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The map label for this gene is ubiE [H]

Identifier: 52843097

GI number: 52843097

Start: 3285417

End: 3286169

Strand: Direct

Name: ubiE [H]

Synonym: lpg2903

Alternate gene names: 52843097

Gene position: 3285417-3286169 (Clockwise)

Preceding gene: 52843096

Following gene: 52843098

Centisome position: 96.69

GC content: 40.24

Gene sequence:

>753_bases
ATGACGAATCAGAAACAAACCACCCATTTTGGTTTTAAATCAGTAGACTGGAATGAGAAAGAAAAGAAAGTAGCAGAAGT
ATTTCATTCTGTTGCTAAAAATTATGATCGTATGAATGATCTGATGTCCTTGGGAATTCATCATCTATGGAAACGCTATA
CCATTGAATTAAGTCATGTTCGACCTGGGCAGAGCGTATTGGATTTGGCCGGGGGCAGCGGTGATTTAACCCGGTTATTA
TTGCAAAAAGTGGGCGACTCCGGACAAGTTATTCTTGCCGACATCAACGCAGCCATGCTCCATGTTGGCCGCGATCGCTT
GCTTGATGAGGGATTATTTAAAAACATTCGTTATGTTCAGGGTAATGCGCAATGCCTCCCTTTTGCGGATAACAGTTTTC
ATTGCATCACTATGGGATTTGGACTTAGAAATGTTACTGATAAAGACGAAGCGCTGCAATCCATGTACAGAGTATGCAAA
CCGGGTGGGAAATTAATGGTGCTTGAATTTTCAACACCAGTTTTTCCTGGACTTAAGCCCGTTTATGATTGGTATTCATT
TAACATTTTGCCAAAAATCGGAAAATTTGTTGCTAACGATGAAGCCAGCTATCAATACCTTGCAGAATCAATCAGAATGC
ATCCTGATCAGGAAACATTAAAAGCAATGATTGAACGGGTTGGATTTGAGGATTGTCATTATCATAATTTAAGTGGCGGT
ATAGTCGCTCTGCATATCGCCTACAAATATTGA

Upstream 100 bases:

>100_bases
TTTCATCTGTACATGGATAAAAAAAAGTATACAATTTTTAACTGGGTATCTTAATGATTATCGGTTAATATGAACACTTT
AATGATACTATCCGGCAAAT

Downstream 100 bases:

>100_bases
GTTGATTATGTTAAAAGAATACTCGCTGAAAGCATTACAAACAGCCATCAATCAGGCGATGAAGCTTGATGAGCAAATGC
CGCAAAAACTTCAAAAACTC

Product: ubiquinone/menaquinone biosynthesis methyltransferase UbiE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTNQKQTTHFGFKSVDWNEKEKKVAEVFHSVAKNYDRMNDLMSLGIHHLWKRYTIELSHVRPGQSVLDLAGGSGDLTRLL
LQKVGDSGQVILADINAAMLHVGRDRLLDEGLFKNIRYVQGNAQCLPFADNSFHCITMGFGLRNVTDKDEALQSMYRVCK
PGGKLMVLEFSTPVFPGLKPVYDWYSFNILPKIGKFVANDEASYQYLAESIRMHPDQETLKAMIERVGFEDCHYHNLSGG
IVALHIAYKY

Sequences:

>Translated_250_residues
MTNQKQTTHFGFKSVDWNEKEKKVAEVFHSVAKNYDRMNDLMSLGIHHLWKRYTIELSHVRPGQSVLDLAGGSGDLTRLL
LQKVGDSGQVILADINAAMLHVGRDRLLDEGLFKNIRYVQGNAQCLPFADNSFHCITMGFGLRNVTDKDEALQSMYRVCK
PGGKLMVLEFSTPVFPGLKPVYDWYSFNILPKIGKFVANDEASYQYLAESIRMHPDQETLKAMIERVGFEDCHYHNLSGG
IVALHIAYKY
>Mature_249_residues
TNQKQTTHFGFKSVDWNEKEKKVAEVFHSVAKNYDRMNDLMSLGIHHLWKRYTIELSHVRPGQSVLDLAGGSGDLTRLLL
QKVGDSGQVILADINAAMLHVGRDRLLDEGLFKNIRYVQGNAQCLPFADNSFHCITMGFGLRNVTDKDEALQSMYRVCKP
GGKLMVLEFSTPVFPGLKPVYDWYSFNILPKIGKFVANDEASYQYLAESIRMHPDQETLKAMIERVGFEDCHYHNLSGGI
VALHIAYKY

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=275, Percent_Identity=42.5454545454545, Blast_Score=217, Evalue=8e-57,
Organism=Escherichia coli, GI48994983, Length=247, Percent_Identity=61.9433198380567, Blast_Score=332, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17557039, Length=246, Percent_Identity=44.3089430894309, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6323526, Length=261, Percent_Identity=42.5287356321839, Blast_Score=181, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24641702, Length=262, Percent_Identity=41.9847328244275, Blast_Score=211, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28376; Mature: 28245

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQKQTTHFGFKSVDWNEKEKKVAEVFHSVAKNYDRMNDLMSLGIHHLWKRYTIELSHV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECC
RPGQSVLDLAGGSGDLTRLLLQKVGDSGQVILADINAAMLHVGRDRLLDEGLFKNIRYVQ
CCCCHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCEEEC
GNAQCLPFADNSFHCITMGFGLRNVTDKDEALQSMYRVCKPGGKLMVLEFSTPVFPGLKP
CCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHH
VYDWYSFNILPKIGKFVANDEASYQYLAESIRMHPDQETLKAMIERVGFEDCHYHNLSGG
HHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEECCCCC
IVALHIAYKY
EEEEEEEECC
>Mature Secondary Structure 
TNQKQTTHFGFKSVDWNEKEKKVAEVFHSVAKNYDRMNDLMSLGIHHLWKRYTIELSHV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECC
RPGQSVLDLAGGSGDLTRLLLQKVGDSGQVILADINAAMLHVGRDRLLDEGLFKNIRYVQ
CCCCHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCEEEC
GNAQCLPFADNSFHCITMGFGLRNVTDKDEALQSMYRVCKPGGKLMVLEFSTPVFPGLKP
CCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHH
VYDWYSFNILPKIGKFVANDEASYQYLAESIRMHPDQETLKAMIERVGFEDCHYHNLSGG
HHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEECCCCC
IVALHIAYKY
EEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA