Click here to switch to the map view.

The map label for this gene is 53720348

Identifier: 53720348

GI number: 53720348

Start: 3279418

End: 3280725

Strand: Reverse

Name: 53720348

Synonym: BPSL2738

Alternate gene names: NA

Gene position: 3280725-3279418 (Counterclockwise)

Preceding gene: 53720349

Following gene: 53720342

Centisome position: 80.52

GC content: 70.34

Gene sequence:

>1308_bases
ATGAGCGCTATTCCCGACACGCTGCGCGCGAGCCTCGATCCGTCCCGCAAGAGCTGGCTCGATACGGCGAACGCGGCCGC
GTGCGACTTCCCGATCCAGAACCTGCCGTTCGGCATCTTCAGCGACGCGCGCGACGCGTCGCGCCGCGCGGGCGTCGCGC
TTGGCGATCAGATCATCGATCTCGCCGCGCTCGCGCGCGCGGGGCTGCTGACGGTCGACGGCGGGGCGGCCGTGTTCGCG
CGGCCGGCGCTCAACGATTTCATCTCGCTCGGCCGCGACGCATGGCGCAGCGTGCGCGCCCAGCTGAGCGCGCTTTTCGA
GCGCGGCGAAGCGCGGCTGCGCGACGACGCGGCGTTGCGCGCGAAGGTGCTCGTCGCGCAGCGCGACGCGGCGCTTCATC
TGCCCGTCGACATTCCCGGCTATACCGATTTCTATTCGTCGAAGGAGCACGCGACGAACGTCGGCTCGATGTTTCGCGAT
CCGAAGAACGCGCTGCTGCCGAACTGGTCGGAGATGCCGATCGGCTACAACGGCCGCGCGTCGTCGGTCGTCGTGAGCGG
CACGCCGGTGCGCCGGCCGAACGGCCAGCTGAAGCTGCCCGACAGCGAGCGCCCGGTGTTCGGCGCGTGCCGCAAGCTCG
ACATCGAGCTCGAGACGGGCTTCATCGTCGGCCGCGGCAACGCGCTCGGCGAGCCGATCGCGTGCGAGGATGCGGAGTCG
CACATCTTCGGGATGGTGCTGCTCAACGACTGGAGCGCGCGCGACATCCAGCAATGGGAATACGTGCCGCTCGGGCCGTT
CAACGCGAAGACGTTCGCGACGTCGATCTCGCCGTGGATCGTCACGCTCGATGCGCTCGAGCCGTTTCGCACCGCGCAGC
CGAGGCAGGAGCCGGAGCCGCTCGCGTATCTGCGCCACGGCGGCGCGCATGCGTTCGACATCGAGCTCGAAGTGCGGCTG
AGGCCGGAGGGCGCCGCCGACGCGACGACGATCGCGCGCACGAACTTCAGGCACATGTACTGGACGATGGCGCAGCAGCT
CGCGCACCACACGGTGTCGGGCTGCAACACGCGGGTCGGCGACCTGATGGGCTCGGGCACGATCAGCGGGCCGGCGAAGC
AGGCGTTCGGCAGCCTGCTCGAGCTGACGTGGAACGGCAAGGAGCCCGTCTCGCTCGCGGGCGGCGGCACGCGCGCGTTC
ATCGAGGACGGCGACGAGCTGACGCTGGCGGGCTGGTGCCAGGGCGACGGGTATCGCGTCGGCTTCGGCACGTGCGTCGG
GGAGATTCTGCCGGCGCGGGGCCGGTGA

Upstream 100 bases:

>100_bases
TGATCCGGCCGACGCGCTTCGCGCTCGACACCGCGCAACTGCAGGCGAACTACTTCGAATGCTGGCAAGGCCTCAAGAAA
CACTTCAATCCGGAGCAACG

Downstream 100 bases:

>100_bases
CGCGCTAGCGCGCGAAGCGGGCCGCGCGCCTGGCGCGGCTCGAGCGCGCGAACGGGACGCACGGTCATCGGATCGGGCGC
TTGCGGCCGCGAGGTTGCAA

Product: putative hydrolase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSAIPDTLRASLDPSRKSWLDTANAAACDFPIQNLPFGIFSDARDASRRAGVALGDQIIDLAALARAGLLTVDGGAAVFA
RPALNDFISLGRDAWRSVRAQLSALFERGEARLRDDAALRAKVLVAQRDAALHLPVDIPGYTDFYSSKEHATNVGSMFRD
PKNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDSERPVFGACRKLDIELETGFIVGRGNALGEPIACEDAES
HIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATSISPWIVTLDALEPFRTAQPRQEPEPLAYLRHGGAHAFDIELEVRL
RPEGAADATTIARTNFRHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPAKQAFGSLLELTWNGKEPVSLAGGGTRAF
IEDGDELTLAGWCQGDGYRVGFGTCVGEILPARGR

Sequences:

>Translated_435_residues
MSAIPDTLRASLDPSRKSWLDTANAAACDFPIQNLPFGIFSDARDASRRAGVALGDQIIDLAALARAGLLTVDGGAAVFA
RPALNDFISLGRDAWRSVRAQLSALFERGEARLRDDAALRAKVLVAQRDAALHLPVDIPGYTDFYSSKEHATNVGSMFRD
PKNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDSERPVFGACRKLDIELETGFIVGRGNALGEPIACEDAES
HIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATSISPWIVTLDALEPFRTAQPRQEPEPLAYLRHGGAHAFDIELEVRL
RPEGAADATTIARTNFRHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPAKQAFGSLLELTWNGKEPVSLAGGGTRAF
IEDGDELTLAGWCQGDGYRVGFGTCVGEILPARGR
>Mature_434_residues
SAIPDTLRASLDPSRKSWLDTANAAACDFPIQNLPFGIFSDARDASRRAGVALGDQIIDLAALARAGLLTVDGGAAVFAR
PALNDFISLGRDAWRSVRAQLSALFERGEARLRDDAALRAKVLVAQRDAALHLPVDIPGYTDFYSSKEHATNVGSMFRDP
KNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDSERPVFGACRKLDIELETGFIVGRGNALGEPIACEDAESH
IFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATSISPWIVTLDALEPFRTAQPRQEPEPLAYLRHGGAHAFDIELEVRLR
PEGAADATTIARTNFRHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPAKQAFGSLLELTWNGKEPVSLAGGGTRAFI
EDGDELTLAGWCQGDGYRVGFGTCVGEILPARGR

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=411, Percent_Identity=57.1776155717762, Blast_Score=509, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17568863, Length=410, Percent_Identity=54.6341463414634, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24657182, Length=407, Percent_Identity=51.8427518427518, Blast_Score=432, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 47057; Mature: 46925

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIPDTLRASLDPSRKSWLDTANAAACDFPIQNLPFGIFSDARDASRRAGVALGDQIID
CCCCCCHHHHCCCCCHHHHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCCHHHHHHHH
LAALARAGLLTVDGGAAVFARPALNDFISLGRDAWRSVRAQLSALFERGEARLRDDAALR
HHHHHHCCEEEECCCCEEEECHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHCCCHHHH
AKVLVAQRDAALHLPVDIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNGRA
EEEEEEECCCEEEEEEECCCCCHHCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCC
SSVVVSGTPVRRPNGQLKLPDSERPVFGACRKLDIELETGFIVGRGNALGEPIACEDAES
CEEEEECCCCCCCCCCEECCCCCCCHHHHCEEEEEEEECCEEEECCCCCCCCCCCCCCCC
HIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATSISPWIVTLDALEPFRTAQPRQEPEP
CEEEEEEECCCCCCCCCCCCEEECCCCCCHHHEECCCCEEEEEECCCCHHCCCCCCCCCH
LAYLRHGGAHAFDIELEVRLRPEGAADATTIARTNFRHMYWTMAQQLAHHTVSGCNTRVG
HHHHHCCCCEEEEEEEEEEECCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHH
DLMGSGTISGPAKQAFGSLLELTWNGKEPVSLAGGGTRAFIEDGDELTLAGWCQGDGYRV
HHHCCCCCCCHHHHHHHHHEEEEECCCCCEEECCCCEEEEEECCCEEEEEEEECCCCEEE
GFGTCVGEILPARGR
EHHHHHHHHCCCCCC
>Mature Secondary Structure 
SAIPDTLRASLDPSRKSWLDTANAAACDFPIQNLPFGIFSDARDASRRAGVALGDQIID
CCCCCHHHHCCCCCHHHHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCCHHHHHHHH
LAALARAGLLTVDGGAAVFARPALNDFISLGRDAWRSVRAQLSALFERGEARLRDDAALR
HHHHHHCCEEEECCCCEEEECHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHCCCHHHH
AKVLVAQRDAALHLPVDIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNGRA
EEEEEEECCCEEEEEEECCCCCHHCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCC
SSVVVSGTPVRRPNGQLKLPDSERPVFGACRKLDIELETGFIVGRGNALGEPIACEDAES
CEEEEECCCCCCCCCCEECCCCCCCHHHHCEEEEEEEECCEEEECCCCCCCCCCCCCCCC
HIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATSISPWIVTLDALEPFRTAQPRQEPEP
CEEEEEEECCCCCCCCCCCCEEECCCCCCHHHEECCCCEEEEEECCCCHHCCCCCCCCCH
LAYLRHGGAHAFDIELEVRLRPEGAADATTIARTNFRHMYWTMAQQLAHHTVSGCNTRVG
HHHHHCCCCEEEEEEEEEEECCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHH
DLMGSGTISGPAKQAFGSLLELTWNGKEPVSLAGGGTRAFIEDGDELTLAGWCQGDGYRV
HHHCCCCCCCHHHHHHHHHEEEEECCCCCEEECCCCEEEEEECCCEEEEEEEECCCCEEE
GFGTCVGEILPARGR
EHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA