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The map label for this gene is dnaZX

Identifier: 52842953

GI number: 52842953

Start: 3103406

End: 3105076

Strand: Direct

Name: dnaZX

Synonym: lpg2754

Alternate gene names: 52842953

Gene position: 3103406-3105076 (Clockwise)

Preceding gene: 52842952

Following gene: 52842954

Centisome position: 91.34

GC content: 40.57

Gene sequence:

>1671_bases
ATGAGCTATCTGGCACTTGCCCGTAAATGGCGACCACGCACATTTTCCCAACTGGTTGGCCAAGAGCATATTAATAAAGC
ACTGATCAACGCGCTGAATCAACAACGTTTGCATCATGCTTATCTATTTACTGGTACTCGCGGGGTCGGGAAAACCAGTG
TTGCCCGTATTTTAGCTAAAGCCCTCAATTGTGAAAAAGGCATCACTTCAGAACCATGCCTTCATTGCGATACCTGTATT
GCCATTGAGCAAGGCCGTTATATTGATCTCATTGAAATAGACGGAGCCTCCAAAACCAGAGTTGAGGACACGCGAGATTT
ACTTGACAACATACAATATGCACCGACAAATGGCCGTTTTAAAGTTTATCTAATTGATGAAGTGCATATGCTATCCCAAC
ATAGCTTTAATGCTTTACTAAAAACATTAGAAGAACCGCCTTCACATGTAAAATTTATTCTGGCAACGACTGACCCACAA
AAATTACCTGTTACTGTCTTATCGCGTTGTTTGCAATTTAATCTAAAACACTTGCCTGCTGAGTTGATAAATCAACAATT
GCAATTAATTCTCCAAGAGGAGCGCTTGGATTTTGAAATACAAGCGCTAGACATATTAGCTCAGGCTGCCCGCGGAAGCA
TGCGCGATGCATTAAGTTTATTGGATCAGGCCATTACCAGTTGTGAAACGAAATTACTGGCAAGTGATGTAAAAATGCTC
TTGGGACATACCCAACAAGATTACGCGTTGCTGCTCTTGCAAGCCCTGGCAAAGCAAGAAGCGCCAATCATGCTTGTATT
AAGTCAGCAAATCATTGCCGAAGGAGGGAATTTTCAATACGTTCTTGATGAAATACTTAGCTATCTGCATCAAATTACCG
TATATCAATGCCTGGGCGACAACAATCCATTAATTAGTCCAAAAGCAGAAATTAAAGAATTAGCAAAACAGTTTTCGGCC
GCGGACACACAATTATTCTATCAAATAGGTATTAAGGGACGTGAGGAGATGCATCTCGCCCCTACACTGGCCATTGGCTT
TAATATGACCATGCTGCGCATGTATACCTTTAAACCAGCTTCTCATGTAACAACACCTCCATTAGCATTCGAGCAAAATA
ATAAAACATGCTCACTAATTGTTGATGATAATACACCAGCGCAAAACCCTATTGGAATTGAACCAATACCCGTTATTAAA
GCGACGGACAACACCGTTGCCTATCAGCAGACCCAATCATTATCAACAGACGATAAAAAATCTGCTAACTCTGGTGAGTC
CATGAGCTGTGACTGGAACGAAATAATACCACAGTTAAAATTATCGGGTTTAGCACTTAATGCCATAGAAAATGCAGAAT
TTCTTGGTAAAAAAGAGCGAGAAATTACATTCGGAGTACATAAAGGTCACCAGTCCTTATTCACCCCCACAACAATTAAC
CGAATTGAAACCGCATTGGCTGGTTATTATAAAAGCCCAGTAAAAATTATTTTAAACACTCAAGATGCCGTGCATGCCTC
TCCAGCTCAACAAAAAGAGAAAGCTAGCCAAGAAAAGCTAGAACAAGCAGAGGCAGCATTACACGCTGACCCAGTATTTC
AACAGTTGCAACAAGAATTTTCAGCAGAATTGGTCAAAAATTCTATTGTCCTGTTAAAAGATGACTTATAA

Upstream 100 bases:

>100_bases
GATTGTGAACCCCGTCAGGCCCGGAAGGGAGCAGCGGTAGCAGTTGATGCGGGCGCCGGGGTGTGGCTCTTAGAGTCGCC
GCCCAACTTGTGAAACACGT

Downstream 100 bases:

>100_bases
TACTTAAACTAACCATAAATAGACGAGGCTGTAATGGATATTAATCAAAATTTAGGCAATTTAATGAAAGAAGCGCAAAA
AATGCAACAACGTATGCAAG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MSYLALARKWRPRTFSQLVGQEHINKALINALNQQRLHHAYLFTGTRGVGKTSVARILAKALNCEKGITSEPCLHCDTCI
AIEQGRYIDLIEIDGASKTRVEDTRDLLDNIQYAPTNGRFKVYLIDEVHMLSQHSFNALLKTLEEPPSHVKFILATTDPQ
KLPVTVLSRCLQFNLKHLPAELINQQLQLILQEERLDFEIQALDILAQAARGSMRDALSLLDQAITSCETKLLASDVKML
LGHTQQDYALLLLQALAKQEAPIMLVLSQQIIAEGGNFQYVLDEILSYLHQITVYQCLGDNNPLISPKAEIKELAKQFSA
ADTQLFYQIGIKGREEMHLAPTLAIGFNMTMLRMYTFKPASHVTTPPLAFEQNNKTCSLIVDDNTPAQNPIGIEPIPVIK
ATDNTVAYQQTQSLSTDDKKSANSGESMSCDWNEIIPQLKLSGLALNAIENAEFLGKKEREITFGVHKGHQSLFTPTTIN
RIETALAGYYKSPVKIILNTQDAVHASPAQQKEKASQEKLEQAEAALHADPVFQQLQQEFSAELVKNSIVLLKDDL

Sequences:

>Translated_556_residues
MSYLALARKWRPRTFSQLVGQEHINKALINALNQQRLHHAYLFTGTRGVGKTSVARILAKALNCEKGITSEPCLHCDTCI
AIEQGRYIDLIEIDGASKTRVEDTRDLLDNIQYAPTNGRFKVYLIDEVHMLSQHSFNALLKTLEEPPSHVKFILATTDPQ
KLPVTVLSRCLQFNLKHLPAELINQQLQLILQEERLDFEIQALDILAQAARGSMRDALSLLDQAITSCETKLLASDVKML
LGHTQQDYALLLLQALAKQEAPIMLVLSQQIIAEGGNFQYVLDEILSYLHQITVYQCLGDNNPLISPKAEIKELAKQFSA
ADTQLFYQIGIKGREEMHLAPTLAIGFNMTMLRMYTFKPASHVTTPPLAFEQNNKTCSLIVDDNTPAQNPIGIEPIPVIK
ATDNTVAYQQTQSLSTDDKKSANSGESMSCDWNEIIPQLKLSGLALNAIENAEFLGKKEREITFGVHKGHQSLFTPTTIN
RIETALAGYYKSPVKIILNTQDAVHASPAQQKEKASQEKLEQAEAALHADPVFQQLQQEFSAELVKNSIVLLKDDL
>Mature_555_residues
SYLALARKWRPRTFSQLVGQEHINKALINALNQQRLHHAYLFTGTRGVGKTSVARILAKALNCEKGITSEPCLHCDTCIA
IEQGRYIDLIEIDGASKTRVEDTRDLLDNIQYAPTNGRFKVYLIDEVHMLSQHSFNALLKTLEEPPSHVKFILATTDPQK
LPVTVLSRCLQFNLKHLPAELINQQLQLILQEERLDFEIQALDILAQAARGSMRDALSLLDQAITSCETKLLASDVKMLL
GHTQQDYALLLLQALAKQEAPIMLVLSQQIIAEGGNFQYVLDEILSYLHQITVYQCLGDNNPLISPKAEIKELAKQFSAA
DTQLFYQIGIKGREEMHLAPTLAIGFNMTMLRMYTFKPASHVTTPPLAFEQNNKTCSLIVDDNTPAQNPIGIEPIPVIKA
TDNTVAYQQTQSLSTDDKKSANSGESMSCDWNEIIPQLKLSGLALNAIENAEFLGKKEREITFGVHKGHQSLFTPTTINR
IETALAGYYKSPVKIILNTQDAVHASPAQQKEKASQEKLEQAEAALHADPVFQQLQQEFSAELVKNSIVLLKDDL

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=294, Percent_Identity=24.1496598639456, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194306571, Length=292, Percent_Identity=23.972602739726, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194306567, Length=292, Percent_Identity=23.972602739726, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786676, Length=370, Percent_Identity=55.9459459459459, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1787341, Length=146, Percent_Identity=30.8219178082192, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71986063, Length=339, Percent_Identity=21.5339233038348, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554730, Length=220, Percent_Identity=27.7272727272727, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=232, Percent_Identity=26.2931034482759, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 62019; Mature: 61888

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLALARKWRPRTFSQLVGQEHINKALINALNQQRLHHAYLFTGTRGVGKTSVARILAK
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHH
ALNCEKGITSEPCLHCDTCIAIEQGRYIDLIEIDGASKTRVEDTRDLLDNIQYAPTNGRF
HHCCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCEECCCCCCE
KVYLIDEVHMLSQHSFNALLKTLEEPPSHVKFILATTDPQKLPVTVLSRCLQFNLKHLPA
EEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCH
ELINQQLQLILQEERLDFEIQALDILAQAARGSMRDALSLLDQAITSCETKLLASDVKML
HHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGHTQQDYALLLLQALAKQEAPIMLVLSQQIIAEGGNFQYVLDEILSYLHQITVYQCLGD
HCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECC
NNPLISPKAEIKELAKQFSAADTQLFYQIGIKGREEMHLAPTLAIGFNMTMLRMYTFKPA
CCCCCCCHHHHHHHHHHHCCHHHHEEEEECCCCCCCEEECEEEEECCCEEEEEEEEECCC
SHVTTPPLAFEQNNKTCSLIVDDNTPAQNPIGIEPIPVIKATDNTVAYQQTQSLSTDDKK
CCCCCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEHHHHHCCCCCCCC
SANSGESMSCDWNEIIPQLKLSGLALNAIENAEFLGKKEREITFGVHKGHQSLFTPTTIN
CCCCCCCCCCCHHHHHHHHHHCCEEEHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHH
RIETALAGYYKSPVKIILNTQDAVHASPAQQKEKASQEKLEQAEAALHADPVFQQLQQEF
HHHHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SAELVKNSIVLLKDDL
HHHHHHCCEEEEECCC
>Mature Secondary Structure 
SYLALARKWRPRTFSQLVGQEHINKALINALNQQRLHHAYLFTGTRGVGKTSVARILAK
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHH
ALNCEKGITSEPCLHCDTCIAIEQGRYIDLIEIDGASKTRVEDTRDLLDNIQYAPTNGRF
HHCCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCEECCCCCCE
KVYLIDEVHMLSQHSFNALLKTLEEPPSHVKFILATTDPQKLPVTVLSRCLQFNLKHLPA
EEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCH
ELINQQLQLILQEERLDFEIQALDILAQAARGSMRDALSLLDQAITSCETKLLASDVKML
HHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGHTQQDYALLLLQALAKQEAPIMLVLSQQIIAEGGNFQYVLDEILSYLHQITVYQCLGD
HCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECC
NNPLISPKAEIKELAKQFSAADTQLFYQIGIKGREEMHLAPTLAIGFNMTMLRMYTFKPA
CCCCCCCHHHHHHHHHHHCCHHHHEEEEECCCCCCCEEECEEEEECCCEEEEEEEEECCC
SHVTTPPLAFEQNNKTCSLIVDDNTPAQNPIGIEPIPVIKATDNTVAYQQTQSLSTDDKK
CCCCCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEHHHHHCCCCCCCC
SANSGESMSCDWNEIIPQLKLSGLALNAIENAEFLGKKEREITFGVHKGHQSLFTPTTIN
CCCCCCCCCCCHHHHHHHHHHCCEEEHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHH
RIETALAGYYKSPVKIILNTQDAVHASPAQQKEKASQEKLEQAEAALHADPVFQQLQQEF
HHHHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SAELVKNSIVLLKDDL
HHHHHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]