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The map label for this gene is hmuU [H]

Identifier: 53721275

GI number: 53721275

Start: 327285

End: 328406

Strand: Reverse

Name: hmuU [H]

Synonym: BPSS0241

Alternate gene names: 53721275

Gene position: 328406-327285 (Counterclockwise)

Preceding gene: 53721276

Following gene: 53721274

Centisome position: 10.35

GC content: 75.85

Gene sequence:

>1122_bases
ATGAGCCTCGCCGCCCGCCGCCATTCGGCCCGCCCGATATCCGCCGAGCGCGGTTCGACCTGCGCGTCGCGCGCCCTCGC
CGCACTGCGCCGGCGACGCGCGCGATGGACGCTCGCCGCGCTGATCGCCGCGCTCGCCGCCGCGTCGATCGCCGCACTCT
GCATCGGCGCGTACCGGCTCTCGCCCGCGCAGTTGCTCGGCGCGCTCACCGCCACCGATGCGCAGCTCGCGGGCGACGCG
GCGCTGCGCCAGGCGCGCGCGGTGCTCGTCGACATCCGCGCGCCGCGCGTCGTGCTCGCGCTCTTCGTCGGCGCGGGCTT
CGGCGCGGCCGGCGCCGCGATGCAAGCGCTCTTTCGCAATCCGCTCGCCGATCCGGGCCTGATCGGCGTATCGAGCGGCG
CGGCGCTCGGCGCATCGGCGCTGATCGTGCTCGGCCCGCTCTTCGCCGCGCGGCTCGCGCTCGGCTTGCTGCCCGTCGCC
GCGTTCGCCGGCGCGCTCGCGGTCGCGGCGCTCGTCTACCGGCTCGCCATCGCGCGCGGCCGGCTCGCGCTGCCGCTGCT
GCTGCTCGCCGGCATCGCGATCAACGCGCTCGCCGGCGCGGGGATCGGGCTTCTCACCTACCTCGCCGACGATGCGCAAC
TGCGGTCGCTGACGTTCTGGAGCCTCGGCAGCGTCGGCGGCGCGCAATGGCGCACGATCGCCGCCGTCGCGCCGTTCGCG
CTCGCCGGCTGCGTGCTGCTCGCGCGCGAGCGACACGCGCTGAACGCGCTGCAGCTCGGCGAAGCCGAAGCGATGCATCT
CGGGGTGCCGGTGCCGCGCGTGAAGCGGCGCGTGCTCGTCGGCACCGCGATGTGCGTCGGCGCGCTCGTGTCGTGCACCG
GCGCGATCGGTTTCATCGGGCTCGTCGCACCGCATTGCGTGCGGCTCGCGGCGGGCGCCGATCAGCGCATCGTGATGCCG
GGCGCGGCGCTTTTCGGCGCGCTGCTCGCGGTGGCCGCCGATCTCGCCGCGCGCACGCTCGCCGCGCCGGCCGAGATTCC
GCTCGGCATCCTGACCGCGCTGATCGGCGCGCCGTTCTTTCTAGCGCTGCTCTGGAAGCGGCGCGGCGCGCTGGGAGGAT
GA

Upstream 100 bases:

>100_bases
CTCGCCTCGCTCGCGCCGCTTACGCCGCGCGCGAGGCGTGCCGCTTTGCGCGCCGCGCATACGCCTCGAGCGCGCCGCCC
CTCCCGTTCGACTTCACGCG

Downstream 100 bases:

>100_bases
CGTTGCGCACGCGCCTCCGGCGCCGACCTGCCGGACAGGCCGACGACGTCCGCGCGCGGCGAGCGTGCCGCCGCATCGGC
ACGCTCGCCGCCCCGATGCC

Product: hemin ABC transport system, membrane protein

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MSLAARRHSARPISAERGSTCASRALAALRRRRARWTLAALIAALAAASIAALCIGAYRLSPAQLLGALTATDAQLAGDA
ALRQARAVLVDIRAPRVVLALFVGAGFGAAGAAMQALFRNPLADPGLIGVSSGAALGASALIVLGPLFAARLALGLLPVA
AFAGALAVAALVYRLAIARGRLALPLLLLAGIAINALAGAGIGLLTYLADDAQLRSLTFWSLGSVGGAQWRTIAAVAPFA
LAGCVLLARERHALNALQLGEAEAMHLGVPVPRVKRRVLVGTAMCVGALVSCTGAIGFIGLVAPHCVRLAAGADQRIVMP
GAALFGALLAVAADLAARTLAAPAEIPLGILTALIGAPFFLALLWKRRGALGG

Sequences:

>Translated_373_residues
MSLAARRHSARPISAERGSTCASRALAALRRRRARWTLAALIAALAAASIAALCIGAYRLSPAQLLGALTATDAQLAGDA
ALRQARAVLVDIRAPRVVLALFVGAGFGAAGAAMQALFRNPLADPGLIGVSSGAALGASALIVLGPLFAARLALGLLPVA
AFAGALAVAALVYRLAIARGRLALPLLLLAGIAINALAGAGIGLLTYLADDAQLRSLTFWSLGSVGGAQWRTIAAVAPFA
LAGCVLLARERHALNALQLGEAEAMHLGVPVPRVKRRVLVGTAMCVGALVSCTGAIGFIGLVAPHCVRLAAGADQRIVMP
GAALFGALLAVAADLAARTLAAPAEIPLGILTALIGAPFFLALLWKRRGALGG
>Mature_372_residues
SLAARRHSARPISAERGSTCASRALAALRRRRARWTLAALIAALAAASIAALCIGAYRLSPAQLLGALTATDAQLAGDAA
LRQARAVLVDIRAPRVVLALFVGAGFGAAGAAMQALFRNPLADPGLIGVSSGAALGASALIVLGPLFAARLALGLLPVAA
FAGALAVAALVYRLAIARGRLALPLLLLAGIAINALAGAGIGLLTYLADDAQLRSLTFWSLGSVGGAQWRTIAAVAPFAL
AGCVLLARERHALNALQLGEAEAMHLGVPVPRVKRRVLVGTAMCVGALVSCTGAIGFIGLVAPHCVRLAAGADQRIVMPG
AALFGALLAVAADLAARTLAAPAEIPLGILTALIGAPFFLALLWKRRGALGG

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=292, Percent_Identity=40.7534246575342, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1790740, Length=298, Percent_Identity=37.5838926174497, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1790741, Length=289, Percent_Identity=34.2560553633218, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1786805, Length=297, Percent_Identity=40.4040404040404, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786804, Length=337, Percent_Identity=32.6409495548961, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786347, Length=289, Percent_Identity=33.2179930795848, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 37559; Mature: 37428

Theoretical pI: Translated: 12.10; Mature: 12.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLAARRHSARPISAERGSTCASRALAALRRRRARWTLAALIAALAAASIAALCIGAYRL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPAQLLGALTATDAQLAGDAALRQARAVLVDIRAPRVVLALFVGAGFGAAGAAMQALFRN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
PLADPGLIGVSSGAALGASALIVLGPLFAARLALGLLPVAAFAGALAVAALVYRLAIARG
CCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RLALPLLLLAGIAINALAGAGIGLLTYLADDAQLRSLTFWSLGSVGGAQWRTIAAVAPFA
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LAGCVLLARERHALNALQLGEAEAMHLGVPVPRVKRRVLVGTAMCVGALVSCTGAIGFIG
HHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAPHCVRLAAGADQRIVMPGAALFGALLAVAADLAARTLAAPAEIPLGILTALIGAPFF
HHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LALLWKRRGALGG
HHHHHHHHCCCCC
>Mature Secondary Structure 
SLAARRHSARPISAERGSTCASRALAALRRRRARWTLAALIAALAAASIAALCIGAYRL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPAQLLGALTATDAQLAGDAALRQARAVLVDIRAPRVVLALFVGAGFGAAGAAMQALFRN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
PLADPGLIGVSSGAALGASALIVLGPLFAARLALGLLPVAAFAGALAVAALVYRLAIARG
CCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RLALPLLLLAGIAINALAGAGIGLLTYLADDAQLRSLTFWSLGSVGGAQWRTIAAVAPFA
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LAGCVLLARERHALNALQLGEAEAMHLGVPVPRVKRRVLVGTAMCVGALVSCTGAIGFIG
HHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAPHCVRLAAGADQRIVMPGAALFGALLAVAADLAARTLAAPAEIPLGILTALIGAPFF
HHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LALLWKRRGALGG
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]