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The map label for this gene is nuoD

Identifier: 52842984

GI number: 52842984

Start: 3138559

End: 3139827

Strand: Reverse

Name: nuoD

Synonym: lpg2786

Alternate gene names: 52842984

Gene position: 3139827-3138559 (Counterclockwise)

Preceding gene: 52842985

Following gene: 52842983

Centisome position: 92.41

GC content: 41.29

Gene sequence:

>1269_bases
ATGAAGGTAGCAAAAATGATTGAACTTAAAAATTATACCTTGAATTTTGGCCCACAACATCCTGCTGCACATGGTGTTTT
AAGATTGGTTCTTGAGTTAGAGGGTGAAACTATCGTTCGTGCTGATCCACATATTGGATTGCTTCATCGTGCAACGGAAA
AATTGGCTGAGACCAAGCCTTACATTCAAAGCATTGGTTACATGGACAGATTAGATTACGTCTCAATGATGTGCAATGAG
CATGCTTATGTCATGGCGATTGAGAAATTATTGGGTATAGAACCGCCTTTGCGAGCCAAGTATATACGAACTATGTTTGA
TGAGGTGACTCGAATTCTGAACCATCTCTTGTGGTTAGGAGCTACTGCATTGGATATTGGTGCAATGACAGTGTTTCTTT
ATTGTTTCAGAGAGAGAGAAGATTTGTTTGATTGCTACGAGGCAGTTTCAGGAGCACGTATGCATGCTACCTACTATAGG
CCAGGAGGGGTAGCAAGAGACTTGCCAGATACTATGCCTCAATACAAACCGTCAAGATGGCATAGCGAAAGAGAGATTGA
AAAAAAGAATCACAATCGTCAGGGCAGTCTTTTGGATTTTCTTTGGGACTTTACTGAACGATTTCCCCACTGTGTGGATG
AATACGAAACATTGTTGACCGATAATCGTATATGGAAGCAACGTACTGTAGATATTGGTGTCGTTTCACCTGAAAATGCG
CTGCAATGGGGGTTTACCGGACCAATGTTAAGAGGCTCCGGTATTGCCTGGGATTTACGCAAGAAACAAAGCTATGCTGC
TTACGACAGGGTTGAATTTGATATTCCTGTTGGCAAGACAGGGGATTGTTATGATCGATATTTGGTAAGAGTCGAGGAAT
TGAGACAATCCAATCGAATTATAAGGCAATGTATTGAATGGTTGCGCAAGCATCCTGGTCCAGTAAAAGTCGATGATTAT
AAAGTGTCGCCTCCACGCCGTGTAGTAATGAAACATGACATGGAAGCATTAATTCATCACTTTAAATTATTTACCGAAGG
CTTTTGTTTACCGCGAGGTGAAGTTTATTCATCTGTTGAAGCGCCAAAGGGCGAGTTTGGGATCTATATGGTGTCAGATG
GAGCTAATAAACCTTACCGTCTGAAAATAAGAGCTCCAGGCTTTGCTCATTTATCAAGCTTTGATGATATGGTTAGAGGT
CACATGCTAGCTGATGGAGTGGCTATATTGGCAAGTCAAGATATAGTGTTTGGAGAAATTGATCGTTAA

Upstream 100 bases:

>100_bases
TATGATGCAAAACTGCAAAAGGTAATATATGCCCCTGTAGACATTGTGCCAAGAATTGTAGTTCCAAAGGTTATTCGTAA
CGATAACCGCTACATAGGTA

Downstream 100 bases:

>100_bases
TTTAACGACATGCTTGCTTAAAGTGTATTAAGAGATAATAAACGATATAAAGGTTTCGAAATGTCTGCTAATTCAGCAAA
AATATTAAGTCAATTGATGC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKVAKMIELKNYTLNFGPQHPAAHGVLRLVLELEGETIVRADPHIGLLHRATEKLAETKPYIQSIGYMDRLDYVSMMCNE
HAYVMAIEKLLGIEPPLRAKYIRTMFDEVTRILNHLLWLGATALDIGAMTVFLYCFREREDLFDCYEAVSGARMHATYYR
PGGVARDLPDTMPQYKPSRWHSEREIEKKNHNRQGSLLDFLWDFTERFPHCVDEYETLLTDNRIWKQRTVDIGVVSPENA
LQWGFTGPMLRGSGIAWDLRKKQSYAAYDRVEFDIPVGKTGDCYDRYLVRVEELRQSNRIIRQCIEWLRKHPGPVKVDDY
KVSPPRRVVMKHDMEALIHHFKLFTEGFCLPRGEVYSSVEAPKGEFGIYMVSDGANKPYRLKIRAPGFAHLSSFDDMVRG
HMLADGVAILASQDIVFGEIDR

Sequences:

>Translated_422_residues
MKVAKMIELKNYTLNFGPQHPAAHGVLRLVLELEGETIVRADPHIGLLHRATEKLAETKPYIQSIGYMDRLDYVSMMCNE
HAYVMAIEKLLGIEPPLRAKYIRTMFDEVTRILNHLLWLGATALDIGAMTVFLYCFREREDLFDCYEAVSGARMHATYYR
PGGVARDLPDTMPQYKPSRWHSEREIEKKNHNRQGSLLDFLWDFTERFPHCVDEYETLLTDNRIWKQRTVDIGVVSPENA
LQWGFTGPMLRGSGIAWDLRKKQSYAAYDRVEFDIPVGKTGDCYDRYLVRVEELRQSNRIIRQCIEWLRKHPGPVKVDDY
KVSPPRRVVMKHDMEALIHHFKLFTEGFCLPRGEVYSSVEAPKGEFGIYMVSDGANKPYRLKIRAPGFAHLSSFDDMVRG
HMLADGVAILASQDIVFGEIDR
>Mature_422_residues
MKVAKMIELKNYTLNFGPQHPAAHGVLRLVLELEGETIVRADPHIGLLHRATEKLAETKPYIQSIGYMDRLDYVSMMCNE
HAYVMAIEKLLGIEPPLRAKYIRTMFDEVTRILNHLLWLGATALDIGAMTVFLYCFREREDLFDCYEAVSGARMHATYYR
PGGVARDLPDTMPQYKPSRWHSEREIEKKNHNRQGSLLDFLWDFTERFPHCVDEYETLLTDNRIWKQRTVDIGVVSPENA
LQWGFTGPMLRGSGIAWDLRKKQSYAAYDRVEFDIPVGKTGDCYDRYLVRVEELRQSNRIIRQCIEWLRKHPGPVKVDDY
KVSPPRRVVMKHDMEALIHHFKLFTEGFCLPRGEVYSSVEAPKGEFGIYMVSDGANKPYRLKIRAPGFAHLSSFDDMVRG
HMLADGVAILASQDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=60.6280193236715, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=59.8039215686275, Blast_Score=496, Evalue=1e-140,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=38.2926829268293, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1789076, Length=422, Percent_Identity=28.1990521327014, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=26.4705882352941, Blast_Score=108, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17568379, Length=415, Percent_Identity=58.3132530120482, Blast_Score=493, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17555284, Length=415, Percent_Identity=58.7951807228916, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24638644, Length=414, Percent_Identity=59.1787439613527, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221459469, Length=409, Percent_Identity=54.0342298288509, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48736; Mature: 48736

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAKMIELKNYTLNFGPQHPAAHGVLRLVLELEGETIVRADPHIGLLHRATEKLAETKP
CCHHHHEECCCCEEECCCCCCHHHHHHHHHHEECCCEEEECCCCCHHHHHHHHHHHHCCH
YIQSIGYMDRLDYVSMMCNEHAYVMAIEKLLGIEPPLRAKYIRTMFDEVTRILNHLLWLG
HHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ATALDIGAMTVFLYCFREREDLFDCYEAVSGARMHATYYRPGGVARDLPDTMPQYKPSRW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHCCCCCCCCC
HSEREIEKKNHNRQGSLLDFLWDFTERFPHCVDEYETLLTDNRIWKQRTVDIGVVSPENA
CCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEEECCCCC
LQWGFTGPMLRGSGIAWDLRKKQSYAAYDRVEFDIPVGKTGDCYDRYLVRVEELRQSNRI
EECCCCCCCCCCCCCEEEHHHCCCHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
IRQCIEWLRKHPGPVKVDDYKVSPPRRVVMKHDMEALIHHFKLFTEGFCLPRGEVYSSVE
HHHHHHHHHCCCCCCEECCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCC
APKGEFGIYMVSDGANKPYRLKIRAPGFAHLSSFDDMVRGHMLADGVAILASQDIVFGEI
CCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHEEECCCEEEECC
DR
CC
>Mature Secondary Structure
MKVAKMIELKNYTLNFGPQHPAAHGVLRLVLELEGETIVRADPHIGLLHRATEKLAETKP
CCHHHHEECCCCEEECCCCCCHHHHHHHHHHEECCCEEEECCCCCHHHHHHHHHHHHCCH
YIQSIGYMDRLDYVSMMCNEHAYVMAIEKLLGIEPPLRAKYIRTMFDEVTRILNHLLWLG
HHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ATALDIGAMTVFLYCFREREDLFDCYEAVSGARMHATYYRPGGVARDLPDTMPQYKPSRW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHCCCCCCCCC
HSEREIEKKNHNRQGSLLDFLWDFTERFPHCVDEYETLLTDNRIWKQRTVDIGVVSPENA
CCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEEECCCCC
LQWGFTGPMLRGSGIAWDLRKKQSYAAYDRVEFDIPVGKTGDCYDRYLVRVEELRQSNRI
EECCCCCCCCCCCCCEEEHHHCCCHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
IRQCIEWLRKHPGPVKVDDYKVSPPRRVVMKHDMEALIHHFKLFTEGFCLPRGEVYSSVE
HHHHHHHHHCCCCCCEECCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCC
APKGEFGIYMVSDGANKPYRLKIRAPGFAHLSSFDDMVRGHMLADGVAILASQDIVFGEI
CCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHEEECCCEEEECC
DR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA