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The map label for this gene is hisM [H]

Identifier: 53718671

GI number: 53718671

Start: 1201221

End: 1201934

Strand: Reverse

Name: hisM [H]

Synonym: BPSL1031

Alternate gene names: 53718671

Gene position: 1201934-1201221 (Counterclockwise)

Preceding gene: 53718672

Following gene: 53718670

Centisome position: 29.5

GC content: 64.29

Gene sequence:

>714_bases
ATGATCGAGCTGATCCAAGAATACTGGCGCAACTACCTGTATACGGACGGGTATCGCTTCACCGGCCTCGCGATCACGAT
GTGGCTGCTCGTCGTGTCGATCGGCATCGGCTTCTGTCTGTCCGTGCCGCTCGCGGTCGCGCGCGTGTCGAAGAAGAAGT
GGCTCGCGGGCGCGGTCTGGCTCTACACGTACGTGTTCCGCGGCACGCCGCTCTACGTGCAGCTCCTGCTCTGCTACACG
GGCCTTTACAGCCTGCAGGCCGTGCGCGGCACGCCGATGCTCGACGCGTTCTTTCGCGACGGGATGAACTGCACGCTGCT
CGCGTTCACGCTGAACACCTGCGCGTACACGACCGAAATCTTCGCGGGCGCGATCAAGGCGACGTCGTACGGCGAGATCG
AGGCGGCCCGCGCTTACGGGATGTCGACCTTCACGCTGTATCGCCGGATCGTGCTGCCTTCGGCGCTGCGCCGCGCGCTG
CCGCTCTACAGCAACGAGGTGATCCTGATGCTGCATGCGACGACGGTCGCGTTCACGGCGACCGTGCCCGATATCCTGAA
GATCGCGCGCGACGTCAATTCGGCGACCTACATGTCGTTCCACGCGTTCGGCATCGCCGCCCTTCTCTACCTCGCGATCT
CGTTTACGCTCGTGTGGCTGTTCCGCCGCGCCGAACGCCGCTGGCTCGCGTATCTGCGCCCGCAAGGCAAATGA

Upstream 100 bases:

>100_bases
TGCTCGCCGGCGCGATCTATCTCGCGATCACGACGATCTCGAACTTCGTGCTGATGTGGCTCGAGAAGCGTTATTCGACC
GGCGTACGCAAGGCGGACCT

Downstream 100 bases:

>100_bases
GTTTCGCCCGGACATGCCTCAGATGAATACCCAGATGCACAAGCTCTTCGTCGACGACCTCCACAAGCGCTACGGCAACA
ACGAAGTTTTGAAGGGCGTC

Product: histidine transport system permease

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIELIQEYWRNYLYTDGYRFTGLAITMWLLVVSIGIGFCLSVPLAVARVSKKKWLAGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQAVRGTPMLDAFFRDGMNCTLLAFTLNTCAYTTEIFAGAIKATSYGEIEAARAYGMSTFTLYRRIVLPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRRAERRWLAYLRPQGK

Sequences:

>Translated_237_residues
MIELIQEYWRNYLYTDGYRFTGLAITMWLLVVSIGIGFCLSVPLAVARVSKKKWLAGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQAVRGTPMLDAFFRDGMNCTLLAFTLNTCAYTTEIFAGAIKATSYGEIEAARAYGMSTFTLYRRIVLPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRRAERRWLAYLRPQGK
>Mature_237_residues
MIELIQEYWRNYLYTDGYRFTGLAITMWLLVVSIGIGFCLSVPLAVARVSKKKWLAGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQAVRGTPMLDAFFRDGMNCTLLAFTLNTCAYTTEIFAGAIKATSYGEIEAARAYGMSTFTLYRRIVLPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRRAERRWLAYLRPQGK

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=236, Percent_Identity=66.5254237288136, Blast_Score=335, Evalue=1e-93,
Organism=Escherichia coli, GI1787086, Length=212, Percent_Identity=33.4905660377358, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788226, Length=209, Percent_Identity=31.1004784688995, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787030, Length=208, Percent_Identity=28.8461538461538, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786873, Length=224, Percent_Identity=29.0178571428571, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788646, Length=218, Percent_Identity=27.0642201834862, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787087, Length=218, Percent_Identity=25.2293577981651, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI48994930, Length=184, Percent_Identity=27.1739130434783, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26883; Mature: 26883

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELIQEYWRNYLYTDGYRFTGLAITMWLLVVSIGIGFCLSVPLAVARVSKKKWLAGAVW
CHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYTYVFRGTPLYVQLLLCYTGLYSLQAVRGTPMLDAFFRDGMNCTLLAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEHHHHHHHHHH
FAGAIKATSYGEIEAARAYGMSTFTLYRRIVLPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRRAERRWLAYLRPQGK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIELIQEYWRNYLYTDGYRFTGLAITMWLLVVSIGIGFCLSVPLAVARVSKKKWLAGAVW
CHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYTYVFRGTPLYVQLLLCYTGLYSLQAVRGTPMLDAFFRDGMNCTLLAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEHHHHHHHHHH
FAGAIKATSYGEIEAARAYGMSTFTLYRRIVLPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRRAERRWLAYLRPQGK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]