKTIMRETNKLKSMIVTSPESNITKSY
HHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHHH
LDLLVALPKKVKKDILDIKNVREKLEEAHYGLDEIKKRIIEYLAALIHRRSQSEGKPELE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
KVGSDYIDSNLFLSHKIRKVRSNSIPILTLVGPPGTGKTSIAMAVAEAIGKEFVKISLGG
HHCCHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHEEEEECCC
IRDEAEIRGHRRTYVGALPGKIIQALKKVGVSNPLILLDEIDKMGADFKGDPSAAMLEVL
CCCHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCCCHHHHHHC
DPEQNRFFQDHYLELEYDLSQVLFVATANEIYDIPEPLLDRVEIIELSSYTFIEKIQIAK
CCCHHCCHHHHHEEEEECHHHEEEEEECHHHHCCCHHHHHHHHEEEECCHHHHHHHHHHH
SHLIPAVLKENALDPKYFPIQDQTIDFLIRHYTREAGVRGLKRVIDKIVRKIIVKLLEKT
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDQNFVIDIEFVRELLGIEKYDPDNVDSSPQIGTVTGLGYSPLGGSTLQIEVSTIPGRGD
CCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCC
IKLTGSLKDVMQESARIALSYVQSKAKDFGINFDFENTLIHIHVPEGAIPKDGPSAGITF
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCCCCCCCHHH
ATAIISALSQKPVSHNIAMTGEITLRGKVLAIGGLKEKTMGAYKNGIKIIFIPKANEKNL
HHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCC
VDIPQEVKDVIQFIPVDTYQQIYDFIFK
CCCCHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA