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The map label for this gene is folE

Identifier: 53721079

GI number: 53721079

Start: 39410

End: 39964

Strand: Reverse

Name: folE

Synonym: BPSS0040

Alternate gene names: 53721079

Gene position: 39964-39410 (Counterclockwise)

Preceding gene: 53721080

Following gene: 53721078

Centisome position: 1.26

GC content: 64.86

Gene sequence:

>555_bases
GTGCTGCTGCGGTGGGCCGGCGACGATCCGCAACGCGAGGGGCTCGTCGATACGCCGGCGCGCGTCGTGCGCGCCTACGA
GGAGTTCTTCGCCGGCTACGCGCTCGAACCGCGCGACATCCTCGCGCGCACGTTCAGCGAGGTCGACGGCTACGACGAAA
TGATCGTGCTGAAGGACATCCGCTTCGAAAGCTATTGCGAGCACCATATGGTGCCGATCATCGGCCGCGCGCACGTCGCA
TATCTGCCGAACCATCGCGTCGTGGGCATCTCGAAGCTCGCGCGCCTCGTCGATGCGTTCGCGAAGCGCCTGCAGATCCA
GGAAAAGATGACGGTGCAGATCGCCGATACGCTGTTCGACGTGCTGCAGCCGAAGGGCGTCGGCGTGATTCTCGAAGCGG
CGCACCAGTGCATCTCGACGCGCGGCATCCACAAGCCCGGCGTCGAGATGGTGACGTCGCGGATGCTCGGCACGTTCCGC
ACCGATCCGGCCACGCGCCGCGAATTCCTGTCGATCGTCGCGAATCCTTCCTCGGTCAACCTGACGAACACCTAA

Upstream 100 bases:

>100_bases
GAACAAAGCGAGCAAGACGGCGAGCTCGGCGGCCACGCACGAGCCGGCCGGCGCGCCCGCGAACCGGCCGAGCCGCGACG
AAGCCGAAGCGGCCGTTCGC

Downstream 100 bases:

>100_bases
ATGCAGTCGAGCGCGAAACCAGCCACCTTACCCGTCGTGCTCGTGACGGGCGCCGCGCGCCGCGCGGGCCGCGCGTTCGC
GTTGCGCTTCGCCGCGCGCG

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MLLRWAGDDPQREGLVDTPARVVRAYEEFFAGYALEPRDILARTFSEVDGYDEMIVLKDIRFESYCEHHMVPIIGRAHVA
YLPNHRVVGISKLARLVDAFAKRLQIQEKMTVQIADTLFDVLQPKGVGVILEAAHQCISTRGIHKPGVEMVTSRMLGTFR
TDPATRREFLSIVANPSSVNLTNT

Sequences:

>Translated_184_residues
MLLRWAGDDPQREGLVDTPARVVRAYEEFFAGYALEPRDILARTFSEVDGYDEMIVLKDIRFESYCEHHMVPIIGRAHVA
YLPNHRVVGISKLARLVDAFAKRLQIQEKMTVQIADTLFDVLQPKGVGVILEAAHQCISTRGIHKPGVEMVTSRMLGTFR
TDPATRREFLSIVANPSSVNLTNT
>Mature_184_residues
MLLRWAGDDPQREGLVDTPARVVRAYEEFFAGYALEPRDILARTFSEVDGYDEMIVLKDIRFESYCEHHMVPIIGRAHVA
YLPNHRVVGISKLARLVDAFAKRLQIQEKMTVQIADTLFDVLQPKGVGVILEAAHQCISTRGIHKPGVEMVTSRMLGTFR
TDPATRREFLSIVANPSSVNLTNT

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=172, Percent_Identity=47.093023255814, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI4503949, Length=172, Percent_Identity=47.093023255814, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI66932970, Length=142, Percent_Identity=43.6619718309859, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI66932972, Length=132, Percent_Identity=46.2121212121212, Blast_Score=132, Evalue=2e-31,
Organism=Escherichia coli, GI1788476, Length=175, Percent_Identity=37.7142857142857, Blast_Score=114, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17560486, Length=172, Percent_Identity=44.1860465116279, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321706, Length=176, Percent_Identity=46.0227272727273, Blast_Score=170, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24656782, Length=173, Percent_Identity=45.6647398843931, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24656791, Length=173, Percent_Identity=45.6647398843931, Blast_Score=156, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24656796, Length=173, Percent_Identity=45.6647398843931, Blast_Score=156, Evalue=9e-39,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 20723; Mature: 20723

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRWAGDDPQREGLVDTPARVVRAYEEFFAGYALEPRDILARTFSEVDGYDEMIVLKDI
CEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECC
RFESYCEHHMVPIIGRAHVAYLPNHRVVGISKLARLVDAFAKRLQIQEKMTVQIADTLFD
CHHHHHHHCCCCEECCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLQPKGVGVILEAAHQCISTRGIHKPGVEMVTSRMLGTFRTDPATRREFLSIVANPSSVN
HHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
LTNT
CCCC
>Mature Secondary Structure
MLLRWAGDDPQREGLVDTPARVVRAYEEFFAGYALEPRDILARTFSEVDGYDEMIVLKDI
CEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECC
RFESYCEHHMVPIIGRAHVAYLPNHRVVGISKLARLVDAFAKRLQIQEKMTVQIADTLFD
CHHHHHHHCCCCEECCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLQPKGVGVILEAAHQCISTRGIHKPGVEMVTSRMLGTFRTDPATRREFLSIVANPSSVN
HHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
LTNT
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]