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The map label for this gene is argH [H]

Identifier: 53718648

GI number: 53718648

Start: 1169883

End: 1171292

Strand: Reverse

Name: argH [H]

Synonym: BPSL1006

Alternate gene names: 53718648

Gene position: 1171292-1169883 (Counterclockwise)

Preceding gene: 53718649

Following gene: 53718647

Centisome position: 28.75

GC content: 68.16

Gene sequence:

>1410_bases
ATGACGTCCCAACTGCACAAAAAGGGCGAGGCCTGGTCGGCCCGCTTTTCGGAACCGATGTCCGAGCTCGTCAAGCGCTA
CACGTCGTCGGTCTTCTTCGACAAGCGGCTCGCGCTCGTCGACATCGCCGGCTCGCTCGCGCACGCGGGCATGCTCGCCG
CGCAGAAGATCATCAGCGCCGACGACCTCGCCGCGATCGAGCGCGGGATGGCGCAAATCAAGGGCGAGATCGAGCGCGGC
GAATTCGAATGGCAGCTCGATCTCGAAGACGTCCACCTGAACATCGAGGCGCGCCTGACCGCGCTCATCGGCGATGCGGG
CAAGCGCCTGCACACGGGCCGCTCGCGCAACGATCAGGTCGCGACCGACATCCGCCTGTGGCTGCGCGGCGAGATCGACC
GGATCGGCGGCCTGCTGAACGACCTGCGCGGCGCGCTGATCGATCTCGCCGAACAGAACGCGGACACGATCCTGCCGGGC
TTCACGCACCTGCAGGTCGCGCAGCCTGTCACGTTCGGCCATCACCTGCTTGCCTACGTCGAGATGTTCTCGCGCGACGC
CGAGCGCATGCGCGACTGCCGCGCGCGCGTGAACCGCCTGCCGCTCGGCGCGGCGGCGCTCGCGGGCACCAGCTATCCGA
TCGACCGCCACGCGGTGGCGAAGACGCTCGGCTTCGACGGCATCTGCGCGAACTCGCTCGACGCGGTGTCCGATCGCGAC
TTCGCGATCGAATTCACGGCCGCGGCCGCGCTCGTGATGACGCACGTGTCGCGCTTCTCGGAAGAACTCGTGCTGTGGAT
GAGCCCGCGCGTGGGCTTCATCGACATCGCCGACCGCTTCTGCACCGGCAGCTCGATCATGCCGCAGAAGAAGAACCCGG
ACGTGCCCGAGCTCGCGCGCGGCAAGACGGGCCGCGTAAACGGCCACCTGATGGCGCTGCTCACGCTGATGAAGGGCCAG
CCGCTCGCGTACAACAAGGACAATCAGGAAGACAAGGAACCGCTGTTCGACACGGTCGACACCGTCGCCGACACGCTGCG
GATCTTCGCGGAGATGGTCGCGGGCATCACGGTGAAGCCGGACGCGATGCGCGCGGCCGCGCTGCAGGGCTTCTCGACCG
CGACGGATCTCGCGGACTACCTGGTCAAGCGCGGGTTGCCGTTCCGCGACGCGCACGAGGCGGTCGCGCACGCGGTGAAG
GTCTGCGACGCGCGCGGCATCGACCTCGCGGATCTGACGCTCGACGAAATGAAGCAGGAACTGCCGAACGTCGCGCATCT
GATCGGCGAGGACGTGTTCGACTATCTGACGCTCGAAGGCTCGGTCGCGAGCCGCAATCATCCGGGCGGCACCGCGCCGG
ACCAGGTGCGCGCGGCGGCGAAGGCCGCGCGCGCGGCGCTCGGCCAGTAG

Upstream 100 bases:

>100_bases
GCCGGGCGAGCGCCGGCATCGGCCGGCCGCCGCCCAAATGCTAGAATCCGCGTTGTCCCTTCGCGGCGCGCGCCGCTCCA
CTCCCCTTCTAAGAATCGCC

Downstream 100 bases:

>100_bases
GCGGGCCGCGCCTTCACGGACGGGACGATCGCATGTTCTCGGCGGCAATCTTCGATATGGACGGCCTGCTCGTCGATTCC
GAGCGGACCATCATGAACGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHAGMLAAQKIISADDLAAIERGMAQIKGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTILPG
FTHLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRARVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
FAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVK
VCDARGIDLADLTLDEMKQELPNVAHLIGEDVFDYLTLEGSVASRNHPGGTAPDQVRAAAKAARAALGQ

Sequences:

>Translated_469_residues
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHAGMLAAQKIISADDLAAIERGMAQIKGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTILPG
FTHLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRARVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
FAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVK
VCDARGIDLADLTLDEMKQELPNVAHLIGEDVFDYLTLEGSVASRNHPGGTAPDQVRAAAKAARAALGQ
>Mature_468_residues
TSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHAGMLAAQKIISADDLAAIERGMAQIKGEIERGE
FEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTILPGF
THLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRARVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRDF
AIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQP
LAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKV
CDARGIDLADLTLDEMKQELPNVAHLIGEDVFDYLTLEGSVASRNHPGGTAPDQVRAAAKAARAALGQ

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=461, Percent_Identity=39.6963123644252, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI68303542, Length=461, Percent_Identity=39.6963123644252, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI68303547, Length=461, Percent_Identity=37.527114967462, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI68303549, Length=461, Percent_Identity=37.3101952277657, Blast_Score=308, Evalue=6e-84,
Organism=Escherichia coli, GI1790398, Length=458, Percent_Identity=44.9781659388646, Blast_Score=397, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6321806, Length=448, Percent_Identity=41.0714285714286, Blast_Score=336, Evalue=5e-93,
Organism=Drosophila melanogaster, GI221473854, Length=457, Percent_Identity=38.074398249453, Blast_Score=307, Evalue=8e-84,
Organism=Drosophila melanogaster, GI78706858, Length=457, Percent_Identity=38.074398249453, Blast_Score=307, Evalue=8e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51174; Mature: 51043

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHAGMLAAQKIISA
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
DDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHHCCCCCCCCH
ATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTILPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
EMFSRDAERMRDCRARVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHCCCCCC
FAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
EEEEHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKVCDARGIDLADLTLDEMKQE
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHH
LPNVAHLIGEDVFDYLTLEGSVASRNHPGGTAPDQVRAAAKAARAALGQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHAGMLAAQKIISA
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
DDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHHCCCCCCCCH
ATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTILPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
EMFSRDAERMRDCRARVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHCCCCCC
FAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
EEEEHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKVCDARGIDLADLTLDEMKQE
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHH
LPNVAHLIGEDVFDYLTLEGSVASRNHPGGTAPDQVRAAAKAARAALGQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA