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The map label for this gene is lpxA

Identifier: 53719756

GI number: 53719756

Start: 2577091

End: 2577879

Strand: Reverse

Name: lpxA

Synonym: BPSL2147

Alternate gene names: 53719756

Gene position: 2577879-2577091 (Counterclockwise)

Preceding gene: 53719757

Following gene: 53719755

Centisome position: 63.27

GC content: 66.03

Gene sequence:

>789_bases
ATGAGCAGGATTCACCCCACGGCGATCATCGAGCCGGGCGCGCAGCTCCACGAGACGGTCGAGGTCGGCCCGTACGCGAT
CGTCGGTTCGCACGTGACGATCGGCGCGCGCACGACGATCGGCTCGCACAGCGTGATCGAAGGCCATACGACGATCGGCG
AAGACAATCGCATCGGCCATTACGCGTCGGTGGGCGGCCGTCCGCAGGACATGAAGTACAAGGACGAGCCGACGCGGCTC
GTGATCGGCGATCGCAACACGATCCGCGAATTCACGACGATCCATACGGGCACCGTCCAGGACACGGGCGTCACGACGCT
CGGCGACGACAACTGGATCATGGCGTACGTGCACATCGGTCATGACTGCCGTGTCGGCAGCCACGTGATCCTGTCGAGCA
ACGCGCAGATGGCGGGGCACGTCGAGATCGGCGATTGGGCGATCGTCGGCGGGATGTCGGGCGTTCACCAGTTCGTGCGA
ATCGGCGCGCACTCGATGCTGGGCGGCGCATCGGCGCTCGTGCAGGACATTCCGCCGTTCGTGATCGCGGCGGGCAACAA
GGCCGAGCCGCATGGGATCAACGTCGAAGGGCTGCGCCGCCGAGGCTTTTCCCCGGATGCGATCTCCGCGCTGCGCAGCG
CGTACCGGATCCTCTACAAGAACAGCCTCTCGCTCGAGGAGGCGAAGGTCCAACTGAGCGAGCTCGCGCAGGCGGGCGGC
GACGGCGATGCGGCGGTGAAGTCGCTCGTCGACTTCGTCGAGTCTTCGCAGCGCGGCATCATTCGCTGA

Upstream 100 bases:

>100_bases
GCCGAGCTGATGTGCACGGTCAAGACGGCCGACGCGGCGCCCTGAGCGCGCGGCACGCAAGGCTACGCAACGCGACATAG
ACATTGAGAGGCAACGGCGC

Downstream 100 bases:

>100_bases
CCGATGGCGTTCCAACTCACACCGCTGCGCGTCGCGCTCGTCGCGGGCGAGCCGTCGGGCGACCTGCTCGGCGCGTCGCT
CCTCGGCGGGCTGCATGCGC

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MSRIHPTAIIEPGAQLHETVEVGPYAIVGSHVTIGARTTIGSHSVIEGHTTIGEDNRIGHYASVGGRPQDMKYKDEPTRL
VIGDRNTIREFTTIHTGTVQDTGVTTLGDDNWIMAYVHIGHDCRVGSHVILSSNAQMAGHVEIGDWAIVGGMSGVHQFVR
IGAHSMLGGASALVQDIPPFVIAAGNKAEPHGINVEGLRRRGFSPDAISALRSAYRILYKNSLSLEEAKVQLSELAQAGG
DGDAAVKSLVDFVESSQRGIIR

Sequences:

>Translated_262_residues
MSRIHPTAIIEPGAQLHETVEVGPYAIVGSHVTIGARTTIGSHSVIEGHTTIGEDNRIGHYASVGGRPQDMKYKDEPTRL
VIGDRNTIREFTTIHTGTVQDTGVTTLGDDNWIMAYVHIGHDCRVGSHVILSSNAQMAGHVEIGDWAIVGGMSGVHQFVR
IGAHSMLGGASALVQDIPPFVIAAGNKAEPHGINVEGLRRRGFSPDAISALRSAYRILYKNSLSLEEAKVQLSELAQAGG
DGDAAVKSLVDFVESSQRGIIR
>Mature_261_residues
SRIHPTAIIEPGAQLHETVEVGPYAIVGSHVTIGARTTIGSHSVIEGHTTIGEDNRIGHYASVGGRPQDMKYKDEPTRLV
IGDRNTIREFTTIHTGTVQDTGVTTLGDDNWIMAYVHIGHDCRVGSHVILSSNAQMAGHVEIGDWAIVGGMSGVHQFVRI
GAHSMLGGASALVQDIPPFVIAAGNKAEPHGINVEGLRRRGFSPDAISALRSAYRILYKNSLSLEEAKVQLSELAQAGGD
GDAAVKSLVDFVESSQRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=259, Percent_Identity=52.8957528957529, Blast_Score=289, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_BURM7 (A3MKT0)

Other databases:

- EMBL:   CP000548
- RefSeq:   YP_001080866.1
- ProteinModelPortal:   A3MKT0
- SMR:   A3MKT0
- GeneID:   4894294
- GenomeReviews:   CP000548_GR
- KEGG:   bmn:BMA10247_1315
- TIGR:   BMA10247_1315
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- ProtClustDB:   PRK05289
- BioCyc:   BMAL320389:BMA10247_1315-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 27942; Mature: 27811

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIHPTAIIEPGAQLHETVEVGPYAIVGSHVTIGARTTIGSHSVIEGHTTIGEDNRIGH
CCCCCCCEEECCCHHHHHHHCCCCEEEECCEEEEEEEEECCCCCEEECCCCCCCCCCCCC
YASVGGRPQDMKYKDEPTRLVIGDRNTIREFTTIHTGTVQDTGVTTLGDDNWIMAYVHIG
CCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHEEECCCCCCCCCEEECCCCEEEEEEEEC
HDCRVGSHVILSSNAQMAGHVEIGDWAIVGGMSGVHQFVRIGAHSMLGGASALVQDIPPF
CCCCCCCEEEEECCCCEEEEEEECCEEEECCHHHHHHHHHHHHHHHHCHHHHHHHHCCCE
VIAAGNKAEPHGINVEGLRRRGFSPDAISALRSAYRILYKNSLSLEEAKVQLSELAQAGG
EEECCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
DGDAAVKSLVDFVESSQRGIIR
CHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SRIHPTAIIEPGAQLHETVEVGPYAIVGSHVTIGARTTIGSHSVIEGHTTIGEDNRIGH
CCCCCCEEECCCHHHHHHHCCCCEEEECCEEEEEEEEECCCCCEEECCCCCCCCCCCCC
YASVGGRPQDMKYKDEPTRLVIGDRNTIREFTTIHTGTVQDTGVTTLGDDNWIMAYVHIG
CCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHEEECCCCCCCCCEEECCCCEEEEEEEEC
HDCRVGSHVILSSNAQMAGHVEIGDWAIVGGMSGVHQFVRIGAHSMLGGASALVQDIPPF
CCCCCCCEEEEECCCCEEEEEEECCEEEECCHHHHHHHHHHHHHHHHCHHHHHHHHCCCE
VIAAGNKAEPHGINVEGLRRRGFSPDAISALRSAYRILYKNSLSLEEAKVQLSELAQAGG
EEECCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
DGDAAVKSLVDFVESSQRGIIR
CHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA