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The map label for this gene is gabP [H]

Identifier: 53720674

GI number: 53720674

Start: 3655322

End: 3656725

Strand: Reverse

Name: gabP [H]

Synonym: BPSL3065

Alternate gene names: 53720674

Gene position: 3656725-3655322 (Counterclockwise)

Preceding gene: 53720675

Following gene: 53720668

Centisome position: 89.75

GC content: 67.59

Gene sequence:

>1404_bases
ATGGAAGGAAGTCAGACAGGCCTCGGAACCGGCCTGAAGCAGCGTCACGTCACGATGCTGTCGATCGCGGGCGTGATCGG
CGCCGGGTTGTTCGTCGGTTCGGGGCATGCGATCGCGGAGGCCGGGCCGGCCGCGCTGATCGCGTACGCGATCGCGGGGC
TGCTCGTCGTGCTCGTGATGCGCATGCTCGGCGAGATGGCGGTTGCGCAGCCGGACAGCGGTTCGTTCTCGACCTACGCC
GATCGCGCGATCGGCCATTGGGCGGGCTTCACGATCGGCTGGCTCTACTGGTGGTTCTGGGTGCTCGTGATTCCGATCGA
GGCGACGGCCGCCGCGACGATCCTCAATGCGTGGTTCCCCGGCGTCGCGACATGGATCTTCGCGCTCGGCATCACGTCGG
TGCTCACCGTCACGAATCTCTTCTCGGTCAAGAACTACGGCGAATTCGAATTCTGGTTCGCGCTCATCAAGGTGGTGGCG
ATCGTGGTGTTCCTCGCGATCGGCGGCGCGGCGATCGTCGGCCTGCTGCCGGGCTCGAACGTGTCGGGCGCGGCGCGCCT
CGTGAACGCGGGCGGCTTCATGCCGAACGGCGTCGGCGCGGTGCTCGCCGCGATGCTGACGACGATGTTCTCGTTCCTCG
GCACCGAGATCGTCACGATCGCCGCGGCCGAATCCGAGCATCCGGAGCGCCAGATCGTCCGCGCGACGAATTCGGTGATC
TGGCGCATCTCGCTGTTCTATCTCGGCTCGATCTTCGTCGTCGCGGCGCTCGTGCCGTGGAACGACGCGCTGCTGCCCGT
GCACGGCTCGTATCAGCGCGCGATGGAGCTGATCGGCGTGCCGCACGCGAAGGGCATCATCGACGTGATCGTGCTGGTGT
CGGTTGCGAGCTGCCTGAATTCGGCGCTCTACACGGCGTCGCGCATGATCTTCTCGCTGTCGACGCGCGGTGACGCGCCG
GCATTCTTGCGCCGCACCGATGCAAGCGGCACCCCGCGCGCGGCGGTGCTCGCGTCGACGGCGTTCGGCTTTCTGACGGT
GATCGCGAACTACGTGATGCCCGAGCAGGTGTTCGGCTTCCTGCTCGCGACGTCGGGCGCGATCGCGCTGCTCGTCTATC
TCGTGATCGCGATCTCGCAACTGCGGATGCGCTCGACGCTCGACGCGACGGGCGAGCGCCTGCCGCTGCGGATGTGGTGC
TTTCCGTGGCTCACGTGGGCGGTGATCGTGTTCATCTGCGGCGTGCTCGTCGTGATGCTGCTGCGCGAGGATCACCGGAT
GGAAGTCGGCGCGACCGCGGTGCTTGCGCTCGCCGTCGTCGTCGCATCGCGGATGAACCGGCGCGCGCGCGGCGGCGACG
AGCCGACGCCCGCCGCGTCGCGAGTGTCCGCTAACCTGCGGTGA

Upstream 100 bases:

>100_bases
CGGCGCGCATTGCGCCGCGCACGGTTCGATAACAACAAAGCCCCCGCGCCGCCTTCATGCGATGCCCGGTCACACCGGAA
CCGTTTTTTTGGAGGGAGAC

Downstream 100 bases:

>100_bases
CGCGGCACCGGCGCGCGGCGCGTGACGGCGCCGCTGGCCGCGCCGAACGTGCCGGCCGTGCCGAACGCACGTTACGCGTC
GAGCAGAATCCGTTTATCCG

Product: putative amino acid permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MEGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEAGPAALIAYAIAGLLVVLVMRMLGEMAVAQPDSGSFSTYA
DRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVA
IVVFLAIGGAAIVGLLPGSNVSGAARLVNAGGFMPNGVGAVLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVI
WRISLFYLGSIFVVAALVPWNDALLPVHGSYQRAMELIGVPHAKGIIDVIVLVSVASCLNSALYTASRMIFSLSTRGDAP
AFLRRTDASGTPRAAVLASTAFGFLTVIANYVMPEQVFGFLLATSGAIALLVYLVIAISQLRMRSTLDATGERLPLRMWC
FPWLTWAVIVFICGVLVVMLLREDHRMEVGATAVLALAVVVASRMNRRARGGDEPTPAASRVSANLR

Sequences:

>Translated_467_residues
MEGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEAGPAALIAYAIAGLLVVLVMRMLGEMAVAQPDSGSFSTYA
DRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVA
IVVFLAIGGAAIVGLLPGSNVSGAARLVNAGGFMPNGVGAVLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVI
WRISLFYLGSIFVVAALVPWNDALLPVHGSYQRAMELIGVPHAKGIIDVIVLVSVASCLNSALYTASRMIFSLSTRGDAP
AFLRRTDASGTPRAAVLASTAFGFLTVIANYVMPEQVFGFLLATSGAIALLVYLVIAISQLRMRSTLDATGERLPLRMWC
FPWLTWAVIVFICGVLVVMLLREDHRMEVGATAVLALAVVVASRMNRRARGGDEPTPAASRVSANLR
>Mature_467_residues
MEGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEAGPAALIAYAIAGLLVVLVMRMLGEMAVAQPDSGSFSTYA
DRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVA
IVVFLAIGGAAIVGLLPGSNVSGAARLVNAGGFMPNGVGAVLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVI
WRISLFYLGSIFVVAALVPWNDALLPVHGSYQRAMELIGVPHAKGIIDVIVLVSVASCLNSALYTASRMIFSLSTRGDAP
AFLRRTDASGTPRAAVLASTAFGFLTVIANYVMPEQVFGFLLATSGAIALLVYLVIAISQLRMRSTLDATGERLPLRMWC
FPWLTWAVIVFICGVLVVMLLREDHRMEVGATAVLALAVVVASRMNRRARGGDEPTPAASRVSANLR

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=442, Percent_Identity=25.5656108597285, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI258645169, Length=378, Percent_Identity=21.6931216931217, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789017, Length=433, Percent_Identity=66.5127020785219, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI1786302, Length=425, Percent_Identity=37.8823529411765, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI1786789, Length=447, Percent_Identity=36.4653243847875, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI48994972, Length=457, Percent_Identity=35.2297592997812, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI87081708, Length=408, Percent_Identity=37.0098039215686, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI1788480, Length=411, Percent_Identity=35.7664233576642, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI87081915, Length=412, Percent_Identity=33.9805825242718, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI1790653, Length=427, Percent_Identity=32.5526932084309, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1786602, Length=389, Percent_Identity=36.5038560411311, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI87081869, Length=262, Percent_Identity=27.0992366412214, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=375, Percent_Identity=22.9333333333333, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=433, Percent_Identity=33.4872979214781, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6320717, Length=413, Percent_Identity=32.9297820823245, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322892, Length=439, Percent_Identity=33.7129840546697, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324061, Length=472, Percent_Identity=29.6610169491525, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324553, Length=402, Percent_Identity=31.8407960199005, Blast_Score=186, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6324059, Length=429, Percent_Identity=31.2354312354312, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6319824, Length=416, Percent_Identity=32.2115384615385, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6319542, Length=404, Percent_Identity=31.4356435643564, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6321629, Length=405, Percent_Identity=29.1358024691358, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=415, Percent_Identity=30.6024096385542, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321053, Length=410, Percent_Identity=29.2682926829268, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319543, Length=401, Percent_Identity=29.1770573566085, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324924, Length=431, Percent_Identity=28.538283062645, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=418, Percent_Identity=29.6650717703349, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322967, Length=398, Percent_Identity=29.3969849246231, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324981, Length=393, Percent_Identity=32.3155216284987, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319608, Length=418, Percent_Identity=25.3588516746411, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320364, Length=470, Percent_Identity=22.9787234042553, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24667468, Length=347, Percent_Identity=24.207492795389, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24666159, Length=442, Percent_Identity=21.7194570135747, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221512776, Length=442, Percent_Identity=21.4932126696833, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49649; Mature: 49649

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEAGPAALIAYAIAGLLVVLVM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHH
RMLGEMAVAQPDSGSFSTYADRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFP
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVAIVVFLAIGGAAIVGLLPGSN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
VSGAARLVNAGGFMPNGVGAVLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVI
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHEEEEECCCCCHHHHHHHHHHHHH
WRISLFYLGSIFVVAALVPWNDALLPVHGSYQRAMELIGVPHAKGIIDVIVLVSVASCLN
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SALYTASRMIFSLSTRGDAPAFLRRTDASGTPRAAVLASTAFGFLTVIANYVMPEQVFGF
HHHHHHHHHHHEECCCCCCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLATSGAIALLVYLVIAISQLRMRSTLDATGERLPLRMWCFPWLTWAVIVFICGVLVVML
HHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LREDHRMEVGATAVLALAVVVASRMNRRARGGDEPTPAASRVSANLR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MEGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEAGPAALIAYAIAGLLVVLVM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHH
RMLGEMAVAQPDSGSFSTYADRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFP
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVAIVVFLAIGGAAIVGLLPGSN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
VSGAARLVNAGGFMPNGVGAVLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVI
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHEEEEECCCCCHHHHHHHHHHHHH
WRISLFYLGSIFVVAALVPWNDALLPVHGSYQRAMELIGVPHAKGIIDVIVLVSVASCLN
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SALYTASRMIFSLSTRGDAPAFLRRTDASGTPRAAVLASTAFGFLTVIANYVMPEQVFGF
HHHHHHHHHHHEECCCCCCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLATSGAIALLVYLVIAISQLRMRSTLDATGERLPLRMWCFPWLTWAVIVFICGVLVVML
HHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LREDHRMEVGATAVLALAVVVASRMNRRARGGDEPTPAASRVSANLR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]