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The map label for this gene is fabG2 [H]

Identifier: 53718513

GI number: 53718513

Start: 1014452

End: 1015210

Strand: Reverse

Name: fabG2 [H]

Synonym: BPSL0874

Alternate gene names: 53718513

Gene position: 1015210-1014452 (Counterclockwise)

Preceding gene: 53718514

Following gene: 53718510

Centisome position: 24.92

GC content: 70.36

Gene sequence:

>759_bases
ATGGAGATTCGCGACAACGTCTTCCTGATCACGGGCGGCGCATCGGGGCTCGGCGCGGGCACCGCGCGGCTGCTGACCGA
AGCGGGCGGCAAGGTCGTGCTCGCCGATCTGAATCAGCAAGCGGGCGAAGCGCTCGCGCGCGAACTGGGCGGCGCGTTCG
TCAAGTGCGACGTCGCGCGCGAGGAGGACGCGCAAGCGGCCGTCGCCGCCGCGGCGAAGCTCGGCACGCTGCGCGGGCTC
GTCAACTGCGCGGGCATCGCGCCGGCGGCGAAGACGGTCGGCAAGGACGGCCCGCATCCGCTCGAGCTGTTCGCGAAGAC
GATCACCGTGAACCTGATCGGCACGTTCAACATGATTCGCGTCGCGGCCGCGGCGATGGCCGCGAACGAGCCGGCGCAGA
CCGGCGAGCGCGGCGTGATCGTCAGCACCGCGTCGGTCGCCGCGTTCGACGGCCAGATCGGCCAGGCCGCCTATGCGGCG
TCGAAGGCGGGCGTCGCCGGCATGACGCTGCCGATCGCGCGCGACCTGTCGCGCAATGCGATTCGCGTGATGACGATCGC
GCCCGGCATCTTCGAGACGCCGATGCTGCTCGGCATGCCGCAGGACGTGCAGGACGCGCTCGGCGCGATGGTGCCGTTTC
CCCCGCGCCTCGGCAAGCCGGCCGAATACGCGATGCTCGTCAAGCAGATCTTCGAGAACCCGATGCTCAACGGCGAGGTG
ATTCGCCTCGACGGCGCGATCCGGATGCAGCCGAAGTGA

Upstream 100 bases:

>100_bases
CGGGCCTCGGCGCCCGCTCGTACAATCGTCGGCAAGCGCGTGTCGCTTCACGGCATTCGTTCGACATTCATACCAATCAA
TCCAAGGACAAGGAGCAAAC

Downstream 100 bases:

>100_bases
CGAAATGACGAGGCGGCGCACGCGGCCGCAACGACGGCAGCCGCGTCGCCCGTCGCGTGTCGTCGAATGGGGAAGGCATG
CCCGCGGATGCGACGGCATC

Product: putative short-chain dehydrogenase family protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MEIRDNVFLITGGASGLGAGTARLLTEAGGKVVLADLNQQAGEALARELGGAFVKCDVAREEDAQAAVAAAAKLGTLRGL
VNCAGIAPAAKTVGKDGPHPLELFAKTITVNLIGTFNMIRVAAAAMAANEPAQTGERGVIVSTASVAAFDGQIGQAAYAA
SKAGVAGMTLPIARDLSRNAIRVMTIAPGIFETPMLLGMPQDVQDALGAMVPFPPRLGKPAEYAMLVKQIFENPMLNGEV
IRLDGAIRMQPK

Sequences:

>Translated_252_residues
MEIRDNVFLITGGASGLGAGTARLLTEAGGKVVLADLNQQAGEALARELGGAFVKCDVAREEDAQAAVAAAAKLGTLRGL
VNCAGIAPAAKTVGKDGPHPLELFAKTITVNLIGTFNMIRVAAAAMAANEPAQTGERGVIVSTASVAAFDGQIGQAAYAA
SKAGVAGMTLPIARDLSRNAIRVMTIAPGIFETPMLLGMPQDVQDALGAMVPFPPRLGKPAEYAMLVKQIFENPMLNGEV
IRLDGAIRMQPK
>Mature_252_residues
MEIRDNVFLITGGASGLGAGTARLLTEAGGKVVLADLNQQAGEALARELGGAFVKCDVAREEDAQAAVAAAAKLGTLRGL
VNCAGIAPAAKTVGKDGPHPLELFAKTITVNLIGTFNMIRVAAAAMAANEPAQTGERGVIVSTASVAAFDGQIGQAAYAA
SKAGVAGMTLPIARDLSRNAIRVMTIAPGIFETPMLLGMPQDVQDALGAMVPFPPRLGKPAEYAMLVKQIFENPMLNGEV
IRLDGAIRMQPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=58.0392156862745, Blast_Score=271, Evalue=5e-73,
Organism=Homo sapiens, GI83715985, Length=256, Percent_Identity=55.46875, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=29.8804780876494, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI15277342, Length=240, Percent_Identity=34.5833333333333, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI59889578, Length=219, Percent_Identity=29.2237442922374, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI31542939, Length=261, Percent_Identity=26.8199233716475, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI5031737, Length=195, Percent_Identity=28.7179487179487, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI33667109, Length=195, Percent_Identity=28.7179487179487, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI32483357, Length=251, Percent_Identity=27.0916334661355, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI87082100, Length=233, Percent_Identity=30.4721030042918, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787905, Length=227, Percent_Identity=30.8370044052863, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082160, Length=196, Percent_Identity=30.6122448979592, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=246, Percent_Identity=51.219512195122, Blast_Score=239, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17555706, Length=222, Percent_Identity=33.7837837837838, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25147288, Length=223, Percent_Identity=32.2869955156951, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17563726, Length=211, Percent_Identity=28.436018957346, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=27.027027027027, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=204, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=58.2677165354331, Blast_Score=282, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=33.7254901960784, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21357041, Length=231, Percent_Identity=30.3030303030303, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571526, Length=229, Percent_Identity=28.3842794759825, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25919; Mature: 25919

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRDNVFLITGGASGLGAGTARLLTEAGGKVVLADLNQQAGEALARELGGAFVKCDVAR
CCCCCCEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCC
EEDAQAAVAAAAKLGTLRGLVNCAGIAPAAKTVGKDGPHPLELFAKTITVNLIGTFNMIR
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHEEEEHHHHHHHH
VAAAAMAANEPAQTGERGVIVSTASVAAFDGQIGQAAYAASKAGVAGMTLPIARDLSRNA
HHHHHHHCCCCCCCCCCEEEEEECEEEEECCCCCHHHHHHHHCCCCCEEHHHHHHCCCCC
IRVMTIAPGIFETPMLLGMPQDVQDALGAMVPFPPRLGKPAEYAMLVKQIFENPMLNGEV
EEEEEECCCHHHCCHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
IRLDGAIRMQPK
EEECCEEEECCC
>Mature Secondary Structure
MEIRDNVFLITGGASGLGAGTARLLTEAGGKVVLADLNQQAGEALARELGGAFVKCDVAR
CCCCCCEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCC
EEDAQAAVAAAAKLGTLRGLVNCAGIAPAAKTVGKDGPHPLELFAKTITVNLIGTFNMIR
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHEEEEHHHHHHHH
VAAAAMAANEPAQTGERGVIVSTASVAAFDGQIGQAAYAASKAGVAGMTLPIARDLSRNA
HHHHHHHCCCCCCCCCCEEEEEECEEEEECCCCCHHHHHHHHCCCCCEEHHHHHHCCCCC
IRVMTIAPGIFETPMLLGMPQDVQDALGAMVPFPPRLGKPAEYAMLVKQIFENPMLNGEV
EEEEEECCCHHHCCHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
IRLDGAIRMQPK
EEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]