Click here to switch to the map view.

The map label for this gene is rutR [H]

Identifier: 53721308

GI number: 53721308

Start: 363494

End: 364213

Strand: Reverse

Name: rutR [H]

Synonym: BPSS0273

Alternate gene names: 53721308

Gene position: 364213-363494 (Counterclockwise)

Preceding gene: 53721309

Following gene: 53721305

Centisome position: 11.48

GC content: 70.69

Gene sequence:

>720_bases
ATGCCACACGACGATCCGACGACGACGCCCCCCGACGCGCCCGCGCCGCGCGCCCGGACGAAAGCGGCGCACGCGCCGAG
CCGCGCGCGCAAGGCGCACATCCGCGAGCTGAACGAGGCGCACCTGCTCGCATGCGCGGAAGCGGTGTTCGCCGAGCGCG
GCTTCGAGGGCGCGAGCACCGCGCTGATCGCCGAGCGCGCGGGGCTGCCGAAGGCGAACCTGCACTATTACTTTCCGACG
AAGCTCGCGCTGTACCGGCGCGTGCTCGACGACCTGCTCGAGGATTGGCACGCCGCCGCCGACAGCTTCGACGTCGGCGA
CGATCCCGTCGCCGCGCTCGGCGGCTACGTGCGCGCGAAGATGGCGCTGTCGCGCGAGCGGCCGCTCGGCTCGAAGGTAT
GGGCGAACGAGATCATCAGCGGCGCAACGCACATGCAGGACCTGCTGCTCGAACGCGTGAAGCCGTGGATGGATACGCGG
ATCGCGCTGATCGAGCGCTGGATCGCGCGCGGGCTGGTCGAACCGGTCGAGCCGAAGACGCTGCTCTACATGATCTGGGC
GACGACCCAGCATTACGCGGACTTCGACGCGCAGATCGTCGCGCTGTCCGGCAAGCACGGGCTATCGGCGAAGGCGTTCG
ATGCGACGACCGATGAAGTCGTGCGGCTGATCCTGCGCGCGTGCGGCGCGCGCTCGCCGCACGCGCGGCAGCCGGCGTAG

Upstream 100 bases:

>100_bases
GCTGTCGCGAATCCGCCGCCGGCGGGCGGCGAAGCGTCGGCAAGCGGCCGCGGCGTCTACAATGACGGCCTCCGATTGCC
GCCCTCCACGAGCGCACGCG

Downstream 100 bases:

>100_bases
CGCGGCACGGCGAGCCGGGAGGGTTCGGGGTTCGGGGTTCGGGGTTCGGACTTTGGACCTCCCGCTTCGAGCCTCGACCG
CCGCTTTGGCTTTGGAGCTC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Rut operon repressor [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MPHDDPTTTPPDAPAPRARTKAAHAPSRARKAHIRELNEAHLLACAEAVFAERGFEGASTALIAERAGLPKANLHYYFPT
KLALYRRVLDDLLEDWHAAADSFDVGDDPVAALGGYVRAKMALSRERPLGSKVWANEIISGATHMQDLLLERVKPWMDTR
IALIERWIARGLVEPVEPKTLLYMIWATTQHYADFDAQIVALSGKHGLSAKAFDATTDEVVRLILRACGARSPHARQPA

Sequences:

>Translated_239_residues
MPHDDPTTTPPDAPAPRARTKAAHAPSRARKAHIRELNEAHLLACAEAVFAERGFEGASTALIAERAGLPKANLHYYFPT
KLALYRRVLDDLLEDWHAAADSFDVGDDPVAALGGYVRAKMALSRERPLGSKVWANEIISGATHMQDLLLERVKPWMDTR
IALIERWIARGLVEPVEPKTLLYMIWATTQHYADFDAQIVALSGKHGLSAKAFDATTDEVVRLILRACGARSPHARQPA
>Mature_238_residues
PHDDPTTTPPDAPAPRARTKAAHAPSRARKAHIRELNEAHLLACAEAVFAERGFEGASTALIAERAGLPKANLHYYFPTK
LALYRRVLDDLLEDWHAAADSFDVGDDPVAALGGYVRAKMALSRERPLGSKVWANEIISGATHMQDLLLERVKPWMDTRI
ALIERWIARGLVEPVEPKTLLYMIWATTQHYADFDAQIVALSGKHGLSAKAFDATTDEVVRLILRACGARSPHARQPA

Specific function: Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginin

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787249, Length=190, Percent_Identity=38.4210526315789, Blast_Score=139, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR019915
- InterPro:   IPR001647
- InterPro:   IPR013573 [H]

Pfam domain/function: PF08362 TetR_C_3; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 26355; Mature: 26224

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHDDPTTTPPDAPAPRARTKAAHAPSRARKAHIRELNEAHLLACAEAVFAERGFEGAST
CCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALIAERAGLPKANLHYYFPTKLALYRRVLDDLLEDWHAAADSFDVGDDPVAALGGYVRAK
HHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
MALSRERPLGSKVWANEIISGATHMQDLLLERVKPWMDTRIALIERWIARGLVEPVEPKT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LLYMIWATTQHYADFDAQIVALSGKHGLSAKAFDATTDEVVRLILRACGARSPHARQPA
EEEEEEHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PHDDPTTTPPDAPAPRARTKAAHAPSRARKAHIRELNEAHLLACAEAVFAERGFEGAST
CCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALIAERAGLPKANLHYYFPTKLALYRRVLDDLLEDWHAAADSFDVGDDPVAALGGYVRAK
HHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
MALSRERPLGSKVWANEIISGATHMQDLLLERVKPWMDTRIALIERWIARGLVEPVEPKT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LLYMIWATTQHYADFDAQIVALSGKHGLSAKAFDATTDEVVRLILRACGARSPHARQPA
EEEEEEHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]