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The map label for this gene is guaC [H]

Identifier: 52843039

GI number: 52843039

Start: 3217663

End: 3218676

Strand: Direct

Name: guaC [H]

Synonym: lpg2843

Alternate gene names: 52843039

Gene position: 3217663-3218676 (Clockwise)

Preceding gene: 52843038

Following gene: 52843041

Centisome position: 94.7

GC content: 46.55

Gene sequence:

>1014_bases
ATGACTGATCAAGCGATCACTTTTGATGATGTTCTGCTCGTTCCATCGTACAACCATCATGAATCCAGGCGAGTTGTTGA
AACAACCAGTACCGACAGGTTAGGTAAACTGACTTTAAATCTTCCGGTAATCAGCGCCAATATGGATACAATTACCGAAA
GTAATATGGCTAATTTTATGCACAGCAAAGGAGCCATGGGCGCTTTACACCGATTTATGACCATAGAAGAAAATATTCAG
GAATTTAAGAAATGCAAAGGACCTGTCTTTGTATCGGTTGGATGTACTGAAAATGAATTACAACGAGCAGAGGCACTGCG
AGATGCAGGAGCCGATTTCTTTTGTGTTGATGTAGCGCATGCCCACGCCAAATACGTTGGCAAAACATTAAAAAGCTTAC
GTCAGTTATTGGGAAGTCGCTGCATTATGGCTGGGAATGTCGCCACTTATGCCGGGGCAGATTATCTTGCGTCTTGTGGC
GCTGATATTATTAAAGCAGGTATTGGAGGAGGCTCAGTATGCAGCACCCGAATTAAAACCGGCTTTGGCGTCCCCATGTT
GACCTGTATTCAGGATTGCTCACGTGCCGATCGTTCCATCGTTGCTGATGGCGGCATCAAAACATCGGGTGATATCGTCA
AAGCATTGGCCTTTGGCGCTGATTTTGTGATGATAGGCGGCATGTTAGCCGGCTCTGCCCCCACGCCAGGAGAGGTCTTT
CAAAAAGATGACGGAAGCAAAGTCAAACGCTATCGAGGCATGGCATCCCGAGAAGCCCAGGAAGCATTCCTTGGACAAAT
GCATGAATGGAAAACAGCAGAAGGTGTTGCGACTGAAGTGCCATTTAAAGAAAACCCTGATGGGATTATTGCTGATATCA
TAGGCGGATTGCGCTCTGGTCTAACCTATGCCGGCGCCGACTCCATCAGCGAATTGCAAAGAAAATTGAATTATGTGATT
GTCACCCAGGCGGGACGCATAGAAAGCTTGCCTCACAAGTTGCTGGAGGGATAA

Upstream 100 bases:

>100_bases
TGGGAACACAGCGCTCATATGACTTTGACTCGGGGAGAGCGCTCAAGGCTGGCTTTTTATGCGGCTGAGCATTTATAGTA
TTTGTTTATGAGGATTAATA

Downstream 100 bases:

>100_bases
CTCACCAACCCGGATAATCTGTTTTCACATCTATCCAGGCATAGACTGACTAGGTGTTGGGACATCAGAAGATGAGCCTG
AGCCAGAAGATTGACCACTC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTDQAITFDDVLLVPSYNHHESRRVVETTSTDRLGKLTLNLPVISANMDTITESNMANFMHSKGAMGALHRFMTIEENIQ
EFKKCKGPVFVSVGCTENELQRAEALRDAGADFFCVDVAHAHAKYVGKTLKSLRQLLGSRCIMAGNVATYAGADYLASCG
ADIIKAGIGGGSVCSTRIKTGFGVPMLTCIQDCSRADRSIVADGGIKTSGDIVKALAFGADFVMIGGMLAGSAPTPGEVF
QKDDGSKVKRYRGMASREAQEAFLGQMHEWKTAEGVATEVPFKENPDGIIADIIGGLRSGLTYAGADSISELQRKLNYVI
VTQAGRIESLPHKLLEG

Sequences:

>Translated_337_residues
MTDQAITFDDVLLVPSYNHHESRRVVETTSTDRLGKLTLNLPVISANMDTITESNMANFMHSKGAMGALHRFMTIEENIQ
EFKKCKGPVFVSVGCTENELQRAEALRDAGADFFCVDVAHAHAKYVGKTLKSLRQLLGSRCIMAGNVATYAGADYLASCG
ADIIKAGIGGGSVCSTRIKTGFGVPMLTCIQDCSRADRSIVADGGIKTSGDIVKALAFGADFVMIGGMLAGSAPTPGEVF
QKDDGSKVKRYRGMASREAQEAFLGQMHEWKTAEGVATEVPFKENPDGIIADIIGGLRSGLTYAGADSISELQRKLNYVI
VTQAGRIESLPHKLLEG
>Mature_336_residues
TDQAITFDDVLLVPSYNHHESRRVVETTSTDRLGKLTLNLPVISANMDTITESNMANFMHSKGAMGALHRFMTIEENIQE
FKKCKGPVFVSVGCTENELQRAEALRDAGADFFCVDVAHAHAKYVGKTLKSLRQLLGSRCIMAGNVATYAGADYLASCGA
DIIKAGIGGGSVCSTRIKTGFGVPMLTCIQDCSRADRSIVADGGIKTSGDIVKALAFGADFVMIGGMLAGSAPTPGEVFQ
KDDGSKVKRYRGMASREAQEAFLGQMHEWKTAEGVATEVPFKENPDGIIADIIGGLRSGLTYAGADSISELQRKLNYVIV
TQAGRIESLPHKLLEG

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI156104880, Length=333, Percent_Identity=38.1381381381381, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI50541956, Length=334, Percent_Identity=37.7245508982036, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI50541954, Length=335, Percent_Identity=37.6119402985075, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI50541952, Length=335, Percent_Identity=37.6119402985075, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI50541948, Length=335, Percent_Identity=37.6119402985075, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI217035146, Length=259, Percent_Identity=32.046332046332, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI217035148, Length=259, Percent_Identity=32.046332046332, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI217035150, Length=259, Percent_Identity=32.046332046332, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI34328928, Length=259, Percent_Identity=32.046332046332, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI34328930, Length=259, Percent_Identity=32.046332046332, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI217035152, Length=259, Percent_Identity=32.046332046332, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI156616279, Length=259, Percent_Identity=32.046332046332, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI66933016, Length=259, Percent_Identity=29.7297297297297, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786293, Length=340, Percent_Identity=35, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1788855, Length=252, Percent_Identity=38.4920634920635, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17560440, Length=346, Percent_Identity=31.7919075144509, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71994385, Length=226, Percent_Identity=33.1858407079646, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71994389, Length=171, Percent_Identity=36.8421052631579, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323585, Length=263, Percent_Identity=30.4182509505703, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323464, Length=263, Percent_Identity=30.0380228136882, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322012, Length=263, Percent_Identity=30.0380228136882, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24641071, Length=267, Percent_Identity=30.3370786516854, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24641073, Length=267, Percent_Identity=30.3370786516854, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28571163, Length=267, Percent_Identity=30.3370786516854, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 36078; Mature: 35946

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQAITFDDVLLVPSYNHHESRRVVETTSTDRLGKLTLNLPVISANMDTITESNMANFM
CCCCEEEECCEEEECCCCCCCCCEEEECCCCCCCEEEEEECEEEECCCHHHHHHHHHHHH
HSKGAMGALHRFMTIEENIQEFKKCKGPVFVSVGCTENELQRAEALRDAGADFFCVDVAH
HCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEHHHH
AHAKYVGKTLKSLRQLLGSRCIMAGNVATYAGADYLASCGADIIKAGIGGGSVCSTRIKT
HHHHHHHHHHHHHHHHHHCCCEEECCCHHHCCHHHHHHCCHHHHHHCCCCCHHHHHHHHC
GFGVPMLTCIQDCSRADRSIVADGGIKTSGDIVKALAFGADFVMIGGMLAGSAPTPGEVF
CCCCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
QKDDGSKVKRYRGMASREAQEAFLGQMHEWKTAEGVATEVPFKENPDGIIADIIGGLRSG
CCCCCHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHC
LTYAGADSISELQRKLNYVIVTQAGRIESLPHKLLEG
CCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHCC
>Mature Secondary Structure 
TDQAITFDDVLLVPSYNHHESRRVVETTSTDRLGKLTLNLPVISANMDTITESNMANFM
CCCEEEECCEEEECCCCCCCCCEEEECCCCCCCEEEEEECEEEECCCHHHHHHHHHHHH
HSKGAMGALHRFMTIEENIQEFKKCKGPVFVSVGCTENELQRAEALRDAGADFFCVDVAH
HCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEHHHH
AHAKYVGKTLKSLRQLLGSRCIMAGNVATYAGADYLASCGADIIKAGIGGGSVCSTRIKT
HHHHHHHHHHHHHHHHHHCCCEEECCCHHHCCHHHHHHCCHHHHHHCCCCCHHHHHHHHC
GFGVPMLTCIQDCSRADRSIVADGGIKTSGDIVKALAFGADFVMIGGMLAGSAPTPGEVF
CCCCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
QKDDGSKVKRYRGMASREAQEAFLGQMHEWKTAEGVATEVPFKENPDGIIADIIGGLRSG
CCCCCHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHC
LTYAGADSISELQRKLNYVIVTQAGRIESLPHKLLEG
CCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA