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The map label for this gene is kdsA1

Identifier: 53719881

GI number: 53719881

Start: 2735121

End: 2735975

Strand: Reverse

Name: kdsA1

Synonym: BPSL2271

Alternate gene names: 53719881

Gene position: 2735975-2735121 (Counterclockwise)

Preceding gene: 53719882

Following gene: 53719880

Centisome position: 67.15

GC content: 67.02

Gene sequence:

>855_bases
ATGAATCTCGCCGGGTTCGAAGTCGGGCTCGACAAGCCGTTCTTCCTGATCGCCGGCACCTGCGTCGTCGAATCGGAGCA
GATGACGATCGACACCGCGGGCCGGCTGAAGGAGATCTGCGCGACGCTCGGCGTGCCGTTCATCTACAAATCGTCGTACG
ACAAGGCCAATCGCAGCTCGGGCAAGTCGTTTCGCGGGCTCGGGATGGACGAGGGGCTGCGGATTCTCGCCGAGGTGAAG
CGCCAGCTGAACGTGCCGGTGCTCACCGACGTGCACGAGATCGACGAGATCGCGCCCGTGGCGGCCGTCGTCGACGTGCT
GCAGACGCCCGCGTTCCTGTGCCGCCAGACCGATTTCATCCGCGCGTGCGCGCAATCGGGCAAGCCCGTGAACATCAAGA
AGGGCCAGTTCCTCGCGCCGCACGACATGAAGAACGTGATCGACAAGGCGCGCGACGCCGCGCGCGACGCGGGGCTCTCG
GAAGACCGTTTCATGGCGTGCGAGCGCGGCGTGTCGTTCGGCTACAACAATCTCGTGTCGGACATGCGATCGCTCGCGAT
CATGCGCGAGACGGGCGCGCCCGTCGTGTTCGACGCGACCCACTCGGTACAACTGCCGGGCGGGCAGGGCACGAGCTCCG
GCGGCCAGCGCGAATTCGTGCCGGTGCTCGCGCGCGCGGCGCTCGCCACGGGCGTCGCGGGGCTTTTCATGGAGACGCAC
CCGAATCCGGCCGAGGCCAAGTCCGACGGCCCGAACGCGGTGCCGCTCGGCAGGATGGCCGCGCTGCTGGAGACGCTCGT
CACGCTCGATCGGGCGGTGAAGCGCGTGCCGTTCCTGGAAAACGATTTCAATTGA

Upstream 100 bases:

>100_bases
ACCCGGAATTCACGTCGACGCCGCGCGACGGCCATCCGCTGTTCAAGTCGTTCGTGCAGGCCGCGCTCGCGTGCCAGCAG
ACGCGCGCCGGAGCGAAGGC

Downstream 100 bases:

>100_bases
TGAACTCGGCGGCCGTAGCGCGCGTCAGTAGCAGGAGCGGCTGCCGCGCCGGATCGACCGCCGTCGCTGAAGACAGGATC
CATCGTCATTTTCAGAGGAA

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase 1; KDO-8-phosphate synthase 1; KDO 8-P synthase 1; KDOPS 1; Phospho-2-dehydro-3-deoxyoctonate aldolase 1

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNLAGFEVGLDKPFFLIAGTCVVESEQMTIDTAGRLKEICATLGVPFIYKSSYDKANRSSGKSFRGLGMDEGLRILAEVK
RQLNVPVLTDVHEIDEIAPVAAVVDVLQTPAFLCRQTDFIRACAQSGKPVNIKKGQFLAPHDMKNVIDKARDAARDAGLS
EDRFMACERGVSFGYNNLVSDMRSLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAALATGVAGLFMETH
PNPAEAKSDGPNAVPLGRMAALLETLVTLDRAVKRVPFLENDFN

Sequences:

>Translated_284_residues
MNLAGFEVGLDKPFFLIAGTCVVESEQMTIDTAGRLKEICATLGVPFIYKSSYDKANRSSGKSFRGLGMDEGLRILAEVK
RQLNVPVLTDVHEIDEIAPVAAVVDVLQTPAFLCRQTDFIRACAQSGKPVNIKKGQFLAPHDMKNVIDKARDAARDAGLS
EDRFMACERGVSFGYNNLVSDMRSLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAALATGVAGLFMETH
PNPAEAKSDGPNAVPLGRMAALLETLVTLDRAVKRVPFLENDFN
>Mature_284_residues
MNLAGFEVGLDKPFFLIAGTCVVESEQMTIDTAGRLKEICATLGVPFIYKSSYDKANRSSGKSFRGLGMDEGLRILAEVK
RQLNVPVLTDVHEIDEIAPVAAVVDVLQTPAFLCRQTDFIRACAQSGKPVNIKKGQFLAPHDMKNVIDKARDAARDAGLS
EDRFMACERGVSFGYNNLVSDMRSLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAALATGVAGLFMETH
PNPAEAKSDGPNAVPLGRMAALLETLVTLDRAVKRVPFLENDFN

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=276, Percent_Identity=42.3913043478261, Blast_Score=243, Evalue=8e-66,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA1_BURPS (Q63SP9)

Other databases:

- EMBL:   BX571965
- RefSeq:   YP_108867.1
- ProteinModelPortal:   Q63SP9
- SMR:   Q63SP9
- GeneID:   3091613
- GenomeReviews:   BX571965_GR
- KEGG:   bps:BPSL2271
- HOGENOM:   HBG575990
- OMA:   GVFLECH
- PhylomeDB:   Q63SP9
- ProtClustDB:   PRK05198
- BioCyc:   BPSE272560:BPSL2271-MONOMER
- BRENDA:   2.5.1.55
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 30570; Mature: 30570

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLAGFEVGLDKPFFLIAGTCVVESEQMTIDTAGRLKEICATLGVPFIYKSSYDKANRSS
CCCCCCCCCCCCCEEEEECCCEEECCCEEECHHHHHHHHHHHHCCCEEECCCCCCCCCCC
GKSFRGLGMDEGLRILAEVKRQLNVPVLTDVHEIDEIAPVAAVVDVLQTPAFLCRQTDFI
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
RACAQSGKPVNIKKGQFLAPHDMKNVIDKARDAARDAGLSEDRFMACERGVSFGYNNLVS
HHHHHCCCCCEECCCCEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHH
DMRSLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAALATGVAGLFMETH
HHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PNPAEAKSDGPNAVPLGRMAALLETLVTLDRAVKRVPFLENDFN
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNLAGFEVGLDKPFFLIAGTCVVESEQMTIDTAGRLKEICATLGVPFIYKSSYDKANRSS
CCCCCCCCCCCCCEEEEECCCEEECCCEEECHHHHHHHHHHHHCCCEEECCCCCCCCCCC
GKSFRGLGMDEGLRILAEVKRQLNVPVLTDVHEIDEIAPVAAVVDVLQTPAFLCRQTDFI
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
RACAQSGKPVNIKKGQFLAPHDMKNVIDKARDAARDAGLSEDRFMACERGVSFGYNNLVS
HHHHHCCCCCEECCCCEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHH
DMRSLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAALATGVAGLFMETH
HHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PNPAEAKSDGPNAVPLGRMAALLETLVTLDRAVKRVPFLENDFN
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA