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The map label for this gene is dhaT [H]

Identifier: 53719614

GI number: 53719614

Start: 2386847

End: 2387995

Strand: Reverse

Name: dhaT [H]

Synonym: BPSL2002

Alternate gene names: 53719614

Gene position: 2387995-2386847 (Counterclockwise)

Preceding gene: 53719616

Following gene: 53719613

Centisome position: 58.61

GC content: 71.71

Gene sequence:

>1149_bases
GTGGCCTACATCTATTATCTGACGCACATCCATCTCGGCGACGACGCGCTCGCGATGCTCGGCGCCGAGTGCGCGCGCAG
CGGCATCGCGCGGCCGCTCGTCGTGACGGACAAGGGCGTCGCGGCGGCGGGGCTCGTCGATCGCGCGCTCGAGGCACTCG
GCCTCGGCGCGCTGCCCGTGTTCGACGACACGCCGTCGAATCCGACCGAAGCCGCCGTGCTCGCCGCCGCGCAGCGTTAT
CGCGACGAGGGCTGCGACGGGCTCGTCGCGGTCGGCGGCGGCTCGGCGATCGATCTCGCCAAAGGCGTCGCGATCGCGGC
GACGCATCCGGCGCCGCTCACCCGATACGCGACGATCGAAGGCGGCAGCGAGCGGATCACCGCGGCCGCCGCGCCGCTCA
TCGCGGTGCCGACGACCTCGGGCACCGGCAGCGAGGTCGCGCGCGGCGCGATCCTGATCCTCGCCGACGGCCGCAAGCTC
GGCTTCCATTCGTGGCACCTGCTGCCGAAGGCGGCGATCTGCGACCCGTCGCTCACGCTCGGCCTGCCGCCCGGGCTCAC
CGCCGCGACCGGCATGGACGCGATCGCGCACTGCATCGAGACCTTCCTCGCGCCGGCGTTCAATCCGCCCGCCGACGGCA
TCGCGCTCGACGGCCTCGAGCGCGCGTGGGCGCATATCGAGCGCGCGACGCACGACGGCGGCGATCGCGCCGCGCGCCTC
GCGATGATGAGCGCGTCGATGCAGGGCGCGATGGCGTTCCAGAAGGGGCTCGGCTGCGTGCACTCGCTGTCGCATCCGTT
GGGCGGCGTGAAGGTCGACGGCAAGACTTCGCTGCATCACGGCACGCTGAACGCGGTCGTGCTGCCCGCGGTGCTGCGCT
TCAACGAAAGCGCGCCGAGCGTCGTCGCCGAGCGCCGCTATGCGCGGATGCGCCGCGTGATGAATCTGCCCGAGCGCGCG
GATCTGTCCCAGGCGCTGCACGACATGACCGCGCGTCTCGGCCTGCCGACGGGGCTGCGGCAAATGGGCGTCGACGAGCA
AGCGTTCGACCACGTGATCGAGGGCGCGCTCGCCGATCATTGCCACAAGACGAACCCGCGTATCGCGTCGGCCGACGATT
ACCGGCGCATGCTCGTCGAATCGCTGTGA

Upstream 100 bases:

>100_bases
CCCGGACGGCGGCCGCTTGTCCAGCGCCGGGCGGCGCGCCGGCCGCGCTTCAGGCGCCGTCCGGCGGTTTGAACGAGCAC
GATCGAAGGAGACGTCCCCC

Downstream 100 bases:

>100_bases
CGGCGGCGCGCATTTCGTCGCGCATGCTCGCGCCGATGCCCGCGCGGCCGTTGCCGCGCGCGTTTTCGCGGGCGTCCGCC
CGCGCGATGACGCCGCGCGC

Product: putative iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MAYIYYLTHIHLGDDALAMLGAECARSGIARPLVVTDKGVAAAGLVDRALEALGLGALPVFDDTPSNPTEAAVLAAAQRY
RDEGCDGLVAVGGGSAIDLAKGVAIAATHPAPLTRYATIEGGSERITAAAAPLIAVPTTSGTGSEVARGAILILADGRKL
GFHSWHLLPKAAICDPSLTLGLPPGLTAATGMDAIAHCIETFLAPAFNPPADGIALDGLERAWAHIERATHDGGDRAARL
AMMSASMQGAMAFQKGLGCVHSLSHPLGGVKVDGKTSLHHGTLNAVVLPAVLRFNESAPSVVAERRYARMRRVMNLPERA
DLSQALHDMTARLGLPTGLRQMGVDEQAFDHVIEGALADHCHKTNPRIASADDYRRMLVESL

Sequences:

>Translated_382_residues
MAYIYYLTHIHLGDDALAMLGAECARSGIARPLVVTDKGVAAAGLVDRALEALGLGALPVFDDTPSNPTEAAVLAAAQRY
RDEGCDGLVAVGGGSAIDLAKGVAIAATHPAPLTRYATIEGGSERITAAAAPLIAVPTTSGTGSEVARGAILILADGRKL
GFHSWHLLPKAAICDPSLTLGLPPGLTAATGMDAIAHCIETFLAPAFNPPADGIALDGLERAWAHIERATHDGGDRAARL
AMMSASMQGAMAFQKGLGCVHSLSHPLGGVKVDGKTSLHHGTLNAVVLPAVLRFNESAPSVVAERRYARMRRVMNLPERA
DLSQALHDMTARLGLPTGLRQMGVDEQAFDHVIEGALADHCHKTNPRIASADDYRRMLVESL
>Mature_381_residues
AYIYYLTHIHLGDDALAMLGAECARSGIARPLVVTDKGVAAAGLVDRALEALGLGALPVFDDTPSNPTEAAVLAAAQRYR
DEGCDGLVAVGGGSAIDLAKGVAIAATHPAPLTRYATIEGGSERITAAAAPLIAVPTTSGTGSEVARGAILILADGRKLG
FHSWHLLPKAAICDPSLTLGLPPGLTAATGMDAIAHCIETFLAPAFNPPADGIALDGLERAWAHIERATHDGGDRAARLA
MMSASMQGAMAFQKGLGCVHSLSHPLGGVKVDGKTSLHHGTLNAVVLPAVLRFNESAPSVVAERRYARMRRVMNLPERAD
LSQALHDMTARLGLPTGLRQMGVDEQAFDHVIEGALADHCHKTNPRIASADDYRRMLVESL

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=347, Percent_Identity=27.0893371757925, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI48994951, Length=369, Percent_Identity=33.8753387533875, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI87082107, Length=370, Percent_Identity=31.8918918918919, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1789163, Length=375, Percent_Identity=30.4, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787493, Length=395, Percent_Identity=29.873417721519, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789386, Length=353, Percent_Identity=30.028328611898, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17537053, Length=396, Percent_Identity=27.020202020202, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321181, Length=362, Percent_Identity=35.3591160220994, Blast_Score=196, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24657991, Length=431, Percent_Identity=29.0023201856148, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 39863; Mature: 39732

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYIYYLTHIHLGDDALAMLGAECARSGIARPLVVTDKGVAAAGLVDRALEALGLGALPV
CEEEEEEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCC
FDDTPSNPTEAAVLAAAQRYRDEGCDGLVAVGGGSAIDLAKGVAIAATHPAPLTRYATIE
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCEEEEECCCCCCEEEEEEC
GGSERITAAAAPLIAVPTTSGTGSEVARGAILILADGRKLGFHSWHLLPKAAICDPSLTL
CCCCHHHHHHCCEEEEECCCCCCHHHHCCEEEEEECCCEECCCHHHCCCCHHHCCCCCEE
GLPPGLTAATGMDAIAHCIETFLAPAFNPPADGIALDGLERAWAHIERATHDGGDRAARL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHH
AMMSASMQGAMAFQKGLGCVHSLSHPLGGVKVDGKTSLHHGTLNAVVLPAVLRFNESAPS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCHH
VVAERRYARMRRVMNLPERADLSQALHDMTARLGLPTGLRQMGVDEQAFDHVIEGALADH
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHH
CHKTNPRIASADDYRRMLVESL
HHCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AYIYYLTHIHLGDDALAMLGAECARSGIARPLVVTDKGVAAAGLVDRALEALGLGALPV
EEEEEEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCC
FDDTPSNPTEAAVLAAAQRYRDEGCDGLVAVGGGSAIDLAKGVAIAATHPAPLTRYATIE
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCEEEEECCCCCCEEEEEEC
GGSERITAAAAPLIAVPTTSGTGSEVARGAILILADGRKLGFHSWHLLPKAAICDPSLTL
CCCCHHHHHHCCEEEEECCCCCCHHHHCCEEEEEECCCEECCCHHHCCCCHHHCCCCCEE
GLPPGLTAATGMDAIAHCIETFLAPAFNPPADGIALDGLERAWAHIERATHDGGDRAARL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHH
AMMSASMQGAMAFQKGLGCVHSLSHPLGGVKVDGKTSLHHGTLNAVVLPAVLRFNESAPS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCHH
VVAERRYARMRRVMNLPERADLSQALHDMTARLGLPTGLRQMGVDEQAFDHVIEGALADH
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHH
CHKTNPRIASADDYRRMLVESL
HHCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]