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The map label for this gene is dapA2 [H]

Identifier: 53717987

GI number: 53717987

Start: 369407

End: 370309

Strand: Reverse

Name: dapA2 [H]

Synonym: BPSL0346

Alternate gene names: 53717987

Gene position: 370309-369407 (Counterclockwise)

Preceding gene: 53717988

Following gene: 53717986

Centisome position: 9.09

GC content: 69.1

Gene sequence:

>903_bases
ATGCACATGCAATCACGTTTCGAAGGTATCTGGCTTCCGATCGTCACGCCGTTCCATGCCCGGGAAACCGGCACGGTCGA
CCACGCGGCGCTCGCGCGCCTCGCGCGGCACTATTCGGATGAAGGGATCGCGGGCTTCGTCGCCGGCGCGACGACGGGCG
AAGGCGCACTGCTGAACGCTGGCGAACAGGAAGCGATTTTCGCGACGCTGCGCGACGCCGCACCGGCGCGGCCGATCGTG
CTCGGCATCACCGCAAGCGCGACGCACGCGGCAGCCGAACGCGCACGCGCGCTCGCTGCGCTGCGCCCGGACGGCTTGCT
CGTCACGCCGCCCGTCTACGTCCGCCCGACGCAAGCGGGCGTGCAGCGGCACATCGAGGCGGTCGTCGAAGCGGCCGATC
TGCCCGTGCTCGTCTACAACATCCCGTACCGCACCGGCGTGAACGTCGAACTCGATACGCTGAAGGCGCTGTCGCGCGAT
GCGCGCGTTGCCGGCGTGAAGGAATGCGGCGGCACGATGGAGCGCATGCTGCGCCTCGTGCACGAAACGCCGCTGCGCAT
CCTCTCCGGCGACGACAATCAGAATTTCGCAGCGCTGTGCGCGGGCGCGCACGGCGCGATCGCAAGCGCCGCACACGTAT
TGCCCGCGTGGCACGTGCGTGTGTACGCACTGCTGCGCGAAGGCCGGCTCGACGATGCGCGACGGATCGCGGTCGCGTTG
CAGCCGCTCGTCGCCGATCTGTTCGCGGAACCGAATCCCGCGCCCGTGAAGGCGCTGCTCGCCGCGCAGGGCTGGTGCGA
TAACGCGTTGCGGCTGCCGTTCCTGCCGGTTGAAGAAGCGCTCGCGACGCGGCTGGTCGCACATTGGGAATCGCTGCGCC
AAAGCGAAGCAGCGGGCGCTTGA

Upstream 100 bases:

>100_bases
GATCGCCGGACGGGATGCCCGCGTGTTCACACACCATTCGCATGCCTCGATCCGGCGCCGGCCGGCGGGACGGTTCCCCT
CCACCCGTTTCACCTAGAGG

Downstream 100 bases:

>100_bases
GCGGACGGAGATGCCGACGGCCGGCGGCATCTCCGCCATGCAGCGGGGAATTACGTTCGTCTACGCGTCGTTCATTGCCG
ACATACCGGATTGCGCGGTC

Product: dihydrodipicolinate synthetase family protein

Products: NA

Alternate protein names: DHDPS 2 [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MHMQSRFEGIWLPIVTPFHARETGTVDHAALARLARHYSDEGIAGFVAGATTGEGALLNAGEQEAIFATLRDAAPARPIV
LGITASATHAAAERARALAALRPDGLLVTPPVYVRPTQAGVQRHIEAVVEAADLPVLVYNIPYRTGVNVELDTLKALSRD
ARVAGVKECGGTMERMLRLVHETPLRILSGDDNQNFAALCAGAHGAIASAAHVLPAWHVRVYALLREGRLDDARRIAVAL
QPLVADLFAEPNPAPVKALLAAQGWCDNALRLPFLPVEEALATRLVAHWESLRQSEAAGA

Sequences:

>Translated_300_residues
MHMQSRFEGIWLPIVTPFHARETGTVDHAALARLARHYSDEGIAGFVAGATTGEGALLNAGEQEAIFATLRDAAPARPIV
LGITASATHAAAERARALAALRPDGLLVTPPVYVRPTQAGVQRHIEAVVEAADLPVLVYNIPYRTGVNVELDTLKALSRD
ARVAGVKECGGTMERMLRLVHETPLRILSGDDNQNFAALCAGAHGAIASAAHVLPAWHVRVYALLREGRLDDARRIAVAL
QPLVADLFAEPNPAPVKALLAAQGWCDNALRLPFLPVEEALATRLVAHWESLRQSEAAGA
>Mature_300_residues
MHMQSRFEGIWLPIVTPFHARETGTVDHAALARLARHYSDEGIAGFVAGATTGEGALLNAGEQEAIFATLRDAAPARPIV
LGITASATHAAAERARALAALRPDGLLVTPPVYVRPTQAGVQRHIEAVVEAADLPVLVYNIPYRTGVNVELDTLKALSRD
ARVAGVKECGGTMERMLRLVHETPLRILSGDDNQNFAALCAGAHGAIASAAHVLPAWHVRVYALLREGRLDDARRIAVAL
QPLVADLFAEPNPAPVKALLAAQGWCDNALRLPFLPVEEALATRLVAHWESLRQSEAAGA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=290, Percent_Identity=27.2413793103448, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1788823, Length=278, Percent_Identity=33.4532374100719, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789620, Length=296, Percent_Identity=25.6756756756757, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082415, Length=233, Percent_Identity=24.8927038626609, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1786463, Length=235, Percent_Identity=25.9574468085106, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32022; Mature: 32022

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHMQSRFEGIWLPIVTPFHARETGTVDHAALARLARHYSDEGIAGFVAGATTGEGALLNA
CCCCHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEECC
GEQEAIFATLRDAAPARPIVLGITASATHAAAERARALAALRPDGLLVTPPVYVRPTQAG
CCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEECCCHHH
VQRHIEAVVEAADLPVLVYNIPYRTGVNVELDTLKALSRDARVAGVKECGGTMERMLRLV
HHHHHHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
HETPLRILSGDDNQNFAALCAGAHGAIASAAHVLPAWHVRVYALLREGRLDDARRIAVAL
HHCCCEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QPLVADLFAEPNPAPVKALLAAQGWCDNALRLPFLPVEEALATRLVAHWESLRQSEAAGA
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHMQSRFEGIWLPIVTPFHARETGTVDHAALARLARHYSDEGIAGFVAGATTGEGALLNA
CCCCHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEECC
GEQEAIFATLRDAAPARPIVLGITASATHAAAERARALAALRPDGLLVTPPVYVRPTQAG
CCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEECCCHHH
VQRHIEAVVEAADLPVLVYNIPYRTGVNVELDTLKALSRDARVAGVKECGGTMERMLRLV
HHHHHHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
HETPLRILSGDDNQNFAALCAGAHGAIASAAHVLPAWHVRVYALLREGRLDDARRIAVAL
HHCCCEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QPLVADLFAEPNPAPVKALLAAQGWCDNALRLPFLPVEEALATRLVAHWESLRQSEAAGA
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]