| Definition | Burkholderia pseudomallei K96243 chromosome 2, complete sequence. |
|---|---|
| Accession | NC_006351 |
| Length | 3,173,005 |
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The map label for this gene is pksJ [H]
Identifier: 53722200
GI number: 53722200
Start: 1568087
End: 1572076
Strand: Reverse
Name: pksJ [H]
Synonym: BPSS1172
Alternate gene names: 53722200
Gene position: 1572076-1568087 (Counterclockwise)
Preceding gene: 53722201
Following gene: 53722199
Centisome position: 49.55
GC content: 69.52
Gene sequence:
>3990_bases GTGAATAATCTTGACGTCGCGATCATCGGGATGAGCGGTGCGTTTCCGGGCGCCTCCGATGTCCGGGAATTCTGGCGCAA TCTCGAGGCCGGCCGTTGTTCGCTGGAGCGCTACACCGAGCAGGAACTGCTCGACGCCGGCGTCGATCCCGCGCATCTGA AGTCGCCGCAGTACGTGCCCGTCGGCGGGCGCATGCGCGACATCGAATGCTTCGACAACGAGTTCTTCGGCATCAGCAAT CACGACGCGCGGCTGATGGACCCGCAGCAGCGCGTGTTCCTGCAACTCGCGTGGCATGCGTTCGAAGACGCGGGCTTCGT GCCGGGCGCGCATCCCGGGCGCGTCGGCGTGTACGCGGGCGTGAGCCTGAACAGCTACCTGCACACGATCGTGTTCCGGT CCGACGAGGTCGATCTCGACCGCGACGGCCAGAGCATTCTGTTCGGCAACCTGAGCGACTATCTGACGACGCGGCTGTCC TATCTGCTCGACCTCAAGGGGCCGAGCGTCAATATCCAGACCGCGTGCTCGACATCGCTCGTCGCGATCCACGAGGCATG CCAGGGTCTGCTGAGCTACCAGGCGGACGTCGCGCTCGCGGGCGCGTGCTCGATCAACGTGCCGAACACGCGCGGCTACC TCTACAGCCAGGACAGTTTCTTCTCGCCGGACGGCCGGGTGCGCGCGTTCGACGAACAGGCGGCGGGCACGGTGTTCAGC AACGGCGCCGGGCTCGTCGTGCTCAAGCGCCTGGACGATGCGCTGCGCGACGGCGATCAGATCTACGCGGTGCTGAAGGC GAGCGCGGTCAACAACGACGGCTCCGACAAGGTCGGCTACGCGGCGCCGAGCGTGTCCGGGCAGAGCGCGGTGATCCGCG ACGCGCTGCACGCGTGCGAGATCCGCCCCGAGCAGATCCAGTATGTCGAGACGCACGGCACGGGCACGTCGCTCGGCGAT CCGATCGAGATCGCCGCGCTCACGCAGGCGTACGCGGGCGAGCGGCGGCGCGGCGCGGCCACGCGGCACGCGACGTGCGC GATCGGTTCGGTGAAGACGAACATCGGGCATATCGACGTGGCGGCGGGCGTCGCCGGCGTGATCAAGACCGCGCTCGCGC TGCGGCACAAGACCCTGCCCGCGTCGCTCGGCTTCGAGAAGGCGAACCCGCGGCTCGGCCTCGAGAGCGGCCCGTTCTAC GTCAACGACCGCACGCGGCCGTGGGCGTCCGATACGCCGCGCGTCGCGGCCGTGAGCAGCTTCGGCATCGGCGGCACGAA CGCGCACGCGATCCTCGAGGAGGCGCCCGCGCGGGAGCCGCTGCCGGCGGCGAAGTCCGCCTACTGCCTGACGCTGTCGG CGCGCACCGCGTCCTCGCTGGAGGCGCTGCGCGCGAGCTATCTGACGTTTCTGAACGGCGACGATCTGCCGGCGTTCGCG GATCTCTGCTTCACGTCGAACGTCGGGCGCAAGCCGTTCGCGCATCGGATCGCCATCGCGGCGAGCGACGCGGCGGACGC CGCGCGGCAACTCGCGGCCGCGGCGGCGACGGCGAGCGACGGACAGCCGCATCGGATCGTGGTGAGCGCGCAGGCGGACG ACGCGAATGCGACGTGGCAGGCGATCCGCGGCGGCGACATCGATCCGCGCGAGCCGCTGTTCGAGGCCGCCGATCGCTTC AGCGCCGCGGAGCGGGTGGCGGCGTACGCGGTCCTGCTCGTCGCGCAACTGCGGCGGCTCGGCCTCGCCGCCGCGTTGCA GCGGCCCGCGCAGTTGCCGCAGAGCCTCGTCGAGCGGCTCGCGCCGCGGCAAGACGATCCGCTGCGCCGGCTGATCGCGG AGCCGCCCATCGAAGCCGCGCAGTCCGACTATGCGCTGACGCTGCGCGCCGCGTGCGAGCTGCGCATCGGCCCGGCCGTC CGCGCGCTGGGCGCGCCGTCGCTGCGGGGGCGCTTCGTCGCGGAGCTGCTCGCGGCCGGCTGGGCGGCCGGCGTGCCGGT GGACTGGGCGTCGTTCCACGCGGACGAGGCGCGGCGCAAGACGTCGCTGCCGGCGTACGCGTTCGCGAAAAAGGTGCTGT GGCTGTCGACCGCGACCGACGCCGAGCGGCGCAACCGCAAGATCGAAGACATCGGCCAGTGGTTCTACAAGCCGACGTGG CGCGAAACCGCCGCGCTCGCCGCGCGCACCCGGCGCGCGGATGAACTGGCCGATGCGAACGTGCTCGTCTTCAGCGCCGA CCGGCTCCATCGGCTGAAAGCGGGCTGGGCGCTGGCCGCGCAATGCCTGTATGTCGTGCCGGGCGCCGAATTCGGCCAGT TGAGCGACGACACCTATTGCATCGATCCCGCCTCCGAGGACGATTACCGGCGCCTGATCGAGGCGCTCGTCGCGCGCGGA CGTCTGCCGCGCCACGTCGTGCATGCGTGGCTCGCGGCCGAGGCCGCGTGGGACGGCACGCCGGCGAACTTCGCGAACTG CCAGGCGCTCGGGCTGTTCAGCCTGATTTTCTTCGCACGATCGCTGAACCGCGTGACGGTCGGCGCCGCCGCGTGCTCGA TCGTCGTCGCCGCGTCGCAGATGGCCGCGCTCACGCCGCAGGAGGCCGTGAACCCGGACAAGGCGACGGTGCTCGGCATC AGCCGGACGTTGCAGAAGGAGTATCCGCTCATCGATTGCCGGGTCGTCGACATCGCGTCGCACGAGCTGTTCGACGCGAC CGATTCGGCGATGCAGCTCGGCCTCGAATTTCTCGCGCCGCTCACGCCCGATAACGAAATCGTCGCGCTGCGCGGCGGGC GCCGCTGGCGGACGGCGTATCAGCGCTTCGCGGTGCCGGCCAGATGCGAGCCGCAGGTGCGCGCCTCCGGCGTCTACGTG ATCTTCGGCGGGCTCGGCGAGCTCGGGCTGAACGTCGCCGGCTATCTCGCGAGCCGCGCGCCGTGCACGCTGCTGCTCGT CAATTCGAAGCGCTTCGTCGCGCGCGACGAGTGGGCGGCGTGGCTCGACGAGCACGGCGCCGATCACCCGTACTCGAAGA AGATCGCGAAGATTCGCGAGATGGAGCAGGCGGGCGCGACGGTGCGCGTGCAGCAATGCGACGTCGCGGACGCCGCGCGC GTCCACGCGGTGCTCGACGAAGCGCGCGAGCGGCATGGCGAGATCCATAGCGTGATCCACGCGGCGGGCCGCGTCGAGAA CGGCATGATCGACAACAAGGACGTGCGCCACTTCGCGACGGTGTTCGAGGCGAAGGTCTACGGCACGTACAACCTGCTGT CGTACCTGAAGCGGCACCCGGTGACGAAGGTCATTCTCTGCTCGAGCATGAACTCGATCATCGGCGGCCTCGGGCAGATC GACAACGCGGCGGCCAACGCGTTCGTCGACGCGCTCGCGCAAACGCCGCTCGCGGCGTCGCTCGGCGACATCTGCTCGAC CAACTGGGGCGCGGTCAACGCCGAGCGGCTCACGCGCCCGAACGTGCTGCCGCAGTTCGCGGACCTGAGCCGCGAGCACA TGCGCAACCACATGACCGAGCGCGAGATCGCGGCGGTCTACGACCGGATCCTGCACTGGAACTTCGGCCCGCGCCTCGTC ATCTCGACGATCGATTTCGATTCGGTGCTCGAGCACTGGGGCGAAGTGAGCAAGGTCACCGAGCTCGCGCGGCTGCGCCA CGTCGCGGCGGAGGCGGGCGAGCGCGCGCCGGAGGACGACGGCTACGCGTATCGCTCGGAGCTGCACCGGTTCGTCGAGA CGAGCTGGGCGCGCATTCTCGGCGTCGCGCACGTCGACTGGGACGGCGTGCTGCTCGAGCTCGGCGCGCATTCGTTGAGC GCGGTTCAGTTCGTATCGATGATCAAGGACCGCTACGACGTCAGCCTGCACGCGATGATCATCTATGAAATCCGGACGTT GGGACTGCTGGTCGAGCACATCGAAACGAAGCTGCTCGAGAAGGCCGCTCAGCTTGAAGTCAGCCAATAA
Upstream 100 bases:
>100_bases GACGCCCCGCGTCCGCCGGCGCAGCCCGATGCGGGCGCGCATGCGGATCGGCGCCGCCGCCACTACTACCAAAGCAGAAA ACACAGCATGGAGTCGAAAA
Downstream 100 bases:
>100_bases CGCCATGAACACGACTGTCGAATTTGATGGAGCCCAGCCATGACCCAATCTGTTTTCGCCCGGTTCGAGCAAGTGTGCCG CAGCAGTGCGCAAGCGGTCG
Product: non-ribosomal peptide synthase/polyketide synthase
Products: L-tryptophan [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]
Alternate protein names: PKS [H]
Number of amino acids: Translated: 1329; Mature: 1329
Protein sequence:
>1329_residues MNNLDVAIIGMSGAFPGASDVREFWRNLEAGRCSLERYTEQELLDAGVDPAHLKSPQYVPVGGRMRDIECFDNEFFGISN HDARLMDPQQRVFLQLAWHAFEDAGFVPGAHPGRVGVYAGVSLNSYLHTIVFRSDEVDLDRDGQSILFGNLSDYLTTRLS YLLDLKGPSVNIQTACSTSLVAIHEACQGLLSYQADVALAGACSINVPNTRGYLYSQDSFFSPDGRVRAFDEQAAGTVFS NGAGLVVLKRLDDALRDGDQIYAVLKASAVNNDGSDKVGYAAPSVSGQSAVIRDALHACEIRPEQIQYVETHGTGTSLGD PIEIAALTQAYAGERRRGAATRHATCAIGSVKTNIGHIDVAAGVAGVIKTALALRHKTLPASLGFEKANPRLGLESGPFY VNDRTRPWASDTPRVAAVSSFGIGGTNAHAILEEAPAREPLPAAKSAYCLTLSARTASSLEALRASYLTFLNGDDLPAFA DLCFTSNVGRKPFAHRIAIAASDAADAARQLAAAAATASDGQPHRIVVSAQADDANATWQAIRGGDIDPREPLFEAADRF SAAERVAAYAVLLVAQLRRLGLAAALQRPAQLPQSLVERLAPRQDDPLRRLIAEPPIEAAQSDYALTLRAACELRIGPAV RALGAPSLRGRFVAELLAAGWAAGVPVDWASFHADEARRKTSLPAYAFAKKVLWLSTATDAERRNRKIEDIGQWFYKPTW RETAALAARTRRADELADANVLVFSADRLHRLKAGWALAAQCLYVVPGAEFGQLSDDTYCIDPASEDDYRRLIEALVARG RLPRHVVHAWLAAEAAWDGTPANFANCQALGLFSLIFFARSLNRVTVGAAACSIVVAASQMAALTPQEAVNPDKATVLGI SRTLQKEYPLIDCRVVDIASHELFDATDSAMQLGLEFLAPLTPDNEIVALRGGRRWRTAYQRFAVPARCEPQVRASGVYV IFGGLGELGLNVAGYLASRAPCTLLLVNSKRFVARDEWAAWLDEHGADHPYSKKIAKIREMEQAGATVRVQQCDVADAAR VHAVLDEARERHGEIHSVIHAAGRVENGMIDNKDVRHFATVFEAKVYGTYNLLSYLKRHPVTKVILCSSMNSIIGGLGQI DNAAANAFVDALAQTPLAASLGDICSTNWGAVNAERLTRPNVLPQFADLSREHMRNHMTEREIAAVYDRILHWNFGPRLV ISTIDFDSVLEHWGEVSKVTELARLRHVAAEAGERAPEDDGYAYRSELHRFVETSWARILGVAHVDWDGVLLELGAHSLS AVQFVSMIKDRYDVSLHAMIIYEIRTLGLLVEHIETKLLEKAAQLEVSQ
Sequences:
>Translated_1329_residues MNNLDVAIIGMSGAFPGASDVREFWRNLEAGRCSLERYTEQELLDAGVDPAHLKSPQYVPVGGRMRDIECFDNEFFGISN HDARLMDPQQRVFLQLAWHAFEDAGFVPGAHPGRVGVYAGVSLNSYLHTIVFRSDEVDLDRDGQSILFGNLSDYLTTRLS YLLDLKGPSVNIQTACSTSLVAIHEACQGLLSYQADVALAGACSINVPNTRGYLYSQDSFFSPDGRVRAFDEQAAGTVFS NGAGLVVLKRLDDALRDGDQIYAVLKASAVNNDGSDKVGYAAPSVSGQSAVIRDALHACEIRPEQIQYVETHGTGTSLGD PIEIAALTQAYAGERRRGAATRHATCAIGSVKTNIGHIDVAAGVAGVIKTALALRHKTLPASLGFEKANPRLGLESGPFY VNDRTRPWASDTPRVAAVSSFGIGGTNAHAILEEAPAREPLPAAKSAYCLTLSARTASSLEALRASYLTFLNGDDLPAFA DLCFTSNVGRKPFAHRIAIAASDAADAARQLAAAAATASDGQPHRIVVSAQADDANATWQAIRGGDIDPREPLFEAADRF SAAERVAAYAVLLVAQLRRLGLAAALQRPAQLPQSLVERLAPRQDDPLRRLIAEPPIEAAQSDYALTLRAACELRIGPAV RALGAPSLRGRFVAELLAAGWAAGVPVDWASFHADEARRKTSLPAYAFAKKVLWLSTATDAERRNRKIEDIGQWFYKPTW RETAALAARTRRADELADANVLVFSADRLHRLKAGWALAAQCLYVVPGAEFGQLSDDTYCIDPASEDDYRRLIEALVARG RLPRHVVHAWLAAEAAWDGTPANFANCQALGLFSLIFFARSLNRVTVGAAACSIVVAASQMAALTPQEAVNPDKATVLGI SRTLQKEYPLIDCRVVDIASHELFDATDSAMQLGLEFLAPLTPDNEIVALRGGRRWRTAYQRFAVPARCEPQVRASGVYV IFGGLGELGLNVAGYLASRAPCTLLLVNSKRFVARDEWAAWLDEHGADHPYSKKIAKIREMEQAGATVRVQQCDVADAAR VHAVLDEARERHGEIHSVIHAAGRVENGMIDNKDVRHFATVFEAKVYGTYNLLSYLKRHPVTKVILCSSMNSIIGGLGQI DNAAANAFVDALAQTPLAASLGDICSTNWGAVNAERLTRPNVLPQFADLSREHMRNHMTEREIAAVYDRILHWNFGPRLV ISTIDFDSVLEHWGEVSKVTELARLRHVAAEAGERAPEDDGYAYRSELHRFVETSWARILGVAHVDWDGVLLELGAHSLS AVQFVSMIKDRYDVSLHAMIIYEIRTLGLLVEHIETKLLEKAAQLEVSQ >Mature_1329_residues MNNLDVAIIGMSGAFPGASDVREFWRNLEAGRCSLERYTEQELLDAGVDPAHLKSPQYVPVGGRMRDIECFDNEFFGISN HDARLMDPQQRVFLQLAWHAFEDAGFVPGAHPGRVGVYAGVSLNSYLHTIVFRSDEVDLDRDGQSILFGNLSDYLTTRLS YLLDLKGPSVNIQTACSTSLVAIHEACQGLLSYQADVALAGACSINVPNTRGYLYSQDSFFSPDGRVRAFDEQAAGTVFS NGAGLVVLKRLDDALRDGDQIYAVLKASAVNNDGSDKVGYAAPSVSGQSAVIRDALHACEIRPEQIQYVETHGTGTSLGD PIEIAALTQAYAGERRRGAATRHATCAIGSVKTNIGHIDVAAGVAGVIKTALALRHKTLPASLGFEKANPRLGLESGPFY VNDRTRPWASDTPRVAAVSSFGIGGTNAHAILEEAPAREPLPAAKSAYCLTLSARTASSLEALRASYLTFLNGDDLPAFA DLCFTSNVGRKPFAHRIAIAASDAADAARQLAAAAATASDGQPHRIVVSAQADDANATWQAIRGGDIDPREPLFEAADRF SAAERVAAYAVLLVAQLRRLGLAAALQRPAQLPQSLVERLAPRQDDPLRRLIAEPPIEAAQSDYALTLRAACELRIGPAV RALGAPSLRGRFVAELLAAGWAAGVPVDWASFHADEARRKTSLPAYAFAKKVLWLSTATDAERRNRKIEDIGQWFYKPTW RETAALAARTRRADELADANVLVFSADRLHRLKAGWALAAQCLYVVPGAEFGQLSDDTYCIDPASEDDYRRLIEALVARG RLPRHVVHAWLAAEAAWDGTPANFANCQALGLFSLIFFARSLNRVTVGAAACSIVVAASQMAALTPQEAVNPDKATVLGI SRTLQKEYPLIDCRVVDIASHELFDATDSAMQLGLEFLAPLTPDNEIVALRGGRRWRTAYQRFAVPARCEPQVRASGVYV IFGGLGELGLNVAGYLASRAPCTLLLVNSKRFVARDEWAAWLDEHGADHPYSKKIAKIREMEQAGATVRVQQCDVADAAR VHAVLDEARERHGEIHSVIHAAGRVENGMIDNKDVRHFATVFEAKVYGTYNLLSYLKRHPVTKVILCSSMNSIIGGLGQI DNAAANAFVDALAQTPLAASLGDICSTNWGAVNAERLTRPNVLPQFADLSREHMRNHMTEREIAAVYDRILHWNFGPRLV ISTIDFDSVLEHWGEVSKVTELARLRHVAAEAGERAPEDDGYAYRSELHRFVETSWARILGVAHVDWDGVLLELGAHSLS AVQFVSMIKDRYDVSLHAMIIYEIRTLGLLVEHIETKLLEKAAQLEVSQ
Specific function: Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism [H]
COG id: COG3321
COG function: function code Q; Polyketide synthase modules and related proteins
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 5 acyl carrier domains [H]
Homologues:
Organism=Homo sapiens, GI41872631, Length=435, Percent_Identity=31.9540229885057, Blast_Score=209, Evalue=1e-53, Organism=Homo sapiens, GI8923559, Length=389, Percent_Identity=25.706940874036, Blast_Score=96, Evalue=2e-19, Organism=Escherichia coli, GI1788663, Length=366, Percent_Identity=27.5956284153005, Blast_Score=95, Evalue=4e-20, Organism=Escherichia coli, GI1787337, Length=446, Percent_Identity=25.1121076233184, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17550940, Length=478, Percent_Identity=35.3556485355649, Blast_Score=253, Evalue=3e-67, Organism=Caenorhabditis elegans, GI212642053, Length=478, Percent_Identity=30.1255230125523, Blast_Score=196, Evalue=1e-49, Organism=Caenorhabditis elegans, GI71983541, Length=274, Percent_Identity=29.9270072992701, Blast_Score=99, Evalue=1e-20, Organism=Caenorhabditis elegans, GI71983535, Length=274, Percent_Identity=29.9270072992701, Blast_Score=98, Evalue=3e-20, Organism=Saccharomyces cerevisiae, GI6320904, Length=454, Percent_Identity=23.7885462555066, Blast_Score=95, Evalue=6e-20, Organism=Drosophila melanogaster, GI221330659, Length=480, Percent_Identity=34.375, Blast_Score=228, Evalue=2e-59, Organism=Drosophila melanogaster, GI19920632, Length=480, Percent_Identity=34.375, Blast_Score=228, Evalue=3e-59, Organism=Drosophila melanogaster, GI24581345, Length=471, Percent_Identity=30.7855626326964, Blast_Score=198, Evalue=2e-50, Organism=Drosophila melanogaster, GI24644341, Length=274, Percent_Identity=29.9270072992701, Blast_Score=81, Evalue=6e-15,
Paralogues:
None
Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR010071 - InterPro: IPR009081 - InterPro: IPR020845 - InterPro: IPR000873 - InterPro: IPR000794 - InterPro: IPR001242 - InterPro: IPR018201 - InterPro: IPR014031 - InterPro: IPR014030 - InterPro: IPR016040 - InterPro: IPR006163 - InterPro: IPR020842 - InterPro: IPR020841 - InterPro: IPR020807 - InterPro: IPR013968 - InterPro: IPR020806 - InterPro: IPR006162 - InterPro: IPR016039 - InterPro: IPR016038 [H]
Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF08659 KR; PF00550 PP-binding [H]
EC number: 2.3.1.41 [C]
Molecular weight: Translated: 144424; Mature: 144424
Theoretical pI: Translated: 6.36; Mature: 6.36
Prosite motif: PS50075 ACP_DOMAIN ; PS00606 B_KETOACYL_SYNTHASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.0 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 1.0 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNNLDVAIIGMSGAFPGASDVREFWRNLEAGRCSLERYTEQELLDAGVDPAHLKSPQYVP CCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCEEC VGGRMRDIECFDNEFFGISNHDARLMDPQQRVFLQLAWHAFEDAGFVPGAHPGRVGVYAG CCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC VSLNSYLHTIVFRSDEVDLDRDGQSILFGNLSDYLTTRLSYLLDLKGPSVNIQTACSTSL CCHHHHHHHHEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEEHHCCHHH VAIHEACQGLLSYQADVALAGACSINVPNTRGYLYSQDSFFSPDGRVRAFDEQAAGTVFS HHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEECCCCCCCCCCEEEECHHHCCCEEE NGAGLVVLKRLDDALRDGDQIYAVLKASAVNNDGSDKVGYAAPSVSGQSAVIRDALHACE CCCCEEEEHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC IRPEQIQYVETHGTGTSLGDPIEIAALTQAYAGERRRGAATRHATCAIGSVKTNIGHIDV CCHHHEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCEEEECCHHCCCCEEEH AAGVAGVIKTALALRHKTLPASLGFEKANPRLGLESGPFYVNDRTRPWASDTPRVAAVSS HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEC FGIGGTNAHAILEEAPAREPLPAAKSAYCLTLSARTASSLEALRASYLTFLNGDDLPAFA CCCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHH DLCFTSNVGRKPFAHRIAIAASDAADAARQLAAAAATASDGQPHRIVVSAQADDANATWQ HHHHHCCCCCCCCHHEEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHH AIRGGDIDPREPLFEAADRFSAAERVAAYAVLLVAQLRRLGLAAALQRPAQLPQSLVERL HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH APRQDDPLRRLIAEPPIEAAQSDYALTLRAACELRIGPAVRALGAPSLRGRFVAELLAAG CCCCCCHHHHHHCCCCHHHCCCCCEEEEEEHEEEEECHHHHHCCCCCHHHHHHHHHHHCC WAAGVPVDWASFHADEARRKTSLPAYAFAKKVLWLSTATDAERRNRKIEDIGQWFYKPTW CCCCCCCCHHHHCHHHHHHHCCCCHHHHHHHHHEEECCCCHHHHCCCHHHHHHHHCCCCH RETAALAARTRRADELADANVLVFSADRLHRLKAGWALAAQCLYVVPGAEFGQLSDDTYC HHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEE IDPASEDDYRRLIEALVARGRLPRHVVHAWLAAEAAWDGTPANFANCQALGLFSLIFFAR ECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH SLNRVTVGAAACSIVVAASQMAALTPQEAVNPDKATVLGISRTLQKEYPLIDCRVVDIAS HCCCEEEHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEHHHHHHHHCCCEEEEEEEEECC HELFDATDSAMQLGLEFLAPLTPDNEIVALRGGRRWRTAYQRFAVPARCEPQVRASGVYV CHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCEECCCEEE IFGGLGELGLNVAGYLASRAPCTLLLVNSKRFVARDEWAAWLDEHGADHPYSKKIAKIRE EECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHH MEQAGATVRVQQCDVADAARVHAVLDEARERHGEIHSVIHAAGRVENGMIDNKDVRHFAT HHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH VFEAKVYGTYNLLSYLKRHPVTKVILCSSMNSIIGGLGQIDNAAANAFVDALAQTPLAAS HHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHH LGDICSTNWGAVNAERLTRPNVLPQFADLSREHMRNHMTEREIAAVYDRILHWNFGPRLV HHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE ISTIDFDSVLEHWGEVSKVTELARLRHVAAEAGERAPEDDGYAYRSELHRFVETSWARIL EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH GVAHVDWDGVLLELGAHSLSAVQFVSMIKDRYDVSLHAMIIYEIRTLGLLVEHIETKLLE EEEEECCCCHHEECCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHH KAAQLEVSQ HHHHCCCCC >Mature Secondary Structure MNNLDVAIIGMSGAFPGASDVREFWRNLEAGRCSLERYTEQELLDAGVDPAHLKSPQYVP CCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCEEC VGGRMRDIECFDNEFFGISNHDARLMDPQQRVFLQLAWHAFEDAGFVPGAHPGRVGVYAG CCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC VSLNSYLHTIVFRSDEVDLDRDGQSILFGNLSDYLTTRLSYLLDLKGPSVNIQTACSTSL CCHHHHHHHHEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEEHHCCHHH VAIHEACQGLLSYQADVALAGACSINVPNTRGYLYSQDSFFSPDGRVRAFDEQAAGTVFS HHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEECCCCCCCCCCEEEECHHHCCCEEE NGAGLVVLKRLDDALRDGDQIYAVLKASAVNNDGSDKVGYAAPSVSGQSAVIRDALHACE CCCCEEEEHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC IRPEQIQYVETHGTGTSLGDPIEIAALTQAYAGERRRGAATRHATCAIGSVKTNIGHIDV CCHHHEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCEEEECCHHCCCCEEEH AAGVAGVIKTALALRHKTLPASLGFEKANPRLGLESGPFYVNDRTRPWASDTPRVAAVSS HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEC FGIGGTNAHAILEEAPAREPLPAAKSAYCLTLSARTASSLEALRASYLTFLNGDDLPAFA CCCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHH DLCFTSNVGRKPFAHRIAIAASDAADAARQLAAAAATASDGQPHRIVVSAQADDANATWQ HHHHHCCCCCCCCHHEEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHH AIRGGDIDPREPLFEAADRFSAAERVAAYAVLLVAQLRRLGLAAALQRPAQLPQSLVERL HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH APRQDDPLRRLIAEPPIEAAQSDYALTLRAACELRIGPAVRALGAPSLRGRFVAELLAAG CCCCCCHHHHHHCCCCHHHCCCCCEEEEEEHEEEEECHHHHHCCCCCHHHHHHHHHHHCC WAAGVPVDWASFHADEARRKTSLPAYAFAKKVLWLSTATDAERRNRKIEDIGQWFYKPTW CCCCCCCCHHHHCHHHHHHHCCCCHHHHHHHHHEEECCCCHHHHCCCHHHHHHHHCCCCH RETAALAARTRRADELADANVLVFSADRLHRLKAGWALAAQCLYVVPGAEFGQLSDDTYC HHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEE IDPASEDDYRRLIEALVARGRLPRHVVHAWLAAEAAWDGTPANFANCQALGLFSLIFFAR ECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH SLNRVTVGAAACSIVVAASQMAALTPQEAVNPDKATVLGISRTLQKEYPLIDCRVVDIAS HCCCEEEHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEHHHHHHHHCCCEEEEEEEEECC HELFDATDSAMQLGLEFLAPLTPDNEIVALRGGRRWRTAYQRFAVPARCEPQVRASGVYV CHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCEECCCEEE IFGGLGELGLNVAGYLASRAPCTLLLVNSKRFVARDEWAAWLDEHGADHPYSKKIAKIRE EECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHH MEQAGATVRVQQCDVADAARVHAVLDEARERHGEIHSVIHAAGRVENGMIDNKDVRHFAT HHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH VFEAKVYGTYNLLSYLKRHPVTKVILCSSMNSIIGGLGQIDNAAANAFVDALAQTPLAAS HHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHH LGDICSTNWGAVNAERLTRPNVLPQFADLSREHMRNHMTEREIAAVYDRILHWNFGPRLV HHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE ISTIDFDSVLEHWGEVSKVTELARLRHVAAEAGERAPEDDGYAYRSELHRFVETSWARIL EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH GVAHVDWDGVLLELGAHSLSAVQFVSMIKDRYDVSLHAMIIYEIRTLGLLVEHIETKLLE EEEEECCCCHHEECCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHH KAAQLEVSQ HHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: 2-Mercaptoethanol; DTT; EDTA [C]
Metal ions: Phosphate [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 0.138 {cis-9-hexadecenoyl-ACP}} 0.017 {cis-9-hexadecenoyl-ACP}} 0.012 {cis-3-decenoyl-ACP}} 0.04 {acetyl-ACP}} 0.031 {acetyl-ACP}} [C]
Substrates: L-tryptophan [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]
Specific reaction: acyl-ACP + malonyl-ACP = beta-keto-enoyl-ACP + [acyl carrier protein] + CO2 acetyl-ACP + malonyl-ACP = [acyl carrier protein] + acetoacetyl-ACP + CO2 acyl-ACP + malonyl-ACP = [acyl carrier protein] + beta-ketoacyl-ACP + CO2 malonyl-ACP = acetyl-ACP + CO2
General reaction: Acyl group transfer [C]
Inhibitor: Acetyl-CoA; Acyl-CoA; Iodoacetamide; N-Ethyl maleimide acyl -ACP-derivatives protect, malonyl -ACP-decarboxyl ation, [C]
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7704258; 9384377; 10568751 [H]