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The map label for this gene is hemN [H]

Identifier: 53719973

GI number: 53719973

Start: 2859237

End: 2860682

Strand: Reverse

Name: hemN [H]

Synonym: BPSL2366

Alternate gene names: 53719973

Gene position: 2860682-2859237 (Counterclockwise)

Preceding gene: 53719974

Following gene: 53719972

Centisome position: 70.21

GC content: 65.98

Gene sequence:

>1446_bases
ATGACAACGCATTCGAACGACGGCGCGGATACGACCGCGCCCGCTCCCCAACACGACGTGTCCGCGTTCGCGGACGTTCA
GATCTCCGAAGCGCTGATTCGGCGCTTCGACCGGCAAGGGCCGCGCTATACGTCCTATCCGACGGCCGACCGGTTCTCCG
ACGCATTCGACGAGCGCGCGTACCGCGAACATCTGTCGCGCCGCGCGTCAGCCGAGCATAATCCGCCGCTGTCGGTCTAT
TTGCATCTGCCGTTTTGCGAGTCGCTCTGCTACTTCTGCGCGTGCAACAAGATCATCACGCAGGATCACACCCGCACGAG
CGCGTACGTCGACTATCTGATCCGCGAAATGGAGCTCGTCGCGCCGGATCTCGGCCGCGATCGGCGGACGACGCAACTGC
ATCTGGGCGGCGGCTCGCCGACGTTCTTCGCGATCGACGAGCTCGCGCGCCTGATGCGCGCGCTGCGCGAGCACTTCGAC
TTCGCGCCGCACGCGGAGCTCGGCGTCGAGATCGATCCGCGCACGGTCAACGAGCGCACCCTGCAGTCGCTCGCGGCGCT
CGGCTTCAACCGGACGAGCTTCGGCGTGCAGGACTTCGATCCGTCGGTGCAGGAGGCGGTGCATCGGATCCAGCCGCTGC
CGATGGTCGAGCGCGCGCTCGAGGCGAGCCGCGCGGCCGGTTTCGAATCGGTCAACATCGATCTGATCTACGGGTTGCCG
CGGCAGACGCCCGCGAGCTTTTCGCGCACGCTCGACGAGGTGATCCGGCTGTCGCCCGAGCGCATCGCGGTCTACAACTA
CGCGCATTTGCCGAGCCGCTTCAAGGCGCAGCGCCTGATCGTCGAAGCGCAGCTGCCGCCCGCGGAAGACCGGCTGCGGA
TCTTCATCGAATCGACGCGGCGGCTGCTCGACGCGGGCTACGTGTACATTGGGCTCGATCACTTCGCGAAGCCGAACGAC
GAGCTCGGCAACGCGCTGCGCGAGCGCAGCCTGCACCGCAATTTCCAGGGCTATACGACGCAGGCCGAATGCGATCTCGT
CGGCTTCGGCGTATCGGCGATCGGCAAGGTCGGCACCTCGTACAGCCAATCGACGCGCTCGCTGAAGACCTATTACCGCC
AGCTCGACGCGGGGCGCCTGCCGATCGAGCGGGGCTTCGCGCTGACAGCCGACGATTTGCTGCGCCGCGAAGTCATCATG
ACGGTGATGTGCAGCACACCCGTCGATTTCGCGGAGATCAGCCACAGGCACGGCATCGATTTCGCCCGGTATTTCGCGCC
CGAGCTCGCGCAGCTCGAGCCGTATCGCGACGCGGGGCTGCTCACGATCGATGCGCAGCGCATCGCCGTCACGCCGAAGG
GGCGCATGTTCGTGCGCGCGATCGGCATGGTGTTCGACGCGTATCTCGGCCGCAGCGCCGCGGCGTCTTATTCGAAATTG
ATCTAG

Upstream 100 bases:

>100_bases
CGGCGTCGGAGGTTGATTTGCATCAAGTCCGTCCGGGCCGCGCGCCCGACAATGGAACGCCGGCGTTTCGCGCGGCATGC
CAGGGTACAAGCAGATGGAC

Downstream 100 bases:

>100_bases
AAGGTGGCGTGATGAAGGAAAGCAAGATTCCCGTGCAGGATTTTCTTGCGCGGCTGCCGCTTTTCAGCGTGCTGTCGCGC
GGCGAGCTCGACAATCTCGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MTTHSNDGADTTAPAPQHDVSAFADVQISEALIRRFDRQGPRYTSYPTADRFSDAFDERAYREHLSRRASAEHNPPLSVY
LHLPFCESLCYFCACNKIITQDHTRTSAYVDYLIREMELVAPDLGRDRRTTQLHLGGGSPTFFAIDELARLMRALREHFD
FAPHAELGVEIDPRTVNERTLQSLAALGFNRTSFGVQDFDPSVQEAVHRIQPLPMVERALEASRAAGFESVNIDLIYGLP
RQTPASFSRTLDEVIRLSPERIAVYNYAHLPSRFKAQRLIVEAQLPPAEDRLRIFIESTRRLLDAGYVYIGLDHFAKPND
ELGNALRERSLHRNFQGYTTQAECDLVGFGVSAIGKVGTSYSQSTRSLKTYYRQLDAGRLPIERGFALTADDLLRREVIM
TVMCSTPVDFAEISHRHGIDFARYFAPELAQLEPYRDAGLLTIDAQRIAVTPKGRMFVRAIGMVFDAYLGRSAAASYSKL
I

Sequences:

>Translated_481_residues
MTTHSNDGADTTAPAPQHDVSAFADVQISEALIRRFDRQGPRYTSYPTADRFSDAFDERAYREHLSRRASAEHNPPLSVY
LHLPFCESLCYFCACNKIITQDHTRTSAYVDYLIREMELVAPDLGRDRRTTQLHLGGGSPTFFAIDELARLMRALREHFD
FAPHAELGVEIDPRTVNERTLQSLAALGFNRTSFGVQDFDPSVQEAVHRIQPLPMVERALEASRAAGFESVNIDLIYGLP
RQTPASFSRTLDEVIRLSPERIAVYNYAHLPSRFKAQRLIVEAQLPPAEDRLRIFIESTRRLLDAGYVYIGLDHFAKPND
ELGNALRERSLHRNFQGYTTQAECDLVGFGVSAIGKVGTSYSQSTRSLKTYYRQLDAGRLPIERGFALTADDLLRREVIM
TVMCSTPVDFAEISHRHGIDFARYFAPELAQLEPYRDAGLLTIDAQRIAVTPKGRMFVRAIGMVFDAYLGRSAAASYSKL
I
>Mature_480_residues
TTHSNDGADTTAPAPQHDVSAFADVQISEALIRRFDRQGPRYTSYPTADRFSDAFDERAYREHLSRRASAEHNPPLSVYL
HLPFCESLCYFCACNKIITQDHTRTSAYVDYLIREMELVAPDLGRDRRTTQLHLGGGSPTFFAIDELARLMRALREHFDF
APHAELGVEIDPRTVNERTLQSLAALGFNRTSFGVQDFDPSVQEAVHRIQPLPMVERALEASRAAGFESVNIDLIYGLPR
QTPASFSRTLDEVIRLSPERIAVYNYAHLPSRFKAQRLIVEAQLPPAEDRLRIFIESTRRLLDAGYVYIGLDHFAKPNDE
LGNALRERSLHRNFQGYTTQAECDLVGFGVSAIGKVGTSYSQSTRSLKTYYRQLDAGRLPIERGFALTADDLLRREVIMT
VMCSTPVDFAEISHRHGIDFARYFAPELAQLEPYRDAGLLTIDAQRIAVTPKGRMFVRAIGMVFDAYLGRSAAASYSKLI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=191, Percent_Identity=24.6073298429319, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI87082341, Length=452, Percent_Identity=47.3451327433628, Blast_Score=427, Evalue=1e-120,
Organism=Escherichia coli, GI1789325, Length=297, Percent_Identity=28.2828282828283, Blast_Score=112, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 54207; Mature: 54076

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHSNDGADTTAPAPQHDVSAFADVQISEALIRRFDRQGPRYTSYPTADRFSDAFDERA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
YREHLSRRASAEHNPPLSVYLHLPFCESLCYFCACNKIITQDHTRTSAYVDYLIREMELV
HHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
APDLGRDRRTTQLHLGGGSPTFFAIDELARLMRALREHFDFAPHAELGVEIDPRTVNERT
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCHHH
LQSLAALGFNRTSFGVQDFDPSVQEAVHRIQPLPMVERALEASRAAGFESVNIDLIYGLP
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCC
RQTPASFSRTLDEVIRLSPERIAVYNYAHLPSRFKAQRLIVEAQLPPAEDRLRIFIESTR
CCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHEEEEECCCCCHHHHHHHHHHHH
RLLDAGYVYIGLDHFAKPNDELGNALRERSLHRNFQGYTTQAECDLVGFGVSAIGKVGTS
HHHHCCEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHCCC
YSQSTRSLKTYYRQLDAGRLPIERGFALTADDLLRREVIMTVMCSTPVDFAEISHRHGID
HHHHHHHHHHHHHHHCCCCCCHHCCCEECHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCC
FARYFAPELAQLEPYRDAGLLTIDAQRIAVTPKGRMFVRAIGMVFDAYLGRSAAASYSKL
HHHHHCCHHHHCCCCCCCCEEEEECCEEEECCCCHHHHHHHHHHHHHHHCHHHHHHHHHC
I
C
>Mature Secondary Structure 
TTHSNDGADTTAPAPQHDVSAFADVQISEALIRRFDRQGPRYTSYPTADRFSDAFDERA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
YREHLSRRASAEHNPPLSVYLHLPFCESLCYFCACNKIITQDHTRTSAYVDYLIREMELV
HHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
APDLGRDRRTTQLHLGGGSPTFFAIDELARLMRALREHFDFAPHAELGVEIDPRTVNERT
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCHHH
LQSLAALGFNRTSFGVQDFDPSVQEAVHRIQPLPMVERALEASRAAGFESVNIDLIYGLP
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCC
RQTPASFSRTLDEVIRLSPERIAVYNYAHLPSRFKAQRLIVEAQLPPAEDRLRIFIESTR
CCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHEEEEECCCCCHHHHHHHHHHHH
RLLDAGYVYIGLDHFAKPNDELGNALRERSLHRNFQGYTTQAECDLVGFGVSAIGKVGTS
HHHHCCEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHCCC
YSQSTRSLKTYYRQLDAGRLPIERGFALTADDLLRREVIMTVMCSTPVDFAEISHRHGID
HHHHHHHHHHHHHHHCCCCCCHHCCCEECHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCC
FARYFAPELAQLEPYRDAGLLTIDAQRIAVTPKGRMFVRAIGMVFDAYLGRSAAASYSKL
HHHHHCCHHHHCCCCCCCCEEEEECCEEEECCCCHHHHHHHHHHHHHHHCHHHHHHHHHC
I
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]