Click here to switch to the map view.

The map label for this gene is bcr [H]

Identifier: 52843037

GI number: 52843037

Start: 3214880

End: 3216079

Strand: Direct

Name: bcr [H]

Synonym: lpg2841

Alternate gene names: 52843037

Gene position: 3214880-3216079 (Clockwise)

Preceding gene: 52843036

Following gene: 52843038

Centisome position: 94.62

GC content: 41.58

Gene sequence:

>1200_bases
ATGTTTATCCGCAACCTGCAACTTTTTATTGTTGTCGCCTCTTGCATACTGGTTTTAATTGGTACAGATATTTTGTTACC
AAGCCTGCCTAACATTGCTCACGCACTGTCTGTCTCATCAAATGAAGCCAAAATGCTCATTTCCATTTTCATGATAGGGC
AATTTTCTACAGTTCTTATTTGGGGCGTTATTGCCGACCGGCTAGGCAGAAGAAAAACATTATTTCTGGGGATGCTTATT
TTCTTTATAGGCTCAATCTTCAGTTTAAAAGCCGATTCAATTCAGTTGTTACTGGCTTGTCGATTCTTGCAAGGTACTGG
CGCAGTCGTTGTCCCTGTTGCAGGTTGGGCTTTAGTCCAGGATCTCTTCCCCAAAGACGAAGGAGCTCGCATCATGACCT
GGATTGGGACACTGACTGCAGTGATTCCACTCTTTGCCCCCGCATTAGGGGGACAATTGGATGTGTTATATGGTTGGCGT
TCAAATCTTTATTGTATCGCATTTTACTCTTTCATTTTATGCGTCATTATGCTGTTTTTACCCAGAACTATCCCCGTGCA
AAAAACGACAACTGCTGACCTGAAGGAAACACTAAGCATTTACATTCGAATTATAAAAAACAAAACATTTATTTCCTATA
TCGCACTATTTGGATTATTAAACTGTGGCGAGTGGTGCTTCCTGACTGTAGCTCCATTTTATTATTCGCACGCACATATT
GCTGCTGACACCATGGGGATATTATTAATGATTACTTCCATGGGATTTGTCTGCGGATCGTTACTGGCCTCCCGCTTATT
TAATCGCCTGGGGATTGATAAAATCATAGCATTGGGAATTCAGTTGGCTGTAATGAGCAGCCTGATGTTGTTAATAGGAG
AATACTTTCACTGGAGCAAGTACCAACTCTATAATGCCATAACTATCGGCGTCTATATTCTAAGCTCAGCCTTGCTATGG
GGCGCAACCACATCCAGAGCCCTGCAATGCTTCGATGATTGCAGAGGCTCAGCCTCTGCAATTCGCAGTTTAATATTACT
GTGCTTTGCTGCTTTTGGCACTTATTCAGGTCGCCTGGTTAATCATAATAGCCTGTTCCCTGTTGGATTGTTTTTACTTT
TTATGGCCTTCATTGCATTCATTGTTTTCAATAATAAAGAATTGAAAACAGAACGGCACATGGAAGGCATACCCATTTAA

Upstream 100 bases:

>100_bases
GATGCTTTAAAAAAATACTTTTTATAGAGTATTTAATTAATTTTTGCTATTATTGTTGCGGATAAATACATCAAATACGC
CCTTTTCTTAAGAGTTCAAT

Downstream 100 bases:

>100_bases
CTTAAAAACAGACACTTAATAATATAATTCTTGACGGAACCACCATAGCTCAGCACAATGAACATAGAATTCAGGGATTT
CAATGTACTCCCTGCCTACG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Sulfonamide resistance protein [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MFIRNLQLFIVVASCILVLIGTDILLPSLPNIAHALSVSSNEAKMLISIFMIGQFSTVLIWGVIADRLGRRKTLFLGMLI
FFIGSIFSLKADSIQLLLACRFLQGTGAVVVPVAGWALVQDLFPKDEGARIMTWIGTLTAVIPLFAPALGGQLDVLYGWR
SNLYCIAFYSFILCVIMLFLPRTIPVQKTTTADLKETLSIYIRIIKNKTFISYIALFGLLNCGEWCFLTVAPFYYSHAHI
AADTMGILLMITSMGFVCGSLLASRLFNRLGIDKIIALGIQLAVMSSLMLLIGEYFHWSKYQLYNAITIGVYILSSALLW
GATTSRALQCFDDCRGSASAIRSLILLCFAAFGTYSGRLVNHNSLFPVGLFLLFMAFIAFIVFNNKELKTERHMEGIPI

Sequences:

>Translated_399_residues
MFIRNLQLFIVVASCILVLIGTDILLPSLPNIAHALSVSSNEAKMLISIFMIGQFSTVLIWGVIADRLGRRKTLFLGMLI
FFIGSIFSLKADSIQLLLACRFLQGTGAVVVPVAGWALVQDLFPKDEGARIMTWIGTLTAVIPLFAPALGGQLDVLYGWR
SNLYCIAFYSFILCVIMLFLPRTIPVQKTTTADLKETLSIYIRIIKNKTFISYIALFGLLNCGEWCFLTVAPFYYSHAHI
AADTMGILLMITSMGFVCGSLLASRLFNRLGIDKIIALGIQLAVMSSLMLLIGEYFHWSKYQLYNAITIGVYILSSALLW
GATTSRALQCFDDCRGSASAIRSLILLCFAAFGTYSGRLVNHNSLFPVGLFLLFMAFIAFIVFNNKELKTERHMEGIPI
>Mature_399_residues
MFIRNLQLFIVVASCILVLIGTDILLPSLPNIAHALSVSSNEAKMLISIFMIGQFSTVLIWGVIADRLGRRKTLFLGMLI
FFIGSIFSLKADSIQLLLACRFLQGTGAVVVPVAGWALVQDLFPKDEGARIMTWIGTLTAVIPLFAPALGGQLDVLYGWR
SNLYCIAFYSFILCVIMLFLPRTIPVQKTTTADLKETLSIYIRIIKNKTFISYIALFGLLNCGEWCFLTVAPFYYSHAHI
AADTMGILLMITSMGFVCGSLLASRLFNRLGIDKIIALGIQLAVMSSLMLLIGEYFHWSKYQLYNAITIGVYILSSALLW
GATTSRALQCFDDCRGSASAIRSLILLCFAAFGTYSGRLVNHNSLFPVGLFLLFMAFIAFIVFNNKELKTERHMEGIPI

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=266, Percent_Identity=26.6917293233083, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI48994889, Length=244, Percent_Identity=25.4098360655738, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790146, Length=178, Percent_Identity=30.3370786516854, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082312, Length=192, Percent_Identity=27.0833333333333, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790794, Length=193, Percent_Identity=24.8704663212435, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787065, Length=265, Percent_Identity=21.8867924528302, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44206; Mature: 44206

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIRNLQLFIVVASCILVLIGTDILLPSLPNIAHALSVSSNEAKMLISIFMIGQFSTVLI
CCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
WGVIADRLGRRKTLFLGMLIFFIGSIFSLKADSIQLLLACRFLQGTGAVVVPVAGWALVQ
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHH
DLFPKDEGARIMTWIGTLTAVIPLFAPALGGQLDVLYGWRSNLYCIAFYSFILCVIMLFL
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHC
PRTIPVQKTTTADLKETLSIYIRIIKNKTFISYIALFGLLNCGEWCFLTVAPFYYSHAHI
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHH
AADTMGILLMITSMGFVCGSLLASRLFNRLGIDKIIALGIQLAVMSSLMLLIGEYFHWSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
YQLYNAITIGVYILSSALLWGATTSRALQCFDDCRGSASAIRSLILLCFAAFGTYSGRLV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEE
NHNSLFPVGLFLLFMAFIAFIVFNNKELKTERHMEGIPI
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MFIRNLQLFIVVASCILVLIGTDILLPSLPNIAHALSVSSNEAKMLISIFMIGQFSTVLI
CCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
WGVIADRLGRRKTLFLGMLIFFIGSIFSLKADSIQLLLACRFLQGTGAVVVPVAGWALVQ
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHH
DLFPKDEGARIMTWIGTLTAVIPLFAPALGGQLDVLYGWRSNLYCIAFYSFILCVIMLFL
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHC
PRTIPVQKTTTADLKETLSIYIRIIKNKTFISYIALFGLLNCGEWCFLTVAPFYYSHAHI
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHH
AADTMGILLMITSMGFVCGSLLASRLFNRLGIDKIIALGIQLAVMSSLMLLIGEYFHWSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
YQLYNAITIGVYILSSALLWGATTSRALQCFDDCRGSASAIRSLILLCFAAFGTYSGRLV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEE
NHNSLFPVGLFLLFMAFIAFIVFNNKELKTERHMEGIPI
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8486276; 9278503; 2694948 [H]