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The map label for this gene is ppnK

Identifier: 52843019

GI number: 52843019

Start: 3186518

End: 3187405

Strand: Direct

Name: ppnK

Synonym: lpg2823

Alternate gene names: 52843019

Gene position: 3186518-3187405 (Clockwise)

Preceding gene: 52843018

Following gene: 52843020

Centisome position: 93.78

GC content: 40.99

Gene sequence:

>888_bases
ATGAAACAAAAATTTAAACGAGCCATCTTGTATGCCCGTCAACACAGAGCGAATCAGGAAGTCAATGAAAGCTTGCATCG
ACTGGTTGACTTTTTAAGCACGCAAGACATAGAAATCTTTCAGGACTCAGATACTGCGGCCAGTTTTGAATTAAAAGCCC
CTGTTTTACCTAGAGAAAAAATGGGGGCAAAACACGACTTGATTATTGTCGTGGGTGGTGATGGCAGTTTACTTTCTGCC
TCACGTATGGCTATAAAAGTTAATACACCGGTCATAGGGATTAACAGGGGGAGGCTAGGTTTTTTAACGGATATTTTACC
CCAAGACATTGAGTCCCATTTAGGCCCTGTGCTTAATGGACAATATAATGAAGAAGAACGCTTCTTATTACATACTAAAA
TATATGATAAGGAAAACAGTTATTTTGAAGGCGATGCACTCAATGATGTCGTATTAGGCAGAGGAAGTGAAACGCATTTG
ATAGAATTTGATGTTTACATCAATCAGCAGCTGGTTAGCCATTACCGTTCAGATGGAATGATTTTATCCACTCCAACTGG
CTCAACAGCCTATGCCTTGTCTGCAGGAGGACCGATAATGCATCCTCAACTCAATGCCATCGTCCTGGTACCCATGTTTT
CACACAGCCTAAGTTCCCGACCACTCGTTATCGATGGGGAAGCAGAAATTGAATTGTATATCAGCAAATCAAATGAAACC
GATTTGCGTATCAGTTGTGATGGTCACGAATCCCGTGTCGTTAAACCGGGACAGAAAGTAGCAGTCAAAAAAAACGGTAA
TCGATTGCGTTTGTTACACCCTCTTGATTATCATTATTATGATACATTACGAAGCAAACTTGGTTGGGAATCAAAGCATC
AGGGATAA

Upstream 100 bases:

>100_bases
TGAGGTTACCCCGTTATCTATTCGTTTACGTAAAAAATTTCTCAAGGAACACGATAGAAAAAAAGCCTCTCGTACCGCCA
CAAGTGAAGAATAACACATT

Downstream 100 bases:

>100_bases
AACATGCTCACGACATTGCGCATTGAACATTTTGCTATTGTTAAACAACTGGAACTCGATTTTACACAAGGCATGACCAC
CTTTACGGGCGAAACAGGCG

Product: inorganic polyphosphate/ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKQKFKRAILYARQHRANQEVNESLHRLVDFLSTQDIEIFQDSDTAASFELKAPVLPREKMGAKHDLIIVVGGDGSLLSA
SRMAIKVNTPVIGINRGRLGFLTDILPQDIESHLGPVLNGQYNEEERFLLHTKIYDKENSYFEGDALNDVVLGRGSETHL
IEFDVYINQQLVSHYRSDGMILSTPTGSTAYALSAGGPIMHPQLNAIVLVPMFSHSLSSRPLVIDGEAEIELYISKSNET
DLRISCDGHESRVVKPGQKVAVKKNGNRLRLLHPLDYHYYDTLRSKLGWESKHQG

Sequences:

>Translated_295_residues
MKQKFKRAILYARQHRANQEVNESLHRLVDFLSTQDIEIFQDSDTAASFELKAPVLPREKMGAKHDLIIVVGGDGSLLSA
SRMAIKVNTPVIGINRGRLGFLTDILPQDIESHLGPVLNGQYNEEERFLLHTKIYDKENSYFEGDALNDVVLGRGSETHL
IEFDVYINQQLVSHYRSDGMILSTPTGSTAYALSAGGPIMHPQLNAIVLVPMFSHSLSSRPLVIDGEAEIELYISKSNET
DLRISCDGHESRVVKPGQKVAVKKNGNRLRLLHPLDYHYYDTLRSKLGWESKHQG
>Mature_295_residues
MKQKFKRAILYARQHRANQEVNESLHRLVDFLSTQDIEIFQDSDTAASFELKAPVLPREKMGAKHDLIIVVGGDGSLLSA
SRMAIKVNTPVIGINRGRLGFLTDILPQDIESHLGPVLNGQYNEEERFLLHTKIYDKENSYFEGDALNDVVLGRGSETHL
IEFDVYINQQLVSHYRSDGMILSTPTGSTAYALSAGGPIMHPQLNAIVLVPMFSHSLSSRPLVIDGEAEIELYISKSNET
DLRISCDGHESRVVKPGQKVAVKKNGNRLRLLHPLDYHYYDTLRSKLGWESKHQG

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=257, Percent_Identity=28.7937743190661, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1788968, Length=294, Percent_Identity=42.8571428571429, Blast_Score=230, Evalue=9e-62,
Organism=Saccharomyces cerevisiae, GI6320794, Length=244, Percent_Identity=27.8688524590164, Blast_Score=122, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6325068, Length=216, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322509, Length=244, Percent_Identity=26.2295081967213, Blast_Score=109, Evalue=5e-25,
Organism=Drosophila melanogaster, GI161077047, Length=210, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28573832, Length=210, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28573830, Length=209, Percent_Identity=33.4928229665072, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28573828, Length=209, Percent_Identity=33.4928229665072, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28573826, Length=210, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI281363321, Length=282, Percent_Identity=27.6595744680851, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24653422, Length=277, Percent_Identity=28.158844765343, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281363323, Length=282, Percent_Identity=27.6595744680851, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20129957, Length=282, Percent_Identity=27.6595744680851, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24653424, Length=282, Percent_Identity=27.6595744680851, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK_LEGPA (Q5X168)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_125180.1
- ProteinModelPortal:   Q5X168
- SMR:   Q5X168
- STRING:   Q5X168
- GeneID:   3116686
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp2876
- LegioList:   lpp2876
- eggNOG:   COG0061
- HOGENOM:   HBG713904
- OMA:   FESFMID
- ProtClustDB:   PRK01231
- BioCyc:   LPNE297246:LPP2876-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 33090; Mature: 33090

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKFKRAILYARQHRANQEVNESLHRLVDFLSTQDIEIFQDSDTAASFELKAPVLPREK
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCHHH
MGAKHDLIIVVGGDGSLLSASRMAIKVNTPVIGINRGRLGFLTDILPQDIESHLGPVLNG
CCCCCCEEEEECCCCCEEECCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
QYNEEERFLLHTKIYDKENSYFEGDALNDVVLGRGSETHLIEFDVYINQQLVSHYRSDGM
CCCCCCEEEEEEEEECCCCCEECCCCCCCEEECCCCCCEEEEEEEEECHHHHHHHCCCCE
ILSTPTGSTAYALSAGGPIMHPQLNAIVLVPMFSHSLSSRPLVIDGEAEIELYISKSNET
EEECCCCCEEEEEECCCCEECCCCCEEEEEEECCCCCCCCCEEEECCCEEEEEEECCCCC
DLRISCDGHESRVVKPGQKVAVKKNGNRLRLLHPLDYHYYDTLRSKLGWESKHQG
EEEEEECCCCCCEECCCCEEEEEECCCEEEEEECCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKQKFKRAILYARQHRANQEVNESLHRLVDFLSTQDIEIFQDSDTAASFELKAPVLPREK
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCHHH
MGAKHDLIIVVGGDGSLLSASRMAIKVNTPVIGINRGRLGFLTDILPQDIESHLGPVLNG
CCCCCCEEEEECCCCCEEECCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
QYNEEERFLLHTKIYDKENSYFEGDALNDVVLGRGSETHLIEFDVYINQQLVSHYRSDGM
CCCCCCEEEEEEEEECCCCCEECCCCCCCEEECCCCCCEEEEEEEEECHHHHHHHCCCCE
ILSTPTGSTAYALSAGGPIMHPQLNAIVLVPMFSHSLSSRPLVIDGEAEIELYISKSNET
EEECCCCCEEEEEECCCCEECCCCCEEEEEEECCCCCCCCCEEEECCCEEEEEEECCCCC
DLRISCDGHESRVVKPGQKVAVKKNGNRLRLLHPLDYHYYDTLRSKLGWESKHQG
EEEEEECCCCCCEECCCCEEEEEECCCEEEEEECCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA