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The map label for this gene is lspA

Identifier: 53718546

GI number: 53718546

Start: 1055825

End: 1056325

Strand: Reverse

Name: lspA

Synonym: BPSL0905

Alternate gene names: 53718546

Gene position: 1056325-1055825 (Counterclockwise)

Preceding gene: 53718547

Following gene: 53718545

Centisome position: 25.92

GC content: 66.27

Gene sequence:

>501_bases
ATGGCGAAGACCCTGTCGAAATCCTCGGGTGGCGCGCTCGCGCCGTGGCTCGGCATCTCGCTGATCGTGATCCTGTTCGA
TCAGTTGACGAAGATCGCCGTGCTCAAGACGTTCGCGTACGGCGCGATGCACGCGCTCACGCCGTTCTTCAACCTGACGC
TGATCTACAACCGCGGCGCCGCGTTCGGCTTTCTCGCGACGGCGGGCGGCTGGCAGCGCTGGGCGTTCACCGCGCTCGGC
ATCGGCGCGACGCTCGTGATCTGCTATCTGCTCAAGCGCCACGGCCACCAGCGGCTCTTCAGCCTGTCGCTCGCGCTGAT
TCTCGGCGGCGCGCTCGGCAACGTGATCGATCGCCTGATCTACGGTCACGTGATCGATTTCCTCGACTTCCACGTCGGCG
CGTGGCACTGGCCCGCGTTCAATCTCGCCGACTCCGCGATCACGGTGGGCGCGGTGCTCCTCATCTACGACGAGCTGCGT
CGCGTGCGCGGCGCGCGCTAA

Upstream 100 bases:

>100_bases
ACTACCGCGAGGACGTCGGCGCGCACGCCGATCATCCGACGCTTTGCGGCCGCTGCTTCTCCAACCTGTTCGAAAACGGC
GAAACCCGGAGCGCTGCGTA

Downstream 100 bases:

>100_bases
GCGCATACACTTCGCGCAGGGGCCGGCGCGCGCCGGCCCCACGTGCTTTCGGAGGCCTCAGTTGGCACACGCAGAACTCG
CTGGAAAACACCTCGTCCTC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MAKTLSKSSGGALAPWLGISLIVILFDQLTKIAVLKTFAYGAMHALTPFFNLTLIYNRGAAFGFLATAGGWQRWAFTALG
IGATLVICYLLKRHGHQRLFSLSLALILGGALGNVIDRLIYGHVIDFLDFHVGAWHWPAFNLADSAITVGAVLLIYDELR
RVRGAR

Sequences:

>Translated_166_residues
MAKTLSKSSGGALAPWLGISLIVILFDQLTKIAVLKTFAYGAMHALTPFFNLTLIYNRGAAFGFLATAGGWQRWAFTALG
IGATLVICYLLKRHGHQRLFSLSLALILGGALGNVIDRLIYGHVIDFLDFHVGAWHWPAFNLADSAITVGAVLLIYDELR
RVRGAR
>Mature_165_residues
AKTLSKSSGGALAPWLGISLIVILFDQLTKIAVLKTFAYGAMHALTPFFNLTLIYNRGAAFGFLATAGGWQRWAFTALGI
GATLVICYLLKRHGHQRLFSLSLALILGGALGNVIDRLIYGHVIDFLDFHVGAWHWPAFNLADSAITVGAVLLIYDELRR
VRGAR

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=163, Percent_Identity=41.7177914110429, Blast_Score=129, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_BURM7 (A3MN08)

Other databases:

- EMBL:   CP000548
- RefSeq:   YP_001081644.1
- GeneID:   4893762
- GenomeReviews:   CP000548_GR
- KEGG:   bmn:BMA10247_2113
- TIGR:   BMA10247_2113
- HOGENOM:   HBG724422
- OMA:   NFELRES
- ProtClustDB:   PRK00376
- BioCyc:   BMAL320389:BMA10247_2113-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18100; Mature: 17968

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 117-117 ACT_SITE 144-144

Signals:

None

Transmembrane regions:

HASH(0x1277c3e0)-; HASH(0x403fb294)-; HASH(0x12fe624c)-; HASH(0x129f2bb8)-; HASH(0x1334f850)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTLSKSSGGALAPWLGISLIVILFDQLTKIAVLKTFAYGAMHALTPFFNLTLIYNRGA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
AFGFLATAGGWQRWAFTALGIGATLVICYLLKRHGHQRLFSLSLALILGGALGNVIDRLI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
YGHVIDFLDFHVGAWHWPAFNLADSAITVGAVLLIYDELRRVRGAR
HHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
AKTLSKSSGGALAPWLGISLIVILFDQLTKIAVLKTFAYGAMHALTPFFNLTLIYNRGA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
AFGFLATAGGWQRWAFTALGIGATLVICYLLKRHGHQRLFSLSLALILGGALGNVIDRLI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
YGHVIDFLDFHVGAWHWPAFNLADSAITVGAVLLIYDELRRVRGAR
HHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA