Click here to switch to the map view.

The map label for this gene is panB

Identifier: 52842867

GI number: 52842867

Start: 3008661

End: 3009527

Strand: Direct

Name: panB

Synonym: lpg2661

Alternate gene names: 52842867

Gene position: 3008661-3009527 (Clockwise)

Preceding gene: 52842862

Following gene: 52842868

Centisome position: 88.55

GC content: 42.21

Gene sequence:

>867_bases
TTGATCCATGAGACAGGTACCTGTATTACCATCATTCTTATCTATTCCAGGCGCATTCTCCTATTCAGGGAGAACGGCAT
GAAAATCCATGATTTTAAAATAAAAAAGCAGGAACAAAAGAAAATTTCCATGTTGACCTGTTACGATTACCCTTCAGCAT
GCATAGTAGCAGAATCAAATATCGATTGTGTTCTCGTGGGTGATTCCGTAGCTATGGCAGTGCACGGCCACCCTACAACC
ATTATGGCCACTATCGAAATGATGGAATTACATACCCAGGCAGTAGCTCGTGGTTTAGGCAAACAGTTTTTGATTACTGA
CTTACCTTTTCTCGGACATAAATCATCTCAAGGTCATACAGTAGAAAACGTAAAAAGGCTGTTACAGGCTGGAGCCCAAG
CAGTTAAAATCGAGGGCGCTGATAAAGACACCTGCCAAACGATTTCCCATTTAGTTAATGCCGGCATCCCTGTTATGGGT
CATATCGGCTTAACTCCCCAATCCATTCATCAATTAGGCGGTTATAAAGTCCAGGGAAAAAACAGCGAACAGGCAGAAAC
TCTATTACAACAGGCAGCCACCCTGGAACAAGCCGGCTGCTTTGCGGTAGTTATTGAATGTGTTCCGCAGGAGCTGGCAA
AAACGATTACCGATTCGTTAGTTATTCCTACTATAGGAATTGGCGCAGGCCCAGGAACTGATGGGCAAGTCCTTGTCTGG
CACGATATGCTAGGTTTACAGACTTCATTTAATCCTAAATTTGTAAAAAAATATTTTAGAGCCAAAGACCATTTTATTGA
AGCCTTAAACAGCTATGTCCAGCAAGTACAACAAATGCATTTCCCAGCTAATGAACATTCTTTCTAG

Upstream 100 bases:

>100_bases
TTAGGCTATTATAGCAATGGATGCGTTGACCCCCAATAGACCTTTTGTATATCTGGTTTATTTTGTTGGCAGCGACTTTT
ATTGACCTTCAGAGGAGGAC

Downstream 100 bases:

>100_bases
GAAAATTATCCATGCAAATTTTTCATAATTTAAATGAGTGGATTCACTTTAGAAACACCCTGTCCCCTGATTTATCCCTG
GGGTTTGCTCCAACTATGGG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MIHETGTCITIILIYSRRILLFRENGMKIHDFKIKKQEQKKISMLTCYDYPSACIVAESNIDCVLVGDSVAMAVHGHPTT
IMATIEMMELHTQAVARGLGKQFLITDLPFLGHKSSQGHTVENVKRLLQAGAQAVKIEGADKDTCQTISHLVNAGIPVMG
HIGLTPQSIHQLGGYKVQGKNSEQAETLLQQAATLEQAGCFAVVIECVPQELAKTITDSLVIPTIGIGAGPGTDGQVLVW
HDMLGLQTSFNPKFVKKYFRAKDHFIEALNSYVQQVQQMHFPANEHSF

Sequences:

>Translated_288_residues
MIHETGTCITIILIYSRRILLFRENGMKIHDFKIKKQEQKKISMLTCYDYPSACIVAESNIDCVLVGDSVAMAVHGHPTT
IMATIEMMELHTQAVARGLGKQFLITDLPFLGHKSSQGHTVENVKRLLQAGAQAVKIEGADKDTCQTISHLVNAGIPVMG
HIGLTPQSIHQLGGYKVQGKNSEQAETLLQQAATLEQAGCFAVVIECVPQELAKTITDSLVIPTIGIGAGPGTDGQVLVW
HDMLGLQTSFNPKFVKKYFRAKDHFIEALNSYVQQVQQMHFPANEHSF
>Mature_288_residues
MIHETGTCITIILIYSRRILLFRENGMKIHDFKIKKQEQKKISMLTCYDYPSACIVAESNIDCVLVGDSVAMAVHGHPTT
IMATIEMMELHTQAVARGLGKQFLITDLPFLGHKSSQGHTVENVKRLLQAGAQAVKIEGADKDTCQTISHLVNAGIPVMG
HIGLTPQSIHQLGGYKVQGKNSEQAETLLQQAATLEQAGCFAVVIECVPQELAKTITDSLVIPTIGIGAGPGTDGQVLVW
HDMLGLQTSFNPKFVKKYFRAKDHFIEALNSYVQQVQQMHFPANEHSF

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=253, Percent_Identity=43.4782608695652, Blast_Score=218, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6319653, Length=284, Percent_Identity=39.0845070422535, Blast_Score=196, Evalue=4e-51,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 31650; Mature: 31650

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHETGTCITIILIYSRRILLFRENGMKIHDFKIKKQEQKKISMLTCYDYPSACIVAESN
CCCCCCHHHHHHHHHHCEEEEEECCCCEEEEEECCHHHHHHEEEEEEECCCCEEEEEECC
IDCVLVGDSVAMAVHGHPTTIMATIEMMELHTQAVARGLGKQFLITDLPFLGHKSSQGHT
CCEEEECCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCEEEHHCCCCCCCCCCCCCC
VENVKRLLQAGAQAVKIEGADKDTCQTISHLVNAGIPVMGHIGLTPQSIHQLGGYKVQGK
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCEEEECC
NSEQAETLLQQAATLEQAGCFAVVIECVPQELAKTITDSLVIPTIGIGAGPGTDGQVLVW
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEECEEECCCCCCCCCCEEEE
HDMLGLQTSFNPKFVKKYFRAKDHFIEALNSYVQQVQQMHFPANEHSF
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIHETGTCITIILIYSRRILLFRENGMKIHDFKIKKQEQKKISMLTCYDYPSACIVAESN
CCCCCCHHHHHHHHHHCEEEEEECCCCEEEEEECCHHHHHHEEEEEEECCCCEEEEEECC
IDCVLVGDSVAMAVHGHPTTIMATIEMMELHTQAVARGLGKQFLITDLPFLGHKSSQGHT
CCEEEECCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCEEEHHCCCCCCCCCCCCCC
VENVKRLLQAGAQAVKIEGADKDTCQTISHLVNAGIPVMGHIGLTPQSIHQLGGYKVQGK
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCEEEECC
NSEQAETLLQQAATLEQAGCFAVVIECVPQELAKTITDSLVIPTIGIGAGPGTDGQVLVW
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEECEEECCCCCCCCCCEEEE
HDMLGLQTSFNPKFVKKYFRAKDHFIEALNSYVQQVQQMHFPANEHSF
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA