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The map label for this gene is nuoF

Identifier: 52842982

GI number: 52842982

Start: 3136699

End: 3137985

Strand: Reverse

Name: nuoF

Synonym: lpg2784

Alternate gene names: 52842982

Gene position: 3137985-3136699 (Counterclockwise)

Preceding gene: 52842983

Following gene: 52842981

Centisome position: 92.35

GC content: 42.89

Gene sequence:

>1287_bases
GTGTTTGCCATGGTTGAACTAAATCAAGTTTGTTACCGAACATTTCATTTACCAGAGTCCTGGTCGCTATCAACTTATGA
AAGTATTGGTGGCTATAGCGCATGGCGAAAAATTTTAAAAGAGCAAACATCACCTCAATTAATAATTGAAGAGTTGAAAA
CTTCTGCCTTGCGCGGACGAGGAGGGGCTGGATTCCCAACCGGTTTAAAATGGAGTTTTATGAATAGAAACTCCCCTGTT
CAAAAATACGTAGTATGTAATTCTGATGAAGGTGAACCGGGTACTTGTAAGGACAGAGAGATTCTTACTTTAAATCCTCA
CCAATTAATCGAAGGAATGGCCATAGCTGGGTATGTTATGGGCGCCACGGTTGGTTACAACTACATAAGAGGAGAATTCT
GGCTACCTTTTGAGCGTACTGAGGCTGCAATAAAAGAAGCATACGATGCTGGCTTGCTAGGTAAAAATATATTAGGCTCC
GGCTTTGATTTTGATTTATATAATCATTTAGGCGCTGGTGCTTACATTTGCGGTGAAGAAACTGCATTGCTTAACTCAAT
TGAAGGAAAAAAGGGAATGCCTCGTTTTAAACCACCATTCCCGGCAAATTATGGCTTGTATGGTAAACCGACAACCATAA
ATAACACGGAAACATTTGCGTCTGTTCCGGTTATTATGGAAAAAGGTGGAGAATGGTTTTTAAAATTAGGTAAACCGAAC
AATGGCGGTGCCAAATGCTTTAGTGTTAGCGGCCATGTTAACAAACCTGGTAACTATGAAATTCCCTTGGGCACGCCATT
CAAAACGCTACTTGATCTGGCTGGCGGCGTGATTAAAGGCCGAAAAATCAAAGCCGTGATTCCTGGTGGTTCCTCTATGC
CAGTGCTCCCAGGCGACGTCATGCTGGGGCTGGATATGGATTATGACAGTATACAGAAAGCCGGCTCAGGCTTGGGTTCA
GGCGCAGTCATTATCATGGATGAAACCACCTGCATGGTGGATGCTTTGTATCGTATTTCTGAGTTCTACATGGATGAATC
CTGTGGACAATGCACACCTTGTCGGGAAGGCACAGGTTGGTTAGTCAGGTTATTACACAGAATTATAAACGGTCATGGCG
AGCCGGGAGACGTGGAGAAATTAGTGAATGTGGCGAATAACATAGAGGGAAGAACCATTTGTGCATTAGGCGAGGCAGCA
GCTTGGCCAGTACAGAGTTTTGTTAAACATTTCTATGATGAATTTGAATATTTCATAAAGCATAAACGCTCGATCGTCGC
AGCATAA

Upstream 100 bases:

>100_bases
TGTGAATGCGCCAATGATGCAAGTTGATAAAGATTATCACGAAAATTTGACTGCTGAATCTATAGATAAAGTATTGGAAC
AGTACCAATAGAAAATAAAG

Downstream 100 bases:

>100_bases
TTAAGAAGGTTAGACCATGGCTACTATTGAAATCGACGGTAAAACATTTGAAGCAGAAAACGGTAAAATGATTATAGAGG
TTGCTGATGAGGCTGGCATC

Product: NADH dehydrogenase I, F subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MFAMVELNQVCYRTFHLPESWSLSTYESIGGYSAWRKILKEQTSPQLIIEELKTSALRGRGGAGFPTGLKWSFMNRNSPV
QKYVVCNSDEGEPGTCKDREILTLNPHQLIEGMAIAGYVMGATVGYNYIRGEFWLPFERTEAAIKEAYDAGLLGKNILGS
GFDFDLYNHLGAGAYICGEETALLNSIEGKKGMPRFKPPFPANYGLYGKPTTINNTETFASVPVIMEKGGEWFLKLGKPN
NGGAKCFSVSGHVNKPGNYEIPLGTPFKTLLDLAGGVIKGRKIKAVIPGGSSMPVLPGDVMLGLDMDYDSIQKAGSGLGS
GAVIIMDETTCMVDALYRISEFYMDESCGQCTPCREGTGWLVRLLHRIINGHGEPGDVEKLVNVANNIEGRTICALGEAA
AWPVQSFVKHFYDEFEYFIKHKRSIVAA

Sequences:

>Translated_428_residues
MFAMVELNQVCYRTFHLPESWSLSTYESIGGYSAWRKILKEQTSPQLIIEELKTSALRGRGGAGFPTGLKWSFMNRNSPV
QKYVVCNSDEGEPGTCKDREILTLNPHQLIEGMAIAGYVMGATVGYNYIRGEFWLPFERTEAAIKEAYDAGLLGKNILGS
GFDFDLYNHLGAGAYICGEETALLNSIEGKKGMPRFKPPFPANYGLYGKPTTINNTETFASVPVIMEKGGEWFLKLGKPN
NGGAKCFSVSGHVNKPGNYEIPLGTPFKTLLDLAGGVIKGRKIKAVIPGGSSMPVLPGDVMLGLDMDYDSIQKAGSGLGS
GAVIIMDETTCMVDALYRISEFYMDESCGQCTPCREGTGWLVRLLHRIINGHGEPGDVEKLVNVANNIEGRTICALGEAA
AWPVQSFVKHFYDEFEYFIKHKRSIVAA
>Mature_428_residues
MFAMVELNQVCYRTFHLPESWSLSTYESIGGYSAWRKILKEQTSPQLIIEELKTSALRGRGGAGFPTGLKWSFMNRNSPV
QKYVVCNSDEGEPGTCKDREILTLNPHQLIEGMAIAGYVMGATVGYNYIRGEFWLPFERTEAAIKEAYDAGLLGKNILGS
GFDFDLYNHLGAGAYICGEETALLNSIEGKKGMPRFKPPFPANYGLYGKPTTINNTETFASVPVIMEKGGEWFLKLGKPN
NGGAKCFSVSGHVNKPGNYEIPLGTPFKTLLDLAGGVIKGRKIKAVIPGGSSMPVLPGDVMLGLDMDYDSIQKAGSGLGS
GAVIIMDETTCMVDALYRISEFYMDESCGQCTPCREGTGWLVRLLHRIINGHGEPGDVEKLVNVANNIEGRTICALGEAA
AWPVQSFVKHFYDEFEYFIKHKRSIVAA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=400, Percent_Identity=52.75, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI260656005, Length=400, Percent_Identity=52.75, Blast_Score=427, Evalue=1e-119,
Organism=Escherichia coli, GI1788620, Length=402, Percent_Identity=46.2686567164179, Blast_Score=357, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17531727, Length=372, Percent_Identity=53.494623655914, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI19920794, Length=372, Percent_Identity=52.6881720430108, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45550452, Length=406, Percent_Identity=48.0295566502463, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24653819, Length=410, Percent_Identity=36.5853658536585, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24653817, Length=352, Percent_Identity=37.2159090909091, Blast_Score=249, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 46853; Mature: 46853

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAMVELNQVCYRTFHLPESWSLSTYESIGGYSAWRKILKEQTSPQLIIEELKTSALRGR
CEEEEHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
GGAGFPTGLKWSFMNRNSPVQKYVVCNSDEGEPGTCKDREILTLNPHQLIEGMAIAGYVM
CCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
GATVGYNYIRGEFWLPFERTEAAIKEAYDAGLLGKNILGSGFDFDLYNHLGAGAYICGEE
HHHHCCCEECCCEECCHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHCCCCEEEECCH
TALLNSIEGKKGMPRFKPPFPANYGLYGKPTTINNTETFASVPVIMEKGGEWFLKLGKPN
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEECCCEEEEEECCCC
NGGAKCFSVSGHVNKPGNYEIPLGTPFKTLLDLAGGVIKGRKIKAVIPGGSSMPVLPGDV
CCCCEEEEECCCCCCCCCEECCCCCCHHHHHHHHCCEECCCEEEEEECCCCCCCCCCCCE
MLGLDMDYDSIQKAGSGLGSGAVIIMDETTCMVDALYRISEFYMDESCGQCTPCREGTGW
EEEECCCHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
LVRLLHRIINGHGEPGDVEKLVNVANNIEGRTICALGEAAAWPVQSFVKHFYDEFEYFIK
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
HKRSIVAA
HHHHHCCC
>Mature Secondary Structure
MFAMVELNQVCYRTFHLPESWSLSTYESIGGYSAWRKILKEQTSPQLIIEELKTSALRGR
CEEEEHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
GGAGFPTGLKWSFMNRNSPVQKYVVCNSDEGEPGTCKDREILTLNPHQLIEGMAIAGYVM
CCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
GATVGYNYIRGEFWLPFERTEAAIKEAYDAGLLGKNILGSGFDFDLYNHLGAGAYICGEE
HHHHCCCEECCCEECCHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHCCCCEEEECCH
TALLNSIEGKKGMPRFKPPFPANYGLYGKPTTINNTETFASVPVIMEKGGEWFLKLGKPN
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEECCCEEEEEECCCC
NGGAKCFSVSGHVNKPGNYEIPLGTPFKTLLDLAGGVIKGRKIKAVIPGGSSMPVLPGDV
CCCCEEEEECCCCCCCCCEECCCCCCHHHHHHHHCCEECCCEEEEEECCCCCCCCCCCCE
MLGLDMDYDSIQKAGSGLGSGAVIIMDETTCMVDALYRISEFYMDESCGQCTPCREGTGW
EEEECCCHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
LVRLLHRIINGHGEPGDVEKLVNVANNIEGRTICALGEAAAWPVQSFVKHFYDEFEYFIK
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
HKRSIVAA
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA