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The map label for this gene is zraS [H]

Identifier: 53722667

GI number: 53722667

Start: 2262606

End: 2263775

Strand: Reverse

Name: zraS [H]

Synonym: BPSS1646

Alternate gene names: 53722667

Gene position: 2263775-2262606 (Counterclockwise)

Preceding gene: 53722668

Following gene: 53722664

Centisome position: 71.34

GC content: 65.47

Gene sequence:

>1170_bases
GTGGCTGAATCGAGTCTCGTCGACGACGCGTCGGCCGACATCCCCTCCCTGAAGAAGGAGATCGTGCGGTTGAACAAGAT
CGTGCGCTCGCTGATGGATCGCGCGGAGCGCAGCACGATCGTCTGCGGATCGGATTTCAGCCTGTTTCAGATGGCCGTCA
CGCTCGAGGATCAGGTGCGGCATCGCACGCGCGAGCTGGAGGCGGCGCTGCACGAGAACCAGAAGATCATGCACGCGCTG
CAGCGCACGCAGGCGCTGATGGCGCAGGAGATCGAGGAGCGCAAGAGGACGCAGGCGGAGCTCGAGACCGAGCGCGAGGC
GCAGCGCCATTTGATCGAGCAGCTGGCGCAGGCGCACGGGCAACTGCTGCAATCGGAGAAGCTCGCGTCGATCGGCCAGC
TCGCGGCGGGCGTCGCGCACGAGATCAACAATCCGATCGGCTTCGTCGATTCGAACCTGCGCACGCTGAAGACATGGGTG
CGGCAATTGCTCGACGTGATGGCGATCGAGGACGCGCTGATCGCCGATTGCGGCGACGCCGCGCTCGCGCGCCTGCGTGC
CGCGCACGCTGAGGTCGATCTCGACTATCTGCGCGGCGACATCGGAACGCTGATCGACGAATCGATCGAAGGCGCGTCGC
GCGTGCGGCGGATCGTGCAGGACCTGCGCGACTTCTCGCGGGCGGGCAGCGAGGAATGGAACTTCGCCGACGTCCACGAG
GGGCTGGAGGCGACGTTGAACGTGTTGCGCAACGAACTGAAGTACAAGGCGGAGGTCGTCAAGGATTACGGCGAGCTGCC
GGCCGTCGAATGCATGCCGTCGCAGTTGAACCAGGTCGTGATGAATCTGCTGATGAACGCCGCGCAGGCGATCGTCGAGC
ACGGCACCATCACGATCCGCACGCGCCGCGAAGGCGACGGCGTGACGATCGCGATCGAGGATACGGGCGTCGGCATTCCG
GCGGACCGGCTCGCGAAGATCTTCGATCCGTTCTACACGACGAAGCCGGTAGGCAAGGGCACCGGGCTCGGGCTATCGGT
TTCGTACGGCATCGTCGAAAAGCACGGCGGCCGGATCACGGTCGACAGCGAGCCGGGCAACGGATCGCGCTTCACGATCT
GGCTGCCGATCGTCCGGCAGCGCTCGTTGCAGGATGCGGCGGCCGGCTAA

Upstream 100 bases:

>100_bases
CATGCCGTCGGCTTCAGCACCTACGGCGAACAGTACGGCGGCGTTCACGTGAACCAGACGCTCACCGGCATCGTCTTCAG
TCGCGCGCCGGAGCCCGACC

Downstream 100 bases:

>100_bases
TCCGCGCGCCCGTTCGGCGGCCGTGGCGCGGCTCGACGCGACGCGAGCCGCTGCGATGCACGGCGGCGCGCGCCGGATGG
CTCGATCGCGCGAAGGGCGG

Product: two-component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MAESSLVDDASADIPSLKKEIVRLNKIVRSLMDRAERSTIVCGSDFSLFQMAVTLEDQVRHRTRELEAALHENQKIMHAL
QRTQALMAQEIEERKRTQAELETEREAQRHLIEQLAQAHGQLLQSEKLASIGQLAAGVAHEINNPIGFVDSNLRTLKTWV
RQLLDVMAIEDALIADCGDAALARLRAAHAEVDLDYLRGDIGTLIDESIEGASRVRRIVQDLRDFSRAGSEEWNFADVHE
GLEATLNVLRNELKYKAEVVKDYGELPAVECMPSQLNQVVMNLLMNAAQAIVEHGTITIRTRREGDGVTIAIEDTGVGIP
ADRLAKIFDPFYTTKPVGKGTGLGLSVSYGIVEKHGGRITVDSEPGNGSRFTIWLPIVRQRSLQDAAAG

Sequences:

>Translated_389_residues
MAESSLVDDASADIPSLKKEIVRLNKIVRSLMDRAERSTIVCGSDFSLFQMAVTLEDQVRHRTRELEAALHENQKIMHAL
QRTQALMAQEIEERKRTQAELETEREAQRHLIEQLAQAHGQLLQSEKLASIGQLAAGVAHEINNPIGFVDSNLRTLKTWV
RQLLDVMAIEDALIADCGDAALARLRAAHAEVDLDYLRGDIGTLIDESIEGASRVRRIVQDLRDFSRAGSEEWNFADVHE
GLEATLNVLRNELKYKAEVVKDYGELPAVECMPSQLNQVVMNLLMNAAQAIVEHGTITIRTRREGDGVTIAIEDTGVGIP
ADRLAKIFDPFYTTKPVGKGTGLGLSVSYGIVEKHGGRITVDSEPGNGSRFTIWLPIVRQRSLQDAAAG
>Mature_388_residues
AESSLVDDASADIPSLKKEIVRLNKIVRSLMDRAERSTIVCGSDFSLFQMAVTLEDQVRHRTRELEAALHENQKIMHALQ
RTQALMAQEIEERKRTQAELETEREAQRHLIEQLAQAHGQLLQSEKLASIGQLAAGVAHEINNPIGFVDSNLRTLKTWVR
QLLDVMAIEDALIADCGDAALARLRAAHAEVDLDYLRGDIGTLIDESIEGASRVRRIVQDLRDFSRAGSEEWNFADVHEG
LEATLNVLRNELKYKAEVVKDYGELPAVECMPSQLNQVVMNLLMNAAQAIVEHGTITIRTRREGDGVTIAIEDTGVGIPA
DRLAKIFDPFYTTKPVGKGTGLGLSVSYGIVEKHGGRITVDSEPGNGSRFTIWLPIVRQRSLQDAAAG

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=272, Percent_Identity=37.1323529411765, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788549, Length=285, Percent_Identity=31.2280701754386, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI145693157, Length=283, Percent_Identity=28.2685512367491, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87081816, Length=171, Percent_Identity=32.7485380116959, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI48994928, Length=106, Percent_Identity=44.3396226415094, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790300, Length=272, Percent_Identity=29.4117647058824, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790346, Length=112, Percent_Identity=31.25, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=178, Percent_Identity=28.0898876404494, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786783, Length=327, Percent_Identity=24.4648318042813, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786600, Length=107, Percent_Identity=31.7757009345794, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42988; Mature: 42857

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESSLVDDASADIPSLKKEIVRLNKIVRSLMDRAERSTIVCGSDFSLFQMAVTLEDQVR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHH
HRTRELEAALHENQKIMHALQRTQALMAQEIEERKRTQAELETEREAQRHLIEQLAQAHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLLQSEKLASIGQLAAGVAHEINNPIGFVDSNLRTLKTWVRQLLDVMAIEDALIADCGDA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ALARLRAAHAEVDLDYLRGDIGTLIDESIEGASRVRRIVQDLRDFSRAGSEEWNFADVHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
GLEATLNVLRNELKYKAEVVKDYGELPAVECMPSQLNQVVMNLLMNAAQAIVEHGTITIR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
TRREGDGVTIAIEDTGVGIPADRLAKIFDPFYTTKPVGKGTGLGLSVSYGIVEKHGGRIT
EEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHCCCCCEEE
VDSEPGNGSRFTIWLPIVRQRSLQDAAAG
EECCCCCCCEEEEEEHHHHHHHHHHHCCC
>Mature Secondary Structure 
AESSLVDDASADIPSLKKEIVRLNKIVRSLMDRAERSTIVCGSDFSLFQMAVTLEDQVR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHH
HRTRELEAALHENQKIMHALQRTQALMAQEIEERKRTQAELETEREAQRHLIEQLAQAHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLLQSEKLASIGQLAAGVAHEINNPIGFVDSNLRTLKTWVRQLLDVMAIEDALIADCGDA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ALARLRAAHAEVDLDYLRGDIGTLIDESIEGASRVRRIVQDLRDFSRAGSEEWNFADVHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
GLEATLNVLRNELKYKAEVVKDYGELPAVECMPSQLNQVVMNLLMNAAQAIVEHGTITIR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
TRREGDGVTIAIEDTGVGIPADRLAKIFDPFYTTKPVGKGTGLGLSVSYGIVEKHGGRIT
EEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHCCCCCEEE
VDSEPGNGSRFTIWLPIVRQRSLQDAAAG
EECCCCCCCEEEEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]