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The map label for this gene is macA [H]

Identifier: 53721661

GI number: 53721661

Start: 853166

End: 854368

Strand: Reverse

Name: macA [H]

Synonym: BPSS0625

Alternate gene names: 53721661

Gene position: 854368-853166 (Counterclockwise)

Preceding gene: 53721664

Following gene: 53721660

Centisome position: 26.93

GC content: 68.66

Gene sequence:

>1203_bases
ATGAAAAAATCCCAACGCCGCTGGATCGCCGTAGCGGCCGGCGGCGTCGTGCTCGTCTCGCTCGCCTTGCTCTATCACCG
CTTCGTGTCGAAAGACAAGGCGCCGCATTACCTCACCGCGAACGTCGCCCGCGCCGATCTCGAGAACGCGGTGCTCGCCA
CCGGCACGCTGCACGCGTTCAAGCAGGTCGACGTCGGCGCGCAGGTGTCCGGCCAGTTGAAATCGCTGAAGGTGAAGCTC
GGCGACAAGGTGACGAAGGATCAATGGCTCGCCGAGATCGATCCGGTGATCTCGCGAAACGAGCTGCGCCAGGCCGAGGC
GAACGTCGAGAACCTCGTCGCGCAGAAGCGCTCGAGCTCCGCGCAGTTCAAGCAGGCCGAGCTCGCGTTCAGGCGGCAGC
AGCAGATGCTGCCCGACGACGCGACCTCGCGCCAGGACTACGAGGCCGCGGCCGCGTCGCTCGACGTGCAGCGCGCGAGC
CTCGCCGCGCTCCACGCGCAGATCCGCGCGGCGCGCATCAAGATCGAGACCGCGCGCGCGAACCTCGGCTATACGCGGAT
CGTCGCGCCGATGGACGGCGAAGTGGTCGCGATCGTCACGCAGGAAGGCCAGACGGTGATCGCGCAGCAGCAGGCGCCCG
TGATCCTGAAGCTCGCGCAGCTCGACACGATGACGGTCAAGGCGCAGGTGTCGGAGGCGGACGTGATCCGCATCCATCCC
GAGCAGGCCGCGTACTTCACGATCCTCGGCGAGCCGGACAAGCGCTACTACGGCAAGCTGCGCGCGATCGAGCCCGCGCC
GCAGAATTTCCTCGACACGCAGGGCGGCATGGGCGGCGCGGGCGGCGGCGGCTCCGCGAAGACGAACACGGCGGTGTTCT
ACAACGCGCTCTTCGAAGTGCCGAATCCCGGCCACCGGCTACGCATCTCGATGACCGCGCAGGTGAACATCCTGCTCGGC
ACCGCGCGCAACGCGCTCAACATTCCCGTCGCCGCGCTCGGCGCGAAGGGCAAGGACGGCGCATACGCGGTGCGCGTCGT
CGGCGCCGATGGCAAGGTGGCCACGCGCCAGGTGCGCACCGGCATCAACAACAACGTGAAGGTCGAGGTGCTGTCGGGCC
TCACCGAGGGCGAGCGCGTGATCATCGGCGATGCGGCCGAGCCCGCCGGCGCCGGCGCGGCCGCGTCCGACGCGAGGAAC
TGA

Upstream 100 bases:

>100_bases
GAAATTTGTCGCTGAATTGAACCCGGCGGCCGTTTCGCATTCCAATATCCGGTTTCATTTTCATTACAATTGCCTGCCAC
GCGTTACCGTCCCGTCTCCC

Downstream 100 bases:

>100_bases
CGATGACCGGGCCGCTGCTTCAGCTCACGCGCGTCACGCGCCGCTTTCCGGCGGGCGAGAAGGACGTCGTCGTGCTCGAC
GACGTGAGCCTGTCGATCGA

Product: drug-efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MKKSQRRWIAVAAGGVVLVSLALLYHRFVSKDKAPHYLTANVARADLENAVLATGTLHAFKQVDVGAQVSGQLKSLKVKL
GDKVTKDQWLAEIDPVISRNELRQAEANVENLVAQKRSSSAQFKQAELAFRRQQQMLPDDATSRQDYEAAAASLDVQRAS
LAALHAQIRAARIKIETARANLGYTRIVAPMDGEVVAIVTQEGQTVIAQQQAPVILKLAQLDTMTVKAQVSEADVIRIHP
EQAAYFTILGEPDKRYYGKLRAIEPAPQNFLDTQGGMGGAGGGGSAKTNTAVFYNALFEVPNPGHRLRISMTAQVNILLG
TARNALNIPVAALGAKGKDGAYAVRVVGADGKVATRQVRTGINNNVKVEVLSGLTEGERVIIGDAAEPAGAGAAASDARN

Sequences:

>Translated_400_residues
MKKSQRRWIAVAAGGVVLVSLALLYHRFVSKDKAPHYLTANVARADLENAVLATGTLHAFKQVDVGAQVSGQLKSLKVKL
GDKVTKDQWLAEIDPVISRNELRQAEANVENLVAQKRSSSAQFKQAELAFRRQQQMLPDDATSRQDYEAAAASLDVQRAS
LAALHAQIRAARIKIETARANLGYTRIVAPMDGEVVAIVTQEGQTVIAQQQAPVILKLAQLDTMTVKAQVSEADVIRIHP
EQAAYFTILGEPDKRYYGKLRAIEPAPQNFLDTQGGMGGAGGGGSAKTNTAVFYNALFEVPNPGHRLRISMTAQVNILLG
TARNALNIPVAALGAKGKDGAYAVRVVGADGKVATRQVRTGINNNVKVEVLSGLTEGERVIIGDAAEPAGAGAAASDARN
>Mature_400_residues
MKKSQRRWIAVAAGGVVLVSLALLYHRFVSKDKAPHYLTANVARADLENAVLATGTLHAFKQVDVGAQVSGQLKSLKVKL
GDKVTKDQWLAEIDPVISRNELRQAEANVENLVAQKRSSSAQFKQAELAFRRQQQMLPDDATSRQDYEAAAASLDVQRAS
LAALHAQIRAARIKIETARANLGYTRIVAPMDGEVVAIVTQEGQTVIAQQQAPVILKLAQLDTMTVKAQVSEADVIRIHP
EQAAYFTILGEPDKRYYGKLRAIEPAPQNFLDTQGGMGGAGGGGSAKTNTAVFYNALFEVPNPGHRLRISMTAQVNILLG
TARNALNIPVAALGAKGKDGAYAVRVVGADGKVATRQVRTGINNNVKVEVLSGLTEGERVIIGDAAEPAGAGAAASDARN

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=384, Percent_Identity=44.0104166666667, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI87082036, Length=347, Percent_Identity=26.2247838616715, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786668, Length=328, Percent_Identity=27.7439024390244, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789929, Length=336, Percent_Identity=25.297619047619, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42655; Mature: 42655

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSQRRWIAVAAGGVVLVSLALLYHRFVSKDKAPHYLTANVARADLENAVLATGTLHAF
CCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHCCCEEEHHHHHHH
KQVDVGAQVSGQLKSLKVKLGDKVTKDQWLAEIDPVISRNELRQAEANVENLVAQKRSSS
HHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCHHCHHHHHHHHCCHHHHHHHHCCCC
AQFKQAELAFRRQQQMLPDDATSRQDYEAAAASLDVQRASLAALHAQIRAARIKIETARA
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECC
NLGYTRIVAPMDGEVVAIVTQEGQTVIAQQQAPVILKLAQLDTMTVKAQVSEADVIRIHP
CCCEEEEEECCCCCEEEEEECCCCEEEEECCCCEEEEEECCCEEEEEEECCCCCEEEECC
EQAAYFTILGEPDKRYYGKLRAIEPAPQNFLDTQGGMGGAGGGGSAKTNTAVFYNALFEV
CCCEEEEEECCCCHHHHCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECC
PNPGHRLRISMTAQVNILLGTARNALNIPVAALGAKGKDGAYAVRVVGADGKVATRQVRT
CCCCCEEEEEEEEEEEEEEECCCCCCCCCEEEECCCCCCCEEEEEEECCCCCEEHHHHHC
GINNNVKVEVLSGLTEGERVIIGDAAEPAGAGAAASDARN
CCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKSQRRWIAVAAGGVVLVSLALLYHRFVSKDKAPHYLTANVARADLENAVLATGTLHAF
CCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHCCCEEEHHHHHHH
KQVDVGAQVSGQLKSLKVKLGDKVTKDQWLAEIDPVISRNELRQAEANVENLVAQKRSSS
HHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCHHCHHHHHHHHCCHHHHHHHHCCCC
AQFKQAELAFRRQQQMLPDDATSRQDYEAAAASLDVQRASLAALHAQIRAARIKIETARA
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECC
NLGYTRIVAPMDGEVVAIVTQEGQTVIAQQQAPVILKLAQLDTMTVKAQVSEADVIRIHP
CCCEEEEEECCCCCEEEEEECCCCEEEEECCCCEEEEEECCCEEEEEEECCCCCEEEECC
EQAAYFTILGEPDKRYYGKLRAIEPAPQNFLDTQGGMGGAGGGGSAKTNTAVFYNALFEV
CCCEEEEEECCCCHHHHCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECC
PNPGHRLRISMTAQVNILLGTARNALNIPVAALGAKGKDGAYAVRVVGADGKVATRQVRT
CCCCCEEEEEEEEEEEEEEECCCCCCCCCEEEECCCCCCCEEEEEEECCCCCEEHHHHHC
GINNNVKVEVLSGLTEGERVIIGDAAEPAGAGAAASDARN
CCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]