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The map label for this gene is napA [H]

Identifier: 53722206

GI number: 53722206

Start: 1585839

End: 1587188

Strand: Reverse

Name: napA [H]

Synonym: BPSS1178

Alternate gene names: 53722206

Gene position: 1587188-1585839 (Counterclockwise)

Preceding gene: 53722215

Following gene: 53722205

Centisome position: 50.02

GC content: 69.7

Gene sequence:

>1350_bases
TTGTTCCGGCCGAGGCTTTGCATTGTACTGACGCGGCTTTGGCGGCCGAATGTCGGCCGGGACACGAACGCTGTCGGATC
GCCCGCCATCACGCCGGTCGAGCCGAGGAGGATCCGGATGGTTATGTGGTTATTGCAGCTCGCGGCGATCATCGCCGCGT
GCGCCTGCTTCGGTTGGCTCGCGCAACGCGTCGGGCAAGCGAAAGTGGTCGGCGAGCTGGCCGCGGGCATCGTGCTCGGC
CCGGCCGTGCTCGGCGCGATCGATTCGAACGTTCATGCGATGATCTTCGGCCCCGCCGCGTCGTCGGGCATGGCGCAACT
GGGCGAGGTCGGCGTGATCGCGCTGATGTTCCAGATCGGGCTGCACATGAATCTCGGCGGCGCGCCGACGCTGCGTTCGC
TGAGGAAGATGCCGCCCGCGGTGGTGGTGGCCGGAATCGGCATGCTGCTGCCGCTGGCGGGCGGCATGGCGATCGGCTGT
CTGTCGCACGACGCGCTCGCGCCGCGAATCGCCGCGTGGCCTTACGTGCTGTTCTGCGGCGTCGCGCTGTCGGTCTCCGC
GCTGCCGGTGATGGCGAGAATCGTCATCGACATGGAGCTCGTCGATGCGCCGCCGTCGCTGCTCGCATTGTCGGCTGCGA
TGCTGACCGACCTCGCGGGCTGGATCATGCTCGCGTTCGTCTCGGCCATCGCCGTCGCCGGCGCGGATGCCGCCGGGCCC
TCGCATATCGTCGCCGGCATCGCCGCGTTCGTGCTGCTGGCGAAGCTCGCCGCGCGGTTCGTCGTCACGCCGCTCGCCGC
CGATGCGGCGAAGCGGGCGTCGCCCGCGAGGCTGATGAGCGTCGTCGTGCCGTACGTGCTGGTTTGCGCGTGGGCGACCA
CGGCGATCGGCGTGCACAGCGCGTTCGGCGCGCTGCTCGCCGCCGTGATGCTGCGCGGCGTGCCGGGGCTGCAGGCGCAA
TGGGAGCGCCAGATGGAAGGCTTCGTGAACGCGGTGCTGCTGCCCGTGTTCTTCGTCCATTCGGGGCTGCGCGTCACCTT
CGACAGCTTCGACGGCGCCTCGCCGTGGCTGTGGCTCGTGCCGTTCCTGTGCGTCGCGTTCGTCGGCAAGTTCGGCGGCG
CGTATCTCGGCGCGCGCCTCTGCGGAATGAACCGGGGCGACGCGGCGCTCGTCGGCTCGCTGATGAACACGCGCGGGCTC
GTCGAGCTGGTCGTGTTGTCGGCGGGGCTGCAGATCCATGCGCTGTCGCAAAGCGCCTATGCGGTGCTTCTGCTCGTCGC
GCTGACGACGACGGCGATGACGACGCCGTTCGTCCGGTTGTGGCGGCGCGCGGTATTGCGCCCCGCCTGA

Upstream 100 bases:

>100_bases
GGCGTGACGCGCCGCTATCCGGATTGCCTTAACCGATCTCCATTCTGGCGTTTCACGATATTCGATATAAAAGAAGCCGA
CCGACTATCAGATTTGATAG

Downstream 100 bases:

>100_bases
CGCCGCGACGCTCGGTTGCGGCGGCCCCTCATCCTGAACGGCTTGCTCACATGGACAGAAGATCGATCATCGCCGACGAC
GGGCGCGAGCTGAACGCGTT

Product: transmembrane antiporter Na+ or K+/H+ exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFRPRLCIVLTRLWRPNVGRDTNAVGSPAITPVEPRRIRMVMWLLQLAAIIAACACFGWLAQRVGQAKVVGELAAGIVLG
PAVLGAIDSNVHAMIFGPAASSGMAQLGEVGVIALMFQIGLHMNLGGAPTLRSLRKMPPAVVVAGIGMLLPLAGGMAIGC
LSHDALAPRIAAWPYVLFCGVALSVSALPVMARIVIDMELVDAPPSLLALSAAMLTDLAGWIMLAFVSAIAVAGADAAGP
SHIVAGIAAFVLLAKLAARFVVTPLAADAAKRASPARLMSVVVPYVLVCAWATTAIGVHSAFGALLAAVMLRGVPGLQAQ
WERQMEGFVNAVLLPVFFVHSGLRVTFDSFDGASPWLWLVPFLCVAFVGKFGGAYLGARLCGMNRGDAALVGSLMNTRGL
VELVVLSAGLQIHALSQSAYAVLLLVALTTTAMTTPFVRLWRRAVLRPA

Sequences:

>Translated_449_residues
MFRPRLCIVLTRLWRPNVGRDTNAVGSPAITPVEPRRIRMVMWLLQLAAIIAACACFGWLAQRVGQAKVVGELAAGIVLG
PAVLGAIDSNVHAMIFGPAASSGMAQLGEVGVIALMFQIGLHMNLGGAPTLRSLRKMPPAVVVAGIGMLLPLAGGMAIGC
LSHDALAPRIAAWPYVLFCGVALSVSALPVMARIVIDMELVDAPPSLLALSAAMLTDLAGWIMLAFVSAIAVAGADAAGP
SHIVAGIAAFVLLAKLAARFVVTPLAADAAKRASPARLMSVVVPYVLVCAWATTAIGVHSAFGALLAAVMLRGVPGLQAQ
WERQMEGFVNAVLLPVFFVHSGLRVTFDSFDGASPWLWLVPFLCVAFVGKFGGAYLGARLCGMNRGDAALVGSLMNTRGL
VELVVLSAGLQIHALSQSAYAVLLLVALTTTAMTTPFVRLWRRAVLRPA
>Mature_449_residues
MFRPRLCIVLTRLWRPNVGRDTNAVGSPAITPVEPRRIRMVMWLLQLAAIIAACACFGWLAQRVGQAKVVGELAAGIVLG
PAVLGAIDSNVHAMIFGPAASSGMAQLGEVGVIALMFQIGLHMNLGGAPTLRSLRKMPPAVVVAGIGMLLPLAGGMAIGC
LSHDALAPRIAAWPYVLFCGVALSVSALPVMARIVIDMELVDAPPSLLALSAAMLTDLAGWIMLAFVSAIAVAGADAAGP
SHIVAGIAAFVLLAKLAARFVVTPLAADAAKRASPARLMSVVVPYVLVCAWATTAIGVHSAFGALLAAVMLRGVPGLQAQ
WERQMEGFVNAVLLPVFFVHSGLRVTFDSFDGASPWLWLVPFLCVAFVGKFGGAYLGARLCGMNRGDAALVGSLMNTRGL
VELVVLSAGLQIHALSQSAYAVLLLVALTTTAMTTPFVRLWRRAVLRPA

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=410, Percent_Identity=25.609756097561, Blast_Score=145, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 46860; Mature: 46860

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRPRLCIVLTRLWRPNVGRDTNAVGSPAITPVEPRRIRMVMWLLQLAAIIAACACFGWL
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQRVGQAKVVGELAAGIVLGPAVLGAIDSNVHAMIFGPAASSGMAQLGEVGVIALMFQIG
HHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHC
LHMNLGGAPTLRSLRKMPPAVVVAGIGMLLPLAGGMAIGCLSHDALAPRIAAWPYVLFCG
CCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCHHEEHHCCHHHCCHHHHHHHHHHHH
VALSVSALPVMARIVIDMELVDAPPSLLALSAAMLTDLAGWIMLAFVSAIAVAGADAAGP
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
SHIVAGIAAFVLLAKLAARFVVTPLAADAAKRASPARLMSVVVPYVLVCAWATTAIGVHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AFGALLAAVMLRGVPGLQAQWERQMEGFVNAVLLPVFFVHSGLRVTFDSFDGASPWLWLV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHH
PFLCVAFVGKFGGAYLGARLCGMNRGDAALVGSLMNTRGLVELVVLSAGLQIHALSQSAY
HHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHH
AVLLLVALTTTAMTTPFVRLWRRAVLRPA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFRPRLCIVLTRLWRPNVGRDTNAVGSPAITPVEPRRIRMVMWLLQLAAIIAACACFGWL
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQRVGQAKVVGELAAGIVLGPAVLGAIDSNVHAMIFGPAASSGMAQLGEVGVIALMFQIG
HHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHC
LHMNLGGAPTLRSLRKMPPAVVVAGIGMLLPLAGGMAIGCLSHDALAPRIAAWPYVLFCG
CCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCHHEEHHCCHHHCCHHHHHHHHHHHH
VALSVSALPVMARIVIDMELVDAPPSLLALSAAMLTDLAGWIMLAFVSAIAVAGADAAGP
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
SHIVAGIAAFVLLAKLAARFVVTPLAADAAKRASPARLMSVVVPYVLVCAWATTAIGVHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AFGALLAAVMLRGVPGLQAQWERQMEGFVNAVLLPVFFVHSGLRVTFDSFDGASPWLWLV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHH
PFLCVAFVGKFGGAYLGARLCGMNRGDAALVGSLMNTRGLVELVVLSAGLQIHALSQSAY
HHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHH
AVLLLVALTTTAMTTPFVRLWRRAVLRPA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]