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The map label for this gene is lpxA [H]

Identifier: 52843137

GI number: 52843137

Start: 3329038

End: 3329868

Strand: Direct

Name: lpxA [H]

Synonym: lpg2943

Alternate gene names: 52843137

Gene position: 3329038-3329868 (Clockwise)

Preceding gene: 52843136

Following gene: 52843138

Centisome position: 97.98

GC content: 41.03

Gene sequence:

>831_bases
ATGCAAATGAGTCAGTTGGATCATGTTCATGCGGTTAACAATTTATATATGCTCTCCCATCAAATTCATCCTACAGCTAT
CGTATCAGCCAACGCCAGAATTGGACGAGATGTGGTTGTAGGTCCATATTCAATTGTTGAAGACAATGTCAGCATTGGAC
AAGGAACCGTCATTGGTTCTCATGTGTCGATAAAGTCCTGGACAGAAATAGGTGAATATAATCAGATTGAAACGGGAGCA
ATCATTGGAGCAATCCCGCAGGATCTGAAGTTCAGCGGAGAAAACAGCACCGCCATAATCGGTAATAATAACATTATTCG
CGAATACGTTACGATCAGTAGAGGAACATCTGGGGGAGGAGGAATTACTCGAATAGGAAACAACAATGTCATAATGACTT
CCGCCCATATAGCCCATGATGTTCAGATGGGTAATCATAATATCATCTCCAATGCGGTAGCCGTAGCCGGGCATGTAATC
ATTGACGATTGGGTAACCATAGGCGGTTTATGCGGCATACACCAATTCGTACAATTAGGACGGATGAGTATGATTGGTTC
TCAAACCAGAATTACAAAAGACGTACTGCCTTTCACGTTGGTTTGCGGAAACCCAGCCAAGCGTTTTGGTATTAACATTG
AAAGATTGCAACGAAATGGATACAGTTCTGTCGCAAGAATGCAAATTCAACGAGCCTACAAGATACTTTTTCATGATGGT
CATCTTTTGACAAATGCCATTGAAATACTCAAGCGTGAATTCATAGACAATAATGATGTGGCTTATATTCTCAAGTTTCT
TGAAAATTCCAAACGCAGCTTTTATCGCTAA

Upstream 100 bases:

>100_bases
CTTTCCCTCTATATCAAATCATTTTCCCAGAACAGATTTAAGAGTAGTATAGAGCACGTTGTAACCAGCATTTAATTTAT
AGTTGTAGTGGAGGTGAACC

Downstream 100 bases:

>100_bases
TTTTTTAGAGTGTGTATGTCAAATTACCAATTTACAAAACCTGCAGGACCATTTCGTTTATTCGAATTAGCTAAGATTTC
TGGTGCTACACTGTATGAAG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MQMSQLDHVHAVNNLYMLSHQIHPTAIVSANARIGRDVVVGPYSIVEDNVSIGQGTVIGSHVSIKSWTEIGEYNQIETGA
IIGAIPQDLKFSGENSTAIIGNNNIIREYVTISRGTSGGGGITRIGNNNVIMTSAHIAHDVQMGNHNIISNAVAVAGHVI
IDDWVTIGGLCGIHQFVQLGRMSMIGSQTRITKDVLPFTLVCGNPAKRFGINIERLQRNGYSSVARMQIQRAYKILFHDG
HLLTNAIEILKREFIDNNDVAYILKFLENSKRSFYR

Sequences:

>Translated_276_residues
MQMSQLDHVHAVNNLYMLSHQIHPTAIVSANARIGRDVVVGPYSIVEDNVSIGQGTVIGSHVSIKSWTEIGEYNQIETGA
IIGAIPQDLKFSGENSTAIIGNNNIIREYVTISRGTSGGGGITRIGNNNVIMTSAHIAHDVQMGNHNIISNAVAVAGHVI
IDDWVTIGGLCGIHQFVQLGRMSMIGSQTRITKDVLPFTLVCGNPAKRFGINIERLQRNGYSSVARMQIQRAYKILFHDG
HLLTNAIEILKREFIDNNDVAYILKFLENSKRSFYR
>Mature_276_residues
MQMSQLDHVHAVNNLYMLSHQIHPTAIVSANARIGRDVVVGPYSIVEDNVSIGQGTVIGSHVSIKSWTEIGEYNQIETGA
IIGAIPQDLKFSGENSTAIIGNNNIIREYVTISRGTSGGGGITRIGNNNVIMTSAHIAHDVQMGNHNIISNAVAVAGHVI
IDDWVTIGGLCGIHQFVQLGRMSMIGSQTRITKDVLPFTLVCGNPAKRFGINIERLQRNGYSSVARMQIQRAYKILFHDG
HLLTNAIEILKREFIDNNDVAYILKFLENSKRSFYR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=255, Percent_Identity=41.9607843137255, Blast_Score=205, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 30333; Mature: 30333

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMSQLDHVHAVNNLYMLSHQIHPTAIVSANARIGRDVVVGPYSIVEDNVSIGQGTVIGS
CCCCHHHHHHHHHHEEEEEECCCCEEEEECCCCCCCEEEECCHHHEECCCCCCCCEEEEC
HVSIKSWTEIGEYNQIETGAIIGAIPQDLKFSGENSTAIIGNNNIIREYVTISRGTSGGG
CEEHHHHHHCCCCCCCCCCEEEECCCCCCEECCCCCEEEEECCCEEEEEEEEECCCCCCC
GITRIGNNNVIMTSAHIAHDVQMGNHNIISNAVAVAGHVIIDDWVTIGGLCGIHQFVQLG
CEEEECCCCEEEEEHHHHEEEECCCCHHHHHHHHHHCEEEEECHHHHHHHHHHHHHHHHH
RMSMIGSQTRITKDVLPFTLVCGNPAKRFGINIERLQRNGYSSVARMQIQRAYKILFHDG
HHHHCCCCHHHHHHCCCEEEEECCCHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCC
HLLTNAIEILKREFIDNNDVAYILKFLENSKRSFYR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQMSQLDHVHAVNNLYMLSHQIHPTAIVSANARIGRDVVVGPYSIVEDNVSIGQGTVIGS
CCCCHHHHHHHHHHEEEEEECCCCEEEEECCCCCCCEEEECCHHHEECCCCCCCCEEEEC
HVSIKSWTEIGEYNQIETGAIIGAIPQDLKFSGENSTAIIGNNNIIREYVTISRGTSGGG
CEEHHHHHHCCCCCCCCCCEEEECCCCCCEECCCCCEEEEECCCEEEEEEEEECCCCCCC
GITRIGNNNVIMTSAHIAHDVQMGNHNIISNAVAVAGHVIIDDWVTIGGLCGIHQFVQLG
CEEEECCCCEEEEEHHHHEEEECCCCHHHHHHHHHHCEEEEECHHHHHHHHHHHHHHHHH
RMSMIGSQTRITKDVLPFTLVCGNPAKRFGINIERLQRNGYSSVARMQIQRAYKILFHDG
HHHHCCCCHHHHHHCCCEEEEECCCHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCC
HLLTNAIEILKREFIDNNDVAYILKFLENSKRSFYR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA