| Definition | Burkholderia pseudomallei K96243 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_006350 |
| Length | 4,074,542 |
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The map label for this gene is fabG [C]
Identifier: 53718661
GI number: 53718661
Start: 1188469
End: 1189227
Strand: Reverse
Name: fabG [C]
Synonym: BPSL1019
Alternate gene names: 53718661
Gene position: 1189227-1188469 (Counterclockwise)
Preceding gene: 53718662
Following gene: 53718660
Centisome position: 29.19
GC content: 70.09
Gene sequence:
>759_bases ATGCGGCTCAGCGGCAAGACGGCCGTCGTCACGGGCGCAGGCTCGGGCTTCGGCGAAGGCATTGCAAAAACGTTCGCGCG CGAAGGCGCGTGCGTCGTCGTCAACGATCTGCACGCGGCGGCGGCCGAGCGCGTCGCGAGCGAAATCGCGCTCGCGGGCG GCCGCGCGCTCGCCGTCGCGGGCGACGTGTCGCGCGGCGAAGACTGGCAAGCGCTGCGCGACGCGGCGCTCGCGGCATTC GGCAGCGTGCAGGTCGTCGTCAACAACGCGGGCACCACGCACCGCAACAAGCCGGTGCTCGACATCACCGAAGCCGAATA CGACCGCGTGTACGCGATCAACATGAAGAGCCTCTTCTGGAGCGTGCAGACATTCGTGCCGTATTTCCGCGGCGCGGGCG GCGGCGCGTTCGTCAACATCGCGTCGACGGCGGCCGTGCGGCCGCGCCCCGGCCTCGTCTGGTACAACAGCACGAAGGGC GCGATGCTCACCGCGAGCAAAACGCTCGCCGCCGAGCTCGGCGCGGACCGGATCCGCGTGAACTGCGTGAATCCCGTGCT CGGCGAAACCGGCCTCACGAGCGAATTCATGGGCGTGCCCGACACACCGGAGAATCGCGCGCGCTTCGTCGCGACGATCC CGCTCGGCCGGCTGTCGACGCCGCAGGACATCGCGAACGCGGCGCTCTATCTCGCGTCCGACGAAGCCGCGTTCGTCACC GGCGCGTGCCTCGAAGTCGACGGCGGCCGCTGCGTCTGA
Upstream 100 bases:
>100_bases CGGCACGGCTGAGCCGGGCGGTGACGCGCGCGCTGCCGCCCGCAGCCGTCTCGGCGGCATTGCGGCATTTGCATTCACAA CAAGACTCAGGAGACAACCG
Downstream 100 bases:
>100_bases GCGCCGCGCGATTCCCCCACACACGAGAGGAGACGTTCATGGCCAGCACCCTGCCCGCGACCACGCCGGACGCGCCGTCC GCCTTCGAGGCGGCCACCTA
Product: 3-ketoacyl-(acyl-carrier-protein) reductase
Products: 3alpha12alpha-dihydroxy-oxobeta-cholanate; NADH [C]
Alternate protein names: NA
Number of amino acids: Translated: 252; Mature: 252
Protein sequence:
>252_residues MRLSGKTAVVTGAGSGFGEGIAKTFAREGACVVVNDLHAAAAERVASEIALAGGRALAVAGDVSRGEDWQALRDAALAAF GSVQVVVNNAGTTHRNKPVLDITEAEYDRVYAINMKSLFWSVQTFVPYFRGAGGGAFVNIASTAAVRPRPGLVWYNSTKG AMLTASKTLAAELGADRIRVNCVNPVLGETGLTSEFMGVPDTPENRARFVATIPLGRLSTPQDIANAALYLASDEAAFVT GACLEVDGGRCV
Sequences:
>Translated_252_residues MRLSGKTAVVTGAGSGFGEGIAKTFAREGACVVVNDLHAAAAERVASEIALAGGRALAVAGDVSRGEDWQALRDAALAAF GSVQVVVNNAGTTHRNKPVLDITEAEYDRVYAINMKSLFWSVQTFVPYFRGAGGGAFVNIASTAAVRPRPGLVWYNSTKG AMLTASKTLAAELGADRIRVNCVNPVLGETGLTSEFMGVPDTPENRARFVATIPLGRLSTPQDIANAALYLASDEAAFVT GACLEVDGGRCV >Mature_252_residues MRLSGKTAVVTGAGSGFGEGIAKTFAREGACVVVNDLHAAAAERVASEIALAGGRALAVAGDVSRGEDWQALRDAALAAF GSVQVVVNNAGTTHRNKPVLDITEAEYDRVYAINMKSLFWSVQTFVPYFRGAGGGAFVNIASTAAVRPRPGLVWYNSTKG AMLTASKTLAAELGADRIRVNCVNPVLGETGLTSEFMGVPDTPENRARFVATIPLGRLSTPQDIANAALYLASDEAAFVT GACLEVDGGRCV
Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=33.6, Blast_Score=126, Evalue=2e-29, Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=31.2252964426877, Blast_Score=110, Evalue=9e-25, Organism=Homo sapiens, GI5031737, Length=249, Percent_Identity=32.9317269076305, Blast_Score=110, Evalue=1e-24, Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=32.6612903225806, Blast_Score=108, Evalue=4e-24, Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=32.295719844358, Blast_Score=105, Evalue=3e-23, Organism=Homo sapiens, GI66933014, Length=250, Percent_Identity=31.2, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI33667109, Length=228, Percent_Identity=32.4561403508772, Blast_Score=98, Evalue=8e-21, Organism=Homo sapiens, GI126723191, Length=185, Percent_Identity=34.0540540540541, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI10190704, Length=250, Percent_Identity=32.8, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=27.34375, Blast_Score=88, Evalue=7e-18, Organism=Homo sapiens, GI4504505, Length=194, Percent_Identity=30.9278350515464, Blast_Score=85, Evalue=5e-17, Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=28.2786885245902, Blast_Score=85, Evalue=6e-17, Organism=Homo sapiens, GI142976729, Length=242, Percent_Identity=26.0330578512397, Blast_Score=84, Evalue=1e-16, Organism=Homo sapiens, GI210032110, Length=195, Percent_Identity=28.7179487179487, Blast_Score=82, Evalue=5e-16, Organism=Homo sapiens, GI59889578, Length=230, Percent_Identity=29.1304347826087, Blast_Score=81, Evalue=8e-16, Organism=Homo sapiens, GI40807363, Length=194, Percent_Identity=27.8350515463918, Blast_Score=76, Evalue=4e-14, Organism=Homo sapiens, GI310128830, Length=203, Percent_Identity=29.064039408867, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI310115468, Length=203, Percent_Identity=29.064039408867, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI302344755, Length=109, Percent_Identity=35.7798165137615, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI4758504, Length=259, Percent_Identity=28.1853281853282, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI31542939, Length=263, Percent_Identity=26.2357414448669, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI4503301, Length=226, Percent_Identity=26.5486725663717, Blast_Score=68, Evalue=9e-12, Organism=Homo sapiens, GI25282469, Length=218, Percent_Identity=24.3119266055046, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI109715829, Length=250, Percent_Identity=28, Blast_Score=65, Evalue=6e-11, Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=39.3574297188755, Blast_Score=151, Evalue=3e-38, Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=33.7301587301587, Blast_Score=120, Evalue=1e-28, Organism=Escherichia coli, GI1787335, Length=249, Percent_Identity=32.5301204819277, Blast_Score=117, Evalue=9e-28, Organism=Escherichia coli, GI1789208, Length=248, Percent_Identity=31.8548387096774, Blast_Score=114, Evalue=6e-27, Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=31.4741035856574, Blast_Score=110, Evalue=7e-26, Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=32.8, Blast_Score=107, Evalue=8e-25, Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=28.4, Blast_Score=105, Evalue=2e-24, Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=31.6602316602317, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI87082160, Length=259, Percent_Identity=30.8880308880309, Blast_Score=93, Evalue=2e-20, Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=27.9352226720648, Blast_Score=82, Evalue=5e-17, Organism=Escherichia coli, GI1787526, Length=251, Percent_Identity=26.2948207171315, Blast_Score=65, Evalue=5e-12, Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=25.2873563218391, Blast_Score=64, Evalue=1e-11, Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=27.8884462151394, Blast_Score=61, Evalue=7e-11, Organism=Caenorhabditis elegans, GI17561402, Length=249, Percent_Identity=30.5220883534137, Blast_Score=130, Evalue=8e-31, Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=35.4838709677419, Blast_Score=117, Evalue=5e-27, Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=32.9317269076305, Blast_Score=115, Evalue=2e-26, Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=31.4516129032258, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=31.0344827586207, Blast_Score=107, Evalue=4e-24, Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=30.4511278195489, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=31.4176245210728, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=31.1023622047244, Blast_Score=104, Evalue=4e-23, Organism=Caenorhabditis elegans, GI17562904, Length=272, Percent_Identity=30.1470588235294, Blast_Score=103, Evalue=7e-23, Organism=Caenorhabditis elegans, GI17560676, Length=247, Percent_Identity=27.1255060728745, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=31.8548387096774, Blast_Score=100, Evalue=6e-22, Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=29.811320754717, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17531453, Length=269, Percent_Identity=28.6245353159851, Blast_Score=98, Evalue=5e-21, Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=28.030303030303, Blast_Score=98, Evalue=5e-21, Organism=Caenorhabditis elegans, GI17538480, Length=266, Percent_Identity=28.9473684210526, Blast_Score=97, Evalue=8e-21, Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=28.7878787878788, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17568967, Length=214, Percent_Identity=32.7102803738318, Blast_Score=94, Evalue=6e-20, Organism=Caenorhabditis elegans, GI17564282, Length=200, Percent_Identity=30, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=28.6792452830189, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=27.3408239700375, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=29.3233082706767, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=28.7878787878788, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17551412, Length=269, Percent_Identity=27.5092936802974, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=27.3764258555133, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17508895, Length=171, Percent_Identity=31.5789473684211, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=26.615969581749, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17565030, Length=267, Percent_Identity=26.9662921348315, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI193203117, Length=194, Percent_Identity=28.8659793814433, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17563726, Length=265, Percent_Identity=26.4150943396226, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI193203115, Length=190, Percent_Identity=28.9473684210526, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=29.1828793774319, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI71982365, Length=167, Percent_Identity=28.1437125748503, Blast_Score=69, Evalue=2e-12, Organism=Saccharomyces cerevisiae, GI6322861, Length=195, Percent_Identity=32.3076923076923, Blast_Score=87, Evalue=2e-18, Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=34.5238095238095, Blast_Score=131, Evalue=4e-31, Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=34.375, Blast_Score=129, Evalue=2e-30, Organism=Drosophila melanogaster, GI24639444, Length=250, Percent_Identity=35.2, Blast_Score=126, Evalue=1e-29, Organism=Drosophila melanogaster, GI24643142, Length=250, Percent_Identity=33.2, Blast_Score=122, Evalue=3e-28, Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=34.8, Blast_Score=117, Evalue=6e-27, Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=29.0322580645161, Blast_Score=110, Evalue=1e-24, Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=33.4661354581673, Blast_Score=107, Evalue=7e-24, Organism=Drosophila melanogaster, GI24644337, Length=258, Percent_Identity=32.9457364341085, Blast_Score=93, Evalue=2e-19, Organism=Drosophila melanogaster, GI24640492, Length=194, Percent_Identity=30.4123711340206, Blast_Score=92, Evalue=4e-19, Organism=Drosophila melanogaster, GI24649181, Length=188, Percent_Identity=32.9787234042553, Blast_Score=92, Evalue=4e-19, Organism=Drosophila melanogaster, GI18859837, Length=194, Percent_Identity=32.9896907216495, Blast_Score=91, Evalue=9e-19, Organism=Drosophila melanogaster, GI281364892, Length=200, Percent_Identity=31, Blast_Score=90, Evalue=1e-18, Organism=Drosophila melanogaster, GI21357673, Length=212, Percent_Identity=29.7169811320755, Blast_Score=81, Evalue=6e-16, Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=28.6274509803922, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI21355631, Length=216, Percent_Identity=28.7037037037037, Blast_Score=71, Evalue=8e-13, Organism=Drosophila melanogaster, GI28574402, Length=183, Percent_Identity=28.4153005464481, Blast_Score=68, Evalue=5e-12, Organism=Drosophila melanogaster, GI24584744, Length=183, Percent_Identity=28.4153005464481, Blast_Score=68, Evalue=5e-12, Organism=Drosophila melanogaster, GI24584748, Length=191, Percent_Identity=27.2251308900524, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI161076933, Length=191, Percent_Identity=27.2251308900524, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI24581726, Length=196, Percent_Identity=27.5510204081633, Blast_Score=65, Evalue=4e-11, Organism=Drosophila melanogaster, GI221331218, Length=260, Percent_Identity=25, Blast_Score=65, Evalue=6e-11, Organism=Drosophila melanogaster, GI24665243, Length=218, Percent_Identity=25.6880733944954, Blast_Score=64, Evalue=6e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.159 [C]
Molecular weight: Translated: 26195; Mature: 26195
Theoretical pI: Translated: 6.52; Mature: 6.52
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRLSGKTAVVTGAGSGFGEGIAKTFAREGACVVVNDLHAAAAERVASEIALAGGRALAVA CCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEE GDVSRGEDWQALRDAALAAFGSVQVVVNNAGTTHRNKPVLDITEAEYDRVYAINMKSLFW CCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEEEHHHHHH SVQTFVPYFRGAGGGAFVNIASTAAVRPRPGLVWYNSTKGAMLTASKTLAAELGADRIRV HHHHHHHHHCCCCCCEEEEEECCEEECCCCCEEEEECCCCEEEEECHHHHHHCCCCEEEE NCVNPVLGETGLTSEFMGVPDTPENRARFVATIPLGRLSTPQDIANAALYLASDEAAFVT EECCCCCCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHHHEEEEEECCCCEEEE GACLEVDGGRCV EEEEEECCCCCC >Mature Secondary Structure MRLSGKTAVVTGAGSGFGEGIAKTFAREGACVVVNDLHAAAAERVASEIALAGGRALAVA CCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEE GDVSRGEDWQALRDAALAAFGSVQVVVNNAGTTHRNKPVLDITEAEYDRVYAINMKSLFW CCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEEEHHHHHH SVQTFVPYFRGAGGGAFVNIASTAAVRPRPGLVWYNSTKGAMLTASKTLAAELGADRIRV HHHHHHHHHCCCCCCEEEEEECCEEECCCCCEEEEECCCCEEEEECHHHHHHCCCCEEEE NCVNPVLGETGLTSEFMGVPDTPENRARFVATIPLGRLSTPQDIANAALYLASDEAAFVT EECCCCCCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHHHEEEEEECCCCEEEE GACLEVDGGRCV EEEEEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: 2-Mercaptoethanol; Dithiothreitol; NAD+; NADH [C]
Metal ions: CaCl2; KCl; MnCl2; NaCl [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 0.8 {cholic} 0.24 {taurochenodeoxycholic} 0.085 {glycochenodeoxycholic} 1 {glycocholic} 0.06 {chenodeoxycholic} [C]
Substrates: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate!; NAD [C]
Specific reaction: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate! + NAD+ = 3alpha12alpha-dihydroxy-oxobeta-cholanate + NADH [C]
General reaction: Redox reaction [C]
Inhibitor: Ascorbicacid; BaCl2; CoCl2; CuCl2; EDTA; FeCl3; HgCl2; MgCl2; NH4Cl; Potassiumoxalate; Sodiumcitrate; Sodiumlaurylsulfate; Sodiumperchlorate; Sodiumperiodate; Sodiumpersulfate; TritonX-100; Tween; ZnCl2 [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9163424 [H]