Click here to switch to the map view.

The map label for this gene is ilvA [H]

Identifier: 53718276

GI number: 53718276

Start: 716147

End: 717670

Strand: Reverse

Name: ilvA [H]

Synonym: BPSL0633

Alternate gene names: 53718276

Gene position: 717670-716147 (Counterclockwise)

Preceding gene: 53718295

Following gene: 53718275

Centisome position: 17.61

GC content: 68.24

Gene sequence:

>1524_bases
ATGGCCTCCCACGATTATCTGAAGAAAATCCTGACCGCCCGGGTGTACGACGTCGCGCTCGAAACCGAGCTCGAACGCGC
GCGCAACCTGTCCGCGCGGCTGGGCAACGCCGTCTACCTGAAGCGCGAGGACAACCAGCCGGTGTTCTCGTTCAAGCTGC
GCGGCGCGTACAACAAGATGGCGCACATCCCGGCCGACGCGCTCGCGCGCGGGGTGATCACCGCGTCGGCGGGCAACCAT
GCGCAGGGCGTCGCGTTCTCGGCCGCGCGGATGAACGTGAAGGCGGTGATCGTCGTGCCGGTGACGACGCCGCAGGTGAA
GGTCGACGCGGTGCGCGCGCACGGCGGGCCGACCGTCGAGGTGATCCAGGCGGGCGAATCGTACAGCGACGCGTACGCGC
ACGCGGTGAAGGTGCAGGCCGAGCGCGGCCTCACGTTCGTCCATCCGTTCGACGATCCGTACGTGATCGCGGGCCAGGGC
ACGGTCGCGATGGAGATCCTGCGTCAGCATCAGGGGCCGATTCACGCGATCTTCGTGCCGATCGGCGGCGGCGGGCTCGC
GGCGGGCGTGGCCGCGTACGTGAAGGCGGTGCGCCCGGAGATCAAGGTGATCGGCGTGCAGACCGACGATTCGTGCGCGA
TGAAGCAATCGCTCGCGGCGGGCCGGCGCATCGAGCTCACCGAGGTGGGGCTCTTCTCCGACGGCACCGCGGTCAAGCTC
GTCGGCGAGGAGACGTTCCGCCTCTGCGCGGCGTATCTCGACGAGGTCGTGACCGTCGATACCGACGCGCTTTGCGCGGC
GATCAAGGACGTGTTCCAGGACACGCGCAGCGTGCTCGAGCCGGCCGGCTCGCTCGCGGTGGCGGGCGCGAAGCGGTATG
CGGAGCAGGCGGGCATCGAGGGCGAGACGCTCGTGGCGGTTACCTCCGGCGCGAACATGAATTTCGACCGGATGCGCTTC
GTCGCCGAGCGCGCCGAGGTGGGCGAGGCGCGCGAGGCGGTGTTCGCGGTGACGATTCCCGAGGAGCGCGGCAGCTTCAA
GCGCTTCTGCGCGCTCGTCGGCGAGCGCAACGTGACCGAGTTCAACTACCGGATCGCCGATGCGCGATCGGCGCATCTCT
TCGTCGGTGTGCAGATCCGGCGGCGCGACGAATCGGACGAGATCGCCGCCAACTTCGCCGCGCACGGTTTCACGAGCGTC
GACCTGTCGGGCGACGAGCTATCGAAGCAGCATATCCGCTACATGGTGGGCGGGCGCTCGCCGCTCGCGCACGACGAGCG
GCTGTTCCGCTTCGAGTTTCCCGAGCGGCCCGGCGCGCTGATGAAGTTCCTGTCGTCGATGGCGCCCGACTGGAACATCA
GCCTGTTCCACTACCGGAACCAGGGCGCCGACTACAGCTCGATCCTCGTCGGCCTGCAGGTGCCGCAGGCCGACCACGCG
GCGTTCGATCGCTTCCTCGCGGCGCTCGGCTATCCGTTCTGGGAAGAAAGCGGCAATCCGGCGTATCGTCTCTTCCTGTC
GTAA

Upstream 100 bases:

>100_bases
CGTCCGGACGGTCGGTAGCCATTCGGCCGAGGCCGAAACGGCGAAGGTTGGCGCTATCATTGCCGTTTTCCGTCGCATCC
ACGCTTTTTCGCGCCTCCTC

Downstream 100 bases:

>100_bases
CCCGTCCATTCCATACGATATGAACCCCGAACACTCCCCGCTCGGCAAGGCGACCGTCTACGCGAACCAGTACGACGCGT
CGCTGCTGTTTCCGATTCCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MASHDYLKKILTARVYDVALETELERARNLSARLGNAVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNH
AQGVAFSAARMNVKAVIVVPVTTPQVKVDAVRAHGGPTVEVIQAGESYSDAYAHAVKVQAERGLTFVHPFDDPYVIAGQG
TVAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSCAMKQSLAAGRRIELTEVGLFSDGTAVKL
VGEETFRLCAAYLDEVVTVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKRYAEQAGIEGETLVAVTSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFKRFCALVGERNVTEFNYRIADARSAHLFVGVQIRRRDESDEIAANFAAHGFTSV
DLSGDELSKQHIRYMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHA
AFDRFLAALGYPFWEESGNPAYRLFLS

Sequences:

>Translated_507_residues
MASHDYLKKILTARVYDVALETELERARNLSARLGNAVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNH
AQGVAFSAARMNVKAVIVVPVTTPQVKVDAVRAHGGPTVEVIQAGESYSDAYAHAVKVQAERGLTFVHPFDDPYVIAGQG
TVAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSCAMKQSLAAGRRIELTEVGLFSDGTAVKL
VGEETFRLCAAYLDEVVTVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKRYAEQAGIEGETLVAVTSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFKRFCALVGERNVTEFNYRIADARSAHLFVGVQIRRRDESDEIAANFAAHGFTSV
DLSGDELSKQHIRYMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHA
AFDRFLAALGYPFWEESGNPAYRLFLS
>Mature_506_residues
ASHDYLKKILTARVYDVALETELERARNLSARLGNAVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNHA
QGVAFSAARMNVKAVIVVPVTTPQVKVDAVRAHGGPTVEVIQAGESYSDAYAHAVKVQAERGLTFVHPFDDPYVIAGQGT
VAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSCAMKQSLAAGRRIELTEVGLFSDGTAVKLV
GEETFRLCAAYLDEVVTVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKRYAEQAGIEGETLVAVTSGANMNFDRMRFV
AERAEVGEAREAVFAVTIPEERGSFKRFCALVGERNVTEFNYRIADARSAHLFVGVQIRRRDESDEIAANFAAHGFTSVD
LSGDELSKQHIRYMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHAA
FDRFLAALGYPFWEESGNPAYRLFLS

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=303, Percent_Identity=32.3432343234323, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI33469958, Length=320, Percent_Identity=28.125, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790207, Length=505, Percent_Identity=53.2673267326733, Blast_Score=517, Evalue=1e-148,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=33.7620578778135, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17537387, Length=342, Percent_Identity=30.9941520467836, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71991565, Length=328, Percent_Identity=28.6585365853659, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17508781, Length=296, Percent_Identity=28.0405405405405, Blast_Score=109, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320930, Length=517, Percent_Identity=47.7756286266925, Blast_Score=466, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322631, Length=304, Percent_Identity=33.2236842105263, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319788, Length=270, Percent_Identity=25.9259259259259, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355833, Length=319, Percent_Identity=30.0940438871473, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24645328, Length=255, Percent_Identity=28.6274509803922, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55173; Mature: 55042

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASHDYLKKILTARVYDVALETELERARNLSARLGNAVYLKREDNQPVFSFKLRGAYNKM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCHHHH
AHIPADALARGVITASAGNHAQGVAFSAARMNVKAVIVVPVTTPQVKVDAVRAHGGPTVE
HCCCHHHHHCCEEEECCCCCCCCEEEEEEEECEEEEEEEECCCCCEEEEEEECCCCCEEE
VIQAGESYSDAYAHAVKVQAERGLTFVHPFDDPYVIAGQGTVAMEILRQHQGPIHAIFVP
EEECCCCCHHHHHHEEEEEHHCCEEEEECCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSCAMKQSLAAGRRIELTEVGLFSDGTAVKL
ECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCEEEEEEEEEECCCCEEEE
VGEETFRLCAAYLDEVVTVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKRYAEQAGIE
ECHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCC
GETLVAVTSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFKRFCALVGERNVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCCHHHHHHHHCCCCCEE
FNYRIADARSAHLFVGVQIRRRDESDEIAANFAAHGFTSVDLSGDELSKQHIRYMVGGRS
EEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHEECCCC
PLAHDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHA
CCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCHHH
AFDRFLAALGYPFWEESGNPAYRLFLS
HHHHHHHHHCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
ASHDYLKKILTARVYDVALETELERARNLSARLGNAVYLKREDNQPVFSFKLRGAYNKM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCHHHH
AHIPADALARGVITASAGNHAQGVAFSAARMNVKAVIVVPVTTPQVKVDAVRAHGGPTVE
HCCCHHHHHCCEEEECCCCCCCCEEEEEEEECEEEEEEEECCCCCEEEEEEECCCCCEEE
VIQAGESYSDAYAHAVKVQAERGLTFVHPFDDPYVIAGQGTVAMEILRQHQGPIHAIFVP
EEECCCCCHHHHHHEEEEEHHCCEEEEECCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSCAMKQSLAAGRRIELTEVGLFSDGTAVKL
ECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCEEEEEEEEEECCCCEEEE
VGEETFRLCAAYLDEVVTVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKRYAEQAGIE
ECHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCC
GETLVAVTSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFKRFCALVGERNVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCCHHHHHHHHCCCCCEE
FNYRIADARSAHLFVGVQIRRRDESDEIAANFAAHGFTSVDLSGDELSKQHIRYMVGGRS
EEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHEECCCC
PLAHDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHA
CCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCHHH
AFDRFLAALGYPFWEESGNPAYRLFLS
HHHHHHHHHCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA