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The map label for this gene is hutU [H]

Identifier: 53719302

GI number: 53719302

Start: 1958040

End: 1959680

Strand: Reverse

Name: hutU [H]

Synonym: BPSL1678

Alternate gene names: 53719302

Gene position: 1959680-1958040 (Counterclockwise)

Preceding gene: 53719303

Following gene: 53719301

Centisome position: 48.1

GC content: 67.82

Gene sequence:

>1641_bases
ATGAACCGCACCTTCGAAGTCACGTCCGGCGATACGCTGCGCTGCAAAGGCTGGCGCCAGGAGGCGCTGCTGCGTCTTCT
GGAAAACGTCCTCGCGGTCGGCGAGAATCCCGATGAGTTGATCGTCTACGCGGCGCTCGGCCGCGCCGCGCGCGACTGGC
CGTCGCACGACGCGATCGTGCGCACGCTGCGCACAATGGACGAGAACCAGACGCTCGTCGTCCAGTCCGGCAAGCCGGTC
GCGCTGCTGCGCACGCATGCGAGCGCACCGCTCGTCGTGATGGCGAACTGCAACCTGGTCGGCCAGTGGGCGAAGGCAGA
GCATTTCTACGAACTGGAACGCCGCAACCTGATCTGCTGGGGCGGCCTCACGGCGGGCGACTGGCAGTACATCGGCTCGC
AGGGCGTGATCCAGGGCACCTATGAAATCTTCTCGCGCATCGCCGAGCGCCACTTCGGCAACGATCTGCGCGGGCGCTTC
ATCCTGACGGCCGGCCTCGGCGGAATGGGCGGCGCGCAGCCGCTCGCGGGGCGCATGGCCAATGCGGCGACGCTCGTCGT
CGAGATCGATCAGACGCGCATCCACAAGCGGCTGCAGGTGGGCTTCCTCGAGCGGCAGGCGCGCGATCTCGACGAGGCGC
TCGCGCTGATCCGCGACGCGCAAGCGCGCCGCGAGCCGATCTCGGTCGGCCTGCTCGGCAACGCGGCCGACGTGTTCCCG
GCGATCCTCGCGCGCGGCGTCGTGCCCGATATCGTCACCGACCAGACCGCCGCGCACGATCTTGTCTACGGCTACGTGCC
GTCGGGCTACACGCTCGAGGAAGCGCGCTCGATGCGCGACACCGACCGGGCGAAGCTGATGCAAGCAAGCCGCGCGTCGA
TCGTGCGCCACGTCGAGGCGATGCTCGGCTTCAAGGATCGTGGCGCGATCGTGTTCGACAACGGCAATCTGATCCGCACA
CATGCGAAGGACGGCGGCGTGGCCCGCGCGTTCGAGATCCCGGTGTTCACCGAGGCGTTCCTGCGCCCGCTGTTTTGCCG
CGCGATCGGCCCGTTTCGCTGGATCGCCCTGTCGAACGACCCCAACGACATCCGCGTCGTCGACGACTACCTGCTCGAAC
ACTTCGCCGAGAACCGGATCGTGACGAACTGGGTCCGGCGCGCACGCGAATGCGTGCCCTTCGAGGGACTGCCTGCGCGT
ATCGCCTGGCTCGGCCACGGCGAGCGCACGCGACTCGCGCTCGCGGTCAATGCGCTCGTGCGCGAACGCGTGCTTGCCGG
GCCGATCGCGTTCACGCGCGATCACCTCGACGCCGGTGCGATGGCGCATCCGAACATCATGACCGAGAACCTGCGCGACG
GCTCCGACGCAGTGGCCGACTGGCCGCTGCTCAACGCGATGATGAACTGCTCTTCGATGGCCGACCTCGTCGCGATCCAT
TCGGGCGGCGGCGGCTACAGCGGCTATATGACGAGCGCGGGCGTCACCGTGGTCGCCGACGGCAGTGCGGCGGCGGACGA
GCGGCTAACGCTGTCGATGACCAACGATACCGCACTCGGCGTGATCCGCTACGCGGACGCCGGCTACGAAGAAGCGCTCG
ATGAAGCGCAACGCCGGCAAATTCCGCATTTCCGGCTGTAA

Upstream 100 bases:

>100_bases
GTCGGTGTTCGATCCCGCGATCTACCCGCCGGTCGAAACCGCGCTCGGCATCTCGATCGCCGACTATGCGCTCGCCCGCT
GAACGCAAAGGCACGGCACG

Downstream 100 bases:

>100_bases
AGGCCGCCCCGCACGACGACAGGACAGGAGATCGAAGTGAAGCAATCCGCAGTTCCCCTCGACACGGGCACGGCCGTGTC
GCCCCCTACGTCGAGCGCCG

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MNRTFEVTSGDTLRCKGWRQEALLRLLENVLAVGENPDELIVYAALGRAARDWPSHDAIVRTLRTMDENQTLVVQSGKPV
ALLRTHASAPLVVMANCNLVGQWAKAEHFYELERRNLICWGGLTAGDWQYIGSQGVIQGTYEIFSRIAERHFGNDLRGRF
ILTAGLGGMGGAQPLAGRMANAATLVVEIDQTRIHKRLQVGFLERQARDLDEALALIRDAQARREPISVGLLGNAADVFP
AILARGVVPDIVTDQTAAHDLVYGYVPSGYTLEEARSMRDTDRAKLMQASRASIVRHVEAMLGFKDRGAIVFDNGNLIRT
HAKDGGVARAFEIPVFTEAFLRPLFCRAIGPFRWIALSNDPNDIRVVDDYLLEHFAENRIVTNWVRRARECVPFEGLPAR
IAWLGHGERTRLALAVNALVRERVLAGPIAFTRDHLDAGAMAHPNIMTENLRDGSDAVADWPLLNAMMNCSSMADLVAIH
SGGGGYSGYMTSAGVTVVADGSAAADERLTLSMTNDTALGVIRYADAGYEEALDEAQRRQIPHFRL

Sequences:

>Translated_546_residues
MNRTFEVTSGDTLRCKGWRQEALLRLLENVLAVGENPDELIVYAALGRAARDWPSHDAIVRTLRTMDENQTLVVQSGKPV
ALLRTHASAPLVVMANCNLVGQWAKAEHFYELERRNLICWGGLTAGDWQYIGSQGVIQGTYEIFSRIAERHFGNDLRGRF
ILTAGLGGMGGAQPLAGRMANAATLVVEIDQTRIHKRLQVGFLERQARDLDEALALIRDAQARREPISVGLLGNAADVFP
AILARGVVPDIVTDQTAAHDLVYGYVPSGYTLEEARSMRDTDRAKLMQASRASIVRHVEAMLGFKDRGAIVFDNGNLIRT
HAKDGGVARAFEIPVFTEAFLRPLFCRAIGPFRWIALSNDPNDIRVVDDYLLEHFAENRIVTNWVRRARECVPFEGLPAR
IAWLGHGERTRLALAVNALVRERVLAGPIAFTRDHLDAGAMAHPNIMTENLRDGSDAVADWPLLNAMMNCSSMADLVAIH
SGGGGYSGYMTSAGVTVVADGSAAADERLTLSMTNDTALGVIRYADAGYEEALDEAQRRQIPHFRL
>Mature_546_residues
MNRTFEVTSGDTLRCKGWRQEALLRLLENVLAVGENPDELIVYAALGRAARDWPSHDAIVRTLRTMDENQTLVVQSGKPV
ALLRTHASAPLVVMANCNLVGQWAKAEHFYELERRNLICWGGLTAGDWQYIGSQGVIQGTYEIFSRIAERHFGNDLRGRF
ILTAGLGGMGGAQPLAGRMANAATLVVEIDQTRIHKRLQVGFLERQARDLDEALALIRDAQARREPISVGLLGNAADVFP
AILARGVVPDIVTDQTAAHDLVYGYVPSGYTLEEARSMRDTDRAKLMQASRASIVRHVEAMLGFKDRGAIVFDNGNLIRT
HAKDGGVARAFEIPVFTEAFLRPLFCRAIGPFRWIALSNDPNDIRVVDDYLLEHFAENRIVTNWVRRARECVPFEGLPAR
IAWLGHGERTRLALAVNALVRERVLAGPIAFTRDHLDAGAMAHPNIMTENLRDGSDAVADWPLLNAMMNCSSMADLVAIH
SGGGGYSGYMTSAGVTVVADGSAAADERLTLSMTNDTALGVIRYADAGYEEALDEAQRRQIPHFRL

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=550, Percent_Identity=28.7272727272727, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI260306182, Length=344, Percent_Identity=27.3255813953488, Blast_Score=126, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71997891, Length=557, Percent_Identity=29.0843806104129, Blast_Score=253, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60033; Mature: 60033

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTFEVTSGDTLRCKGWRQEALLRLLENVLAVGENPDELIVYAALGRAARDWPSHDAIV
CCCEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHCCCCCHHHHH
RTLRTMDENQTLVVQSGKPVALLRTHASAPLVVMANCNLVGQWAKAEHFYELERRNLICW
HHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCEEECHHHHHHHHHHHHCCEEEE
GGLTAGDWQYIGSQGVIQGTYEIFSRIAERHFGNDLRGRFILTAGLGGMGGAQPLAGRMA
CCCCCCCHHCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHCC
NAATLVVEIDQTRIHKRLQVGFLERQARDLDEALALIRDAQARREPISVGLLGNAADVFP
CCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHH
AILARGVVPDIVTDQTAAHDLVYGYVPSGYTLEEARSMRDTDRAKLMQASRASIVRHVEA
HHHHCCCCCCHHCCCHHHHHEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
MLGFKDRGAIVFDNGNLIRTHAKDGGVARAFEIPVFTEAFLRPLFCRAIGPFRWIALSND
HHCCCCCCEEEEECCCEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCC
PNDIRVVDDYLLEHFAENRIVTNWVRRARECVPFEGLPARIAWLGHGERTRLALAVNALV
CCCEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEHHHHHHHHH
RERVLAGPIAFTRDHLDAGAMAHPNIMTENLRDGSDAVADWPLLNAMMNCSSMADLVAIH
HHHHHHCCHHHHHHCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEE
SGGGGYSGYMTSAGVTVVADGSAAADERLTLSMTNDTALGVIRYADAGYEEALDEAQRRQ
CCCCCCCCEEECCCEEEEECCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHC
IPHFRL
CCCCCC
>Mature Secondary Structure
MNRTFEVTSGDTLRCKGWRQEALLRLLENVLAVGENPDELIVYAALGRAARDWPSHDAIV
CCCEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHCCCCCHHHHH
RTLRTMDENQTLVVQSGKPVALLRTHASAPLVVMANCNLVGQWAKAEHFYELERRNLICW
HHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCEEECHHHHHHHHHHHHCCEEEE
GGLTAGDWQYIGSQGVIQGTYEIFSRIAERHFGNDLRGRFILTAGLGGMGGAQPLAGRMA
CCCCCCCHHCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHCC
NAATLVVEIDQTRIHKRLQVGFLERQARDLDEALALIRDAQARREPISVGLLGNAADVFP
CCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHH
AILARGVVPDIVTDQTAAHDLVYGYVPSGYTLEEARSMRDTDRAKLMQASRASIVRHVEA
HHHHCCCCCCHHCCCHHHHHEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
MLGFKDRGAIVFDNGNLIRTHAKDGGVARAFEIPVFTEAFLRPLFCRAIGPFRWIALSND
HHCCCCCCEEEEECCCEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCC
PNDIRVVDDYLLEHFAENRIVTNWVRRARECVPFEGLPARIAWLGHGERTRLALAVNALV
CCCEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEHHHHHHHHH
RERVLAGPIAFTRDHLDAGAMAHPNIMTENLRDGSDAVADWPLLNAMMNCSSMADLVAIH
HHHHHHCCHHHHHHCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEE
SGGGGYSGYMTSAGVTVVADGSAAADERLTLSMTNDTALGVIRYADAGYEEALDEAQRRQ
CCCCCCCCEEECCCEEEEECCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHC
IPHFRL
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA