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The map label for this gene is hemF [H]

Identifier: 53718799

GI number: 53718799

Start: 1341540

End: 1342463

Strand: Reverse

Name: hemF [H]

Synonym: BPSL1163

Alternate gene names: 53718799

Gene position: 1342463-1341540 (Counterclockwise)

Preceding gene: 53718800

Following gene: 53718798

Centisome position: 32.95

GC content: 69.26

Gene sequence:

>924_bases
ATGACCGATTCGACTTACGACGTCAACCGAGTACGCGCTTACCTGCAAGGGCTGCAGATGCGCATCGCCGATGCGCTCGG
CGCCTTCGACGGCACGCCGCTCGCCGCCGACACGTGGCGGCGCGGCCCCGGCGAGCGGCTGCGCGGCGGCGGCTGCACGC
GCATTCTCGAGGCAGGCGGCTTCTTCGAGCGCGCGGGCATCGGCTTTTCCGACGTCGCGGGCGACGCGCTGCCGCCGTCG
GCGAGCGCATCGCGCCCGCAGCTCGCCGGGCGCGGCTTCGAGGCGCTCGGCGTATCGCTCGTGCTGCACCCGCGCAATCC
GTACTGCCCGACCGTCCACATGAACGTGCGGATGCTGATCGCGACGAAGCCGGGCGAGGCGCCCGTGTTCTGGTTCGGCG
GCGGCATGGATCTGACGCCGATTTACGGCTTCGAAGAGGATGCACGGCACTTCCACCGCACGTGCCGCGCGGCGCTCGAG
CCGTTCGGCGCCGAGCTGTACCCGCGCTTCAAGAAATGGTGCGACGACTATTTCTTCCTGAAACATCGCAACGAGGCGCG
CGGGATCGGCGGCATCTTCTTCGACGACTTCTCCGAGCTCGGCTTCGAACGCTCGTTCGAGATGCTGCAAAGCGTCGGCG
ACGCGTTCCTGCCGTCGTACCTGCCGATCGTCGAGCGCCGCCGCGACACGCCGTACGGCGAGCGCGAGCGCGCGTTCCAG
GCATACCGGCGCGGCCGCTACGTCGAGTTCAACCTGGTGTTCGACCGCGGCACGCTGTTCGGGCTGCAAAGCGGCGGGCG
CACCGAGTCCATCCTGCTGTCGATGCCGCCGACGGCGGGCTGGCGCTATGACTGGCATCCGGACCCGGGCACGCCCGAAG
CACGCCTGCAAAGCGAGTTCCTCGTGCCGCGCGACTGGGCATGA

Upstream 100 bases:

>100_bases
CAAGCCGGCCGGCGCGCCCTCTCCTCTGCCGGGGTTCGCTAGAATGCCCGGCAGAAGCATTTTTCGACGGCGTCCGCCAA
GCGGATGCCGCCCCACACCG

Downstream 100 bases:

>100_bases
GCCGCGCCGCCACCGGCCGAGCGGCCGCCCCGCAAGGCCCCACGCCGAACGCCGAGCCCGCGGGCCTGCCCGCGCTGCCG
CGCCGCATCGGCATCCTCGG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTDSTYDVNRVRAYLQGLQMRIADALGAFDGTPLAADTWRRGPGERLRGGGCTRILEAGGFFERAGIGFSDVAGDALPPS
ASASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPIYGFEEDARHFHRTCRAALE
PFGAELYPRFKKWCDDYFFLKHRNEARGIGGIFFDDFSELGFERSFEMLQSVGDAFLPSYLPIVERRRDTPYGERERAFQ
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPDPGTPEARLQSEFLVPRDWA

Sequences:

>Translated_307_residues
MTDSTYDVNRVRAYLQGLQMRIADALGAFDGTPLAADTWRRGPGERLRGGGCTRILEAGGFFERAGIGFSDVAGDALPPS
ASASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPIYGFEEDARHFHRTCRAALE
PFGAELYPRFKKWCDDYFFLKHRNEARGIGGIFFDDFSELGFERSFEMLQSVGDAFLPSYLPIVERRRDTPYGERERAFQ
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPDPGTPEARLQSEFLVPRDWA
>Mature_306_residues
TDSTYDVNRVRAYLQGLQMRIADALGAFDGTPLAADTWRRGPGERLRGGGCTRILEAGGFFERAGIGFSDVAGDALPPSA
SASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPIYGFEEDARHFHRTCRAALEP
FGAELYPRFKKWCDDYFFLKHRNEARGIGGIFFDDFSELGFERSFEMLQSVGDAFLPSYLPIVERRRDTPYGERERAFQA
YRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPDPGTPEARLQSEFLVPRDWA

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=302, Percent_Identity=44.7019867549669, Blast_Score=253, Evalue=2e-67,
Organism=Escherichia coli, GI1788777, Length=301, Percent_Identity=61.4617940199336, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320249, Length=317, Percent_Identity=44.4794952681388, Blast_Score=274, Evalue=1e-74,
Organism=Drosophila melanogaster, GI17864388, Length=313, Percent_Identity=45.3674121405751, Blast_Score=260, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34569; Mature: 34438

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSTYDVNRVRAYLQGLQMRIADALGAFDGTPLAADTWRRGPGERLRGGGCTRILEAGG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHCCC
FFERAGIGFSDVAGDALPPSASASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLI
CHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHEECEEEEEECCCCCCCEEEEEEEEEE
ATKPGEAPVFWFGGGMDLTPIYGFEEDARHFHRTCRAALEPFGAELYPRFKKWCDDYFFL
EECCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHEEE
KHRNEARGIGGIFFDDFSELGFERSFEMLQSVGDAFLPSYLPIVERRRDTPYGERERAFQ
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPDPGTPEARLQSEF
HHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHCC
LVPRDWA
CCCCCCC
>Mature Secondary Structure 
TDSTYDVNRVRAYLQGLQMRIADALGAFDGTPLAADTWRRGPGERLRGGGCTRILEAGG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHCCC
FFERAGIGFSDVAGDALPPSASASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLI
CHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHEECEEEEEECCCCCCCEEEEEEEEEE
ATKPGEAPVFWFGGGMDLTPIYGFEEDARHFHRTCRAALEPFGAELYPRFKKWCDDYFFL
EECCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHEEE
KHRNEARGIGGIFFDDFSELGFERSFEMLQSVGDAFLPSYLPIVERRRDTPYGERERAFQ
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPDPGTPEARLQSEF
HHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHCC
LVPRDWA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA