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The map label for this gene is lysR [H]

Identifier: 53719304

GI number: 53719304

Start: 1960971

End: 1961861

Strand: Reverse

Name: lysR [H]

Synonym: BPSL1680

Alternate gene names: 53719304

Gene position: 1961861-1960971 (Counterclockwise)

Preceding gene: 53719309

Following gene: 53719303

Centisome position: 48.15

GC content: 65.88

Gene sequence:

>891_bases
GTGCGTCTGAACCTGCGCCAAATCGAAGTGTTTCGCGCCATCATGCTGACCGGCTCGATCAGCGGTGCCGCGAAGCTGTT
GCACGTGTCGCAACCGGCCGTGTCGCGACTCATTTCGTATGCGGAGCAGCGGCTCGGCCTCGCGCTATTCGAACGCATCA
AGGGCCGGCTCTACCCGACGCCGGAGGCGCAACGGCTGTTCGTCGAGGTCAACGCTGTGTACCAGGGCGTGCAGCGCGTC
AACGAAATCGCCGAGGATCTGATCGAGAATCGTATGGGCCATCTGCGCATCGCGTGCAGCCCCAACCTCGGGCAATCACT
GTTGCCGCGCGCAATCGCGGCGTTCTACGAGCGCCTACCTGACGTGCGGATCATCCTGCACACGATGATCCCGAACGTGC
TGCTGCAGGCCGTGCTCACGCAGCAGGTGGAACTCGGCATCGCGTTCCTGCAGGACACGCACCCGAACGTCGAAAGCCAA
CTCCTTTACGAGAACCGTATGGTGGCAGCCGTGCCCGCGTCGCATCCATTCGCGCGACGCAAGACGCTTGCCGTGCGCGA
TCTCGCGAACCAGCCGCTGATCGGCTACGGCAGCGACATTCCGCTCGGGCAACTGGTGCGGCGCCTGTTCAGCGACGAAA
GCCTCGTGCCGCAGGTCAAGGTCGAAGTACAGCAGGCGCACGTCGCATGCGCGCTCGCGCAGGCCGGCACCGGCATCGCG
CTGATCGACGAGCTGACGGTCGCGGGCCCCGTGTGGCCGCAGATCGTCGTGAAGCCGATCGTACCGACGCTCGCCGCGCC
GGTCAGCGTGCTGCACCCCGTGCCGACGCCGCTGTCGCGCCTCGCGCACGCGTTCATCGACACACTGCACTCGCTCGCTG
CGCACGCGTGA

Upstream 100 bases:

>100_bases
TTTCAGTCTCCTGCATTTTTGATCACGAGCAGTTTAGGCAGCGCTCTGCCAGAATGTCCTATGCCGATTTATCGTCTCGA
CATAACACGGAGTTAAGGCT

Downstream 100 bases:

>100_bases
ATTCCGCTGCCGTAAGGGCATGGCGGGAATACCCTAGCCTTAACATCGCGTTATGAAGTCTCCATAAAATAGCAATAACG
CTCAATATTCGGTGTCCCTA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MRLNLRQIEVFRAIMLTGSISGAAKLLHVSQPAVSRLISYAEQRLGLALFERIKGRLYPTPEAQRLFVEVNAVYQGVQRV
NEIAEDLIENRMGHLRIACSPNLGQSLLPRAIAAFYERLPDVRIILHTMIPNVLLQAVLTQQVELGIAFLQDTHPNVESQ
LLYENRMVAAVPASHPFARRKTLAVRDLANQPLIGYGSDIPLGQLVRRLFSDESLVPQVKVEVQQAHVACALAQAGTGIA
LIDELTVAGPVWPQIVVKPIVPTLAAPVSVLHPVPTPLSRLAHAFIDTLHSLAAHA

Sequences:

>Translated_296_residues
MRLNLRQIEVFRAIMLTGSISGAAKLLHVSQPAVSRLISYAEQRLGLALFERIKGRLYPTPEAQRLFVEVNAVYQGVQRV
NEIAEDLIENRMGHLRIACSPNLGQSLLPRAIAAFYERLPDVRIILHTMIPNVLLQAVLTQQVELGIAFLQDTHPNVESQ
LLYENRMVAAVPASHPFARRKTLAVRDLANQPLIGYGSDIPLGQLVRRLFSDESLVPQVKVEVQQAHVACALAQAGTGIA
LIDELTVAGPVWPQIVVKPIVPTLAAPVSVLHPVPTPLSRLAHAFIDTLHSLAAHA
>Mature_296_residues
MRLNLRQIEVFRAIMLTGSISGAAKLLHVSQPAVSRLISYAEQRLGLALFERIKGRLYPTPEAQRLFVEVNAVYQGVQRV
NEIAEDLIENRMGHLRIACSPNLGQSLLPRAIAAFYERLPDVRIILHTMIPNVLLQAVLTQQVELGIAFLQDTHPNVESQ
LLYENRMVAAVPASHPFARRKTLAVRDLANQPLIGYGSDIPLGQLVRRLFSDESLVPQVKVEVQQAHVACALAQAGTGIA
LIDELTVAGPVWPQIVVKPIVPTLAAPVSVLHPVPTPLSRLAHAFIDTLHSLAAHA

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=283, Percent_Identity=35.6890459363958, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI145693105, Length=293, Percent_Identity=24.5733788395904, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI157672245, Length=221, Percent_Identity=28.5067873303167, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787530, Length=249, Percent_Identity=25.7028112449799, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1790399, Length=251, Percent_Identity=26.6932270916335, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788481, Length=196, Percent_Identity=30.6122448979592, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1788296, Length=243, Percent_Identity=25.5144032921811, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081904, Length=171, Percent_Identity=26.3157894736842, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788887, Length=246, Percent_Identity=23.9837398373984, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787879, Length=252, Percent_Identity=22.6190476190476, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32456; Mature: 32456

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS00847 MCM_1 ; PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLNLRQIEVFRAIMLTGSISGAAKLLHVSQPAVSRLISYAEQRLGLALFERIKGRLYPT
CCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PEAQRLFVEVNAVYQGVQRVNEIAEDLIENRMGHLRIACSPNLGQSLLPRAIAAFYERLP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCC
DVRIILHTMIPNVLLQAVLTQQVELGIAFLQDTHPNVESQLLYENRMVAAVPASHPFARR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEECCCCCCHHHH
KTLAVRDLANQPLIGYGSDIPLGQLVRRLFSDESLVPQVKVEVQQAHVACALAQAGTGIA
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
LIDELTVAGPVWPQIVVKPIVPTLAAPVSVLHPVPTPLSRLAHAFIDTLHSLAAHA
EHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLNLRQIEVFRAIMLTGSISGAAKLLHVSQPAVSRLISYAEQRLGLALFERIKGRLYPT
CCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PEAQRLFVEVNAVYQGVQRVNEIAEDLIENRMGHLRIACSPNLGQSLLPRAIAAFYERLP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCC
DVRIILHTMIPNVLLQAVLTQQVELGIAFLQDTHPNVESQLLYENRMVAAVPASHPFARR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEECCCCCCHHHH
KTLAVRDLANQPLIGYGSDIPLGQLVRRLFSDESLVPQVKVEVQQAHVACALAQAGTGIA
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
LIDELTVAGPVWPQIVVKPIVPTLAAPVSVLHPVPTPLSRLAHAFIDTLHSLAAHA
EHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]