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The map label for this gene is uvrC [H]

Identifier: 53720026

GI number: 53720026

Start: 2924091

End: 2926328

Strand: Reverse

Name: uvrC [H]

Synonym: BPSL2420

Alternate gene names: 53720026

Gene position: 2926328-2924091 (Counterclockwise)

Preceding gene: 53720030

Following gene: 53720025

Centisome position: 71.82

GC content: 69.79

Gene sequence:

>2238_bases
TTGAGCATGACATCCCCCGACGCACCCGAATCCCGTTTCGAACCCAAGCCGATCCTCGCCCAACTGCCGCATCTGCCTGG
CGTCTACCGTTACTACGACGCGCAGGACGCGGTGCTGTACGTCGGCAAGGCGCGCGACCTGAAAAAGCGCGTGTCGAGCT
ACTTCACGAAAACGCAGCTGTCGCCGCGCATCGCGATGATGATCACGCGCATCGCGCGCATCGAGACCACGGTCACGCGC
TCGGAGGCCGAGGCGCTGCTGCTCGAGAACAACCTGATCAAGGCGCTCGCGCCGCGCTACAACATTCTGTTTCGCGACGA
CAAGTCGTATCCGTACCTGAAGCTCACGGGCCATCGGTTTCCGCGAATGGCGTACTACCGCGGCGCGGTCGACAAGAAGA
ACCAGTACTTCGGGCCGTTTCCGAGCGCGTGGGCGGTGCGCGAGAGCATCCAGATCCTGCAGCGCGTGTTCCAGTTGCGC
ACCTGCGAGGACTCGGTGTTCAACAACCGCACGCGCCCGTGCCTGCTGCACCAGATCGGCCGCTGCTCGGCGCCGTGCGT
CGGCGCGATCGGCGAGGAGGATTACGCGCGCGACGTCGACAACGCGTCGCGTTTCCTGCTCGGCCGGCAGGGCGAGGTGA
TGGGCGAGCTCGAGCGAAAGATGCACGCGTTTGCCGCCGAGCTGAAGTTCGAGCAGGCCGCGGCCGTGCGCAACCAGATG
AGCTCGCTCGCGAAGGTGCTGCATCAGCAGGCGATCGACGTTGGCGGCGACAGCGACGTCGACATCCTCGCGGTCGTCGC
GCAGGGCGGCCGTGTGTGCGTGAACCTTGCGATGGTGCGCGGCGGCCGGCATCTCGGCGACAAGGCGTATTTCCCGGCGC
ACGTCGAAACCGCGCTCGCGCTCGCGGGCGATATCGAAGCGCTGGCCGGCGAAGGCGCCGGCGACGGCGTGCAGGCCGCG
CAAGCGCCGCTCGCGACGGACGCGGATGCGACGGATGCGGCGGCGACTGAGGCGAAGACCGTGACGGCGGCCGCGGCGGC
GCGCGCGGGCGCTCGCACGGCGCAGGCCGCCGGAGCGCGCGCCGCCGCGAGCGCCGAAGGCGATGTCGAGCGACGTGCGG
AGGGAGAAACGCACGCGCGCGCCGACGCGCGCGAAGCCGCCGCACTGCCCGACGGCGCCGCCGCTGCTCAGGAAGCGGAC
GCGGACGTCGACGCCGCGCCGCTCGAAACCGAGGTGCTCGAAGCGTTCATCGCACAGCACTATCTCGGCAATCGCGTGCC
GCCGGTTCTCGTCGTGAGCCATGCGCCCGCGAATCGCGAGCTGATCGATCTGCTCGTCGAACAGGCGGGGCACAAGGTCG
CGGTCGTGCGGCAGCCGCAGGGCCAGAAGCGCGCGTGGCTCACGATGGCCGAGCAGAACGCGCGCCTCGCGCTCGCGCGG
CTGTTGTCCGAGCAGGGCTCGCAGCAGGCGCGCACGCGCTCGCTCGCCGACGTGCTCGGCTACGAGAGCGACGATCTCGC
GCAGCTGCGCATCGAGTGCTTCGACATCAGCCACACGATGGGCGAGGCGACGCAAGCGTCGTGCGTCGTCTATCACCATC
ACAGGATGCAGTCGTCCGAGTACCGCCGCTACAACATCGCGGGAATCACGCCCGGCGACGACTACGCGGCGATGCGCCAG
GTGCTCACGCGCCGCTACGAGAAGATGGTCGAGGAGGCGGCTGCCGAGGCGTCGGCCGACGAGGCGGCCGGCATCGACGG
CAATGCGGTGCATGCGGCCGCTTCGGCGGGGCGGCTGCCGAACGTCGTGCTGATCGACGGCGGCCGGGGCCAGGTCGAGA
TCGCGCGCCAGGTGTTTTCCGAGCTCGGGCTCGATATCTCGATGCTCGTCGGCGTCGCGAAGGGCGAGGGACGCAAGGTC
GGGCTCGAGACGCTGATCTTCGCCGACGGCCGCGCGCCGCTCGAGCTCGGCAAGGAGAGCGCGGCGCTGATGCTCGTCGC
GCAGATCCGCGACGAGGCGCACCGTTTCGCGATCACCGGGATGCGCGCGAAGCGGGCGAAGACGCGGCAGACGTCGCGGC
TCGAGGAACTGGAGGGCGTCGGTGCGAAGCGCCGGCAGCGGCTGCTCGCGCGCTTCGGCGGCCTGCGCGGCGTCGTCGCC
GCGAGCGTCGACGAGCTCGCGAGCGTCGAAGGCATTTCCCGCGCGCTCGCCGAGCAGATCTACCGGCAACTCCACTGA

Upstream 100 bases:

>100_bases
CGCTGACGCGCGGCGGCGGCCGGGCCGCGTTCGCGCGCGGCGAATGCTCTACACTGGCGATTCTAAATGACCTTGTTCGC
GCGCGCCGCTCGCGCCCGCA

Downstream 100 bases:

>100_bases
GCGCGGGCGCGCCGCCGGGCGGCCTTGCGCGGCTCGCGCCGGGCGGCGCGGCCCGTGCCGGGCGCCTTGCTTGTGGCGGC
GCGGGCGACGCGGCACAATG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MSMTSPDAPESRFEPKPILAQLPHLPGVYRYYDAQDAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMITRIARIETTVTR
SEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHRFPRMAYYRGAVDKKNQYFGPFPSAWAVRESIQILQRVFQLR
TCEDSVFNNRTRPCLLHQIGRCSAPCVGAIGEEDYARDVDNASRFLLGRQGEVMGELERKMHAFAAELKFEQAAAVRNQM
SSLAKVLHQQAIDVGGDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPAHVETALALAGDIEALAGEGAGDGVQAA
QAPLATDADATDAAATEAKTVTAAAAARAGARTAQAAGARAAASAEGDVERRAEGETHARADAREAAALPDGAAAAQEAD
ADVDAAPLETEVLEAFIAQHYLGNRVPPVLVVSHAPANRELIDLLVEQAGHKVAVVRQPQGQKRAWLTMAEQNARLALAR
LLSEQGSQQARTRSLADVLGYESDDLAQLRIECFDISHTMGEATQASCVVYHHHRMQSSEYRRYNIAGITPGDDYAAMRQ
VLTRRYEKMVEEAAAEASADEAAGIDGNAVHAAASAGRLPNVVLIDGGRGQVEIARQVFSELGLDISMLVGVAKGEGRKV
GLETLIFADGRAPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKTRQTSRLEELEGVGAKRRQRLLARFGGLRGVVA
ASVDELASVEGISRALAEQIYRQLH

Sequences:

>Translated_745_residues
MSMTSPDAPESRFEPKPILAQLPHLPGVYRYYDAQDAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMITRIARIETTVTR
SEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHRFPRMAYYRGAVDKKNQYFGPFPSAWAVRESIQILQRVFQLR
TCEDSVFNNRTRPCLLHQIGRCSAPCVGAIGEEDYARDVDNASRFLLGRQGEVMGELERKMHAFAAELKFEQAAAVRNQM
SSLAKVLHQQAIDVGGDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPAHVETALALAGDIEALAGEGAGDGVQAA
QAPLATDADATDAAATEAKTVTAAAAARAGARTAQAAGARAAASAEGDVERRAEGETHARADAREAAALPDGAAAAQEAD
ADVDAAPLETEVLEAFIAQHYLGNRVPPVLVVSHAPANRELIDLLVEQAGHKVAVVRQPQGQKRAWLTMAEQNARLALAR
LLSEQGSQQARTRSLADVLGYESDDLAQLRIECFDISHTMGEATQASCVVYHHHRMQSSEYRRYNIAGITPGDDYAAMRQ
VLTRRYEKMVEEAAAEASADEAAGIDGNAVHAAASAGRLPNVVLIDGGRGQVEIARQVFSELGLDISMLVGVAKGEGRKV
GLETLIFADGRAPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKTRQTSRLEELEGVGAKRRQRLLARFGGLRGVVA
ASVDELASVEGISRALAEQIYRQLH
>Mature_744_residues
SMTSPDAPESRFEPKPILAQLPHLPGVYRYYDAQDAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMITRIARIETTVTRS
EAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHRFPRMAYYRGAVDKKNQYFGPFPSAWAVRESIQILQRVFQLRT
CEDSVFNNRTRPCLLHQIGRCSAPCVGAIGEEDYARDVDNASRFLLGRQGEVMGELERKMHAFAAELKFEQAAAVRNQMS
SLAKVLHQQAIDVGGDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPAHVETALALAGDIEALAGEGAGDGVQAAQ
APLATDADATDAAATEAKTVTAAAAARAGARTAQAAGARAAASAEGDVERRAEGETHARADAREAAALPDGAAAAQEADA
DVDAAPLETEVLEAFIAQHYLGNRVPPVLVVSHAPANRELIDLLVEQAGHKVAVVRQPQGQKRAWLTMAEQNARLALARL
LSEQGSQQARTRSLADVLGYESDDLAQLRIECFDISHTMGEATQASCVVYHHHRMQSSEYRRYNIAGITPGDDYAAMRQV
LTRRYEKMVEEAAAEASADEAAGIDGNAVHAAASAGRLPNVVLIDGGRGQVEIARQVFSELGLDISMLVGVAKGEGRKVG
LETLIFADGRAPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKTRQTSRLEELEGVGAKRRQRLLARFGGLRGVVAA
SVDELASVEGISRALAEQIYRQLH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=313, Percent_Identity=44.0894568690096, Blast_Score=288, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 80659; Mature: 80528

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMTSPDAPESRFEPKPILAQLPHLPGVYRYYDAQDAVLYVGKARDLKKRVSSYFTKTQL
CCCCCCCCCCCCCCCCCHHHHCCCCCCHHEEECCCCCEEEECCHHHHHHHHHHHHHHHCC
SPRIAMMITRIARIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHRF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCC
PRMAYYRGAVDKKNQYFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIG
CCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
RCSAPCVGAIGEEDYARDVDNASRFLLGRQGEVMGELERKMHAFAAELKFEQAAAVRNQM
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLAKVLHQQAIDVGGDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPAHVETALA
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHH
LAGDIEALAGEGAGDGVQAAQAPLATDADATDAAATEAKTVTAAAAARAGARTAQAAGAR
HHCCHHHHCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCH
AAASAEGDVERRAEGETHARADAREAAALPDGAAAAQEADADVDAAPLETEVLEAFIAQH
HHCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHH
YLGNRVPPVLVVSHAPANRELIDLLVEQAGHKVAVVRQPQGQKRAWLTMAEQNARLALAR
HHCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEHHCCHHHHHHH
LLSEQGSQQARTRSLADVLGYESDDLAQLRIECFDISHTMGEATQASCVVYHHHRMQSSE
HHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHEEECHHHHCCCCCCCEEEEEHHHCCCCC
YRRYNIAGITPGDDYAAMRQVLTRRYEKMVEEAAAEASADEAAGIDGNAVHAAASAGRLP
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHCCCCC
NVVLIDGGRGQVEIARQVFSELGLDISMLVGVAKGEGRKVGLETLIFADGRAPLELGKES
EEEEEECCCCHHHHHHHHHHHHCCCHHHHHEECCCCCCEECCEEEEEECCCCHHHHCCCH
AALMLVAQIRDEAHRFAITGMRAKRAKTRQTSRLEELEGVGAKRRQRLLARFGGLRGVVA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHH
ASVDELASVEGISRALAEQIYRQLH
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SMTSPDAPESRFEPKPILAQLPHLPGVYRYYDAQDAVLYVGKARDLKKRVSSYFTKTQL
CCCCCCCCCCCCCCCCHHHHCCCCCCHHEEECCCCCEEEECCHHHHHHHHHHHHHHHCC
SPRIAMMITRIARIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHRF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCC
PRMAYYRGAVDKKNQYFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIG
CCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
RCSAPCVGAIGEEDYARDVDNASRFLLGRQGEVMGELERKMHAFAAELKFEQAAAVRNQM
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLAKVLHQQAIDVGGDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPAHVETALA
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHH
LAGDIEALAGEGAGDGVQAAQAPLATDADATDAAATEAKTVTAAAAARAGARTAQAAGAR
HHCCHHHHCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCH
AAASAEGDVERRAEGETHARADAREAAALPDGAAAAQEADADVDAAPLETEVLEAFIAQH
HHCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHH
YLGNRVPPVLVVSHAPANRELIDLLVEQAGHKVAVVRQPQGQKRAWLTMAEQNARLALAR
HHCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEHHCCHHHHHHH
LLSEQGSQQARTRSLADVLGYESDDLAQLRIECFDISHTMGEATQASCVVYHHHRMQSSE
HHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHEEECHHHHCCCCCCCEEEEEHHHCCCCC
YRRYNIAGITPGDDYAAMRQVLTRRYEKMVEEAAAEASADEAAGIDGNAVHAAASAGRLP
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHCCCCC
NVVLIDGGRGQVEIARQVFSELGLDISMLVGVAKGEGRKVGLETLIFADGRAPLELGKES
EEEEEECCCCHHHHHHHHHHHHCCCHHHHHEECCCCCCEECCEEEEEECCCCHHHHCCCH
AALMLVAQIRDEAHRFAITGMRAKRAKTRQTSRLEELEGVGAKRRQRLLARFGGLRGVVA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHH
ASVDELASVEGISRALAEQIYRQLH
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA