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The map label for this gene is nahM [H]

Identifier: 52842887

GI number: 52842887

Start: 3028993

End: 3029880

Strand: Direct

Name: nahM [H]

Synonym: lpg2681

Alternate gene names: 52842887

Gene position: 3028993-3029880 (Clockwise)

Preceding gene: 52842886

Following gene: 52842888

Centisome position: 89.15

GC content: 36.26

Gene sequence:

>888_bases
ATGAATCCTGTATCGATTTTAGATGCCTCATTAAGAGATGGTGGACATAGAACTAATTTTCATTTTAAGGATGATGATTT
AAAAAAAATACTACTTCCTCTTGATAACTCAGGTATTGAATACATTGAAATTGGCTACCGTAATGGTTCACTTCACCCTA
TTGAAAATATAGGGAAAGCTGGAATGTGTCCCCAAGATTATCTCCTGTATTGCCAATCTCTAATAAAAAAAGCAAAAATT
GCAGTGATGGTTCATCCTCATAATGTAAACGAACAGGATCTGTTCGAGCTAAAAAATTGCGGTGTGAAATTAATAAGAAT
ATGTATAGCAAAAGGTGATCTGGTAAATGCTGTCCCTCTGATTAAACTGGCTAAGAATTTGAATTTTGAAACCTCAGTGA
ACATCATCCATATTTCTTATTATACGGAAAGCGAACTGGATAGTTTGATTGAGGAAGTAAGCGAACACGAACCGGATATG
ATCTATTTTGCTGATTCTAATGGAAGCTTATTTCCTGACAGGATAAATTGCCTGTATAAAAAATACACCCGTCAATATAA
AGTTTCTTTTGGATTTCATGCTCATGATAACCTTGGATTGGCGCAAGCCAACGCTCTTGCGGCGGTAAACGCCGGGGTTC
ATTTTATTGATGCCTCACTGGCAGGAATGGGCAAGGGAACAGGTAATCTAAAAACTGAATTTTTTATCGCTTATTTACAT
GCGAACAATATAAAAAAATACAATTTGGAAGATGTGTTGACAGCAGCTAATTATGTAAGAGATGCCTTGAAAATAGGACA
AGAACCTATTGAAATGAGTGAATTCATAAGGGGAATTTCTGATCTGTCTACAGCAGACCTGAAAAGCTATAAACCAGGCA
AGCTCTAG

Upstream 100 bases:

>100_bases
GCTTAATTGAACAACATATTGAACATGCTCATTTTGCAAGTGGTCTTTTAAAGTTTATACTTAATAATAATGAGGTTAAA
TTATTATTACGAGGTATTAA

Downstream 100 bases:

>100_bases
AAAATGCTTATATTTCCAATATAGGAATATAAGGCTGGGACACCTTGATTCCCCAAGATTTGATGCTCCAGAAAGCAACG
TACTTTCAAAATTAAGCTGG

Product: 4-hydroxy-2-oxovalerate aldolase

Products: NA

Alternate protein names: HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MNPVSILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYRNGSLHPIENIGKAGMCPQDYLLYCQSLIKKAKI
AVMVHPHNVNEQDLFELKNCGVKLIRICIAKGDLVNAVPLIKLAKNLNFETSVNIIHISYYTESELDSLIEEVSEHEPDM
IYFADSNGSLFPDRINCLYKKYTRQYKVSFGFHAHDNLGLAQANALAAVNAGVHFIDASLAGMGKGTGNLKTEFFIAYLH
ANNIKKYNLEDVLTAANYVRDALKIGQEPIEMSEFIRGISDLSTADLKSYKPGKL

Sequences:

>Translated_295_residues
MNPVSILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYRNGSLHPIENIGKAGMCPQDYLLYCQSLIKKAKI
AVMVHPHNVNEQDLFELKNCGVKLIRICIAKGDLVNAVPLIKLAKNLNFETSVNIIHISYYTESELDSLIEEVSEHEPDM
IYFADSNGSLFPDRINCLYKKYTRQYKVSFGFHAHDNLGLAQANALAAVNAGVHFIDASLAGMGKGTGNLKTEFFIAYLH
ANNIKKYNLEDVLTAANYVRDALKIGQEPIEMSEFIRGISDLSTADLKSYKPGKL
>Mature_295_residues
MNPVSILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYRNGSLHPIENIGKAGMCPQDYLLYCQSLIKKAKI
AVMVHPHNVNEQDLFELKNCGVKLIRICIAKGDLVNAVPLIKLAKNLNFETSVNIIHISYYTESELDSLIEEVSEHEPDM
IYFADSNGSLFPDRINCLYKKYTRQYKVSFGFHAHDNLGLAQANALAAVNAGVHFIDASLAGMGKGTGNLKTEFFIAYLH
ANNIKKYNLEDVLTAANYVRDALKIGQEPIEMSEFIRGISDLSTADLKSYKPGKL

Specific function: Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4-hydroxy-2-oxovalerate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1786548, Length=235, Percent_Identity=29.7872340425532, Blast_Score=81, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017629
- InterPro:   IPR013785
- InterPro:   IPR012425
- InterPro:   IPR000891
- ProDom:   PD005364 [H]

Pfam domain/function: PF07836 DmpG_comm; PF00682 HMGL-like [H]

EC number: =4.1.3.39 [H]

Molecular weight: Translated: 32926; Mature: 32926

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPVSILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYRNGSLHPIENIGKA
CCCHHHEEHHHCCCCCCCCCCCCCCCHHEEEEECCCCCCEEEEEECCCCCCCCHHHCCCC
GMCPQDYLLYCQSLIKKAKIAVMVHPHNVNEQDLFELKNCGVKLIRICIAKGDLVNAVPL
CCCHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHH
IKLAKNLNFETSVNIIHISYYTESELDSLIEEVSEHEPDMIYFADSNGSLFPDRINCLYK
HHHHHCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
KYTRQYKVSFGFHAHDNLGLAQANALAAVNAGVHFIDASLAGMGKGTGNLKTEFFIAYLH
HHHHHEEEEECEECCCCCCHHHHHHHHHHHCCEEEEEHHHHCCCCCCCCCCEEEEEEEEE
ANNIKKYNLEDVLTAANYVRDALKIGQEPIEMSEFIRGISDLSTADLKSYKPGKL
ECCCCEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCCCCCC
>Mature Secondary Structure
MNPVSILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYRNGSLHPIENIGKA
CCCHHHEEHHHCCCCCCCCCCCCCCCHHEEEEECCCCCCEEEEEECCCCCCCCHHHCCCC
GMCPQDYLLYCQSLIKKAKIAVMVHPHNVNEQDLFELKNCGVKLIRICIAKGDLVNAVPL
CCCHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHH
IKLAKNLNFETSVNIIHISYYTESELDSLIEEVSEHEPDMIYFADSNGSLFPDRINCLYK
HHHHHCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
KYTRQYKVSFGFHAHDNLGLAQANALAAVNAGVHFIDASLAGMGKGTGNLKTEFFIAYLH
HHHHHEEEEECEECCCCCCHHHHHHHHHHHCCEEEEEHHHHCCCCCCCCCCEEEEEEEEE
ANNIKKYNLEDVLTAANYVRDALKIGQEPIEMSEFIRGISDLSTADLKSYKPGKL
ECCCCEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA