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The map label for this gene is pgsA2 [H]

Identifier: 52842997

GI number: 52842997

Start: 3156161

End: 3156715

Strand: Direct

Name: pgsA2 [H]

Synonym: lpg2801

Alternate gene names: 52842997

Gene position: 3156161-3156715 (Clockwise)

Preceding gene: 52842996

Following gene: 52842998

Centisome position: 92.89

GC content: 36.76

Gene sequence:

>555_bases
ATGATACTAAAACATATTCCCAATACCTTAACATTGCTAAGATTAGTTTTAATAGCTCCTTTTCTAATGTATTTATTTCA
TCATGAATACGTTAAGGCCTTTTATATATTTATCGCCGCAGGATTAACTGATGGTTTGGATGGTTGGTTAGCCAGGCATT
TTCAATGGCAAAGTTTTTTTGGCTCATTTGTTGACCCTCTTGCAGATAAATTGTTAGTTGCCTCCAGCTTCATTTCTTTA
GCTCTCTTAAACTCCTTGCCCTGGTGGTTAGTGCTTCTTGTTTTTTTAAGAGACTTCACTATTTCAATGGGAGTATTAGC
CTGGTATTACTTTATACAGCGCAAACTGGATTTTGAGCCCTCTCGACTCAGTAAACTCAATACCGGCTTCCAGTTAACTT
TAGTCACTTTATGTTTATTTGAATTAGCTTACTTTAGATTCCCCTATGATTTAGTTGATATACTCATCTATTTAACTGCC
TTTACCACCGTTACTTCCTACCTTGATTATGTTTGGACCTGGAGCAGAAAAGCCTGGTCCCCCAAAGAATCGTAA

Upstream 100 bases:

>100_bases
CGCCATTTGAAACACTCAAATAATAGAGTATTGTTGGCACAATATATTCCCTCCTCAGCGATAAATAAAAAAAGAGGAGG
AACTAATTTTCGTATAACAG

Downstream 100 bases:

>100_bases
AAATGAATAAACAGCTGGCCCTGGCAATAAAATTGAATGATGAAGCAACCCTGGACGACTTCAATTGGGGTAATAATACC
TTGTTGCAGCAGCAATTAAT

Product: phosphatidylglycerophosphate synthase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MILKHIPNTLTLLRLVLIAPFLMYLFHHEYVKAFYIFIAAGLTDGLDGWLARHFQWQSFFGSFVDPLADKLLVASSFISL
ALLNSLPWWLVLLVFLRDFTISMGVLAWYYFIQRKLDFEPSRLSKLNTGFQLTLVTLCLFELAYFRFPYDLVDILIYLTA
FTTVTSYLDYVWTWSRKAWSPKES

Sequences:

>Translated_184_residues
MILKHIPNTLTLLRLVLIAPFLMYLFHHEYVKAFYIFIAAGLTDGLDGWLARHFQWQSFFGSFVDPLADKLLVASSFISL
ALLNSLPWWLVLLVFLRDFTISMGVLAWYYFIQRKLDFEPSRLSKLNTGFQLTLVTLCLFELAYFRFPYDLVDILIYLTA
FTTVTSYLDYVWTWSRKAWSPKES
>Mature_184_residues
MILKHIPNTLTLLRLVLIAPFLMYLFHHEYVKAFYIFIAAGLTDGLDGWLARHFQWQSFFGSFVDPLADKLLVASSFISL
ALLNSLPWWLVLLVFLRDFTISMGVLAWYYFIQRKLDFEPSRLSKLNTGFQLTLVTLCLFELAYFRFPYDLVDILIYLTA
FTTVTSYLDYVWTWSRKAWSPKES

Specific function: This Protein Catalyzes The Committed Step To The Synthesis Of The Acidic Phospholipids. [C]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=191, Percent_Identity=34.5549738219895, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI10092647, Length=191, Percent_Identity=34.5549738219895, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI1788220, Length=135, Percent_Identity=33.3333333333333, Blast_Score=61, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71984838, Length=191, Percent_Identity=34.5549738219895, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71984834, Length=191, Percent_Identity=34.5549738219895, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320059, Length=206, Percent_Identity=28.6407766990291, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650130, Length=184, Percent_Identity=37.5, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24650126, Length=184, Percent_Identity=37.5, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24650128, Length=184, Percent_Identity=37.5, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 21635; Mature: 21635

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKHIPNTLTLLRLVLIAPFLMYLFHHEYVKAFYIFIAAGLTDGLDGWLARHFQWQSFF
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GSFVDPLADKLLVASSFISLALLNSLPWWLVLLVFLRDFTISMGVLAWYYFIQRKLDFEP
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SRLSKLNTGFQLTLVTLCLFELAYFRFPYDLVDILIYLTAFTTVTSYLDYVWTWSRKAWS
HHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PKES
CCCC
>Mature Secondary Structure
MILKHIPNTLTLLRLVLIAPFLMYLFHHEYVKAFYIFIAAGLTDGLDGWLARHFQWQSFF
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GSFVDPLADKLLVASSFISLALLNSLPWWLVLLVFLRDFTISMGVLAWYYFIQRKLDFEP
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SRLSKLNTGFQLTLVTLCLFELAYFRFPYDLVDILIYLTAFTTVTSYLDYVWTWSRKAWS
HHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PKES
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036; 10889206 [H]