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The map label for this gene is deoA

Identifier: 53722981

GI number: 53722981

Start: 2648584

End: 2649906

Strand: Reverse

Name: deoA

Synonym: BPSS1960

Alternate gene names: 53722981

Gene position: 2649906-2648584 (Counterclockwise)

Preceding gene: 53722983

Following gene: 53722980

Centisome position: 83.51

GC content: 73.77

Gene sequence:

>1323_bases
ATGACCTTCCTGCCGCAGGAATTCATCCGCAAGGTGCGCGACCGCGCGCCGCTCGACACGGCCGACGTCGCGCGTTTCGT
CCAAGGCGTGACGGCGGGCGACGTGACCGAAGGCCAGATCGCCGCGTTCGCGATGGCGGTCTATTTCAACGAGTTGCCGC
TGTCCGCGCGCATCGCGCTGACGCTCGCGCAGCGCGATTCCGGCGACGTGCTCGACTGGCGCGGCGCGCGCCTGAACGGG
CCGGTGGTCGACAAGCACTCGACGGGCGGCGTCGGCGATCTGACCTCGCTCGTGATCGGGCCGATGGTGGCCGCGTGCGG
CGGCTACGTGCCGATGATCTCGGGCCGCGGCCTCGGCCACACGGGCGGCACGCTCGACAAGCTCGAGGCGATTCCCGGTT
ACGATGTCGCGCCGTCCGTCGACATGCTGCGCCGCGTCGTGCGCGACGCGGGCCTTGCGATCGTCGGCCAGACCGCGCAG
CTCGCGCCCGCCGACAAGCGGATCTATGCGGTGCGCGACGTGACGGCGACCGTCGAATCGATCTCGCTGATCACCGCGTC
GATCCTGTCGAAGAAGCTCGCGGCGGGCGTCGGCGCGCTCGCGATGGACGTGAAGGTCGGCTCCGGCGCGTTCATGCCGA
GCGCGGAGCAATCGGCCGAACTCGCGCGCAGCATCGTCGACGTCGGCAACGGCGCGGGGATGAGGACGGCCGCGACGCTC
ACCGACATGAACCAGGCGCTCGCGCCATGCGCGGGCAACGCGATCGAGGTGCGCTGCGCGATCGATTTCCTGACGGGCGC
GGCGCGCCCCGCGCGGCTCGAAGCGGTCAGCTTCGCGCTCGCCGCGCAGATGCTGACGATGGGCGGGCTTGCCGCGGACG
CGCACGATGCGCGCCGCCGGTTGCGCGCGGTGCTCGAATCGGGCGCGGCCGCGGAGCGGTTCGCGCGGATGGTCGCGGCG
CTCGGCGGGCCCGCCGATCTGGTCGAGCGGCCCGAGCGGCATCTGCCGCGCGCGGCTGCCGCCGCCCCCGTGGCCGCCGC
GCGCGCCGGCTGGATCGAGCGGATCGACGCGCGCGCGCTCGGCCTGGCGGTCGTCGGCCTGGGCGGCGGGCGCGCGAAGA
TCGGCGACACGCTCGATTACTCGGTCGGACTGTCCGCGCTCGCGGAGCTGGGCGAGCGCGTCGAGGCGGGCCAGCCGCTC
GCGACCGTTCACGCGCGCGACGCCGATTCGGCCGCGCAGGCGACCGACGCGGTGCGGCGCGCCTACCGGATCGGCGCGGA
GCCGCCGGCGCAGACGCGCGTCGTTCATGCCGTGATCGAATGA

Upstream 100 bases:

>100_bases
AAACGGCTGGGCCGCCGGTGCAGATAGTGGACGGCATTCGCCGTTTCGAATGCATTTCGAATGCAATTGCGCCGTTGAAA
ATCAACCGCTTATGCAAACC

Downstream 100 bases:

>100_bases
TCGAACGTGTTGCGCGCATCGGCGCGTCGTATCTGTCGACGCATGGCGGATGTCGAAACGGCGCGGTATGCCGCGCGGCG
GCGCGTTTGCGTAGGACGGC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MTFLPQEFIRKVRDRAPLDTADVARFVQGVTAGDVTEGQIAAFAMAVYFNELPLSARIALTLAQRDSGDVLDWRGARLNG
PVVDKHSTGGVGDLTSLVIGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGYDVAPSVDMLRRVVRDAGLAIVGQTAQ
LAPADKRIYAVRDVTATVESISLITASILSKKLAAGVGALAMDVKVGSGAFMPSAEQSAELARSIVDVGNGAGMRTAATL
TDMNQALAPCAGNAIEVRCAIDFLTGAARPARLEAVSFALAAQMLTMGGLAADAHDARRRLRAVLESGAAAERFARMVAA
LGGPADLVERPERHLPRAAAAAPVAAARAGWIERIDARALGLAVVGLGGGRAKIGDTLDYSVGLSALAELGERVEAGQPL
ATVHARDADSAAQATDAVRRAYRIGAEPPAQTRVVHAVIE

Sequences:

>Translated_440_residues
MTFLPQEFIRKVRDRAPLDTADVARFVQGVTAGDVTEGQIAAFAMAVYFNELPLSARIALTLAQRDSGDVLDWRGARLNG
PVVDKHSTGGVGDLTSLVIGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGYDVAPSVDMLRRVVRDAGLAIVGQTAQ
LAPADKRIYAVRDVTATVESISLITASILSKKLAAGVGALAMDVKVGSGAFMPSAEQSAELARSIVDVGNGAGMRTAATL
TDMNQALAPCAGNAIEVRCAIDFLTGAARPARLEAVSFALAAQMLTMGGLAADAHDARRRLRAVLESGAAAERFARMVAA
LGGPADLVERPERHLPRAAAAAPVAAARAGWIERIDARALGLAVVGLGGGRAKIGDTLDYSVGLSALAELGERVEAGQPL
ATVHARDADSAAQATDAVRRAYRIGAEPPAQTRVVHAVIE
>Mature_439_residues
TFLPQEFIRKVRDRAPLDTADVARFVQGVTAGDVTEGQIAAFAMAVYFNELPLSARIALTLAQRDSGDVLDWRGARLNGP
VVDKHSTGGVGDLTSLVIGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGYDVAPSVDMLRRVVRDAGLAIVGQTAQL
APADKRIYAVRDVTATVESISLITASILSKKLAAGVGALAMDVKVGSGAFMPSAEQSAELARSIVDVGNGAGMRTAATLT
DMNQALAPCAGNAIEVRCAIDFLTGAARPARLEAVSFALAAQMLTMGGLAADAHDARRRLRAVLESGAAAERFARMVAAL
GGPADLVERPERHLPRAAAAAPVAAARAGWIERIDARALGLAVVGLGGGRAKIGDTLDYSVGLSALAELGERVEAGQPLA
TVHARDADSAAQATDAVRRAYRIGAEPPAQTRVVHAVIE

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Homologues:

Organism=Homo sapiens, GI166158925, Length=407, Percent_Identity=44.4717444717445, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI4503445, Length=407, Percent_Identity=44.4717444717445, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI166158922, Length=407, Percent_Identity=44.4717444717445, Blast_Score=279, Evalue=4e-75,
Organism=Escherichia coli, GI1790842, Length=434, Percent_Identity=56.4516129032258, Blast_Score=490, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_BURM7 (A3MAQ6)

Other databases:

- EMBL:   CP000547
- RefSeq:   YP_001077342.1
- ProteinModelPortal:   A3MAQ6
- SMR:   A3MAQ6
- GeneID:   4891296
- GenomeReviews:   CP000547_GR
- KEGG:   bmn:BMA10247_A0136
- TIGR:   BMA10247_A0136
- HOGENOM:   HBG288505
- OMA:   AEIFGRM
- ProtClustDB:   PRK05820
- BioCyc:   BMAL320389:BMA10247_A0136-MONOMER
- HAMAP:   MF_01628
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02643
- TIGRFAMs:   TIGR02644

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 45404; Mature: 45272

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLPQEFIRKVRDRAPLDTADVARFVQGVTAGDVTEGQIAAFAMAVYFNELPLSARIAL
CCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEE
TLAQRDSGDVLDWRGARLNGPVVDKHSTGGVGDLTSLVIGPMVAACGGYVPMISGRGLGH
EEEECCCCCEECCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCC
TGGTLDKLEAIPGYDVAPSVDMLRRVVRDAGLAIVGQTAQLAPADKRIYAVRDVTATVES
CCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEHHHHHHHHH
ISLITASILSKKLAAGVGALAMDVKVGSGAFMPSAEQSAELARSIVDVGNGAGMRTAATL
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
TDMNQALAPCAGNAIEVRCAIDFLTGAARPARLEAVSFALAAQMLTMGGLAADAHDARRR
HHHHHHHHCCCCCEEEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LRAVLESGAAAERFARMVAALGGPADLVERPERHLPRAAAAAPVAAARAGWIERIDARAL
HHHHHHCCHHHHHHHHHHHHHCCCHHHHCCCHHHCCHHHHHCHHHHHHHHHHHHHHHHHE
GLAVVGLGGGRAKIGDTLDYSVGLSALAELGERVEAGQPLATVHARDADSAAQATDAVRR
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
AYRIGAEPPAQTRVVHAVIE
HHHCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
TFLPQEFIRKVRDRAPLDTADVARFVQGVTAGDVTEGQIAAFAMAVYFNELPLSARIAL
CCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEE
TLAQRDSGDVLDWRGARLNGPVVDKHSTGGVGDLTSLVIGPMVAACGGYVPMISGRGLGH
EEEECCCCCEECCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCC
TGGTLDKLEAIPGYDVAPSVDMLRRVVRDAGLAIVGQTAQLAPADKRIYAVRDVTATVES
CCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEHHHHHHHHH
ISLITASILSKKLAAGVGALAMDVKVGSGAFMPSAEQSAELARSIVDVGNGAGMRTAATL
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
TDMNQALAPCAGNAIEVRCAIDFLTGAARPARLEAVSFALAAQMLTMGGLAADAHDARRR
HHHHHHHHCCCCCEEEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LRAVLESGAAAERFARMVAALGGPADLVERPERHLPRAAAAAPVAAARAGWIERIDARAL
HHHHHHCCHHHHHHHHHHHHHCCCHHHHCCCHHHCCHHHHHCHHHHHHHHHHHHHHHHHE
GLAVVGLGGGRAKIGDTLDYSVGLSALAELGERVEAGQPLATVHARDADSAAQATDAVRR
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
AYRIGAEPPAQTRVVHAVIE
HHHCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA