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The map label for this gene is gpo [C]

Identifier: 53719784

GI number: 53719784

Start: 2611872

End: 2612351

Strand: Reverse

Name: gpo [C]

Synonym: BPSL2175

Alternate gene names: 53719784

Gene position: 2612351-2611872 (Counterclockwise)

Preceding gene: 53719786

Following gene: 53719776

Centisome position: 64.11

GC content: 61.04

Gene sequence:

>480_bases
ATGTCGAAACTGTATTCATTCAACGCGCAGGCGCTTTCGGGGGGCGAGGTGCCGCTCGAGCAATACCGGGGCAAGGTGCT
CCTCATCGTCAACACGGCGAGCGAGTGCGGATTCACGCCGCAGTACGCGGGGCTGCAGCAACTGTACGATCGCTTTCGCG
AACGCGGGCTTGTCGTGCTCGGCTTTCCGTGCAATCAGTTCGGCAAGCAGGAGCCGGGCGATGCGTCGCAGATCGGCGCG
TTCTGCGAGAAGAATTACGGCGTCACGTTCCCGATGTTCGGGAAGATCGATGTGAACGGCGCGAACGCGCACCCGCTATA
CCGGTATCTGACCGAGGAGGCGCCCGGCATTCTCGGCCTGAAGGCGATCAAGTGGAATTTCACGAAGTTCCTCGTGAACC
GGGAAGGCGAGATCGTGAAGCGCTATGCGCCGTCGACGAAGCCCGAGGATATCGCCGCGGACGTCGAAAAGCTGCTTTGA

Upstream 100 bases:

>100_bases
TTCGGGGGATCGTCCGGATGGCGGAATGTGCGCGCCGCGCCGAATTCGCCTAGACTTCCGCGGACGGCGCAACCATATCA
AAACAGGGAGGAACGAGCCG

Downstream 100 bases:

>100_bases
GCCCGGCGGCGCGCCGCGCGGCCGGGATCGGGCATGCGGGCTGCGCGGGCTGTGCGGCCGCCGGGGCCGTTCGGGCGGGC
CCGCGCGGCGCCCGCTCGCG

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MSKLYSFNAQALSGGEVPLEQYRGKVLLIVNTASECGFTPQYAGLQQLYDRFRERGLVVLGFPCNQFGKQEPGDASQIGA
FCEKNYGVTFPMFGKIDVNGANAHPLYRYLTEEAPGILGLKAIKWNFTKFLVNREGEIVKRYAPSTKPEDIAADVEKLL

Sequences:

>Translated_159_residues
MSKLYSFNAQALSGGEVPLEQYRGKVLLIVNTASECGFTPQYAGLQQLYDRFRERGLVVLGFPCNQFGKQEPGDASQIGA
FCEKNYGVTFPMFGKIDVNGANAHPLYRYLTEEAPGILGLKAIKWNFTKFLVNREGEIVKRYAPSTKPEDIAADVEKLL
>Mature_158_residues
SKLYSFNAQALSGGEVPLEQYRGKVLLIVNTASECGFTPQYAGLQQLYDRFRERGLVVLGFPCNQFGKQEPGDASQIGAF
CEKNYGVTFPMFGKIDVNGANAHPLYRYLTEEAPGILGLKAIKWNFTKFLVNREGEIVKRYAPSTKPEDIAADVEKLL

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=155, Percent_Identity=47.0967741935484, Blast_Score=137, Evalue=4e-33,
Organism=Homo sapiens, GI90903240, Length=155, Percent_Identity=47.0967741935484, Blast_Score=136, Evalue=6e-33,
Organism=Homo sapiens, GI192455698, Length=160, Percent_Identity=41.25, Blast_Score=133, Evalue=6e-32,
Organism=Homo sapiens, GI15618997, Length=157, Percent_Identity=43.312101910828, Blast_Score=133, Evalue=6e-32,
Organism=Homo sapiens, GI90903238, Length=130, Percent_Identity=48.4615384615385, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI41406084, Length=186, Percent_Identity=39.7849462365591, Blast_Score=106, Evalue=9e-24,
Organism=Homo sapiens, GI4557629, Length=177, Percent_Identity=37.8531073446328, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI6006001, Length=177, Percent_Identity=36.7231638418079, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI32967607, Length=180, Percent_Identity=34.4444444444444, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI33186887, Length=176, Percent_Identity=32.9545454545455, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI41406082, Length=70, Percent_Identity=55.7142857142857, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1788003, Length=158, Percent_Identity=44.3037974683544, Blast_Score=147, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17506887, Length=160, Percent_Identity=46.875, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17535473, Length=160, Percent_Identity=46.25, Blast_Score=155, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI71993584, Length=157, Percent_Identity=42.0382165605096, Blast_Score=135, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI193210707, Length=161, Percent_Identity=44.0993788819876, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17550320, Length=180, Percent_Identity=32.7777777777778, Blast_Score=109, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI193209493, Length=183, Percent_Identity=31.6939890710383, Blast_Score=105, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71993573, Length=94, Percent_Identity=40.4255319148936, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71999642, Length=76, Percent_Identity=40.7894736842105, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193210709, Length=71, Percent_Identity=47.887323943662, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507603, Length=106, Percent_Identity=35.8490566037736, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319721, Length=158, Percent_Identity=51.2658227848101, Blast_Score=187, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6322228, Length=159, Percent_Identity=50.9433962264151, Blast_Score=187, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6322826, Length=159, Percent_Identity=45.2830188679245, Blast_Score=160, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24656772, Length=160, Percent_Identity=50, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24656767, Length=160, Percent_Identity=50, Blast_Score=160, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24656777, Length=160, Percent_Identity=50, Blast_Score=160, Evalue=5e-40,
Organism=Drosophila melanogaster, GI85726443, Length=158, Percent_Identity=41.1392405063291, Blast_Score=119, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 17690; Mature: 17559

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLYSFNAQALSGGEVPLEQYRGKVLLIVNTASECGFTPQYAGLQQLYDRFRERGLVVL
CCCCCCCCCCCCCCCCCCHHHHCCCEEEEEECCHHCCCCCCHHHHHHHHHHHHHCCEEEE
GFPCNQFGKQEPGDASQIGAFCEKNYGVTFPMFGKIDVNGANAHPLYRYLTEEAPGILGL
ECCCHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCEEEE
KAIKWNFTKFLVNREGEIVKRYAPSTKPEDIAADVEKLL
EEHHHHHHHEEECCCCHHHHHCCCCCCCHHHHHHHHHHC
>Mature Secondary Structure 
SKLYSFNAQALSGGEVPLEQYRGKVLLIVNTASECGFTPQYAGLQQLYDRFRERGLVVL
CCCCCCCCCCCCCCCCCHHHHCCCEEEEEECCHHCCCCCCHHHHHHHHHHHHHCCEEEE
GFPCNQFGKQEPGDASQIGAFCEKNYGVTFPMFGKIDVNGANAHPLYRYLTEEAPGILGL
ECCCHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCEEEE
KAIKWNFTKFLVNREGEIVKRYAPSTKPEDIAADVEKLL
EEHHHHHHHEEECCCCHHHHHCCCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]