Click here to switch to the map view.

The map label for this gene is fdh [H]

Identifier: 53723042

GI number: 53723042

Start: 2734375

End: 2735583

Strand: Reverse

Name: fdh [H]

Synonym: BPSS2024

Alternate gene names: 53723042

Gene position: 2735583-2734375 (Counterclockwise)

Preceding gene: 53723043

Following gene: 53723039

Centisome position: 86.21

GC content: 69.73

Gene sequence:

>1209_bases
ATGAAAGCGGTCGTATTTCACGGCATCGGCGACATCCGGATCGACACGGTGCCCGACCCCGGCCTCGCGCAGACGACCGA
CGCGGTCGTGCGGCTCACGTCGAGCGCGATCTGCGGCACCGATCTGCACATGGTGCGCGGCACGCTGGGCGGCATGAAAC
CGGGGACGATTCTCGGGCACGAGGGCGTCGGGCTCGTCGAGGAAGTCGGGCGCGACGTGCGCAACCTTCGCCGCGGCGAC
CGCGTGCTGATTCCGTCGACGATCTCGTGCGGGCATTGCGCATACTGCCGCGCGGGCTACACCGCGCAGTGCGACACCGC
GAATCCCGGCGGTCCGCTCGCCGGCACCGCGTTCTTCGGCGGCCCGCAGGCGAGCGGCGCATTCGACGGCCTGCAGGCCG
AATACGCGCGCACGCCGTTCGCGCATGCGAGCCTGATCCGCCTGCCCGATTCGCTCGACGACGAGCGCGCGATCCTGATG
TCCGACATCTTTCCGACCGGCTATTTCGGCGCGCAGCTCGCCGAGGTCCGCATGGGCGACACGGTCGCGGTATTCGGCGC
GGGGCCCGTCGGCCAGTTCGCGATCGCGAGCGCGAAGCTGATGGGCGCGGGGCGCGTGATCGCGATCGATCGCGTCGTAT
CGCGGCTCGAGATGGCGTGCGCGCAGGGCGCGGAGGTCATCAATTTCGACGACGACGATCCGGTCGACACGATCCTGCAA
CTGACGGGCGGCATCGGCGTGGATCGGGTGATCGATGCGGTCGGCGTCGACGCGGTGCGGCCCACGCGCGGGCCGGCCGC
GCCGCACGACGCGCAGAGCCGGCGCGCGTTCGACGACGAGGTGCGCGAACTCGCGCCGCGCACGCGCGCGGACGGCGGCC
ACTGGGTGCCGGGCGACGCGCCGTCGCAGGTGCTGCAATGGGCGGTGCGCGCGGTCGCGAAGGCGGGGACGGTCTCGATC
ATCGGCGTGTATCCGATGAACGACCGCTTCTTCCCGATCGGCGCGGCGATGAACCGCAATCTGACCGTCAAGATGGGCAA
CTGCAATCATCGCGCGATCACGCCGAAGCTGATCGAGATCGTGCGCAGCGGCGCGTTCGATCCGATCACGGTGCTTACGC
AGGCCGAGCCGCTGACGAGCGCGATCGACGCGTATCGCGCGTTCGATACGCGCGAGCCCGGATGGATCAAGGTGAAGCTC
GAACCGTAA

Upstream 100 bases:

>100_bases
GTGCGCCCCACCCGCGCGACAGGCCCCGCGCTTGCTCGCCGGCAGGCGGCGCGGCATGCGCCGCGGGTTCGATTCAGCAC
GTCACACGGAGGGCAACATC

Downstream 100 bases:

>100_bases
GCGCCGGGGCGTCAGCGCCGGCGTCGCCCGTCGTCATGGCCGCCGCCATCGCCGCTGTCGCCGCCGCCGTTGCGCGATCG
CTCGCCGCGGCCGGGCGTGC

Product: zinc-containing alcohol dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKAVVFHGIGDIRIDTVPDPGLAQTTDAVVRLTSSAICGTDLHMVRGTLGGMKPGTILGHEGVGLVEEVGRDVRNLRRGD
RVLIPSTISCGHCAYCRAGYTAQCDTANPGGPLAGTAFFGGPQASGAFDGLQAEYARTPFAHASLIRLPDSLDDERAILM
SDIFPTGYFGAQLAEVRMGDTVAVFGAGPVGQFAIASAKLMGAGRVIAIDRVVSRLEMACAQGAEVINFDDDDPVDTILQ
LTGGIGVDRVIDAVGVDAVRPTRGPAAPHDAQSRRAFDDEVRELAPRTRADGGHWVPGDAPSQVLQWAVRAVAKAGTVSI
IGVYPMNDRFFPIGAAMNRNLTVKMGNCNHRAITPKLIEIVRSGAFDPITVLTQAEPLTSAIDAYRAFDTREPGWIKVKL
EP

Sequences:

>Translated_402_residues
MKAVVFHGIGDIRIDTVPDPGLAQTTDAVVRLTSSAICGTDLHMVRGTLGGMKPGTILGHEGVGLVEEVGRDVRNLRRGD
RVLIPSTISCGHCAYCRAGYTAQCDTANPGGPLAGTAFFGGPQASGAFDGLQAEYARTPFAHASLIRLPDSLDDERAILM
SDIFPTGYFGAQLAEVRMGDTVAVFGAGPVGQFAIASAKLMGAGRVIAIDRVVSRLEMACAQGAEVINFDDDDPVDTILQ
LTGGIGVDRVIDAVGVDAVRPTRGPAAPHDAQSRRAFDDEVRELAPRTRADGGHWVPGDAPSQVLQWAVRAVAKAGTVSI
IGVYPMNDRFFPIGAAMNRNLTVKMGNCNHRAITPKLIEIVRSGAFDPITVLTQAEPLTSAIDAYRAFDTREPGWIKVKL
EP
>Mature_402_residues
MKAVVFHGIGDIRIDTVPDPGLAQTTDAVVRLTSSAICGTDLHMVRGTLGGMKPGTILGHEGVGLVEEVGRDVRNLRRGD
RVLIPSTISCGHCAYCRAGYTAQCDTANPGGPLAGTAFFGGPQASGAFDGLQAEYARTPFAHASLIRLPDSLDDERAILM
SDIFPTGYFGAQLAEVRMGDTVAVFGAGPVGQFAIASAKLMGAGRVIAIDRVVSRLEMACAQGAEVINFDDDDPVDTILQ
LTGGIGVDRVIDAVGVDAVRPTRGPAAPHDAQSRRAFDDEVRELAPRTRADGGHWVPGDAPSQVLQWAVRAVAKAGTVSI
IGVYPMNDRFFPIGAAMNRNLTVKMGNCNHRAITPKLIEIVRSGAFDPITVLTQAEPLTSAIDAYRAFDTREPGWIKVKL
EP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=234, Percent_Identity=34.1880341880342, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI156627571, Length=264, Percent_Identity=29.5454545454545, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4501933, Length=237, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI34577061, Length=236, Percent_Identity=34.3220338983051, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI71743840, Length=241, Percent_Identity=30.7053941908714, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI262073058, Length=241, Percent_Identity=30.7053941908714, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI71565152, Length=239, Percent_Identity=30.5439330543933, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4501939, Length=234, Percent_Identity=29.0598290598291, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI156523966, Length=234, Percent_Identity=29.0598290598291, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI71565154, Length=239, Percent_Identity=31.3807531380753, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1786825, Length=413, Percent_Identity=36.5617433414044, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI87082125, Length=217, Percent_Identity=35.4838709677419, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI87081918, Length=220, Percent_Identity=32.7272727272727, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790045, Length=241, Percent_Identity=33.195020746888, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1787863, Length=256, Percent_Identity=29.6875, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788073, Length=258, Percent_Identity=28.2945736434109, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786552, Length=257, Percent_Identity=31.9066147859922, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788075, Length=265, Percent_Identity=29.0566037735849, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788407, Length=224, Percent_Identity=29.4642857142857, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790718, Length=211, Percent_Identity=27.0142180094787, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI226510992, Length=175, Percent_Identity=28, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=228, Percent_Identity=31.140350877193, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=228, Percent_Identity=29.8245614035088, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25146526, Length=211, Percent_Identity=33.6492890995261, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=239, Percent_Identity=31.7991631799163, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=217, Percent_Identity=34.1013824884793, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=236, Percent_Identity=32.2033898305085, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=242, Percent_Identity=33.8842975206612, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=276, Percent_Identity=31.1594202898551, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=276, Percent_Identity=31.1594202898551, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=264, Percent_Identity=26.8939393939394, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=246, Percent_Identity=28.0487804878049, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=288, Percent_Identity=25.3472222222222, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=249, Percent_Identity=30.1204819277108, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=253, Percent_Identity=31.2252964426877, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=273, Percent_Identity=27.4725274725275, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137530, Length=264, Percent_Identity=30.6818181818182, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI17737897, Length=226, Percent_Identity=31.858407079646, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17737895, Length=245, Percent_Identity=31.0204081632653, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45550770, Length=216, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45551930, Length=216, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221457811, Length=216, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42539; Mature: 42539

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVFHGIGDIRIDTVPDPGLAQTTDAVVRLTSSAICGTDLHMVRGTLGGMKPGTILGH
CCEEEEECCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEECC
EGVGLVEEVGRDVRNLRRGDRVLIPSTISCGHCAYCRAGYTAQCDTANPGGPLAGTAFFG
CCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHCCCCEEECCCCCCCCCCEEEEECC
GPQASGAFDGLQAEYARTPFAHASLIRLPDSLDDERAILMSDIFPTGYFGAQLAEVRMGD
CCCCCCCCCCCHHHHHCCCCHHHHHEECCCCCCCCHHHHHHHCCCCCCCHHHHHEEECCC
TVAVFGAGPVGQFAIASAKLMGAGRVIAIDRVVSRLEMACAQGAEVINFDDDDPVDTILQ
EEEEEECCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
LTGGIGVDRVIDAVGVDAVRPTRGPAAPHDAQSRRAFDDEVRELAPRTRADGGHWVPGDA
HHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PSQVLQWAVRAVAKAGTVSIIGVYPMNDRFFPIGAAMNRNLTVKMGNCNHRAITPKLIEI
HHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEECCCCCCCEEEEECCCCCCCCCHHHHHH
VRSGAFDPITVLTQAEPLTSAIDAYRAFDTREPGWIKVKLEP
HHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEEECC
>Mature Secondary Structure
MKAVVFHGIGDIRIDTVPDPGLAQTTDAVVRLTSSAICGTDLHMVRGTLGGMKPGTILGH
CCEEEEECCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEECC
EGVGLVEEVGRDVRNLRRGDRVLIPSTISCGHCAYCRAGYTAQCDTANPGGPLAGTAFFG
CCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHCCCCEEECCCCCCCCCCEEEEECC
GPQASGAFDGLQAEYARTPFAHASLIRLPDSLDDERAILMSDIFPTGYFGAQLAEVRMGD
CCCCCCCCCCCHHHHHCCCCHHHHHEECCCCCCCCHHHHHHHCCCCCCCHHHHHEEECCC
TVAVFGAGPVGQFAIASAKLMGAGRVIAIDRVVSRLEMACAQGAEVINFDDDDPVDTILQ
EEEEEECCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
LTGGIGVDRVIDAVGVDAVRPTRGPAAPHDAQSRRAFDDEVRELAPRTRADGGHWVPGDA
HHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PSQVLQWAVRAVAKAGTVSIIGVYPMNDRFFPIGAAMNRNLTVKMGNCNHRAITPKLIEI
HHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEECCCCCCCEEEEECCCCCCCCCHHHHHH
VRSGAFDPITVLTQAEPLTSAIDAYRAFDTREPGWIKVKLEP
HHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]