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The map label for this gene is yveA [H]

Identifier: 53721365

GI number: 53721365

Start: 460891

End: 462516

Strand: Reverse

Name: yveA [H]

Synonym: BPSS0330

Alternate gene names: 53721365

Gene position: 462516-460891 (Counterclockwise)

Preceding gene: 53721366

Following gene: 53721364

Centisome position: 14.58

GC content: 69.19

Gene sequence:

>1626_bases
ATGCCCGCCCAAGGCAATGCCCAGCGAACCGCGCCGCTCGCGCGGCCCGCGCCCACCGACGCCGGCCACGGCAAGTTCAA
GAAACAGCTGTCGCTCACCGATCTGACGTTCATCGGCCTCGGCGCGATCTTCGGCTCGGGGTGGCTGTTCGCCGCGAGCC
ACGTATCGATGATCGCGGGCCCGGCCGGCATCCTCTCGTGGCTGCTCGGCGGCTTCGCGGTGCTGCTGCTCGGCATCGTC
TACTGCGAGCTCGGCGCGGCGCTGCCGCGCGCGGGCGGCGTCGTCCGCTATCCGGTGTTCTCGCACGGCCCGCTGCTCGG
CTACCTGATGGGCGCGATCACGCTGATCGCGTTCTCGAGCCTGATCGCGATCGAAGTCGTCGCCGCGCGCCAGTATGCGG
CCGCGTGGTTTGCGGGCCTGACCGTCGAGGGCTCGGGCAATCCGACGACGCTCGGCTGGCTCGTGCAGGCGGCGCTGCTC
TGTTTCTTCTTCTACCTGAACTATTCGAGCGTGAAGACGTTCGCGAAGGCGAACAACGTCATCAGCGTGTTCAAGTTCGT
CGTGCCGCTCGCGGTGATCGTCGTGCTGTTCGCGTTCTTCAAGCCCGCGAACCTCACCCTGCACGGCTTCGCGCCGTTCG
GCATGCCCGGCGTCGAGATGGCCGTGTCCGCGGGCGGCATCATCTTCGCGTATCTCGGCCTCACGCCGATCGTCTCGGTC
GCGAGCGAGGTGCGCGACCCGCAGCGCACGATTCCGATCGCGCTGATCCTGTCGATCGTGCTCTCGACGCTGATCTATGT
GCTGCTGCAGCTCGCGTTCCTCGGCGGCATCCCGAGCGCGATGCTCGCGGGCGGCTGGCACGACATCGGCAAGGCTTTCT
CGCTGCCGTACCGCGACATCGCGCTCGCGCTCGGCGTCGGCTGGCTCGCGTACATGGTCGTCGCCGACGCGATGATCTCG
CCGTCCGGCTGCGGCAACATCTACATGAACGCGACGCCGCGCGTCGTCTACGGCTGGGCGAAGACGGGCACGTTCTTCAA
GGTGTTCGCGCGCGTCGACGAGGCCTCCGGCATTCCGCGCGCGGGGCTGTGGCTCACGTTCGCGCTGGCGCTCTTCTGGA
CGCTGCCGTTCCCGTCGTGGGAGGCGCTCATCAACACCGTGTCGGCCGCGCTCGTGCTGAGCTACGCGGTCGCGCCGGTA
TCGGTCGCCGCGCTGCGCCGCACCGCGCCCGGGCTGCCGCGGCCGTTTCGCGCGAGCGCGTTCGCGCTCACCGGCCCCGC
CTCGTTCGTGATCGCCGCGCTGATCGTCTACTGGTCCGGCTGGCGCACCGTGTCGTGGCTGCTCGGGCTGCAGATCGCGA
TGTTCGCCGTCTATCTCGCGTGCCGCCGCCGGGTGCCCACCGCGCATCTGAGCCTCGCCGAGCAGGTGCGCTCGTGCGCG
TGGCTGATCGCGTTCTACGCGCTGATGATCGTCGCGTCGTATTTCGGCGGCTTCGGCGGCACCGGGCAGCTCGCGCACCC
GTACGACACGTTCGCCGTCGCGGCCGTCGCGCTCGTCATCTACTACTGGGGCGCGCATACCGGCGTGCCGTCCGCGAAGC
TGCAGCTCGACGACGACGAGAACTGA

Upstream 100 bases:

>100_bases
GCCGTCAGTTCCGCCCGCCGCGGCCCTCCCATGCGCCGCCGCGCCCCGCCCGCCGCTCGAGACGATCGAAACCCGTCCAT
CAAATCAAGGAGACAAGCCC

Downstream 100 bases:

>100_bases
CGCGCGGCGCGGGCGCATCCGCTTTTTCAACGGCCGCGCGGCGACGCGCGGCCCGCACTTTCTGCGAGGAGAACCATGCG
ACTCACTGGCGAGCTTTTGA

Product: amino-acid permease membrane protein

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: L-aspartate transporter [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MPAQGNAQRTAPLARPAPTDAGHGKFKKQLSLTDLTFIGLGAIFGSGWLFAASHVSMIAGPAGILSWLLGGFAVLLLGIV
YCELGAALPRAGGVVRYPVFSHGPLLGYLMGAITLIAFSSLIAIEVVAARQYAAAWFAGLTVEGSGNPTTLGWLVQAALL
CFFFYLNYSSVKTFAKANNVISVFKFVVPLAVIVVLFAFFKPANLTLHGFAPFGMPGVEMAVSAGGIIFAYLGLTPIVSV
ASEVRDPQRTIPIALILSIVLSTLIYVLLQLAFLGGIPSAMLAGGWHDIGKAFSLPYRDIALALGVGWLAYMVVADAMIS
PSGCGNIYMNATPRVVYGWAKTGTFFKVFARVDEASGIPRAGLWLTFALALFWTLPFPSWEALINTVSAALVLSYAVAPV
SVAALRRTAPGLPRPFRASAFALTGPASFVIAALIVYWSGWRTVSWLLGLQIAMFAVYLACRRRVPTAHLSLAEQVRSCA
WLIAFYALMIVASYFGGFGGTGQLAHPYDTFAVAAVALVIYYWGAHTGVPSAKLQLDDDEN

Sequences:

>Translated_541_residues
MPAQGNAQRTAPLARPAPTDAGHGKFKKQLSLTDLTFIGLGAIFGSGWLFAASHVSMIAGPAGILSWLLGGFAVLLLGIV
YCELGAALPRAGGVVRYPVFSHGPLLGYLMGAITLIAFSSLIAIEVVAARQYAAAWFAGLTVEGSGNPTTLGWLVQAALL
CFFFYLNYSSVKTFAKANNVISVFKFVVPLAVIVVLFAFFKPANLTLHGFAPFGMPGVEMAVSAGGIIFAYLGLTPIVSV
ASEVRDPQRTIPIALILSIVLSTLIYVLLQLAFLGGIPSAMLAGGWHDIGKAFSLPYRDIALALGVGWLAYMVVADAMIS
PSGCGNIYMNATPRVVYGWAKTGTFFKVFARVDEASGIPRAGLWLTFALALFWTLPFPSWEALINTVSAALVLSYAVAPV
SVAALRRTAPGLPRPFRASAFALTGPASFVIAALIVYWSGWRTVSWLLGLQIAMFAVYLACRRRVPTAHLSLAEQVRSCA
WLIAFYALMIVASYFGGFGGTGQLAHPYDTFAVAAVALVIYYWGAHTGVPSAKLQLDDDEN
>Mature_540_residues
PAQGNAQRTAPLARPAPTDAGHGKFKKQLSLTDLTFIGLGAIFGSGWLFAASHVSMIAGPAGILSWLLGGFAVLLLGIVY
CELGAALPRAGGVVRYPVFSHGPLLGYLMGAITLIAFSSLIAIEVVAARQYAAAWFAGLTVEGSGNPTTLGWLVQAALLC
FFFYLNYSSVKTFAKANNVISVFKFVVPLAVIVVLFAFFKPANLTLHGFAPFGMPGVEMAVSAGGIIFAYLGLTPIVSVA
SEVRDPQRTIPIALILSIVLSTLIYVLLQLAFLGGIPSAMLAGGWHDIGKAFSLPYRDIALALGVGWLAYMVVADAMISP
SGCGNIYMNATPRVVYGWAKTGTFFKVFARVDEASGIPRAGLWLTFALALFWTLPFPSWEALINTVSAALVLSYAVAPVS
VAALRRTAPGLPRPFRASAFALTGPASFVIAALIVYWSGWRTVSWLLGLQIAMFAVYLACRRRVPTAHLSLAEQVRSCAW
LIAFYALMIVASYFGGFGGTGQLAHPYDTFAVAAVALVIYYWGAHTGVPSAKLQLDDDEN

Specific function: Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=413, Percent_Identity=26.634382566586, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI258614005, Length=442, Percent_Identity=24.4343891402715, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI258614003, Length=442, Percent_Identity=24.4343891402715, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI258645169, Length=442, Percent_Identity=23.7556561085973, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI187423910, Length=429, Percent_Identity=23.5431235431235, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI7657591, Length=429, Percent_Identity=23.5431235431235, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI115648063, Length=486, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI115648022, Length=486, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI33286428, Length=439, Percent_Identity=23.9179954441913, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI186910308, Length=423, Percent_Identity=22.4586288416076, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI186910306, Length=423, Percent_Identity=22.4586288416076, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI186910304, Length=423, Percent_Identity=22.4586288416076, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1788480, Length=364, Percent_Identity=29.3956043956044, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786602, Length=437, Percent_Identity=24.0274599542334, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI87082250, Length=358, Percent_Identity=27.0949720670391, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081708, Length=362, Percent_Identity=23.4806629834254, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786302, Length=404, Percent_Identity=22.5247524752475, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=418, Percent_Identity=27.7511961722488, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17531343, Length=410, Percent_Identity=27.3170731707317, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17533459, Length=436, Percent_Identity=26.605504587156, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24667468, Length=407, Percent_Identity=25.5528255528256, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21357367, Length=445, Percent_Identity=26.7415730337079, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24666159, Length=438, Percent_Identity=25.1141552511416, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI221512776, Length=438, Percent_Identity=25.1141552511416, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI45550968, Length=494, Percent_Identity=26.5182186234818, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19921172, Length=494, Percent_Identity=26.5182186234818, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24668806, Length=435, Percent_Identity=23.2183908045977, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356285, Length=435, Percent_Identity=23.2183908045977, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24668802, Length=435, Percent_Identity=23.2183908045977, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221331183, Length=279, Percent_Identity=28.3154121863799, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17647653, Length=279, Percent_Identity=28.3154121863799, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24664379, Length=279, Percent_Identity=28.3154121863799, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24641993, Length=426, Percent_Identity=24.4131455399061, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24641995, Length=426, Percent_Identity=24.4131455399061, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651635, Length=414, Percent_Identity=22.7053140096618, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24651633, Length=414, Percent_Identity=22.7053140096618, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 57482; Mature: 57351

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAQGNAQRTAPLARPAPTDAGHGKFKKQLSLTDLTFIGLGAIFGSGWLFAASHVSMIAG
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
PAGILSWLLGGFAVLLLGIVYCELGAALPRAGGVVRYPVFSHGPLLGYLMGAITLIAFSS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
LIAIEVVAARQYAAAWFAGLTVEGSGNPTTLGWLVQAALLCFFFYLNYSSVKTFAKANNV
HHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISVFKFVVPLAVIVVLFAFFKPANLTLHGFAPFGMPGVEMAVSAGGIIFAYLGLTPIVSV
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHH
ASEVRDPQRTIPIALILSIVLSTLIYVLLQLAFLGGIPSAMLAGGWHDIGKAFSLPYRDI
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHCCCHHHH
ALALGVGWLAYMVVADAMISPSGCGNIYMNATPRVVYGWAKTGTFFKVFARVDEASGIPR
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCC
AGLWLTFALALFWTLPFPSWEALINTVSAALVLSYAVAPVSVAALRRTAPGLPRPFRASA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
FALTGPASFVIAALIVYWSGWRTVSWLLGLQIAMFAVYLACRRRVPTAHLSLAEQVRSCA
EEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
WLIAFYALMIVASYFGGFGGTGQLAHPYDTFAVAAVALVIYYWGAHTGVPSAKLQLDDDE
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCC
N
C
>Mature Secondary Structure 
PAQGNAQRTAPLARPAPTDAGHGKFKKQLSLTDLTFIGLGAIFGSGWLFAASHVSMIAG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
PAGILSWLLGGFAVLLLGIVYCELGAALPRAGGVVRYPVFSHGPLLGYLMGAITLIAFSS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
LIAIEVVAARQYAAAWFAGLTVEGSGNPTTLGWLVQAALLCFFFYLNYSSVKTFAKANNV
HHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISVFKFVVPLAVIVVLFAFFKPANLTLHGFAPFGMPGVEMAVSAGGIIFAYLGLTPIVSV
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHH
ASEVRDPQRTIPIALILSIVLSTLIYVLLQLAFLGGIPSAMLAGGWHDIGKAFSLPYRDI
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHCCCHHHH
ALALGVGWLAYMVVADAMISPSGCGNIYMNATPRVVYGWAKTGTFFKVFARVDEASGIPR
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCC
AGLWLTFALALFWTLPFPSWEALINTVSAALVLSYAVAPVSVAALRRTAPGLPRPFRASA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
FALTGPASFVIAALIVYWSGWRTVSWLLGLQIAMFAVYLACRRRVPTAHLSLAEQVRSCA
EEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
WLIAFYALMIVASYFGGFGGTGQLAHPYDTFAVAAVALVIYYWGAHTGVPSAKLQLDDDE
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 12730183 [H]