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The map label for this gene is fba

Identifier: 54019983

GI number: 54019983

Start: 14755

End: 15618

Strand: Direct

Name: fba

Synonym: mhp014

Alternate gene names: 54019983

Gene position: 14755-15618 (Clockwise)

Preceding gene: 54019982

Following gene: 54019984

Centisome position: 1.65

GC content: 35.65

Gene sequence:

>864_bases
ATGCAACTAGTAAATACTAAAGAAATGTTGGAAAAAGCACTGAAAAATAACTACGCAATTCCACATATTAACATTAACAA
TCTCGAATGAACAAAAGCGGCACTTTTAGCGGCCCAAGCAAAAAAATCACCTTTAATTATTGGCACTTCCGAGAGAGTAC
TGACATATATGGGCGGACTCAAAACTATTTATAATTTAGTAACAAATTTAATTGACTATTTTAAAATAACAGTCCCAGTC
GCTCTCCATTTGGATCATGGAACTTATCTTACCTGCAAAGAAGCACTAAAAAACGGGTATACCTCAGTGATGTATGATGG
TTCTAAAGAAAAATTTGAACTAAATTTTGAAAGGACAGAGGAAATTGTTAGGCTAGCAAACAAAGTAAATGCAACCGTTG
AAGCTGAAGTTGGCCAAATTGGGGGTGAGGAAGATGGTGTAATTGGTAATGGAGAAATTGCTAATCCGGAAAATGCAAAA
AAAATAACAGAAACTGGAATTACATGTCTGGCAGCTGGCATTGGTAATATTCACGGTATTTATCCCCCAGATTGAAAGTC
CCTGAATTTTGAGATTTTAGAAAAAATCTCAAAAGTAACAAAGATTCCGCTGGTTTTACACGGAGGGAGCGGAATACCAA
AAGACCAAATCCAGAAGGCAATAAAACTTGGGATTGCAAAAATTAATGTAAATACGGAATTACAACAGGCAAATGCGGCC
GCAATTTCCGAATTTGTTCTTTCAGGAAAAGTAAAACAAGGTAAAAATTTTGATCCTCGAAAATTATTAGCACCCGGAAC
TGATGCCATTCAGCTTCTTATTGAAGAAAAAATCACAGAATTTGGTTCTGCAAATCAAGCATAA

Upstream 100 bases:

>100_bases
TTGAACACTTAGATCAGATCTTAACGCTTAGTTTTTTTTTTTTTTTTTTTTAAAGGTTTCGACTGCAAAAAAAAAAAAAA
AAAAGTATCCAAAGGGAAAA

Downstream 100 bases:

>100_bases
GTTTTAATGATTAAGTTTGTCGCAACAAAAAATCAAAGCGGCCAAAAATTAATTCAGTTAATTAAGAAAATACTTTTGAA
GTCGAAATATAACGAAATTC

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MQLVNTKEMLEKALKNNYAIPHININNLEWTKAALLAAQAKKSPLIIGTSERVLTYMGGLKTIYNLVTNLIDYFKITVPV
ALHLDHGTYLTCKEALKNGYTSVMYDGSKEKFELNFERTEEIVRLANKVNATVEAEVGQIGGEEDGVIGNGEIANPENAK
KITETGITCLAAGIGNIHGIYPPDWKSLNFEILEKISKVTKIPLVLHGGSGIPKDQIQKAIKLGIAKINVNTELQQANAA
AISEFVLSGKVKQGKNFDPRKLLAPGTDAIQLLIEEKITEFGSANQA

Sequences:

>Translated_287_residues
MQLVNTKEMLEKALKNNYAIPHININNLE*TKAALLAAQAKKSPLIIGTSERVLTYMGGLKTIYNLVTNLIDYFKITVPV
ALHLDHGTYLTCKEALKNGYTSVMYDGSKEKFELNFERTEEIVRLANKVNATVEAEVGQIGGEEDGVIGNGEIANPENAK
KITETGITCLAAGIGNIHGIYPPD*KSLNFEILEKISKVTKIPLVLHGGSGIPKDQIQKAIKLGIAKINVNTELQQANAA
AISEFVLSGKVKQGKNFDPRKLLAPGTDAIQLLIEEKITEFGSANQA
>Mature_287_residues
MQLVNTKEMLEKALKNNYAIPHININNLE*TKAALLAAQAKKSPLIIGTSERVLTYMGGLKTIYNLVTNLIDYFKITVPV
ALHLDHGTYLTCKEALKNGYTSVMYDGSKEKFELNFERTEEIVRLANKVNATVEAEVGQIGGEEDGVIGNGEIANPENAK
KITETGITCLAAGIGNIHGIYPPD*KSLNFEILEKISKVTKIPLVLHGGSGIPKDQIQKAIKLGIAKINVNTELQQANAA
AISEFVLSGKVKQGKNFDPRKLLAPGTDAIQLLIEEKITEFGSANQA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=291, Percent_Identity=36.426116838488, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI1789526, Length=290, Percent_Identity=35.1724137931034, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1788072, Length=250, Percent_Identity=36.8, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1789293, Length=346, Percent_Identity=25.7225433526012, Blast_Score=87, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6322790, Length=339, Percent_Identity=28.9085545722714, Blast_Score=93, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 30889; Mature: 30889

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLVNTKEMLEKALKNNYAIPHININNLETKAALLAAQAKKSPLIIGTSERVLTYMGGLK
CCCCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHH
TIYNLVTNLIDYFKITVPVALHLDHGTYLTCKEALKNGYTSVMYDGSKEKFELNFERTEE
HHHHHHHHHHHHHHEEEEEEEEECCCCEEEHHHHHHCCCEEEEECCCCCEEEECHHHHHH
IVRLANKVNATVEAEVGQIGGEEDGVIGNGEIANPENAKKITETGITCLAAGIGNIHGIY
HHHHHHHHCCEEEEHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PPDKSLNFEILEKISKVTKIPLVLHGGSGIPKDQIQKAIKLGIAKINVNTELQQANAAAI
CCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHHH
SEFVLSGKVKQGKNFDPRKLLAPGTDAIQLLIEEKITEFGSANQA
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQLVNTKEMLEKALKNNYAIPHININNLETKAALLAAQAKKSPLIIGTSERVLTYMGGLK
CCCCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHH
TIYNLVTNLIDYFKITVPVALHLDHGTYLTCKEALKNGYTSVMYDGSKEKFELNFERTEE
HHHHHHHHHHHHHHEEEEEEEEECCCCEEEHHHHHHCCCEEEEECCCCCEEEECHHHHHH
IVRLANKVNATVEAEVGQIGGEEDGVIGNGEIANPENAKKITETGITCLAAGIGNIHGIY
HHHHHHHHCCEEEEHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PPDKSLNFEILEKISKVTKIPLVLHGGSGIPKDQIQKAIKLGIAKINVNTELQQANAAAI
CCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHHH
SEFVLSGKVKQGKNFDPRKLLAPGTDAIQLLIEEKITEFGSANQA
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]