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The map label for this gene is ilvD [H]

Identifier: 53718611

GI number: 53718611

Start: 1126530

End: 1128203

Strand: Reverse

Name: ilvD [H]

Synonym: BPSL0969

Alternate gene names: 53718611

Gene position: 1128203-1126530 (Counterclockwise)

Preceding gene: 53718614

Following gene: 53718610

Centisome position: 27.69

GC content: 67.32

Gene sequence:

>1674_bases
ATGTCGTACAACCGCCGCTCGAAGAACATCACGCAAGGCGTGGCCCGTTCGCCGAACCGCTCGATGTATTACGCGCTCGG
CTATCAGAAGGAAGATTTCGACAAGCCGATGATCGGCATCGCGAACGGCCACTCGACGATCACGCCGTGCAACGCGGGCC
TGCAGCGTCTGTCGGACGCCGCCGTCGCGGCCGTCAAGGACGCCGGCGCGAATCCGCAGATCTTCGGCACGCCGACGATC
TCGGACGGCATGTCGATGGGCACCGAAGGGATGAAGTACTCGCTCGTGTCGCGCGAGGTGATCGCCGATTGCATCGAGAC
CTGCGTGCAGGGCCAATGGATGGACGGCGTCGTCGTCGTGGGCGGCTGCGACAAGAACATGCCGGGCGGCATGATCGCGC
TCGCGCGGATCAACGTGCCGGGCATCTACGTGTACGGCGGCACGATCCGCCCCGGCCACTGGAAAGGCCACGACCTGACG
ATCGTGTCGTCGTTCGAGGCGGTCGGCGAGTTCACCGCCGGACGCATGTCGCAGGAGGATTTCGAAGGGGTCGAAAAGAA
CGCGTGCCCGACGACGGGCTCGTGCGGCGGCATGTATACCGCGAACACGATGAGCTCGTCGTTCGAGGCGCTCGGCATGT
CGCTGCTGTACTCGTCGACGATGGCCAATCCCGATCAGGAGAAGGTCGATTCGGCGGCGGAATCGGCGCGCGTGCTGGTC
GAGGCGGTGAAGAAGGACCTGAAGCCGCGCGACATCATCACGAAGCAGTCGATCGAGAACGCGGTGTCGGTGATCATGGC
CACGGGCGGCTCGACCAACGCGGTGCTCCACTATCTGGCGATCGCGCACGCGGCCGAGATCGACTGGTCGATCGAGGATT
TCGAGCGCATCAGGAAGCGCGTGCCGGTGATTTGCGACCTGAAGCCGTCGGGCCAGTACGTCGCGACCGATCTGCACGCG
GCGGGCGGCATTCCGCAGGTGATGAAGCTGCTGCTCGACGCGGGCCTGCTGCACGGCGACTGCATGACGATCACGGGCCG
CACGCTCGCCGAGGAGCTGAAGGACGTGCCGAGCGTGCCGCGCGCCGATCAGAAGGTGATCCATCCGATCGACCAGGCGC
TGTACAAGGAAGGCCACCTCGCGATCCTGAAGGGCAACCTCGCCGAGGACGGCGCGGTCGCGAAGATCACCGGCCTGAAG
AACCCGGTCATCACCGGCCCGGCGCGCGTGTTCGACGACGAGCAGAGCGCGCTCGCCGCGATCCTCGACGACAGGATCCG
CGCGGGCGATGTCGTCGTGCTGCGCTACCTCGGCCCGCAAGGCGGCCCGGGGATGCCCGAGATGCTCGCGCCGACGTCGG
CGATCATCGGCAAGGGCCTCGGCGAATCGGTCGGCCTGATCACCGACGGCCGCTTCTCCGGCGGCACGTGGGGGATGGTG
GTCGGCCACGTCGCGCCGGAAGCGTTCGTCGGCGGCACGATCGCGCTCGTGCAGGAAGGCGATTCGATCACGATCGACGC
GCACAAGCTGCTGCTGCAATTGAACGTCGACGACGCCGAACTCGCGCGCCGCCGCGCCGCGTGGAAGCAGCCGGCGCCGC
GCTACACGCGCGGCGTGCTCGCGAAGTACGCGGCACTCGCCCGCCCGGCGAACCAGGGCGCCGTCACGGGCTGA

Upstream 100 bases:

>100_bases
TTCTCTAACAGAAACTGCATTCTTGCCCACCTGAGCCGGATCGCGCCGATGCAGCGCGCCGAGCAACCCCACAGTCAACC
AGTCGATGATGGAGTTCCCC

Downstream 100 bases:

>100_bases
CGCACCGCGGCGGCACGGCGGTTGCGCGAGCAGAAAGCGCAGGCCGCTTGCTCGCATGCGCCCGCCTCGCGCCACTGCGG
CCGCGCCGCGATGGCGCTGA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 2 [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MSYNRRSKNITQGVARSPNRSMYYALGYQKEDFDKPMIGIANGHSTITPCNAGLQRLSDAAVAAVKDAGANPQIFGTPTI
SDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGHDLT
IVSSFEAVGEFTAGRMSQEDFEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
EAVKKDLKPRDIITKQSIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKRVPVICDLKPSGQYVATDLHA
AGGIPQVMKLLLDAGLLHGDCMTITGRTLAEELKDVPSVPRADQKVIHPIDQALYKEGHLAILKGNLAEDGAVAKITGLK
NPVITGPARVFDDEQSALAAILDDRIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMV
VGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANQGAVTG

Sequences:

>Translated_557_residues
MSYNRRSKNITQGVARSPNRSMYYALGYQKEDFDKPMIGIANGHSTITPCNAGLQRLSDAAVAAVKDAGANPQIFGTPTI
SDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGHDLT
IVSSFEAVGEFTAGRMSQEDFEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
EAVKKDLKPRDIITKQSIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKRVPVICDLKPSGQYVATDLHA
AGGIPQVMKLLLDAGLLHGDCMTITGRTLAEELKDVPSVPRADQKVIHPIDQALYKEGHLAILKGNLAEDGAVAKITGLK
NPVITGPARVFDDEQSALAAILDDRIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMV
VGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANQGAVTG
>Mature_556_residues
SYNRRSKNITQGVARSPNRSMYYALGYQKEDFDKPMIGIANGHSTITPCNAGLQRLSDAAVAAVKDAGANPQIFGTPTIS
DGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGHDLTI
VSSFEAVGEFTAGRMSQEDFEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLVE
AVKKDLKPRDIITKQSIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKRVPVICDLKPSGQYVATDLHAA
GGIPQVMKLLLDAGLLHGDCMTITGRTLAEELKDVPSVPRADQKVIHPIDQALYKEGHLAILKGNLAEDGAVAKITGLKN
PVITGPARVFDDEQSALAAILDDRIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMVV
GHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANQGAVTG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=604, Percent_Identity=37.2516556291391, Blast_Score=374, Evalue=1e-104,
Organism=Escherichia coli, GI2367371, Length=493, Percent_Identity=34.2799188640974, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1786464, Length=466, Percent_Identity=34.9785407725322, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1788157, Length=482, Percent_Identity=31.5352697095436, Blast_Score=191, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6322476, Length=560, Percent_Identity=46.0714285714286, Blast_Score=506, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59039; Mature: 58908

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYNRRSKNITQGVARSPNRSMYYALGYQKEDFDKPMIGIANGHSTITPCNAGLQRLSDA
CCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
AVAAVKDAGANPQIFGTPTISDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVV
HHHHHHCCCCCCCEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGHDLTIVSSFEAVGEFTAGRMSQED
ECCCCCCCCCEEEEEEECCCEEEEECCEECCCCCCCCCEEEEECHHHHHHHHHCCCCHHH
FEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
HHCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EAVKKDLKPRDIITKQSIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKR
HHHHHCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VPVICDLKPSGQYVATDLHAAGGIPQVMKLLLDAGLLHGDCMTITGRTLAEELKDVPSVP
CCEEEEECCCCCEEEEEHHHCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCC
RADQKVIHPIDQALYKEGHLAILKGNLAEDGAVAKITGLKNPVITGPARVFDDEQSALAA
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCHHHCCCHHHHHHH
ILDDRIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMV
HHHHCCCCCCEEEEEEECCCCCCCCCHHHCCHHHHHHCCCCCCCCEEECCCCCCCCHHEE
VGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVL
EECCCCHHHCCCEEEEEECCCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHH
AKYAALARPANQGAVTG
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SYNRRSKNITQGVARSPNRSMYYALGYQKEDFDKPMIGIANGHSTITPCNAGLQRLSDA
CCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
AVAAVKDAGANPQIFGTPTISDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVV
HHHHHHCCCCCCCEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGHDLTIVSSFEAVGEFTAGRMSQED
ECCCCCCCCCEEEEEEECCCEEEEECCEECCCCCCCCCEEEEECHHHHHHHHHCCCCHHH
FEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
HHCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EAVKKDLKPRDIITKQSIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKR
HHHHHCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VPVICDLKPSGQYVATDLHAAGGIPQVMKLLLDAGLLHGDCMTITGRTLAEELKDVPSVP
CCEEEEECCCCCEEEEEHHHCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCC
RADQKVIHPIDQALYKEGHLAILKGNLAEDGAVAKITGLKNPVITGPARVFDDEQSALAA
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCHHHCCCHHHHHHH
ILDDRIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMV
HHHHCCCCCCEEEEEEECCCCCCCCCHHHCCHHHHHHCCCCCCCCEEECCCCCCCCHHEE
VGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVL
EECCCCHHHCCCEEEEEECCCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHH
AKYAALARPANQGAVTG
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA