| Definition | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome. |
|---|---|
| Accession | NC_002942 |
| Length | 3,397,754 |
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The map label for this gene is parC
Identifier: 52843173
GI number: 52843173
Start: 3371925
End: 3374180
Strand: Reverse
Name: parC
Synonym: lpg2980
Alternate gene names: 52843173
Gene position: 3374180-3371925 (Counterclockwise)
Preceding gene: 52843174
Following gene: 52843171
Centisome position: 99.31
GC content: 39.89
Gene sequence:
>2256_bases ATGAAGAAAATACCCAATATGAATGAAGTAACTGAAAAAAAACCGCTTACTGAGTTTACAGAAAAAGCTTATCTTGATTA TTCAATGTATGTCATTTTGGACAGAGCATTACCGAGCATCGCAGATGGACTTAAGCCTGTTCAACGCAGAATTGTTTATG CTATGTCTGAGTTGGGTTTGAAAGCAACAGCAAAATATAAAAAATCAGCGCGTACAGTAGGGGATGTTCTTGGTAAATTC CATCCTCATGGTGATAGTGCATGCTATGAGGCTATGGTTTTAATGGCTCAACCCTTTTCATATCGCTATCCATTTGTTGA TGGACAAGGAAATTGGGGATCCCCGGATGATCCCAAATCATTTGCTGCAATGAGGTATACAGAAGCAAGATTATCTCATT ATGCTGATGTGTTACTCGGAGAACTGCTACAAGGAACTGTAGATTGGGTAGATAATTTTGATGGCACTTTGCAAGAGCCC GCTCTTTTACCAGCTCGTTTGCCTAATATTTTATTGAATGGTGCAACAGGTATAGCTGTTGGTATGGCTTCAGATATTCT TCCGCACAATTTGACTGAAGTTGCTAATGCGTGTATTCATCTGCTGGATAACCCCCAAGCAGATATTAAGACTATTTGTG AATATATTAAAGGCCCTGATTTTCCAACAGAAGCAGAAATCATTAGCCCAAGTGAAACAATTAGAGCTATATACGAGTCC GGTAATGGCTCAATTAAAATGCGAGCAATTTATACTCAAGAAAAACAAAACATCGTCATAACAGCTTTGCCTTATCAAGT ATCCGGAGCCAGGGTAATGGAGCAAATCGCGTTGCAGATGCAACAGAAAAAATTACCGATGGTTGAGGATTTACGTGATG AATCAGATCACGAGCATCCAACACGGTTGGTTATTATCCCTCGCTCTAATCGAGTAGATATAGAAAGTTTAATGTCGCAT TTATTTGCTACCACGGATTTGGAGCGTAGCTATCGAGTTAATTTTAATATGATTGGGCTTGATGGCAAGCCAAGAGTTAA AGGACTGTTAGCAATCTTGACTGAATGGTTGGAATTTAGGCTTGCCACAGTAAAAAGACGTCTTCAATTCAGATTGGAAA AGGTACTGGAGCGTATTCATATTCTTGAAGGACTGCTTATTGCCTATCTTAATATAGATGAAGTCATTGCAATCATCAGA GAACATGATCAACCAAAACAAGGATTAATTTCACGCTTTAACTTAACCGAAAGACAGGCTGAAGCAATTTTGGAAATGAA ACTGCGGCATTTAGCCAAATTGGAAGAGATTAAATTGCGTGGTGAACTGGATGAGCTGTCTGATGAACGTGATACTTTAC AAAAAACACTGGCTAGTCATTCTCTCTTAAAAGAACTGGTAAAAGAAGAGATAACGAAAGATCGAGATGAGTTTGGTGAC CCACGCCTTTCACCCATTATTACAAGGGAAGACTCTCAGGCATTAAAAGAAGAGGATATTTTGCCTAATGAGCCTATTAC GGTTGTATTGTCTAAAAATGGATGGGTCAGAGCGGCCAAGGGGCATGATGTCGATGGTAAGGAACTCAGCTATAAAGCGG GAGATGAATTCAAAGCCCAAACGCTAGCTCGTACTAATCAGCAAGTTTTATTTTTTGATGGAGAGGGAAAGGTCTATTCG CTTCCAGGACATGTATTGCCATCGGCACGTGGTCAAGGCGAGCCTTTGACCGGAAAATTAAACCCTGCTGAAGGAGTATT GTTTGAAGCAATTGTTGGCGGAGAGCCTGAACAAAAGGTGTTATTGGCTACCGATTCCGGGTATGGATTTATCGCCAAAA TTGAAGATTTATATGTAAAAAATCGTAATGGAAAGGCATGCATCAAATTAAGTGAAAACAGTCATATATTGCCGCCAAGG CTAATACCAAATCGAGAGCAATTATTTGTTGCTTGTGCCACTAATGTAGGGCGTTTATTGATTTTTTCTCTTGAGGAGTT GCCTGAATTATCTCGAGGAAAAGGGAATAAATTGATCAGTATCCCTGTCGCTAAAGCGGTCTCACGAGAAGAGTATATAG TTGATATGCAAGTTTTAACAACGAATGATTCGCTGACGGTTTATGCTGGTAAACGGCATTTTACTCTGAAAGGTGAGGAT TTGACTCACTATAAGGGTGAAAGGGGCAGGAGAGGAAACCGGTTGCCAAGAGGTTTACAAAATGTTTCTCAATTGCATGT TACTCAATCTGAGTAA
Upstream 100 bases:
>100_bases GATAATACGATGATTATAATTCTAACAGCATGAATATTCTGTTAAAATTGTTTTGCATTGTCTTATACGATTCACTAGGA TGATGGATAGCAATTAATAT
Downstream 100 bases:
>100_bases CATGGCCGTTAGGGACTGTATGTTTCCCGTGAAACACCTTTAAGTGATGATTTGAAATCAAACAGAATAGTGCACAGAGC TGGCTTATTGTTCAATAACT
Product: DNA topoisomerase IV subunit A
Products: NA
Alternate protein names: Topoisomerase IV subunit A [H]
Number of amino acids: Translated: 751; Mature: 751
Protein sequence:
>751_residues MKKIPNMNEVTEKKPLTEFTEKAYLDYSMYVILDRALPSIADGLKPVQRRIVYAMSELGLKATAKYKKSARTVGDVLGKF HPHGDSACYEAMVLMAQPFSYRYPFVDGQGNWGSPDDPKSFAAMRYTEARLSHYADVLLGELLQGTVDWVDNFDGTLQEP ALLPARLPNILLNGATGIAVGMASDILPHNLTEVANACIHLLDNPQADIKTICEYIKGPDFPTEAEIISPSETIRAIYES GNGSIKMRAIYTQEKQNIVITALPYQVSGARVMEQIALQMQQKKLPMVEDLRDESDHEHPTRLVIIPRSNRVDIESLMSH LFATTDLERSYRVNFNMIGLDGKPRVKGLLAILTEWLEFRLATVKRRLQFRLEKVLERIHILEGLLIAYLNIDEVIAIIR EHDQPKQGLISRFNLTERQAEAILEMKLRHLAKLEEIKLRGELDELSDERDTLQKTLASHSLLKELVKEEITKDRDEFGD PRLSPIITREDSQALKEEDILPNEPITVVLSKNGWVRAAKGHDVDGKELSYKAGDEFKAQTLARTNQQVLFFDGEGKVYS LPGHVLPSARGQGEPLTGKLNPAEGVLFEAIVGGEPEQKVLLATDSGYGFIAKIEDLYVKNRNGKACIKLSENSHILPPR LIPNREQLFVACATNVGRLLIFSLEELPELSRGKGNKLISIPVAKAVSREEYIVDMQVLTTNDSLTVYAGKRHFTLKGED LTHYKGERGRRGNRLPRGLQNVSQLHVTQSE
Sequences:
>Translated_751_residues MKKIPNMNEVTEKKPLTEFTEKAYLDYSMYVILDRALPSIADGLKPVQRRIVYAMSELGLKATAKYKKSARTVGDVLGKF HPHGDSACYEAMVLMAQPFSYRYPFVDGQGNWGSPDDPKSFAAMRYTEARLSHYADVLLGELLQGTVDWVDNFDGTLQEP ALLPARLPNILLNGATGIAVGMASDILPHNLTEVANACIHLLDNPQADIKTICEYIKGPDFPTEAEIISPSETIRAIYES GNGSIKMRAIYTQEKQNIVITALPYQVSGARVMEQIALQMQQKKLPMVEDLRDESDHEHPTRLVIIPRSNRVDIESLMSH LFATTDLERSYRVNFNMIGLDGKPRVKGLLAILTEWLEFRLATVKRRLQFRLEKVLERIHILEGLLIAYLNIDEVIAIIR EHDQPKQGLISRFNLTERQAEAILEMKLRHLAKLEEIKLRGELDELSDERDTLQKTLASHSLLKELVKEEITKDRDEFGD PRLSPIITREDSQALKEEDILPNEPITVVLSKNGWVRAAKGHDVDGKELSYKAGDEFKAQTLARTNQQVLFFDGEGKVYS LPGHVLPSARGQGEPLTGKLNPAEGVLFEAIVGGEPEQKVLLATDSGYGFIAKIEDLYVKNRNGKACIKLSENSHILPPR LIPNREQLFVACATNVGRLLIFSLEELPELSRGKGNKLISIPVAKAVSREEYIVDMQVLTTNDSLTVYAGKRHFTLKGED LTHYKGERGRRGNRLPRGLQNVSQLHVTQSE >Mature_751_residues MKKIPNMNEVTEKKPLTEFTEKAYLDYSMYVILDRALPSIADGLKPVQRRIVYAMSELGLKATAKYKKSARTVGDVLGKF HPHGDSACYEAMVLMAQPFSYRYPFVDGQGNWGSPDDPKSFAAMRYTEARLSHYADVLLGELLQGTVDWVDNFDGTLQEP ALLPARLPNILLNGATGIAVGMASDILPHNLTEVANACIHLLDNPQADIKTICEYIKGPDFPTEAEIISPSETIRAIYES GNGSIKMRAIYTQEKQNIVITALPYQVSGARVMEQIALQMQQKKLPMVEDLRDESDHEHPTRLVIIPRSNRVDIESLMSH LFATTDLERSYRVNFNMIGLDGKPRVKGLLAILTEWLEFRLATVKRRLQFRLEKVLERIHILEGLLIAYLNIDEVIAIIR EHDQPKQGLISRFNLTERQAEAILEMKLRHLAKLEEIKLRGELDELSDERDTLQKTLASHSLLKELVKEEITKDRDEFGD PRLSPIITREDSQALKEEDILPNEPITVVLSKNGWVRAAKGHDVDGKELSYKAGDEFKAQTLARTNQQVLFFDGEGKVYS LPGHVLPSARGQGEPLTGKLNPAEGVLFEAIVGGEPEQKVLLATDSGYGFIAKIEDLYVKNRNGKACIKLSENSHILPPR LIPNREQLFVACATNVGRLLIFSLEELPELSRGKGNKLISIPVAKAVSREEYIVDMQVLTTNDSLTVYAGKRHFTLKGED LTHYKGERGRRGNRLPRGLQNVSQLHVTQSE
Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cell membrane; Peripheral membrane protein [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Escherichia coli, GI1789396, Length=741, Percent_Identity=62.4831309041835, Blast_Score=974, Evalue=0.0, Organism=Escherichia coli, GI1788562, Length=738, Percent_Identity=36.3143631436314, Blast_Score=407, Evalue=1e-114, Organism=Caenorhabditis elegans, GI212645845, Length=383, Percent_Identity=23.2375979112272, Blast_Score=71, Evalue=3e-12, Organism=Saccharomyces cerevisiae, GI6324241, Length=402, Percent_Identity=22.3880597014925, Blast_Score=69, Evalue=2e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013757 - InterPro: IPR013760 - InterPro: IPR005742 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: 5.99.1.-
Molecular weight: Translated: 84341; Mature: 84341
Theoretical pI: Translated: 6.53; Mature: 6.53
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKIPNMNEVTEKKPLTEFTEKAYLDYSMYVILDRALPSIADGLKPVQRRIVYAMSELGL CCCCCCCHHHHHCCCHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC KATAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPFVDGQGNWGSPDDPKS HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHH FAAMRYTEARLSHYADVLLGELLQGTVDWVDNFDGTLQEPALLPARLPNILLNGATGIAV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHEECCCCCEEH GMASDILPHNLTEVANACIHLLDNPQADIKTICEYIKGPDFPTEAEIISPSETIRAIYES HHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHC GNGSIKMRAIYTQEKQNIVITALPYQVSGARVMEQIALQMQQKKLPMVEDLRDESDHEHP CCCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCC TRLVIIPRSNRVDIESLMSHLFATTDLERSYRVNFNMIGLDGKPRVKGLLAILTEWLEFR EEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHH LATVKRRLQFRLEKVLERIHILEGLLIAYLNIDEVIAIIREHDQPKQGLISRFNLTERQA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHH EAILEMKLRHLAKLEEIKLRGELDELSDERDTLQKTLASHSLLKELVKEEITKDRDEFGD HHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC PRLSPIITREDSQALKEEDILPNEPITVVLSKNGWVRAAKGHDVDGKELSYKAGDEFKAQ CCCCCEEECCHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCHHHH TLARTNQQVLFFDGEGKVYSLPGHVLPSARGQGEPLTGKLNPAEGVLFEAIVGGEPEQKV HHHCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCEE LLATDSGYGFIAKIEDLYVKNRNGKACIKLSENSHILPPRLIPNREQLFVACATNVGRLL EEEECCCCEEEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHEEEEECCCCCCEE IFSLEELPELSRGKGNKLISIPVAKAVSREEYIVDMQVLTTNDSLTVYAGKRHFTLKGED EEEHHHCCHHHCCCCCEEEEEHHHHHHCCCCEEEEEEEEEECCCEEEEECCEEEEEECCC LTHYKGERGRRGNRLPRGLQNVSQLHVTQSE CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC >Mature Secondary Structure MKKIPNMNEVTEKKPLTEFTEKAYLDYSMYVILDRALPSIADGLKPVQRRIVYAMSELGL CCCCCCCHHHHHCCCHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC KATAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPFVDGQGNWGSPDDPKS HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHH FAAMRYTEARLSHYADVLLGELLQGTVDWVDNFDGTLQEPALLPARLPNILLNGATGIAV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHEECCCCCEEH GMASDILPHNLTEVANACIHLLDNPQADIKTICEYIKGPDFPTEAEIISPSETIRAIYES HHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHC GNGSIKMRAIYTQEKQNIVITALPYQVSGARVMEQIALQMQQKKLPMVEDLRDESDHEHP CCCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCC TRLVIIPRSNRVDIESLMSHLFATTDLERSYRVNFNMIGLDGKPRVKGLLAILTEWLEFR EEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHH LATVKRRLQFRLEKVLERIHILEGLLIAYLNIDEVIAIIREHDQPKQGLISRFNLTERQA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHH EAILEMKLRHLAKLEEIKLRGELDELSDERDTLQKTLASHSLLKELVKEEITKDRDEFGD HHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC PRLSPIITREDSQALKEEDILPNEPITVVLSKNGWVRAAKGHDVDGKELSYKAGDEFKAQ CCCCCEEECCHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCHHHH TLARTNQQVLFFDGEGKVYSLPGHVLPSARGQGEPLTGKLNPAEGVLFEAIVGGEPEQKV HHHCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCEE LLATDSGYGFIAKIEDLYVKNRNGKACIKLSENSHILPPRLIPNREQLFVACATNVGRLL EEEECCCCEEEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHEEEEECCCCCCEE IFSLEELPELSRGKGNKLISIPVAKAVSREEYIVDMQVLTTNDSLTVYAGKRHFTLKGED EEEHHHCCHHHCCCCCEEEEEHHHHHHCCCCEEEEEEEEEECCCEEEEECCEEEEEECCC LTHYKGERGRRGNRLPRGLQNVSQLHVTQSE CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10984043 [H]