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The map label for this gene is cbs [H]

Identifier: 52843145

GI number: 52843145

Start: 3340034

End: 3340984

Strand: Direct

Name: cbs [H]

Synonym: lpg2951

Alternate gene names: 52843145

Gene position: 3340034-3340984 (Clockwise)

Preceding gene: 52843138

Following gene: 52843147

Centisome position: 98.3

GC content: 43.95

Gene sequence:

>951_bases
ATGATTTACCCTAACATCCTGGCCACTATAGGCCATACTCCCGTTGTAAAAATTAACAGGCTTGGAAAAGATCTGGAATG
TGAGCTGTATGCCAAATGCGAATTCTTTAATCCTGGCGGCTCCGTAAAAGATCGTATTGGCTATGAAATGGTAGTAAAAG
CAGAAAAGGAAGGGAGAATTAAACCGGGAGATACCTTGATCGAGCCTACTTCCGGGAACACCGGCATAGGTATAGCCCTG
GCAGGCGCTGTATTAGGCTACAAAGTGATTATTACCATGCCAGAAAAAATGAGCCAGGAAAAGCAATCCGTGCTCGAACG
CCTGGGAGCCATCATTTATCGAACGCCAACAGAAGCGGCGTATAATGATCCAGACAGTCATATTTCTCTGGCTAAAAAAT
TACAAGCTGAAATCCCTAACTCCCATATCCTTGATCAATACGCGAACCCCAATAACCCCAATGCCCATTATTTTGGGACC
GCTCAGGAAATTATTGACGACTTCGGAAAAGATTTACATATGGTTGTTGCTGGCGTTGGGACAGGCGGAACAATTACAGG
CATTGCCAAACGCCTTAAAGAATTTAACCCTGCCATCAAAATCATTGGAGCAGATCCCGAAGGCTCAATTCTCGGTGGCG
GCACAGAAATCAAATCTTATCATGTTGAAGGGATAGGTTATGATTTCTTCCCTGATGTGCTGGATAATACGTTGATTGAT
GCCTACATAAAAACCAATGATGCGGATTCTTTCCGTACTGCCAGACGCCTCATTAAAGAAGAAGGACTGTTAATTGGCGG
CTCATGTGGAGCAGCGATGTGGGCCGCATTGCAAGCAGCCAAATCCTTAAGCAAAGGACAAAAATGTCTGGTGATTTTAC
CCGACTCTATCCGTAATTACATGTCCAAATTTGCCAATGATGAATGGATGAAAGAAATGGGCTTTCTTTAA

Upstream 100 bases:

>100_bases
CCGTTAATAAGAGAAAATAACTTGATTGTAGAAACCACCATTTTGCTATTTTACCTTATCCGCTTATAATCAACTCATTT
CACCATGACAAAGGACTACC

Downstream 100 bases:

>100_bases
TTGAAAGCCATAAAAAACTATCGTATTGCTATTTCATCAAAAAATGATCGTTGACAATCCGCTTTGAAAAAATGATCCGG
ATTGCCAACACACTTTAACC

Product: cystathionine beta synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MIYPNILATIGHTPVVKINRLGKDLECELYAKCEFFNPGGSVKDRIGYEMVVKAEKEGRIKPGDTLIEPTSGNTGIGIAL
AGAVLGYKVIITMPEKMSQEKQSVLERLGAIIYRTPTEAAYNDPDSHISLAKKLQAEIPNSHILDQYANPNNPNAHYFGT
AQEIIDDFGKDLHMVVAGVGTGGTITGIAKRLKEFNPAIKIIGADPEGSILGGGTEIKSYHVEGIGYDFFPDVLDNTLID
AYIKTNDADSFRTARRLIKEEGLLIGGSCGAAMWAALQAAKSLSKGQKCLVILPDSIRNYMSKFANDEWMKEMGFL

Sequences:

>Translated_316_residues
MIYPNILATIGHTPVVKINRLGKDLECELYAKCEFFNPGGSVKDRIGYEMVVKAEKEGRIKPGDTLIEPTSGNTGIGIAL
AGAVLGYKVIITMPEKMSQEKQSVLERLGAIIYRTPTEAAYNDPDSHISLAKKLQAEIPNSHILDQYANPNNPNAHYFGT
AQEIIDDFGKDLHMVVAGVGTGGTITGIAKRLKEFNPAIKIIGADPEGSILGGGTEIKSYHVEGIGYDFFPDVLDNTLID
AYIKTNDADSFRTARRLIKEEGLLIGGSCGAAMWAALQAAKSLSKGQKCLVILPDSIRNYMSKFANDEWMKEMGFL
>Mature_316_residues
MIYPNILATIGHTPVVKINRLGKDLECELYAKCEFFNPGGSVKDRIGYEMVVKAEKEGRIKPGDTLIEPTSGNTGIGIAL
AGAVLGYKVIITMPEKMSQEKQSVLERLGAIIYRTPTEAAYNDPDSHISLAKKLQAEIPNSHILDQYANPNNPNAHYFGT
AQEIIDDFGKDLHMVVAGVGTGGTITGIAKRLKEFNPAIKIIGADPEGSILGGGTEIKSYHVEGIGYDFFPDVLDNTLID
AYIKTNDADSFRTARRLIKEEGLLIGGSCGAAMWAALQAAKSLSKGQKCLVILPDSIRNYMSKFANDEWMKEMGFL

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=322, Percent_Identity=59.9378881987578, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI295821200, Length=322, Percent_Identity=59.9378881987578, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI4557415, Length=322, Percent_Identity=59.9378881987578, Blast_Score=392, Evalue=1e-109,
Organism=Escherichia coli, GI2367138, Length=276, Percent_Identity=38.768115942029, Blast_Score=187, Evalue=5e-49,
Organism=Escherichia coli, GI1788754, Length=311, Percent_Identity=40.1929260450161, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25147552, Length=326, Percent_Identity=51.5337423312883, Blast_Score=305, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17534315, Length=328, Percent_Identity=50.9146341463415, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17535051, Length=296, Percent_Identity=40.8783783783784, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI115535073, Length=304, Percent_Identity=42.7631578947368, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=37.9084967320261, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=38.9078498293515, Blast_Score=190, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17561720, Length=279, Percent_Identity=38.3512544802867, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI32566672, Length=221, Percent_Identity=33.0316742081448, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6321594, Length=324, Percent_Identity=54.320987654321, Blast_Score=334, Evalue=9e-93,
Organism=Saccharomyces cerevisiae, GI6321449, Length=323, Percent_Identity=35.6037151702786, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24643623, Length=321, Percent_Identity=57.9439252336449, Blast_Score=356, Evalue=1e-98,
Organism=Drosophila melanogaster, GI20129101, Length=321, Percent_Identity=57.9439252336449, Blast_Score=356, Evalue=1e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 34358; Mature: 34358

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYPNILATIGHTPVVKINRLGKDLECELYAKCEFFNPGGSVKDRIGYEMVVKAEKEGRI
CCCCHHHHHCCCCCEEEECCCCCCCCEEEEEEEEEECCCCCCHHHCCEEEEEEECCCCCC
KPGDTLIEPTSGNTGIGIALAGAVLGYKVIITMPEKMSQEKQSVLERLGAIIYRTPTEAA
CCCCCEEECCCCCCCHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHEEEECCCCCC
YNDPDSHISLAKKLQAEIPNSHILDQYANPNNPNAHYFGTAQEIIDDFGKDLHMVVAGVG
CCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEECCHHHHHHHHCCCEEEEEEECC
TGGTITGIAKRLKEFNPAIKIIGADPEGSILGGGTEIKSYHVEGIGYDFFPDVLDNTLID
CCCHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCEEEEEEECCCCCCCCHHHHHHHHEE
AYIKTNDADSFRTARRLIKEEGLLIGGSCGAAMWAALQAAKSLSKGQKCLVILPDSIRNY
HEEECCCCHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
MSKFANDEWMKEMGFL
HHHHCCHHHHHHHCCC
>Mature Secondary Structure
MIYPNILATIGHTPVVKINRLGKDLECELYAKCEFFNPGGSVKDRIGYEMVVKAEKEGRI
CCCCHHHHHCCCCCEEEECCCCCCCCEEEEEEEEEECCCCCCHHHCCEEEEEEECCCCCC
KPGDTLIEPTSGNTGIGIALAGAVLGYKVIITMPEKMSQEKQSVLERLGAIIYRTPTEAA
CCCCCEEECCCCCCCHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHEEEECCCCCC
YNDPDSHISLAKKLQAEIPNSHILDQYANPNNPNAHYFGTAQEIIDDFGKDLHMVVAGVG
CCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEECCHHHHHHHHCCCEEEEEEECC
TGGTITGIAKRLKEFNPAIKIIGADPEGSILGGGTEIKSYHVEGIGYDFFPDVLDNTLID
CCCHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCEEEEEEECCCCCCCCHHHHHHHHEE
AYIKTNDADSFRTARRLIKEEGLLIGGSCGAAMWAALQAAKSLSKGQKCLVILPDSIRNY
HEEECCCCHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
MSKFANDEWMKEMGFL
HHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]